Postdoctoral Research Scientist, Icahn School of Medicine at Mount Sinai, 1/19/2023
Ginzburg Laboratory
Tisch Cancer Institute; Institute of Translational Medicine and Pharmacology
Icahn School of Medicine at Mount Sinai
New York, NY
OBJECTIVE: Hiring Postdoctoral Research Scientists to promote research projects
If interested, please send CV and a cover letter with names and emails of 3 referees to Professor Yelena Ginzburg at yelena.ginzburg@mssm.edu
These are exciting opportunities for several Postdoctoral Research Scientists to join the Ginzburg lab and contribute to our research. Our world class team is a senior interdisciplinary group with extensive experience in translational medicine in iron metabolism, erythropoiesis, bone homeostasis, neurophysiology and in the study of a wide range of diseases with dysregulation and these areas of biology.
The purpose of this group is to increase our knowledge of iron metabolism regulation, understand how it is dysregulated in a variety of diseases, and target these mechanisms for translational purposes.
CANDIDATE REQUIREMENTS:
- MD, PhD, or MD/PhD obtained after 2018 (reasonable exceptions will be made)
- Degree / experience in Genetics, Biology, Biomedicine, Biochemistry or similar
- Good CV with at least one publication as first author in important recognized research journal IF>6
- Proven experience in Genetics, Bone Biology or Iron Metabolism will be a plus
- Proven experience with animal modelling handling (mouse) will be a plus
JOB DESCRIPTION OVERVIEW:
Reporting to Prof Ginzburg, the successful candidate will function as a member of a research group for carrying out research to understand 1) the mechanistic role of erythroferrone in bone homeostasis in normal and thalassemic mice or 2) how transferrin and transferrin receptors 1 and 2 cooperate to regulate normal and β-thalassemic erythropoiesis.
The researcher will be managing either of these 2 projects, carrying out experiments independently and contributing to data analysis and interpretation. They will also, in collaboration with the lab manager/research associate, manage all the mouse colonies for Prof Ginzburg’s lab, by genotyping the animals and ensuring all breeding is carried out to meet experimental demands.
They will be responsible for running bone mineral density measurements using DEXA and microCT in mice, serum samples to measure the level of Hepcidin, IL-6, Erythroferrone, and Erythropoietin by ELISA in mice, perform flow cytometry analyses and cell sorting as needed, measure gene expression by RT-PCR and protein concentration by western blotting and or flow cytometry in a complementary manner, and assess localization of parameters of interest using RNAScope and other microscopy methods.
They will meet with Prof Ginzburg and the group regularly to analyze and interpret the data and are expected to contribute new ideas and hypotheses to develop the project further. The post holder provides guidance to the junior lab membranes and less experienced members of the research group, including students, technicians, research assistants and postdocs.
The position is funded until 2026.
Postdoc Scholar, UCLA, 5/3/22
Position: Postdoctoral scholar
Start date: immediate; negotiable
Institution: UCLA David Geffen School of Medicine; Department of Medicine
Laboratory: Center For Iron Disorders (PIs: Tomas Ganz, Elizabeta Nemeth, Airie Kim); http://iron.med.ucla.edu
Project description: The research project investigates the role of iron in the development of pulmonary arterial hypertension (PAH), a chronic and severe cardiopulmonary disease that results in heart failure and death. Iron deficiency is associated with worse PAH clinical outcomes, and treatment has been shown to improve exercise tolerance and quality of life, but the underlying mechanisms remain unclear. Our preliminary data indicate that rat models can be used to replicate this clinical phenomenon, thus we propose to use mouse and rat models of PAH to define the mechanisms that link iron homeostasis and PAH outcomes. We are a medium-large biomedical research laboratory interested in iron homeostasis and its disorders, and have a dynamic team of faculty members, postdocs, graduate students, and staff. We prioritize the nurturing of young scientific careers, and have a decades-long track record in placing our trainees in their desired careers, including academics and industry.
Eligibility: By the time of hire, applicants should have completed a graduate program in a field related to molecular cell biology, physiology, or microbiology. The applicant must be willing to work with murine models. We will provide any specific training necessary.
