The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover.  Rondelli CM, Perfetto M, Danoff A, Bergonia H, Gillis S, O’Neill L, Jackson L, Nicolas G, Puy H, West R, Phillips JD, Yien YY. J Biol Chem. 2021 Jul 16:100972. doi: 10.1016/j.jbc.2021.100972. Online ahead of print. PMID: 34280433


Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage.  Zhao S, Wang X, Zheng X, Liang X, Wang Z, Zhang J, Zhao X, Zhuang S, Pan Q, Sun F, Shang W, Barasch J, Qiu A. Free Radic Biol Med. 2021 Jul 21;173:81-96. doi: 10.1016/j.freeradbiomed.2021.07.025. Online ahead of print. PMID: 34298093


Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy.  Fisher AL, Sangkhae V, Balušíková K, Palaskas NJ, Ganz T, Nemeth E. Nat Commun. 2021 Jun 29;12(1):4026. doi: 10.1038/s41467-021-24333-z. PMID: 34188052