Available Grants

The NIDDK aims to foster and support diversity amongst our researchers and trainees. Please see the attached link for more information.  link
Interested individuals should feel free to contact the NIDDK Program Director, Hematology Dr. Cindy Roy for further assistance.
Cindy N. Roy, PhD, Program Director, Hematology
Division of Kidney, Urologic and Hematologic Diseases (KUH)
NIH/NIDDK, Bethesda, MD 20817
Office: 301-594-8805; Mobile:301-356-2931; Fax: 301-480-3510
Email: cindy.roy@nih.gov   www.niddk.nih.gov

Funding  Available

The NIDDK CCEH consortium provides support for nonmalignant hematology research using pilot and feasibility funds.

Postdocs, with signed approval of their mentor, may apply for support to begin a research track of their own.  Investigators with outside funding who want to start a new line of research in nonmalignant hematology can apply provided there is no overlap between their funded research and the proposal submitted for this mechanism. Preference will be given to junior investigators who are requesting support for a project that will generate preliminary data for use in an application for an NIDDK Hematology award (either F-series, K-series or research project grant). Depending on the nature of preliminary studies, two different P&F opportunities are available. More information.

 

2020-2021 Grants Extramural Funding

Adam Hughes, University of Utah School of Medicine
NIH/NIGMS R35 GM 119694 utilized CIHD-sponsored metabolism core for application
Investigating the Mitochondrial-Derived Compartment Pathway
6/1/2021-5/51/2026

 

R01 DK125740 PI: Iqbal Hamza, PhD
NIH/NIDDK
7/1/20 – 6/30/24
Heme trafficking and recycling in iron metabolism

 

Philpott lab postdoc
PI: Shyamalagauri Jadhav, Ph.D.
ODS Research Scholars Award
10/1/2018-9/30/2019
Liver-specific loss of iron chaperone PCBP1 leads to dysregulated iron and hepatic steatosis

 

R01 DK128068-01 PI: J. Christian and Jodie Babitt, MPIs
NIDDK
2021-2026
BMP Ligands in Hepcidin Regulation

 

R21 HD102668-01, PI: J. Christian
NICHD
2020-2021
Analysis of BMP Heterodimer formation and function, Diversity supplement

 

 

2019 Grants Extramural Funding

Matthew F. Barber, PhD, University of Oregon:
Recently awarded an NIH R35 MIRA award in which he included CIHD-sponsored work in his application. Here is the grant info:
NIH Maximizing Investigators’ Research Award (R35GM133652) 2019 – 2024
National Institutes of Health (NIGMS)
Title: Molecular mechanisms of evolution at the host-microbe interface

Paul Sigala, PhD, University of Utah:
Received a 5-year R35 MIRA (1R35GM133764) from NIGMS based on last year’s PF award, entitled “Comparative Heme Metabolism in Divergent Eukaryotes”, that featured preliminary data obtained during out CIHD Pilot Grant period.

Amy Medlock, PhD, University of Georgia
Awarded a SHINE grant 2018
R01 DK111653 Title: Identifying the function of the mitochondrial heme biosynthesis complex in erythropoiesis

Adam Hughes, Ph.D. University of Utah
Awarded R01 2019
R01 AG061376 Title: The role of the lysosome in aging

Diane Ward and June Round – University of Utah Immunity, Inflammation, Infection P&F grant: The effects of low iron diet on gut immunity and the development of Fatty Liver Disease 01/2019-12/31/2019.