Contact Person: Airie Kim (airiekim@mednet.ucla.edu)
Postdoc associate, University of Pittsburgh Postdoc, 5/3/22
The postdoctoral associate will work at the lab of Dr. Yvette Yien of the Department of Medicine,
Vascular Medicine Institute at the University of Pittsburgh. The research will be focused on identifying
the role of iron metabolism in facilitating the terminal steps of red cell development. The postdoc will
work independently to design and perform experiments in embryology, biochemistry/molecular biology,
and cell biology. The lab uses a wide variety of model organisms, including zebrafish, mouse, and
mammalian cell culture. Other responsibilities include presenting data at lab meetings and scientific
conferences, preparing research articles for publication, assisting with lab administration, and training
other lab personnel. This position may require the need to lift 20 lb while working with the fish tanks.
Qualifications:
A Ph.D. degree and strong background in molecular, cell, and developmental biology are required. Must
be familiar with basic techniques in molecular biology, cell culture, biochemistry, and microscopy.
Experience working with mice and/or zebrafish is strongly preferred. Good written and oral
communication skills and an excellent teamwork attitude are expected.
Please apply here:
https://cfopitt.taleo.net/careersection/pitt_faculty_external_pd/jobdetail.ftl?job=22000658&tz=GMT-04%3A00&tzname=America%2FNew_York
Postdoc associate, Georgia institute of Technology in the School of Chemistry and Biochemistry, 2/24/22
The Reddi laboratory at the Georgia Institute of Technology in the School of
Chemistry and Biochemistry in Atlanta, GA is seeking to hire a post-doctoral
associate to work on NIH and NSF-funded projects elucidating heme trafficking and
signaling pathways. The lab is broadly interested in the cell biology and
biochemistry of metals and metalloproteins relevant to health and disease, with a
focus on heme cell biology. Available projects include understanding heme
trafficking and signaling at the host-pathogen interface and in neuroimmune
signaling.
We work at the interface of inorganic chemistry, chemical biology, cell biology,
protein biophysics, and molecular genetics. The ideal candidate will have
experience with mammalian cell culture techniques, molecular genetics,
microscopy, and flow cytometry. However, all interested candidates will be
considered.
Please e-mail Prof. Amit Reddi at amit.reddi@chemistry.gatech.edu to express your
interest. Include a CV and a brief statement (2 pages or less) summarizing your
educational background, past research experience, relevant skills, future research
interests, career goals, and what you are seeking to learn as a part of your postdoctoral
training. Please also arrange to have at least two letters of recommendation
e-mailed to the address above.
Contact Amit Reddi : amit.reddi@chemistry.gatech.edu
Postdoc search, Molecular Medicine Program, University of Utah, 1/25/22
Using genomic and transcriptomic screens, the Bray lab has discovered novel genes and gene variants regulating human hematopoiesis, megakaryocytopoiesis and platelet production. We identified the actin-bundling protein L-plastin (gene name: LCP1) as negatively associated with human platelet number. CRISPR/Cas9 deletion of LCP1 in primary human hematopoietic stem cells differentiated to megakaryocytes resulted in an increase in megakaryocyte proplatelet formation. Our studies with L-plastin null mice showed decreased megakaryocyte migration, megakaryocytes with “stiff” membranes and altered outside-in integrin signaling. A Postdoctoral Fellowship at the University of Utah is available to characterize the molecular and biophysical mechanisms by which L-plastin links both quantitative and qualitative effects on bone marrow stem cells and megakaryocytes. A background in cell signaling, mouse genetics, and/or animal models would be viewed favorably. This position provides an excellent opportunity to grow scientifically and work with a dynamic group of well-funded investigators in a Molecular Medicine Program of translational and basic research in hematopoiesis.
Contact Paul Bray: paul.bray@hsc.utah.edu; https://medicine.utah.edu/internalmedicine/hematology/labs/bray/
Postdoctoral Research Fellow in Iron Biology at Massachusetts General Hospital and Harvard Medical School 1/3/22
A funded postdoctoral fellow position is available immediately in the Babitt laboratory at Massachusetts General Hospital (MGH) and Harvard Medical School to elucidate novel molecular and cellular mechanisms involved in iron homeostasis. A particular focus of the laboratory is to identify the molecular basis by which bone morphogenetic proteins regulate iron metabolism and the links between these pathways and the crippling complications of iron disorders and chronic kidney disease. We employ state-of-the-art multidisciplinary experimental approaches, including novel mouse genetic models, primary cell isolation and culture, signal transduction assays, advanced microscopy techniques, flow cytometry, and multiomic approaches, among others. Postdoctoral fellows will benefit from a highly collaborative environment and connections to premier biomedical institutions in the greater Boston area.
