Postdoc opportunity

     

    2 Postdoctoral Training Positions Available  5/14/21

    Postdoctoral positions in the

      Enns/Zhang Labs in the Department
    of Cell, Developmental, and Cancer Biology at Oregon Health &
    Science University, Portland, OR USA. Detail link

     

    Postdoctoral Training Position Available Fellowship   5/7/21 

    Bone Marrow Spatial Transcriptomics to Enhance In Vitro Platelet Production:
    The Moffitt and Cantor Laboratories at Boston Children’s Hospital/Harvard Medical School (HMS) are currently
    accepting applications for an entry-level joint post-doctoral training position. The Moffitt lab focuses on
    development and utilization of in situ single-molecule imaging methods to further understand tissue
    architecture, developmental signaling, and novel cell type identification. The Cantor lab specializes in
    hematopoiesis and platelet production. This joint project will develop and apply Multiplexed Error-robust
    Fluorescence In Situ Hybridization (MERFISH) to the mouse and human bone marrow to further understand
    how megakaryocytes generate platelets in the context of their native microenvironment. This knowledge will
    then be applied to enhance in vitro platelet production from induced pluripotent stem cells (hIPSCs) for
    transfusion purposes. The candidate will also interact with the Allon Klein’s laboratory at HMS to develop and
    correlate scRNA-seq and in situ transcriptomic datasets. The candidate will be jointly advised by Dr. Moffitt and
    Dr. Cantor and will have the opportunity to learn and develop a cutting-edge spatial transcriptomics tool while
    substantially advancing our understanding of bone micro-environment and its critical role in the important
    process of platelet production and stem cell biology.
    Candidates should have recently (within ~1 year) obtained a PhD or an MD/PhD degree in the fields of
    Computational Biology, Genomics, Molecular Biology, Cellular Biology, Biochemistry, Development, or
    Genetics. The candidate should have evidence of prior productive scientific work in the form of publications in
    peer-reviewed journals. Prior experience in computational biology, scRNAseq, and/or other “-omics” type
    approaches is strongly preferred. U.S. citizenship or Permanent Resident status (i.e., “Green Card” holders) is
    not necessary, but is favored.
    Interested candidates should send their Curriculum Vitae and a cover letter describing their background and
    research interests to jeffrey.moffitt@childrens.harvard.edu and alan.cantor@childrens.harvard.edu.
    Candidates should also arrange for two letters of recommendation, which may be requested. Jeffrey Moffitt, PhD

    Alan Cantor, MD, PhD
    Assistant Professor of Pediatrics Associate Professor of Pediatrics
    Program in Cellular and Molecular Medicine Division of Pediatric Hematology/Oncology
    Office: 617-713-8902 Office:617-919-2026
    Boston Children’s Hospital is an equal opportunity employer. Women and members of under-represented
    minorities are encouraged to apply

     

    Postdoctoral Fellowship in Iron Trafficking in Cell Biology  5/6/21

    Genetics and Metabolism Section, Liver Diseases Branch
    The Position:
    The National Institute of Diabetes and Digestive and Kidney Diseases
    (NIDDK), a major component of the National Institutes of Health (NIH), Department of
    Health and Human Services (DHHS) has an opening for a postdoctoral fellow. This fullyfunded
    postdoctoral position is available to study the distribution and utilization of iron
    cofactors within mammalian cells and tissues. Iron is an essential nutrient for every cell
    in the human body because enzymes that require iron co-factors (namely, heme, ironsulfur
    clusters, mononuclear and dinuclear iron centers) are involved in virtually every
    major metabolic process in the cell. We identified the first cytosolic iron chaperones –
    proteins that specifically bind iron ions and deliver them to target proteins through direct
    protein-protein interactions (Shi, et al. 2008, Science 320, 1207-10). Current research
    focuses on identifying new components of cellular iron trafficking pathways and
    exploring the roles of iron chaperones in mammalian cells and tissues. Successful
    candidates will join a team of talented young investigators working in mammalian cell
    and genetically modified mouse models. Using the tools of cell biology, genetics and
    biochemistry, we explore the systems by which iron cofactors are distributed within the
    cells and tissues of mice and humans.
    For more information, visit http://irp.nih.gov/pi/caroline-philpott
    Qualifications:
    Successful applicants must be highly motivated, recent recipients of Ph. D. or M. D.
    degrees with experience in cell biology, genetics, biochemistry, microbiology or
    molecular biology.
    To Apply:
    Interested individuals should send a brief statement of research interest, curriculum vitae
    with bibliography, and contact information for three references by email to:
     Caroline C. Philpott, M. D.
    Chief, Genetics and Metabolism Section
    Liver Diseases Branch, NIDDK, NIH
    Carolinep@mail.nih.gov
    The NIH is dedicated to building a diverse community in its training and employment
    programs. DHHS AND NIH ARE EQUAL OPPORTUNITY EMPLOYERS.