Dennis Winge and Jared Rutter: National Institutes of Health RO1 GM110755-05. Mitochondrial Fatty Acid Synthesis and the Coordinate Regulation of Respiration.  Funded 9/20/2018-8/31/2022

 

1 Postdoctoral Training Position Available  9/16/21

Postdoctoral Position Available at the National Institutes of Health

 Iron Chaperones and the Distribution of Iron Cofactors within Cells

 

Caroline C. Philpott, M. D.
Genetics and Metabolism Section, LDB, NIDDK, NIH

Postdoctoral position available to study the distribution and utilization of iron cofactors within mammalian cells and tissues. Iron is an essential nutrient for every cell in the human body, yet it can also be a potent cellular toxin. Iron is essential because enzymes that require iron co-factors (namely, heme, iron-sulfur clusters, mononuclear and diiron centers) are involved in virtually every major metabolic process in the cell. Iron deficiency continues to be the most common nutritional deficiency in the world, especially among children and women of childbearing age, where it causes anemia and impairs neurological development and function. Although the pathogenesis of anemia in iron deficiency is well understood, other manifestations of iron deficiency are not understood at the cellular or metabolic level. Iron overload is a feature of an increasing number of human diseases, including genetic disorders such as hereditary hemochromatosis, thalassemias, and Friedreich ataxia, as well as chronic inflammatory diseases of the liver, such as hepatitis C. Hundreds of iron, zinc, copper, and manganese proteins are expressed in human cells, yet little is known about the mechanisms by which these metalloproteins acquire their native metal ligands and avoid mis-metallation. We have made significant advances in understanding the delivery of iron to iron-dependent enzymes in the cytosol.

We identified Poly rC-Binding Protein 1 (PCBP1) as an iron-binding protein that delivers iron to ferritin in human cells (Shi, et al. 2008, Science 320, 1207-10). This was the first description of a cytosolic iron chaperone – a protein that specifically binds iron ions and delivers them to target proteins through direct protein-protein interactions.  PCBP1 and its human paralogs are multifunctional adaptor proteins that also bind single-stranded DNA and RNA in a sequence-specific manner to regulate the fate of the nucleic acid. PCBP2, a human paralog of PCBP1, is independently required for the delivery of iron to ferritin. PCBP1 and PCBP2 deliver iron to additional families of target enzymes: the prolyl hydroxylases (PHDs) that regulate the degradation of hypoxia inducible factor 1 (HIF1) and deoxyhypusine hydroxylase (DOHH). Projects currently underway explore the roles of PCBPs in erythroid cell development, duodenal iron absorption, macrophage iron recycling, and the intersection of iron ion chaperones with the Fe-S cluster machinery. Mouse models of PCBP1 and PCBP2 deficiency have been developed and are revealing new functions of these proteins in maintaining iron homeostasis in mammals.

We use the tools of cell biology, genetics and biochemistry to address questions about how cells and animals use iron. The postdoctoral position is fully funded, available immediately, and open to any motivated Ph.D./M.D. with less than five years of postdoctoral experience. NIH is an equal opportunity employer.

Contact:

 Caroline C. Philpott, M. D.Chief, Genetics and Metabolism Section
Liver Diseases Branch, NIDDK, NIH
Bldg 10, Rm 9B-16
10 Center Drive
Bethesda, MD 20892-1800

Web: http://irp.nih.gov/pi/caroline-philpott
Phone: 301-435-4018
Fax: 301-402-0491
Email: carolinep@mail.nih.gov

 

CIHD Pilot and Feasibility Program Grant Awards

CIHD Pilot and Feasibility Program Grant Awards 2021-22

Iqbal Hamza, Ph.D. University of Maryland, College Park, Interactors of HRG1 heme transporter in reticuloendothelial macrophages.

