Postdoc opportunity

     

    Open position 4/1/2021

    Postdoctoral Training Program in Developmental Biology and Regenerative Medicine – University of
    Colorado Anschutz Medical Campus, Aurora, Colorado

    Our mission
    The Section of Developmental Biology, headed by Dr. Bruce Appel, at the University of Colorado
    School of Medicine, with support from the Gates Frontiers Fund, established the DevBioPostDoc
    Program to advance the next generation of scientific leaders in Developmental Biology and
    Regenerative Medicine. The DevBioPostDoc Program trains future postdoctoral fellows to become
    scientific experts through cutting-edge research and close guidance from principal investigators at
    the CU Anschutz Medical Campus.

    The position
    The DevBioPostDoc Program intends to attract research-driven scientists from across the world and
    encourages those who want to pursue an academic scientific research to apply. Postdoc trainees are
    provided with a salary support in accordance with the NIH pay scale and a full benefits
    package from the University of Colorado. Successful applicants will be appointed as
    Gates Fellows with initial appointments made for one year and continued support contingent
    on satisfactory progress.

    Our story
    Member labs of the DevBioPostDoc program use diverse model systems to address a broad range of
    questions in the areas of Developmental Biology, Disease Modeling, and Regenerative Medicine. Read
    more about the research of our principal investigators at the Section of Developmental Biology
    here: https://medschool.cuanschutz.edu/pediatrics/sections/developmental-biology/faculty
    Read the stories of our current DevBioPostDoc trainees here: https://tinyurl.com/yzt8azxv

    Application process
    Applicants must have a Ph.D. degree and less than two years of postdoctoral
    experience. Interested candidates submit 1) a statement explaining their motivation to join the
    program and indicating their preferred host lab (2-page maximum), 2) CV and 3) arrange for three
    references. Review of applications will begin immediately and finalists will be invited for virtual
    interviews. Applications should be submitted here:
    https://cu.taleo.net/careersection/2/jobdetail.ftl?job=20570&lang=en
    For more information, we encourage you to contact Dr. Charles Sagerström, Co-Director of the
    Postdoctoral Training Program, charles.sagerstrom@cuanschutz.edu and Dr. Alexa Burger, Co-Director
    of the Postdoctoral Training Program, alexa.burger@cuanschutz.edu.
    If you want to learn more about the DevBioPostDoc program and to communicate with the postdoctoral
    trainees, please email them directly cudevbiopostdocs@gmail.com.

     

    Open positions 3/19/2021

    New BioIron funding announcement 2/24/2021

    Postdoctoral Research Fellow in Iron Biology at Massachusetts General Hospital and Harvard Medical School
    An NIH-funded postdoctoral fellow position is available immediately in the Babitt laboratory at Massachusetts General Hospital (MGH) and Harvard Medical School to elucidate novel molecular and cellular mechanisms involved in iron homeostasis. A particular focus of the laboratory is to identify the molecular basis by which bone morphogenetic proteins regulate iron metabolism and the links between these pathways and the crippling complications of iron disorders and chronic kidney disease. We employ state-of-the-art multidisciplinary experimental approaches, including novel mouse genetic models, primary cell isolation and culture, signal transduction assays, advanced microscopy techniques, flow cytometry, and multiomic approaches, among others. Postdoctoral fellows will benefit from a highly collaborative environment and connections to premier biomedical institutions in the greater Boston area.

    Candidates for this position must have a Ph.D. (or equivalent) in the biomedical sciences. Ideal applicants will have an experimental background in molecular/cellular biology and mouse models of disease, a strong publication record, and excellent communication/interpersonal skills.

    If interested, please email a cover letter, CV, and the contact information for three references to:

    Jodie L. Babitt, M.D.
    Associate Professor of Medicine
    Director of Translational Nephrology
    Massachusetts General Hospital
    Harvard Medical School
    Babitt.jodie@mgh.harvard.edu

     

    New BioIron funding announcement 2/23/21

    Post-Doctoral Position Available

    A post-doctoral position is immediately available in the laboratories of Drs. John J. Lemasters and Anna-Liisa Nieminen in the Departments of Biochemistry & Molecular Biology, and Drug Discovery & Biomedical Sciences at the Medical University of South Carolina in Charleston, South Carolina. This is a joint NIH-funded research project to examine the molecular pathways of mitochondrial iron uptake and release in hepatocytes and ultimately in the liver. To address the questions posed, we will utilize a variety of hepatocyte-specific transgenic mouse strains, affinity enrichment-mass spectrometry, confocal/super-resolution/intravital multiphoton microscopy, and a newly developed mitochondrial iron sensor. Collectively, information gained from this project will impact several different pathologies where mitochondrial iron uptake plays a pathogenic role.