Candidates for this position must have a Ph.D. (or equivalent) in the biomedical sciences. Ideal applicants will have an experimental background in molecular/cellular biology and mouse models of disease, a strong publication record, and excellent communication/interpersonal skills.
If interested, please email a cover letter, CV, and the contact information for three references to:
Jodie L. Babitt, M.D.
Associate Professor of Medicine
Director of Translational Nephrology
Massachusetts General Hospital
Harvard Medical School
Babitt.jodie@mgh.harvard.edu
Available Postdoctoral Fellow in Iron Biology, New York Blood Center (NYBC, New York, NY) 10/29/21
The New York Blood Center (NYBC) is seeking a highly motivated and enthusiastic PostDoctoral Research Fellow to work on research projects aimed at investigating mechanisms of iron-altered hematopoiesis within the Iron Research Laboratory. Our laboratory is part of the Lindsley F. Kimball Research Institute, the research branch of the New York Blood Center, one of the most comprehensive blood centers in the world. The main goal of the Iron Research Laboratory is to investigate the impact of iron overload and deficiency on the pathogenesis of human hematological diseases, including sickle cell disease, thalassemia and cancer. Our research investigates the molecular mechanisms of heme and iron-driven toxicity, including inflammation, oxidative stress and altered erythropoiesis, and the role of detoxification systems in counteracting these effects. The candidate will work in an academic environment and perform cutting-edge research that integrates hematology and immunology with novel therapies using innovative technologies and approaches, including classic molecular, cellular, and biochemical techniques, as well as modern imaging techniques, sequencing and single cell analysis techniques, bioinformatics, and preclinical in vivo and in vitro models. In addition, he/she will collaborate with other research scientists across the NYBC, including basic and translational investigators, as well as with pharma companies. The current position is funded for 3 years.
Requirements include:
- Ph.D. and/or M.D. degree in the biomedical sciences;
- A good record of high impact publications and a strong scholarly record;
- An experimental background in molecular and cellular biology (research experience with mouse models is required);
- Ability to work independently with minimal supervision and within a strong team environment; to identify problems in a timely manner; to evaluate options and implement solutions; to pay strong attention to detail in all work processes;
- Contribution to experimental design and participation in team
For immediate consideration, please submit an application to Dr. Francesca Vinchi, Head of Iron Research Laboratory (FVinchi@nybc.org), including:
- a full CV, with list of publications;
- a motivational letter concisely describing your past research experience, your research interests and why you are applying;
- contact information of at least 3
To learn more about the Iron Research Program and the NYBC visit:
www.nybloodcenter.org 
Francesca Vinchi, PhD | New York Blood Center (nybloodcenter.org)
Available postdoctoral positions in stem cells and immunology 9/30/21
Up to two full-time postdoctoral fellowship positions are available (open until filled) at the University of Utah School of Medicine and Huntsman Cancer Institute in Salt Lake City, UT, to investigate gene regulatory circuitries underlying adaptive immunity. Talented and motivated candidates with a track record of success in gene regulation and immunology will be considered. Experience with basic molecular biological methods and cell culture is required. Experience with mouse models and bioinformatic analysis is ideal. Candidates must have PhD or equivalent training. The successful candidate will be able to work independently as well as in a collaborative setting. Starting salaries will be based on the NIH postdoc scale. Send cover letter, current CV and contact information for three potential references to Dr. Dean Tantin, dean.tantin@path.utah.edu. Be sure to include “PD position 1” in the subject line.
The Tantin laboratory is committed to creating an inclusive work environment. All qualified individuals, including minorities, women, individuals with disabilities, and veterans are encouraged to apply.