     

     

     

    Postdoc Fellow/Staff Scientist 5/6/21

    Location: Boston Children’s Hospital, Harvard Medical School

    Job Description:
    The Bauer laboratory seeks highly motivated post-doctoral research fellows and staff scientists to investigate
    therapeutic gene editing to address human diseases with unmet clinical needs and to explore the functional
    genomics of human hematopoiesis. We conduct studies ranging from technology development, target discovery,
    preclinical validation and first-in-human clinical application.
    We have identified regulatory elements that are subject to naturally occurring disease associated genetic variation
    and are critical determinants of fetal hemoglobin level and hemoglobin disorder clinical severity. We have
    developed methodologies for high-throughput and high-resolution functional evaluation of coding and noncoding
    genetic elements. We have demonstrated highly efficient and specific methods for nuclease and base editing of
    human hematopoietic stem and progenitor cells. We use molecular genetic, biochemical, and genome editing
    methodologies to perturb and observe blood cells. Our studies are meant to elucidate fundamental mechanisms
    of gene regulatory elements in their endogenous chromosomal environment, to explore determinants of blood cell
    development, homeostasis, and disease, and to define structure-function relationships of disease relevant protein
    complexes. A major motivation of our work is to translate findings into novel therapies for patients with blood
    disorders. We are advancing therapeutic gene editing from preclinical studies to first-in-human trials.
    Prior experience in gene editing/gene therapy, protein engineering, hematopoiesis, molecular and cell biology,
    genetics, biochemistry, systems biology, structural/chemical biology, and/or bioinformatics/computational biology
    is highly desirable. The candidate must be independent in scientific research and writing, self-motivated, ethical,
    team spirited, and must have exceptional laboratory, communication, organizational, and writing skills.
    Interested applicants should send a CV, cover letter, statement of research interest and contact information for
    three references via email to

    Daniel Bauer, MD PhD (daniel.bauer@childrens.harvard.edu), Division of
    Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA. Boston Children’s
    Hospital is one of the top pediatric research centers in the world, and a major research and teaching affiliate of
    Harvard Medical School. The Bauer Laboratory is also affiliated with the Dana-Farber Cancer Institute, Harvard
    Stem Cell Institute, and Broad Institute of Harvard and MIT.

     

     

     

    Postdoc Opportunity Innate Immunity/ Inflammation at the Univ. of Utah 5/6/21


    Job Summary
    A postdoctoral position to study innate immune signaling pathways and inflammation is available immediately in the Microbiology & Immunology Division, University of Utah, Department of Pathology.

    The research project is aimed at deciphering the cellular and molecular regulation of innate immunity in the context of inflammatory and autoimmune disease. In particular, we study the function of Toll-like receptors (TLRs), which are essential for pathogen recognition, but can also promote inflammatory and autoimmune diseases. In previous work we identified a key negative regulator of Toll-like receptor (TLR) signaling pathways, which is essential for protection from inflammatory diseases (Nature 2006 PMID: 16306937; PNAS 2009, PMID: 22011580; PNAS 2016, PMID: 27671649, JCI 2019, PMID: 31033479). More detailed work related to the mechanism of tissue injury revealed deregulation of myeloid cell differentiation, specifically monocyte development, as a major culprit. The goal of this project is to reveal the signaling mechanisms and genes controlling TLR biology, in particular in context with myelopoiesis and their impact on in vivo inflammation. The long-term goal is to identify novel targets for therapeutic intervention in inflammatory human diseases.

    Responsibilities
    The project provides an ideal opportunity for fellows who are interested in (i) innate immunity and inflammation regulation in context of hematopoiesis/ myelopoiesis and (ii) molecular mechanisms of signal transduction, applying cutting edge protein identification/ interaction analyses, such as quantitative MS.

