Postdoc opportunity

     

    Postdoc Scholar, UCLA, 5/3/22

    Position: Postdoctoral scholar

    Start date: immediate; negotiable

    Institution: UCLA David Geffen School of Medicine; Department of Medicine

    Laboratory:  Center For Iron Disorders (PIs: Tomas Ganz, Elizabeta Nemeth, Airie Kim); http://iron.med.ucla.edu

    Project description: The research project investigates the role of iron in the development of pulmonary arterial hypertension (PAH), a chronic and severe cardiopulmonary disease that results in heart failure and death. Iron deficiency is associated with worse PAH clinical outcomes, and treatment has been shown to improve exercise tolerance and quality of life, but the underlying mechanisms remain unclear. Our preliminary data indicate that rat models can be used to replicate this clinical phenomenon, thus we propose to use mouse and rat models of PAH to define the mechanisms that link iron homeostasis and PAH outcomes. We are a medium-large biomedical research laboratory interested in iron homeostasis and its disorders, and have a dynamic team of faculty members, postdocs, graduate students, and staff. We prioritize the nurturing of young scientific careers, and have a decades-long track record in placing our trainees in their desired careers, including academics and industry.

    Eligibility: By the time of hire, applicants should have completed a graduate program in a field related to molecular cell biology, physiology, or microbiology. The applicant must be willing to work with murine models. We will provide any specific training necessary.

    Contact Person: Airie Kim (airiekim@mednet.ucla.edu)

     

    Postdoc associate, University of Pittsburgh Postdoc, 5/3/22

    The postdoctoral associate will work at the lab of Dr. Yvette Yien of the Department of Medicine,

    Vascular Medicine Institute at the University of Pittsburgh. The research will be focused on identifying

    the role of iron metabolism in facilitating the terminal steps of red cell development. The postdoc will

    work independently to design and perform experiments in embryology, biochemistry/molecular biology,

    and cell biology. The lab uses a wide variety of model organisms, including zebrafish, mouse, and

    mammalian cell culture. Other responsibilities include presenting data at lab meetings and scientific

    conferences, preparing research articles for publication, assisting with lab administration, and training

    other lab personnel. This position may require the need to lift 20 lb while working with the fish tanks.

    Qualifications:

    A Ph.D. degree and strong background in molecular, cell, and developmental biology are required. Must

    be familiar with basic techniques in molecular biology, cell culture, biochemistry, and microscopy.

    Experience working with mice and/or zebrafish is strongly preferred. Good written and oral

    communication skills and an excellent teamwork attitude are expected.

    Please apply here:

    https://cfopitt.taleo.net/careersection/pitt_faculty_external_pd/jobdetail.ftl?job=22000658&tz=GMT-04%3A00&tzname=America%2FNew_York

     

    Postdoc associate, Georgia institute of Technology in the School of Chemistry and Biochemistry, 2/24/22

    The Reddi laboratory at the Georgia Institute of Technology in the School of
    Chemistry and Biochemistry in Atlanta, GA is seeking to hire a post-doctoral
    associate to work on NIH and NSF-funded projects elucidating heme trafficking and
    signaling pathways. The lab is broadly interested in the cell biology and
    biochemistry of metals and metalloproteins relevant to health and disease, with a
    focus on heme cell biology. Available projects include understanding heme
    trafficking and signaling at the host-pathogen interface and in neuroimmune
    signaling.
    We work at the interface of inorganic chemistry, chemical biology, cell biology,
    protein biophysics, and molecular genetics. The ideal candidate will have
    experience with mammalian cell culture techniques, molecular genetics,
    microscopy, and flow cytometry. However, all interested candidates will be
    considered.
    Please e-mail Prof. Amit Reddi at amit.reddi@chemistry.gatech.edu to express your
    interest. Include a CV and a brief statement (2 pages or less) summarizing your
    educational background, past research experience, relevant skills, future research
    interests, career goals, and what you are seeking to learn as a part of your postdoctoral
    training. Please also arrange to have at least two letters of recommendation
    e-mailed to the address above.

    Contact Amit Reddi :  amit.reddi@chemistry.gatech.edu

     

    Postdoc search, Molecular Medicine Program, University of Utah, 1/25/22

    Using genomic and transcriptomic screens, the Bray lab has discovered novel genes and gene variants regulating human hematopoiesis, megakaryocytopoiesis and platelet production.  We identified the actin-bundling protein L-plastin (gene name: LCP1) as negatively associated with human platelet number.  CRISPR/Cas9 deletion of LCP1 in primary human hematopoietic stem cells differentiated to megakaryocytes resulted in an increase in megakaryocyte proplatelet formation.  Our studies with L-plastin null mice showed decreased megakaryocyte migration, megakaryocytes with “stiff” membranes and altered outside-in integrin signaling.  A Postdoctoral Fellowship at the University of Utah is available to characterize the molecular and biophysical mechanisms by which L-plastin links both quantitative and qualitative effects on bone marrow stem cells and megakaryocytes.  A background in cell signaling, mouse genetics, and/or animal models would be viewed favorably. This position provides an excellent opportunity to grow scientifically and work with a dynamic group of well-funded investigators in a Molecular Medicine Program of translational and basic research in hematopoiesis.