Dean Tantin, PhD
Professor of Pathology
Division of Microbiology&Immunology
University of Utah School of Medicine
Huntsman Cancer Institute
2000 Circle of Hope, Research South 3707
Salt Lake City, UT 84112-5550
Email dean.tantin@path.utah.edu
medicine.utah.edu/pathology/research/labs/dean-tantin/
1 Postdoctoral Training Position Available 9/16/21
Postdoctoral Position Available at the National Institutes of Health
Iron Chaperones and the Distribution of Iron Cofactors within Cells
Caroline C. Philpott, M. D.
Genetics and Metabolism Section, LDB, NIDDK, NIH
Postdoctoral position available to study the distribution and utilization of iron cofactors within mammalian cells and tissues. Iron is an essential nutrient for every cell in the human body, yet it can also be a potent cellular toxin. Iron is essential because enzymes that require iron co-factors (namely, heme, iron-sulfur clusters, mononuclear and diiron centers) are involved in virtually every major metabolic process in the cell. Iron deficiency continues to be the most common nutritional deficiency in the world, especially among children and women of childbearing age, where it causes anemia and impairs neurological development and function. Although the pathogenesis of anemia in iron deficiency is well understood, other manifestations of iron deficiency are not understood at the cellular or metabolic level. Iron overload is a feature of an increasing number of human diseases, including genetic disorders such as hereditary hemochromatosis, thalassemias, and Friedreich ataxia, as well as chronic inflammatory diseases of the liver, such as hepatitis C. Hundreds of iron, zinc, copper, and manganese proteins are expressed in human cells, yet little is known about the mechanisms by which these metalloproteins acquire their native metal ligands and avoid mis-metallation. We have made significant advances in understanding the delivery of iron to iron-dependent enzymes in the cytosol.
We identified Poly rC-Binding Protein 1 (PCBP1) as an iron-binding protein that delivers iron to ferritin in human cells (Shi, et al. 2008, Science 320, 1207-10). This was the first description of a cytosolic iron chaperone – a protein that specifically binds iron ions and delivers them to target proteins through direct protein-protein interactions. PCBP1 and its human paralogs are multifunctional adaptor proteins that also bind single-stranded DNA and RNA in a sequence-specific manner to regulate the fate of the nucleic acid. PCBP2, a human paralog of PCBP1, is independently required for the delivery of iron to ferritin. PCBP1 and PCBP2 deliver iron to additional families of target enzymes: the prolyl hydroxylases (PHDs) that regulate the degradation of hypoxia inducible factor 1 (HIF1) and deoxyhypusine hydroxylase (DOHH). Projects currently underway explore the roles of PCBPs in erythroid cell development, duodenal iron absorption, macrophage iron recycling, and the intersection of iron ion chaperones with the Fe-S cluster machinery. Mouse models of PCBP1 and PCBP2 deficiency have been developed and are revealing new functions of these proteins in maintaining iron homeostasis in mammals.
We use the tools of cell biology, genetics and biochemistry to address questions about how cells and animals use iron. The postdoctoral position is fully funded, available immediately, and open to any motivated Ph.D./M.D. with less than five years of postdoctoral experience. NIH is an equal opportunity employer.
Contact:
Caroline C. Philpott, M. D.Chief, Genetics and Metabolism Section
Liver Diseases Branch, NIDDK, NIH
Bldg 10, Rm 9B-16
10 Center Drive
Bethesda, MD 20892-1800
Web: http://irp.nih.gov/pi/caroline-philpott
Phone: 301-435-4018
Fax: 301-402-0491
Email: carolinep@mail.nih.gov
2 Postdoctoral Training Positions Available 5/14/21
Postdoctoral positions in the
Enns/Zhang Labs in the Department
of Cell, Developmental, and Cancer Biology at Oregon Health &
Science University, Portland, OR USA. Detail link
Postdoctoral Training Position Available Fellowship 5/7/21
Bone Marrow Spatial Transcriptomics to Enhance In Vitro Platelet Production:
The Moffitt and Cantor Laboratories at Boston Children’s Hospital/Harvard Medical School (HMS) are currently
accepting applications for an entry-level joint post-doctoral training position. The Moffitt lab focuses on
development and utilization of in situ single-molecule imaging methods to further understand tissue
architecture, developmental signaling, and novel cell type identification. The Cantor lab specializes in
hematopoiesis and platelet production. This joint project will develop and apply Multiplexed Error-robust
Fluorescence In Situ Hybridization (MERFISH) to the mouse and human bone marrow to further understand
how megakaryocytes generate platelets in the context of their native microenvironment. This knowledge will
then be applied to enhance in vitro platelet production from induced pluripotent stem cells (hIPSCs) for
transfusion purposes. The candidate will also interact with the Allon Klein’s laboratory at HMS to develop and
correlate scRNA-seq and in situ transcriptomic datasets. The candidate will be jointly advised by Dr. Moffitt and
Dr. Cantor and will have the opportunity to learn and develop a cutting-edge spatial transcriptomics tool while
substantially advancing our understanding of bone micro-environment and its critical role in the important
process of platelet production and stem cell biology.