    For more information related to the lab, the breadth of resources at the University of Utah and the stunning environment of Salt Lake City/ Utah please see: https://medicine.utah.edu/pathology/research/labs/hans-haecker/

    Qualifications and Preferences
    Applicants should hold a PhD and/or MD degree in Biochemistry, Biology or Immunology. The ideal candidate should have expertise in molecular biology and protein analysis and, preferably, experience with animal (mouse) in vivo experimentation.

    Work Schedule Summary
    Monday – Friday with some occasional evening and weekend work.

    Pay Rate Range $52,704 to $55,596

    Application: To apply, please send a cover letter as well as CV including publication history and three professional references to Dr. Hans Haecker, Professor at the Microbiology & Immunology Division of the Pathology Department, University of Utah, using the following link: https://utah.peopleadmin.com/postings/106232

     

    Open position 4/1/2021

    Postdoctoral Training Program in Developmental Biology and Regenerative Medicine – University of
    Colorado Anschutz Medical Campus, Aurora, Colorado

    Our mission
    The Section of Developmental Biology, headed by Dr. Bruce Appel, at the University of Colorado
    School of Medicine, with support from the Gates Frontiers Fund, established the DevBioPostDoc
    Program to advance the next generation of scientific leaders in Developmental Biology and
    Regenerative Medicine. The DevBioPostDoc Program trains future postdoctoral fellows to become
    scientific experts through cutting-edge research and close guidance from principal investigators at
    the CU Anschutz Medical Campus.

    The position
    The DevBioPostDoc Program intends to attract research-driven scientists from across the world and
    encourages those who want to pursue an academic scientific research to apply. Postdoc trainees are
    provided with a salary support in accordance with the NIH pay scale and a full benefits
    package from the University of Colorado. Successful applicants will be appointed as
    Gates Fellows with initial appointments made for one year and continued support contingent
    on satisfactory progress.

    Our story
    Member labs of the DevBioPostDoc program use diverse model systems to address a broad range of
    questions in the areas of Developmental Biology, Disease Modeling, and Regenerative Medicine. Read
    more about the research of our principal investigators at the Section of Developmental Biology
    here: https://medschool.cuanschutz.edu/pediatrics/sections/developmental-biology/faculty
    Read the stories of our current DevBioPostDoc trainees here: https://tinyurl.com/yzt8azxv

    Application process
    Applicants must have a Ph.D. degree and less than two years of postdoctoral
    experience. Interested candidates submit 1) a statement explaining their motivation to join the
    program and indicating their preferred host lab (2-page maximum), 2) CV and 3) arrange for three
    references. Review of applications will begin immediately and finalists will be invited for virtual
    interviews. Applications should be submitted here:
    https://cu.taleo.net/careersection/2/jobdetail.ftl?job=20570&lang=en
    For more information, we encourage you to contact Dr. Charles Sagerström, Co-Director of the
    Postdoctoral Training Program, charles.sagerstrom@cuanschutz.edu and Dr. Alexa Burger, Co-Director
    of the Postdoctoral Training Program, alexa.burger@cuanschutz.edu.
    If you want to learn more about the DevBioPostDoc program and to communicate with the postdoctoral
    trainees, please email them directly cudevbiopostdocs@gmail.com.

     

    Open positions 3/19/2021

    New BioIron funding announcement 2/24/2021

    Postdoctoral Research Fellow in Iron Biology at Massachusetts General Hospital and Harvard Medical School
    An NIH-funded postdoctoral fellow position is available immediately in the Babitt laboratory at Massachusetts General Hospital (MGH) and Harvard Medical School to elucidate novel molecular and cellular mechanisms involved in iron homeostasis. A particular focus of the laboratory is to identify the molecular basis by which bone morphogenetic proteins regulate iron metabolism and the links between these pathways and the crippling complications of iron disorders and chronic kidney disease. We employ state-of-the-art multidisciplinary experimental approaches, including novel mouse genetic models, primary cell isolation and culture, signal transduction assays, advanced microscopy techniques, flow cytometry, and multiomic approaches, among others. Postdoctoral fellows will benefit from a highly collaborative environment and connections to premier biomedical institutions in the greater Boston area.

    Candidates for this position must have a Ph.D. (or equivalent) in the biomedical sciences. Ideal applicants will have an experimental background in molecular/cellular biology and mouse models of disease, a strong publication record, and excellent communication/interpersonal skills.