Paul Sigala, Ph.D., University of Utah, Unraveling the Mechanism and Biological Significance of Hemozoin Motion in Malaria Parasites

Diane Ward, Ph.D., University of Utah, The role of macrophage Cyb561a3/Lcytb in lysosomal iron recycling for erythropoiesis

 

CIHD Pilot and Feasibility Program Grant Awards 2020-21

Dr Bob Christensen: Neonatal iron deficiency; defining pathogenic mechanisms & improving detection

Dr Tom Ganz: Metabolic Effects of Pathologically Increased Erythroferrone in Anemias with Ineffective Erythropoiesis

Adam Hughes: Elucidating the role of the LON protease in the regulation of cellular iron metabolism

Paul Sigala: Mechanism of Iron Acquisition by Malaria Parasites

 

CIHD Pilot and Feasibility Program Grant Awards 2019-20

Ryan O’Connell, PhD:  The role of Rab27a/b during mitochondria release from maturing erythroblasts.
Paul Sigala, PhD: Mechanism of Iron Acquisition by Malaria Parasites 3.
Diane Ward, PhD:  The role of the reductases Lcytb and Steap3 in lysosomal iron recycling in macrophages
Richard Eisenstein, PhD, University of Wisconsin-Madison: Iron regulation of erythropoiein expression
Amy Medlock, PhD and Amit Reddi, PhD, University of Georgia:  Creation of Transgenic Zebrafish with Hepatic and Erythroid Expressed Heme Sensors
Yvette Yien, PhD, University of Delaware:  Regulation of erythroid heme synthesis and vertebrate development by the mitochondrial unfoldase, CLPX

 

CIHD Pilot and Feasibility Program Grant Awards 2018-19

Dean Tantin, Tracey Lamb, Associate Professor. Does Oct1 loss-of-function in bone marrow progenitor cells exacerbate the severity of malarial anemia?

Oleh Khalimonchuk, Amit Reddi. co-investigator Assoc Prof, University of Nebraska, Department of Biochemistry Mitochondrial Behavior and Heme Transport in Erythropoiesis

Betty Leibold. Professor, University of Utah. Cell-Cycle Regulation of IRP2 Phosphorylation during Hematopoiesis

Amy Medlock, Amit Reddi. co-investigator Assoc Prof, University of Georgia. Creation of Transgenic Zebrafish with Erythroid Expressed Heme Sensors

Ryan O’Connell. Assoc Prof University of Utah Dept of Pathology. Determine the role of Rab27a/b during mitochondria release from maturing erythroblasts

Joe Prchal. Professor, University of Utah. Search for Novel Parameters of Augmentation of Erythropoiesis. Deciphering Molecular Differences of VHL Mutated Congenital

Polycythemia versus Tumor-Predisposition

Paul Sigala. Assistant Professor, University of Utah. Structure and Function of a Divergent Eukaryotic Cytochrome c

Diane Ward. Research Associate Professor, University of Utah. The role of Abcb10 in red cell hemoglobinization

 

CIHD Pilot and Feasibility Program Grant Awards 2017-18

Congratulations to the the following five investigators whose proposals were funded in the CIHD 2017 Pilot and Feasibility Grants Program:

Matthew Barber: Host-pathogen conflicts shaping bloodstream hemeprotein evolution

Adam Hughes: The role of lysosomes in maintenance of cellular iron metabolism

Elizabeth Leibold: Cell-cycle regulation of IRP2 phosphorylation during hematopoiesis

Paul Sigala: Role of Acyl Carrier Protein in Iron/Sulfur Cluster Biogenesis by Malaria Parasites

Diane Ward: The role of Abcb10 in red cell hemoglobinization

 

Utah CIHD Pilot and Feasibility Grant Awards for 2016-17

Our NIDDK-funded Center for Iron and Hematology Disorders has awarded three pilot research grants for the 2016/2017 fiscal year. Six proposals were considered for funding and the three successful applicants include the following:

Dr. Paul Sigala, Assistant Professor, Department of Biochemistry, University of Utah

Dr. Sigala will focus on the role of the acyl-carrier proteins present in the mitochondria and apicoplast of Plasmodium in iron-sulfur cluster biogenesis in the two organelles and the role of each pathway in the physiology of Plasmodium parasites. A long-term goal of his research is developing new therapeutic targets in treating malaria.