    Contact Paul Bray: paul.bray@hsc.utah.edu; https://medicine.utah.edu/internalmedicine/hematology/labs/bray/

     

    Postdoctoral Research Fellow in Iron Biology at Massachusetts General Hospital and Harvard Medical School 1/3/22

    A funded postdoctoral fellow position is available immediately in the Babitt laboratory at Massachusetts General Hospital (MGH) and Harvard Medical School to elucidate novel molecular and cellular mechanisms involved in iron homeostasis. A particular focus of the laboratory is to identify the molecular basis by which bone morphogenetic proteins regulate iron metabolism and the links between these pathways and the crippling complications of iron disorders and chronic kidney disease. We employ state-of-the-art multidisciplinary experimental approaches, including novel mouse genetic models, primary cell isolation and culture, signal transduction assays, advanced microscopy techniques, flow cytometry, and multiomic approaches, among others. Postdoctoral fellows will benefit from a highly collaborative environment and connections to premier biomedical institutions in the greater Boston area.

    Candidates for this position must have a Ph.D. (or equivalent) in the biomedical sciences. Ideal applicants will have an experimental background in molecular/cellular biology and mouse models of disease, a strong publication record, and excellent communication/interpersonal skills.

    If interested, please email a cover letter, CV, and the contact information for three references to:

    Jodie L. Babitt, M.D.
    Associate Professor of Medicine
    Director of Translational Nephrology
    Massachusetts General Hospital
    Harvard Medical School
    Babitt.jodie@mgh.harvard.edu

     

    Available Postdoctoral Fellow in Iron Biology, New York Blood Center (NYBC, New York, NY) 10/29/21

    The New York Blood Center (NYBC) is seeking a highly motivated and enthusiastic PostDoctoral Research Fellow to work on research projects aimed at investigating mechanisms of iron-altered hematopoiesis within the Iron Research Laboratory. Our laboratory is part of the Lindsley F. Kimball Research Institute, the research branch of the New York Blood Center, one of the most comprehensive blood centers in the world. The main goal of the Iron Research Laboratory is to investigate the impact of iron overload and deficiency on the pathogenesis of human hematological diseases, including sickle cell disease, thalassemia and cancer. Our research investigates the molecular mechanisms of heme and iron-driven toxicity, including inflammation, oxidative stress and altered erythropoiesis, and the role of detoxification systems in counteracting these effects. The candidate will work in an academic environment and perform cutting-edge research that integrates hematology and immunology with novel therapies using innovative technologies and approaches, including classic molecular, cellular, and biochemical techniques, as well as modern imaging techniques, sequencing and single cell analysis techniques, bioinformatics, and preclinical in vivo and in vitro models. In addition, he/she will collaborate with other research scientists across the NYBC, including basic and translational investigators, as well as with pharma companies. The current position is funded for 3 years.

    Requirements include:

    • Ph.D. and/or M.D. degree in the biomedical sciences;
    • A good record of high impact publications and a strong scholarly record;
    • An experimental background in molecular and cellular biology (research experience with mouse models is required);
    • Ability to work independently with minimal supervision and within a strong team environment; to identify problems in a timely manner; to evaluate options and implement solutions; to pay strong attention to detail in all work processes;
    • Contribution to experimental design and participation in team

    For immediate consideration, please submit an application to Dr. Francesca Vinchi, Head of Iron Research Laboratory (FVinchi@nybc.org), including:

    • a full CV, with list of publications;
    • a motivational letter concisely describing your past research experience, your research interests and why you are applying;
    • contact information of at least 3

    To learn more about the Iron Research Program and the NYBC visit:

    www.nybloodcenter.org

    Francesca Vinchi, PhD | New York Blood Center (nybloodcenter.org)

     

     

     

     

     

     

    Available postdoctoral positions in stem cells and immunology 9/30/21

    Up to two full-time postdoctoral fellowship positions are available (open until filled) at the University of Utah School of Medicine and Huntsman Cancer Institute in Salt Lake City, UT, to investigate gene regulatory circuitries underlying adaptive immunity. Talented and motivated candidates with a track record of success in gene regulation and immunology will be considered. Experience with basic molecular biological methods and cell culture is required. Experience with mouse models and bioinformatic analysis is ideal. Candidates must have PhD or equivalent training. The successful candidate will be able to work independently as well as in a collaborative setting. Starting salaries will be based on the NIH postdoc scale. Send cover letter, current CV and contact information for three potential references to Dr. Dean Tantin, dean.tantin@path.utah.edu. Be sure to include “PD position 1” in the subject line.