    If interested, please email a cover letter, CV, and the contact information for three references to:

    Jodie L. Babitt, M.D.
    Associate Professor of Medicine
    Director of Translational Nephrology
    Massachusetts General Hospital
    Harvard Medical School
    Babitt.jodie@mgh.harvard.edu

     

    New BioIron funding announcement 1/27/21

    The International Society for the Study of Iron in Biology and Medicine is offering two COVID Relief Grants, to support trainees whose research has been disrupted by the COVID-19 pandemic.

    Eligibility

    Applicant must be a graduate student or a postdoctoral researcher in their first postdoctoral post.

    Applicants must be affiliated with an established iron research lab at the time of application and during the proposed period of the award (as shown by the PI and/or the applicant’s membership of the International Society for the Study of Iron in Biology and Medicine).

    Applicants must be able to detail how their existing research has been disrupted by the COVID-19 pandemic. Examples include, but are not limited to:

    • Funding for the research group has been cut or significantly reduced.
    • The period of funding has elapsed for trainees holding time-limited research studentships/ fellowships.
    • A need to extend the duration of their contracts, to account for time lost due to the closure of research facilities.

    The award is for up to €5000/USD $6057.75 and can be used to fund salary costs (for contract extensions), consumables, animal costs, and core facilities access. Awardees are expected to write a report outlining the research outcomes achieved during the period of the award.

    Application Process

    1. Applicants must complete the application form.
    2. Applicants must provide a letter of support from their PI, and evidence of affiliation with the host lab during the proposed period of the award.

    The application form and associated documents must be submitted as a single pdf to info@bioiron.org, no later than Friday 26, February.

    Applicants will be informed of the outcome by Friday 26, March, with grants commencing 1 to 3 months later.

     

    New funding announcement at The NIDDK Hematology Centers Program – open 1/5/21

    The NIDDK Hematology Centers Program is providing a novel support mechanism for trainees, postdocs, and junior faculty who want to pursue new directions in non-malignant hematology. Center Directors welcome applicants from across the U.S. and will strive to provide equal access to the cutting-edge resources and expertise available in their center cores.

    new funding link

     

    UM-Madison Postdoctoral Position open 1/22/21

    Postdoctoral Training Opportunities with the
    Metabolism and Nutrition Training Program (MANTP) at UW-Madison
    – An NIH-funded T32 Training Program –

    • Up to 3 years of funding of your salary at NIH postdoctoral rates in a highly collegial
    community of scientists focused on the molecular, genetic, biochemical and clinical and
    population-based aspects of nutrition-related biomedical research (trainers listed on back/next
    page).

    • Mock-review of your F32 or similar postdoctoral fellowship proposal in study section composed
    of other trainees and faculty trainers.

    • Gain experience at grant reviewing via participation as a reviewer in MANTP mock study
    section.

    • Funds (up to $2500) to pay help pay for unique professional development opportunities such as
    a class at Cold Spring Harbor Laboratories.

    • Trainee-specific meetings (2-4 / semester) with outside speakers from academia, industry and
    other venues to discuss career trajectories and opportunities.

    • Annual meetings to discuss the research progress of all trainees including opportunities to
    deliver a “chalk-talk” that addresses the broad relevance of your work and its applicability to the
    NIH mission.

    • Integrative annual retreat with U Chicago T32 on “Digestive Diseases and Nutrition” where the
    focus is on increased exposure to cutting edge translational research, improving research
    presentations at national meetings, professional development activities and networking.

    • Opportunities to mentor young investigators.

    • Guidance from the MANTP Executive Committee in planning your career trajectory – both short-
    and long-term.

    • Input regarding application letters, CVs, research presentation and what to expect in
    interviews.

    Applicants should send a cover letter describing research background and career goals, curriculum
    vitae and three letters of reference to:
    Rick Eisenstein Ph.D.
    Dept. of Nutritional Sciences, University of Wisconsin 1415 Linden Drive, Madison, WI 53706
    Email contact: eisenstein@nutrisci.wisc.edu

    UW-Madison is an equal opportunity/affirmative action employer.
    We promote excellence through diversity and encourage all qualified individuals to apply.
    Positions are open only to U.S. citizens and non-citizen nationals per NIH policy.

     

     

    Student/Postdoctoral Fellow Exchange Program

    Postdoc/Student Exchange March 30-April 2, 2020 postponed

    application link

     

     

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