Dr. Amy Medlock, Assistant Professor, University of Georgia

Dr. Medlock is addressing the role of two novel proteins PGRMC1 and PGRMC2 in modulating heme synthesis in mammalian cells. She demonstrated that these proteins interact with ferrochelatase and regulate its activity. She proposes to generate knockout cell lines in culture and zebrafish to investigate the physiological consequences of loss of these proteins on heme production.

Dr. Matt Barber, Assistant Professor, University of Oregon

Dr. Barber is focused on the evolutionary battle between pathogens and primate hosts for access to iron and heme. He will address how primates evolved in response to iron and heme piracy by pathogenic bacteria. In his proposed studies, Dr. Barber will focus on phylogenetic analyses of hemoglobin and hemeopexin.

 

T32 HEMATOLOGY PROGRAM TRAINEES (2016-present)

Current predoctoral trainees

Alexandria Van Scoyk, BS, Departments of Oncological Sciences and Medicine

The role of SIRT5 in hematopoiesis
Preceptor: Michael Deininger, MD, PhD

Tanya Espino, BS, Department of Biochemistry
Mechanism of cytochrome c maturation and function in mitochondrial respiration
Preceptor: Paul Sigala, PhD

Lucas Bush, BS, Department of Biomedical Engineering
Controlling cues that drive differentiation of platelets from a hematopoietic precursor
Preceptor: Tara Deans, PhD

Amanda Mixon, BS, Department of Biochemistry

Heme-dependent regulation of organelle gene expression in blood-stage malaria parasites
Preceptor: Paul Sigala, PhD

Casey Hughes, BS, Department of  Biochemistry

Iron homeostasis disruption by elevated levels of cytoplasmic amino acids
Preceptor: Adam Hughes, PhD

 

Current postdoctoral fellows

Melissa Ilardo, PhD, Department of Medicine, Division of Hematology, Molecular Medicine
A functional genomics investigation of hypoxia tolerance adaptation in Bajau Sea Nomads
Preceptor: Elizabeth Leibold, PhD

Daniel Fuja, PhD, Department of Pharmacology and Toxicology
Coordinated regulation of oxygen-sensing and iron-sulfur cluster assembly pathways
Preceptor: Mei Koh, PhD

Kevin Hicks, PhD, Department of Biochemistry
Systematic discovery of protein-metabolite interactions that control heme biosynthesis
Preceptor: Jared Rutter, PhD

 

Past predoctoral trainees  

David McClellan, BS, Department of Oncological Sciences
GFI1B splice variants in megakaryocyte and erythrocyte differentiation
Preceptor: Michael Engel, MD, PhD

Mattie Casey, BS, Department of Oncological Sciences
GFI1B SNAG domain methylation in megakaryocyte-erythrocyte lineage allocation
Preceptor: Michael Engel, MD, PhD

Megan Okada, BS, Department of Biochemistry
Unraveling organelle function in blood-stage malaria parasites
Preceptor: Paul Sigala, PhD

Jared Wallace, BS, Department of Pathology
Investigating the role of mir-155 and the interferon response in the hematopoietic stem cell compartment during inflammatory hematopoiesis
Preceptor: Ryan O’Connell, PhD

Past postdoctoral fellows

Eric Kyle Fredrickson, PhD, Department of Biochemistry
Mechanisms of mitochondrial protein quality control and iron sulfur cluster biogenesis
Preceptor: Jared Rutter, PhD

Christopher Ours, MD,  Pediatric Hematology/Oncology
A novel mutation identified in a patient with severe congenital neutropenia suggests a
connection between Aurora A kinase and GFI1-directed hematopoietic lineage allocation
Preceptor: Michael Engel, MD, PhD

Radhika Gangaraju, MD, Department of Medicine, Division of Hematology
Role of hypoxia sensing pathways and inflammation in disorders of increased erythropoiesis
Preceptor: Josef Prchal, MD

[/vc_row]
[/vc_row]
[/vc_column][/vc_row]
[/vc_row]