Postdoctoral and Research Assistant 2 Positions Available. Postdoctoral positions in the Zhang and Enns Lab in the Department of Cell, Developmental, and Cancer Biology at Oregon Health & Science University, Portland, OR USA 5/24/23
The lab is focused on identifying the molecular mechanisms by which the body senses iron and the pathways involved maintaining iron homeostasis. Diseases that result in the disruption of the homeostatic mechanisms include but are not limited to hereditary hemochromatosis, infectious diseases, heart failure, cancer and hematopoietic diseases.
We use a combination of state-of-the-art approaches involving mouse models, gene therapy, mass spectrometry, advanced light microscopy and bio-informatics as tools of discovery in a collaborative environment.
The candidate must have a PhD. Expertise in molecular biology, cell biology, and/or protein chemistry are preferred.
Please submit a cover letter, Curriculum Vitae, and contact information for three references to:
An-Sheng Zhang, MD or Caroline Enns PhD
Department of Cell, Developmental, and Cancer Biology L215
3181 SW Sam Jackson Park Rd
Oregon Health & Science University, Portland, OR 97239
Postdoctoral Research Fellow in Iron Metabolism and Therapeutics at Massachusetts General Hospital and Harvard Medical School 5/23/2023
A postdoctoral fellow position is available immediately in the Babitt laboratory at Massachusetts General Hospital (MGH) and Harvard Medical School. Our laboratory conducts basic and translational research in the areas of iron biology, bone morphogenetic protein (BMP) signaling, and kidney disease. Current projects aim to understand the prodomain function, proteolytic processing, and dimerization of BMP proteins, with a particular focus on how these processes impact systemic iron homeostasis regulation. A second project will collaborate with a chemistry lab and clinical investigators for the pre-clinical development and clinical translation of novel compounds for the treatment of iron disorders. We employ state-of-the-art multidisciplinary experimental approaches, including gene editing, novel genetic mouse models, primary cell isolation and culture, signal transduction assays, flow cytometry, single cell sequencing and multiomic approaches, among others. Postdoctoral fellows will benefit from a highly collaborative environment and connections to premier biomedical institutions in the greater Boston area.
Candidates for this position must have a Ph.D. (or equivalent) in the biomedical sciences. Ideal applicants will have an experimental background in cell signaling, molecular biology, and mouse genetics; a strong publication record; and excellent communication/interpersonal skills.
If interested, please email a cover letter and CV to:
Jodie L. Babitt, M.D.
Associate Professor of Medicine
Director of Translational Nephrology
Massachusetts General Hospital
Harvard Medical School
Postdoctoral Research Fellow in Iron Biology, New York Blood Center, NYBC, New York, NY, 4/13/2023
The New York Blood Center (NYBC) is seeking a highly motivated and enthusiastic PostDoctoral Research Fellow to work on research projects aimed at investigating mechanisms of iron-altered hematopoiesis within the Iron Research Laboratory. Our laboratory is part of the Lindsley F. Kimball Research Institute, the research branch of the New York Blood Center, one of the most comprehensive blood centers in the world. The main goal of the Iron Research Laboratory is to investigate the impact of iron overload and deficiency on the pathogenesis of human hematological diseases, including sickle cell disease, thalassemia and cancer. Our research investigates the molecular mechanisms of heme and iron-driven toxicity, including inflammation, oxidative stress and altered erythropoiesis, and the role of detoxification systems in counteracting these effects. The candidate will work in an academic environment and perform cutting-edge research that integrates hematology and immunology with novel therapies using innovative technologies and approaches, including classic molecular, cellular, and biochemical techniques, as well as modern imaging techniques, sequencing and single cell analysis techniques, bioinformatics, and preclinical in vivo and in vitro models. In addition, he/she will collaborate with other research scientists across the NYBC, including basic and translational investigators, as well as with pharma companies. The current position is funded for 3 years.
Requirements include: • Ph.D. and/or M.D. degree in the biomedical sciences; • A good record of high impact publications and a strong scholarly record;
• An experimental background in molecular and cellular biology (research experience with mouse models is required);
• Ability to work independently and within a strong team environment; to identify problems in a timely manner; to evaluate options and implement solutions; to pay strong attention to detail in all work processes;
• Contribution to experimental design and participation in team meetings.
For immediate consideration, please submit an application to Dr. Francesca Vinchi, Head of Iron Research Laboratory, FVinchi@nybc.org, including:
– a full CV, with list of publications;
– a motivational letter concisely describing your past research experience, your research interests and why you are applying;
– contact information of at least 3 references.
To learn more about the Iron Research Program and the NYBC visit:
Francesca Vinchi, PhD | New York Blood Center (nybloodcenter.org)
Postdoctoral Research Scientist, Icahn School of Medicine at Mount Sinai, 1/19/2023
Tisch Cancer Institute; Institute of Translational Medicine and Pharmacology
Icahn School of Medicine at Mount Sinai
New York, NY
OBJECTIVE: Hiring Postdoctoral Research Scientists to promote research projects
If interested, please send CV and a cover letter with names and emails of 3 referees to Professor Yelena Ginzburg at email@example.com
These are exciting opportunities for several Postdoctoral Research Scientists to join the Ginzburg lab and contribute to our research. Our world class team is a senior interdisciplinary group with extensive experience in translational medicine in iron metabolism, erythropoiesis, bone homeostasis, neurophysiology and in the study of a wide range of diseases with dysregulation and these areas of biology.
The purpose of this group is to increase our knowledge of iron metabolism regulation, understand how it is dysregulated in a variety of diseases, and target these mechanisms for translational purposes.
- MD, PhD, or MD/PhD obtained after 2018 (reasonable exceptions will be made)
- Degree / experience in Genetics, Biology, Biomedicine, Biochemistry or similar
- Good CV with at least one publication as first author in important recognized research journal IF>6
- Proven experience in Genetics, Bone Biology or Iron Metabolism will be a plus
- Proven experience with animal modelling handling (mouse) will be a plus
JOB DESCRIPTION OVERVIEW:
Reporting to Prof Ginzburg, the successful candidate will function as a member of a research group for carrying out research to understand 1) the mechanistic role of erythroferrone in bone homeostasis in normal and thalassemic mice or 2) how transferrin and transferrin receptors 1 and 2 cooperate to regulate normal and β-thalassemic erythropoiesis.
The researcher will be managing either of these 2 projects, carrying out experiments independently and contributing to data analysis and interpretation. They will also, in collaboration with the lab manager/research associate, manage all the mouse colonies for Prof Ginzburg’s lab, by genotyping the animals and ensuring all breeding is carried out to meet experimental demands.
They will be responsible for running bone mineral density measurements using DEXA and microCT in mice, serum samples to measure the level of Hepcidin, IL-6, Erythroferrone, and Erythropoietin by ELISA in mice, perform flow cytometry analyses and cell sorting as needed, measure gene expression by RT-PCR and protein concentration by western blotting and or flow cytometry in a complementary manner, and assess localization of parameters of interest using RNAScope and other microscopy methods.
They will meet with Prof Ginzburg and the group regularly to analyze and interpret the data and are expected to contribute new ideas and hypotheses to develop the project further. The post holder provides guidance to the junior lab membranes and less experienced members of the research group, including students, technicians, research assistants and postdocs.
The position is funded until 2026.