Tisch Cancer Institute Postdoctoral Position open 10/23/20
Division of Hematology/Medical Oncology
Job Title: Postdoctoral Fellow
Job Class: TR04
Pay frequency: Bi–weekly
Exempt status: Exempt
A Postdoctoral position is currently available within the lab of Dr. Yelena Ginzburg at the Tisch Cancer Institute at the Icahn School of Medicine of Mount Sinai. The lab focuses on iron metabolism and erythropoiesis in health and disease, using mouse models and human samples ex vivo to ask questions about basic biology, physiology, and pathophysiology.
The candidate PhD or MD/PhD in biochemistry, physiology, or molecular biology will have an opportunity to contribute to and shape several ongoing projects within the lab.
The Ginzburg laboratory is a team of scientists and student scientists with deep interest in understanding the crosstalk between erythropoiesis and iron metabolism. We recently also generated preliminary data focused on understanding the crosstalk with bone homeostasis. We are looking for a highly motivated postdoctoral fellow to lead a research project aimed at understanding in detail how iron transport influences erythropoiesis, how the erythron communicates iron requirements to the liver, the main organ involved in hepcidin production, and how the known regulatory nodes influence bone homeostasis.
To accomplish these goals, we aim to utilize standard molecular biology techniques, novel mouse models with mutations in erythropoiesis- and iron-related genes, and state-of-the-art genetic manipulation tools.
Iron transport for erythropoiesis, crosstalk between them, and erythroid regulation of iron metabolism are central tenets in recovery during stress erythropoiesis and are dysregulated in multiple hematological disorders and thus of great interest to the hematology field. Coordination with bone homeostasis is critically important given the proximal physical relationship between bone marrow and bone. The successful completion of this work will provide insight into the pathophysiology of human diseases in which erythropoiesis is disturbed (e.g. β-thalassemia, polycythemia vera, and MDS), extend current knowledge in iron metabolism and bone homeostasis, and add new paradigms for further exploring erythroid regulation of hepcidin in health and disease.
We are looking for a scientist with a solid background in biochemistry, physiology, and molecular biology. Skills in microscopy, flow cytometry, ex vivo hematopoietic stem cell proliferation and differentiation, immunoprecipitation, western blot, ELISA, RT-PCR, transfection using plasmid for knockdown and overexpression, and cell sorting techniques as well as mouse husbandry (i.e. breeding and handling)) are advantageous. The candidate should be able to work independently, in a collaborative manner. A track record of publications in peer-reviewed journals is required.
- Conduct and design experiments under the direction of lab PI.
- Report to PI research progress and maintain a current knowledge of literature in relevant fields.
- Maintain good records and contact with collaborators.
- Nurture collaborative relationships with fellow scientists within the institution, locally, nationally and internationally.
- Summarize experimental data timely and assist in drafting publications under the direction of the PI.
- Master computer and technical skills necessary for experimental execution as well as data input and analysis.
- Performs other related duties as assigned.
- A Ph.D. in molecular or cellular biology, biochemistry, genetics, or immunology.
- Previous experience in basic molecular and cellular biology methods including DNA and RNA isolation, siRNA methods, construct engineering, tissue culture and preparation and analysis of samples through flow cytometry.
- Previous experience with biochemistry techniques including Western blots and immuno-precipitations among others.
- Expertise in code writing and/or bioinformatics will be weighed as a plus.
- The candidate is also expected to be self-motivated, creative and capable of contributing productively in a team environment.
- Excellent communication skills in written and oral English are essential.
Yelena Ginzburg, MD
Office Tel: 212-241-0579
Area of Interest:
The Ginzburg Lab has been continuously funded for the last 15 years to focus on molecular mechanisms involved in the crosstalk between erythropoiesis and iron metabolism in multiple diseases.
The goals of our multiple projects are to elucidate a mechanistic understanding of the crosstalk between erythropoiesis and iron metabolism. We focus on diseases such as β-thalassemia, sickle cell anemia, iron deficiency anemia, anemia of renal failure, myelodysplastic syndrome, and most recently polycythemia vera. We have generated and analyzed mouse models and human cells in culture with the ultimate goal of developing novel therapeutics for diseases of disordered erythropoiesis and or iron metabolism. Clinical trials are on-going as a consequence of the research done in our lab and that of our collaborators. Most recently, we have focused also on the crosstalk of iron metabolism and inflammation and with bone homeostasis.
Specifically, the current projects in the laboratory involve:
- analyzing the role of transferrin and its receptor partners, hepcidin, and erythroferrone in ineffective erythropoiesis in a mouse model of β-thalassemia;
- exploring the role of erythroferrone in coordinating erythropoiesis, iron metabolism, and bone homeostasis using mice models in vivo and in vitro;
- evaluating the mechanisms leading to persistent erythropoiesis in polycythemia vera despite iron deficiency in vivo and in vitro; and
- determining the effect of iron overload and iron chelation on erythropoiesis in a mouse model of myelodysplastic syndrome.
We are also engaged in several collaborative clinical projects in various stages, including using macrophage iron status in sputum of sickle cell patients to predict acute chest syndrome, evaluating the effect of iron chelation on survival in patients with myelofibrosis, and eliminating phlebotomy requirements in patients with polycythemia vera treated with hepcidin mimetics. We are always looking for hard-working and passionate junior physician scientists interested in engaging on topics of mutual interest.
UCLA Postdoctoral Position open 7/23/20
UCLA Center for Iron Disorders is looking for a postdoctoral fellow for a project studying the interaction between iron and phosphate homeostasis. We are focusing on the hormone FGF23, a physiological regulator of phosphate homeostasis, which likely plays a pathogenic role in cardiovascular complications in chronic kidney disease. The project will explore the regulation of FGF23 production and processing (including by iron and erythropoiesis), and the mechanism by which FGF23 mediates its pathogenic effects in CKD. The project is led by Mark Hanudel, pediatric nephrologist and a junior faculty at the Center. The senior mentors will be Tomas Ganz and Elizabeta Nemeth. The position is available now. Please send inquiries to email@example.com.
Student/Postdoctoral Fellow Exchange Program
Postdoc/Student Exchange March 30-April 2, 2020 postponed