    The Tantin laboratory is committed to creating an inclusive work environment. All qualified individuals, including minorities, women, individuals with disabilities, and veterans are encouraged to apply.

    Dean Tantin, PhD
    Professor of Pathology
    Division of Microbiology&Immunology
    University of Utah School of Medicine
    Huntsman Cancer Institute
    2000 Circle of Hope, Research South 3707
    Salt Lake City, UT 84112-5550
    Email dean.tantin@path.utah.edu
    medicine.utah.edu/pathology/research/labs/dean-tantin/

    1 Postdoctoral Training Position Available  9/16/21

    Postdoctoral Position Available at the National Institutes of Health

     Iron Chaperones and the Distribution of Iron Cofactors within Cells

     

    Caroline C. Philpott, M. D.
    Genetics and Metabolism Section, LDB, NIDDK, NIH

    Postdoctoral position available to study the distribution and utilization of iron cofactors within mammalian cells and tissues. Iron is an essential nutrient for every cell in the human body, yet it can also be a potent cellular toxin. Iron is essential because enzymes that require iron co-factors (namely, heme, iron-sulfur clusters, mononuclear and diiron centers) are involved in virtually every major metabolic process in the cell. Iron deficiency continues to be the most common nutritional deficiency in the world, especially among children and women of childbearing age, where it causes anemia and impairs neurological development and function. Although the pathogenesis of anemia in iron deficiency is well understood, other manifestations of iron deficiency are not understood at the cellular or metabolic level. Iron overload is a feature of an increasing number of human diseases, including genetic disorders such as hereditary hemochromatosis, thalassemias, and Friedreich ataxia, as well as chronic inflammatory diseases of the liver, such as hepatitis C. Hundreds of iron, zinc, copper, and manganese proteins are expressed in human cells, yet little is known about the mechanisms by which these metalloproteins acquire their native metal ligands and avoid mis-metallation. We have made significant advances in understanding the delivery of iron to iron-dependent enzymes in the cytosol.

    We identified Poly rC-Binding Protein 1 (PCBP1) as an iron-binding protein that delivers iron to ferritin in human cells (Shi, et al. 2008, Science 320, 1207-10). This was the first description of a cytosolic iron chaperone – a protein that specifically binds iron ions and delivers them to target proteins through direct protein-protein interactions.  PCBP1 and its human paralogs are multifunctional adaptor proteins that also bind single-stranded DNA and RNA in a sequence-specific manner to regulate the fate of the nucleic acid. PCBP2, a human paralog of PCBP1, is independently required for the delivery of iron to ferritin. PCBP1 and PCBP2 deliver iron to additional families of target enzymes: the prolyl hydroxylases (PHDs) that regulate the degradation of hypoxia inducible factor 1 (HIF1) and deoxyhypusine hydroxylase (DOHH). Projects currently underway explore the roles of PCBPs in erythroid cell development, duodenal iron absorption, macrophage iron recycling, and the intersection of iron ion chaperones with the Fe-S cluster machinery. Mouse models of PCBP1 and PCBP2 deficiency have been developed and are revealing new functions of these proteins in maintaining iron homeostasis in mammals.

    We use the tools of cell biology, genetics and biochemistry to address questions about how cells and animals use iron. The postdoctoral position is fully funded, available immediately, and open to any motivated Ph.D./M.D. with less than five years of postdoctoral experience. NIH is an equal opportunity employer.

    Contact:

    Caroline C. Philpott, M. D.Chief, Genetics and Metabolism Section
    Liver Diseases Branch, NIDDK, NIH
    Bldg 10, Rm 9B-16
    10 Center Drive
    Bethesda, MD 20892-1800

    Web: http://irp.nih.gov/pi/caroline-philpott
    Phone: 301-435-4018
    Fax: 301-402-0491
    Email: carolinep@mail.nih.gov

    2 Postdoctoral Training Positions Available  5/14/21

    Postdoctoral positions in the

      Enns/Zhang Labs in the Department
    of Cell, Developmental, and Cancer Biology at Oregon Health &
    Science University, Portland, OR USA. Detail link

     