Candidates should have recently (within ~1 year) obtained a PhD or an MD/PhD degree in the fields of
Computational Biology, Genomics, Molecular Biology, Cellular Biology, Biochemistry, Development, or
Genetics. The candidate should have evidence of prior productive scientific work in the form of publications in
peer-reviewed journals. Prior experience in computational biology, scRNAseq, and/or other “-omics” type
approaches is strongly preferred. U.S. citizenship or Permanent Resident status (i.e., “Green Card” holders) is
not necessary, but is favored.
Interested candidates should send their Curriculum Vitae and a cover letter describing their background and
research interests to jeffrey.moffitt@childrens.harvard.edu and alan.cantor@childrens.harvard.edu.
Candidates should also arrange for two letters of recommendation, which may be requested. Jeffrey Moffitt, PhD
Alan Cantor, MD, PhD 
Assistant Professor of Pediatrics Associate Professor of Pediatrics
Program in Cellular and Molecular Medicine Division of Pediatric Hematology/Oncology
Office: 617-713-8902 Office:617-919-2026
Boston Children’s Hospital is an equal opportunity employer. Women and members of under-represented
minorities are encouraged to apply
Postdoc Fellow/Staff Scientist 5/6/21
Location: Boston Children’s Hospital, Harvard Medical School
Job Description:
The Bauer laboratory seeks highly motivated post-doctoral research fellows and staff scientists to investigate
therapeutic gene editing to address human diseases with unmet clinical needs and to explore the functional
genomics of human hematopoiesis. We conduct studies ranging from technology development, target discovery,
preclinical validation and first-in-human clinical application.
We have identified regulatory elements that are subject to naturally occurring disease associated genetic variation
and are critical determinants of fetal hemoglobin level and hemoglobin disorder clinical severity. We have
developed methodologies for high-throughput and high-resolution functional evaluation of coding and noncoding
genetic elements. We have demonstrated highly efficient and specific methods for nuclease and base editing of
human hematopoietic stem and progenitor cells. We use molecular genetic, biochemical, and genome editing
methodologies to perturb and observe blood cells. Our studies are meant to elucidate fundamental mechanisms
of gene regulatory elements in their endogenous chromosomal environment, to explore determinants of blood cell
development, homeostasis, and disease, and to define structure-function relationships of disease relevant protein
complexes. A major motivation of our work is to translate findings into novel therapies for patients with blood
disorders. We are advancing therapeutic gene editing from preclinical studies to first-in-human trials.
Prior experience in gene editing/gene therapy, protein engineering, hematopoiesis, molecular and cell biology,
genetics, biochemistry, systems biology, structural/chemical biology, and/or bioinformatics/computational biology
is highly desirable. The candidate must be independent in scientific research and writing, self-motivated, ethical,
team spirited, and must have exceptional laboratory, communication, organizational, and writing skills.
Interested applicants should send a CV, cover letter, statement of research interest and contact information for
three references via email to 
Daniel Bauer, MD PhD (daniel.bauer@childrens.harvard.edu), Division of
Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA. Boston Children’s
Hospital is one of the top pediatric research centers in the world, and a major research and teaching affiliate of
Harvard Medical School. The Bauer Laboratory is also affiliated with the Dana-Farber Cancer Institute, Harvard
Stem Cell Institute, and Broad Institute of Harvard and MIT.
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