Collaboration with other CHSCC

 

Cooperative Centers of Excellence in Hematology website: cceh

 

CCEH Meet-the-Expert Virtual Seminar Series  Seminar Flyer

 

Sept 1, 2021, Jodie Babitt, MD, Harvard/Mass General Hospital, “New insights into hepcidin regulation and systemic iron homeostasis” video link

 

July 7, 2021, Roland Lill, PhD, University of Marburg, “Biogenesis of Iron-Sulfur proteins in eukaryotes: Mitochondria, Mitosomes, Mechanisms, and Maladies” video link

 

May 5, 2021, Shangqin Guo, Ph.D. Yale, “Reading live cell cycle speed by fluorescence”  video link

 

Mar 3, 2021, Mohandas Narla, M.D. New York Blood Center, “Normal and Disordered Human Erythropoiesis”  video link

 

 

Feb 3, 2021 Stephanie Halene, M.D. PhD. Yale, “Humanized Mouse Models for the Study of Hematopoiesis in Health and Disease” video link

 

 

The CCEH program supports pilot and feasibility program grants funding small projects aimed at generating preliminary data for inclusion in larger grant applications as well as short-term enrichment activities to learn new techniques. The grants will be awarded competitively and are designed to support collaborative research projects that utilize core resources at one of the five CCEH centers.

Current CCEH P&F Projects and application form  link. To read the abstracts for these projects, please click here.

Current CCEH P&F Projects

Title

PI, Key Personnel, Mentor, etc.

Investigator institutions

Center/Core(s) to Be Used

At Center/Core Institutions

Resolving a controversy about the bone marrow hematopoitic niche

Konstantinos Kokkaliaris, PI David T. Scadden, mentor

Harvard

Viral Vectors & Gene Editing tools (Hutch); Mouse Embryonic Stem (ES) Cell and Gene Targeting Core (Boston)

Fred Hutch, boston Children’s Hospital

Modeling a-thalassemia using HiPSCs to investigate the role of telomere cohesion on aglobin expression

Mahest Rammamoothy and Merlin Nithya Gnanapragasam, MPI

Cleveland State University

Stem Cell Core Facility

Boston Children’s Hospital

HMGA1 Chromatin Regulators in Regenative Capacity of human Hematopoietic Stem Cells

Linda M. S. Resar, PI

Johns Hopkins University School of Medicine

Engineering of primary human CD34+ cells

Yale University

The Role of Intercellular Communication between Bone Marrow Niche Cells and Megakaryocytic-Erythroid Progenitors

Vanessa Scanlon, PI; Beverly Torok-Storb and Diane Krause, Mentors

Yale University

Hematopoietic Cell Procurement and Processing Services

Fred Hutch

Evaluating Insulin-Like growth Factor-1 (IGF1) As a Targetable Mechanism to Rescue Human Hematopoietic Stem Cell Aging

Jennifer J. Trowbridge, PI

JAX

Hematopoietic Cell Procurement and Processing Services

Fred Hutch

Characterization of macrophage immune-metabolic skewing induced by heme, iron and erythrophagocytosis

Francesca Vinchi, PI

NY Blood Center

Metabolomics Core

University of Utah

The role of the reductases Lcyth and Steap3 in lysosomal iron recycling in macrophages

Diane M. Ward, PI

University of Utah School  of Medicine

Metabolomics and Iron and Heme Cores

University of Utah

Metabolomic Investigation of Mitochondrial Heme Metabolon Proteins

Amy E. Medlock, PI

University of Georgia, Augusta University/University of Georgia Medical Partnership

Metabolomics, Iron and Heme, and MGD Cores

University of Utah

Characterization of maternal erythropoiesis during pregnancy

Yvette Yien, PI

University of Delaware

Mouse Facility Core, and FACS Core

Indiana University

CIHD 2021 Type B Funded projects

Timothy Marvin Bahr, MS, MD

Dept of Pediatrics/Neonatology

University of Utah School of Medicine

Core – Iron and Heme, Metabolomics University of Utah

Lab link – https://medicine.utah.edu/pediatrics/neonatology/fellowship/current-fellows.php

Title: Iron deficiency in preterm neonates: prevalence, surveillance, contributing factors

 

Makiko Yasuda, MD, PhD

Dept of Genetics and Genomic Sciences

Icahn School of Medicine at Mt Sinai

Core – Iron and Heme Utah

Lab link – https://www.mountsinai.org/profiles/makiko-yasuda

Title: Investigations of hepatic heme homeostatic mechanisms using ALAS-deficient mice

 

Prajwal C. Boddu, MD

Yale Cancer Center/Hematology

Yale School of Medicine

Core – Cell Prep and Analysis Yale and Iron and Heme Utah

Lab link – https://medicine.yale.edu/lab/pillai/

Title: Role of Mitoferrin-1 isoforms and intron retention in iron homeostasis and mitochondrial biology

List of grants awarded using Utah cores – 2019 Grants Extramural Funding

link