    Postdoctoral Training Position Available Fellowship   5/7/21 

    Bone Marrow Spatial Transcriptomics to Enhance In Vitro Platelet Production:
    The Moffitt and Cantor Laboratories at Boston Children’s Hospital/Harvard Medical School (HMS) are currently
    accepting applications for an entry-level joint post-doctoral training position. The Moffitt lab focuses on
    development and utilization of in situ single-molecule imaging methods to further understand tissue
    architecture, developmental signaling, and novel cell type identification. The Cantor lab specializes in
    hematopoiesis and platelet production. This joint project will develop and apply Multiplexed Error-robust
    Fluorescence In Situ Hybridization (MERFISH) to the mouse and human bone marrow to further understand
    how megakaryocytes generate platelets in the context of their native microenvironment. This knowledge will
    then be applied to enhance in vitro platelet production from induced pluripotent stem cells (hIPSCs) for
    transfusion purposes. The candidate will also interact with the Allon Klein’s laboratory at HMS to develop and
    correlate scRNA-seq and in situ transcriptomic datasets. The candidate will be jointly advised by Dr. Moffitt and
    Dr. Cantor and will have the opportunity to learn and develop a cutting-edge spatial transcriptomics tool while
    substantially advancing our understanding of bone micro-environment and its critical role in the important
    process of platelet production and stem cell biology.
    Candidates should have recently (within ~1 year) obtained a PhD or an MD/PhD degree in the fields of
    Computational Biology, Genomics, Molecular Biology, Cellular Biology, Biochemistry, Development, or
    Genetics. The candidate should have evidence of prior productive scientific work in the form of publications in
    peer-reviewed journals. Prior experience in computational biology, scRNAseq, and/or other “-omics” type
    approaches is strongly preferred. U.S. citizenship or Permanent Resident status (i.e., “Green Card” holders) is
    not necessary, but is favored.
    Interested candidates should send their Curriculum Vitae and a cover letter describing their background and
    research interests to jeffrey.moffitt@childrens.harvard.edu and alan.cantor@childrens.harvard.edu.
    Candidates should also arrange for two letters of recommendation, which may be requested. Jeffrey Moffitt, PhD

    Alan Cantor, MD, PhD
    Assistant Professor of Pediatrics Associate Professor of Pediatrics
    Program in Cellular and Molecular Medicine Division of Pediatric Hematology/Oncology
    Office: 617-713-8902 Office:617-919-2026
    Boston Children’s Hospital is an equal opportunity employer. Women and members of under-represented
    minorities are encouraged to apply

     

    Postdoc Fellow/Staff Scientist 5/6/21

    Location: Boston Children’s Hospital, Harvard Medical School

    Job Description:
    The Bauer laboratory seeks highly motivated post-doctoral research fellows and staff scientists to investigate
    therapeutic gene editing to address human diseases with unmet clinical needs and to explore the functional
    genomics of human hematopoiesis. We conduct studies ranging from technology development, target discovery,
    preclinical validation and first-in-human clinical application.
    We have identified regulatory elements that are subject to naturally occurring disease associated genetic variation
    and are critical determinants of fetal hemoglobin level and hemoglobin disorder clinical severity. We have
    developed methodologies for high-throughput and high-resolution functional evaluation of coding and noncoding
    genetic elements. We have demonstrated highly efficient and specific methods for nuclease and base editing of
    human hematopoietic stem and progenitor cells. We use molecular genetic, biochemical, and genome editing
    methodologies to perturb and observe blood cells. Our studies are meant to elucidate fundamental mechanisms
    of gene regulatory elements in their endogenous chromosomal environment, to explore determinants of blood cell
    development, homeostasis, and disease, and to define structure-function relationships of disease relevant protein
    complexes. A major motivation of our work is to translate findings into novel therapies for patients with blood
    disorders. We are advancing therapeutic gene editing from preclinical studies to first-in-human trials.
    Prior experience in gene editing/gene therapy, protein engineering, hematopoiesis, molecular and cell biology,
    genetics, biochemistry, systems biology, structural/chemical biology, and/or bioinformatics/computational biology
    is highly desirable. The candidate must be independent in scientific research and writing, self-motivated, ethical,
    team spirited, and must have exceptional laboratory, communication, organizational, and writing skills.
    Interested applicants should send a CV, cover letter, statement of research interest and contact information for
    three references via email to

    Daniel Bauer, MD PhD (daniel.bauer@childrens.harvard.edu), Division of
    Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA. Boston Children’s
    Hospital is one of the top pediatric research centers in the world, and a major research and teaching affiliate of
    Harvard Medical School. The Bauer Laboratory is also affiliated with the Dana-Farber Cancer Institute, Harvard
    Stem Cell Institute, and Broad Institute of Harvard and MIT.

     

     

     

     

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