Congratulations to postdoctoral fellow Richard Coffey in the Ganz and Nemeth lab from the
UCLA Center for Iron Disorders for his recent work on the erythroid ERFE production and iron overload.
Drs. Ganz and Nemeth are members of the Utah CCEH.  pubmed link


Congratulations to postdoctoral fellow Esther Nuebel from Jared Rutter’s lab in the Department of Biochemistry
at the University of Utah School of Medicine for her recent work on Zellweger Spectrum Disorders and mitochondrial
dysfunction. Dr. Rutter is a member of the Utah CIHD and the Metabolomics/Lipidomics core, which is funded by
the U54 CIHD was utilized in this study. pubmed link


Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acids synthesis in malaria parasites. Falekun S, Sepulveda J, Jami-Alahmadi Y, Park H, Wigkscgkegek H, Sigala P. eLife 2021;10e71636 DOI 10.7554/eLife.71636, 6 October 2021


The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover.  Rondelli CM, Perfetto M, Danoff A, Bergonia H, Gillis S, O’Neill L, Jackson L, Nicolas G, Puy H, West R, Phillips JD, Yien YY. J Biol Chem. 2021 Jul 16:100972. doi: 10.1016/j.jbc.2021.100972. Online ahead of print. PMID: 34280433


Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage.  Zhao S, Wang X, Zheng X, Liang X, Wang Z, Zhang J, Zhao X, Zhuang S, Pan Q, Sun F, Shang W, Barasch J, Qiu A. Free Radic Biol Med. 2021 Jul 21;173:81-96. doi: 10.1016/j.freeradbiomed.2021.07.025. Online ahead of print. PMID: 34298093

Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy.  Fisher AL, Sangkhae V, Balušíková K, Palaskas NJ, Ganz T, Nemeth E. Nat Commun. 2021 Jun 29;12(1):4026. doi: 10.1038/s41467-021-24333-z. PMID: 34188052