    We are seeking a motivated and energetic scientist who can work independently, and who will be mentored in a collaborative and productive research environment addressing mitochondrial biology and cell injury. Extensive training in confocal/super-resolution/intravital imaging will be provided.

    The successful candidate should have a recent PhD, MD, or equivalent. Priority will be given to qualified candidates with a strong background in molecular and cellular biology. Experience with rodent models is also preferred, but not required. Salary will follow NIH guidelines commensurate with training and experience.

    If interested, please send a letter describing your research experience/interests/future career goals, CV, and contact information for three references electronically to:

    John J. Lemasters, MD, PhD

    jjlemasters@musc.edu

    Anna-Liisa Nieminen, PhD

    nieminen@musc.edu

    New BioIron funding announcement 1/27/21

    The International Society for the Study of Iron in Biology and Medicine is offering two COVID Relief Grants, to support trainees whose research has been disrupted by the COVID-19 pandemic.

    Eligibility

    Applicant must be a graduate student or a postdoctoral researcher in their first postdoctoral post.

    Applicants must be affiliated with an established iron research lab at the time of application and during the proposed period of the award (as shown by the PI and/or the applicant’s membership of the International Society for the Study of Iron in Biology and Medicine).

    Applicants must be able to detail how their existing research has been disrupted by the COVID-19 pandemic. Examples include, but are not limited to:

    • Funding for the research group has been cut or significantly reduced.
    • The period of funding has elapsed for trainees holding time-limited research studentships/ fellowships.
    • A need to extend the duration of their contracts, to account for time lost due to the closure of research facilities.

    The award is for up to €5000/USD $6057.75 and can be used to fund salary costs (for contract extensions), consumables, animal costs, and core facilities access. Awardees are expected to write a report outlining the research outcomes achieved during the period of the award.

    Application Process

    1. Applicants must complete the application form.
    2. Applicants must provide a letter of support from their PI, and evidence of affiliation with the host lab during the proposed period of the award.

    The application form and associated documents must be submitted as a single pdf to info@bioiron.org, no later than Friday 26, February.

    Applicants will be informed of the outcome by Friday 26, March, with grants commencing 1 to 3 months later.

     

    New funding announcement at The NIDDK Hematology Centers Program – open 1/5/21

    The NIDDK Hematology Centers Program is providing a novel support mechanism for trainees, postdocs, and junior faculty who want to pursue new directions in non-malignant hematology. Center Directors welcome applicants from across the U.S. and will strive to provide equal access to the cutting-edge resources and expertise available in their center cores.

    new funding link

     

    UM-Madison Postdoctoral Position open 1/22/21

    Postdoctoral Training Opportunities with the
    Metabolism and Nutrition Training Program (MANTP) at UW-Madison
    – An NIH-funded T32 Training Program –

    • Up to 3 years of funding of your salary at NIH postdoctoral rates in a highly collegial
    community of scientists focused on the molecular, genetic, biochemical and clinical and
    population-based aspects of nutrition-related biomedical research (trainers listed on back/next
    page).

    • Mock-review of your F32 or similar postdoctoral fellowship proposal in study section composed
    of other trainees and faculty trainers.

    • Gain experience at grant reviewing via participation as a reviewer in MANTP mock study
    section.

    • Funds (up to $2500) to pay help pay for unique professional development opportunities such as
    a class at Cold Spring Harbor Laboratories.

    • Trainee-specific meetings (2-4 / semester) with outside speakers from academia, industry and
    other venues to discuss career trajectories and opportunities.

    • Annual meetings to discuss the research progress of all trainees including opportunities to
    deliver a “chalk-talk” that addresses the broad relevance of your work and its applicability to the
    NIH mission.

    • Integrative annual retreat with U Chicago T32 on “Digestive Diseases and Nutrition” where the
    focus is on increased exposure to cutting edge translational research, improving research
    presentations at national meetings, professional development activities and networking.

    • Opportunities to mentor young investigators.

    • Guidance from the MANTP Executive Committee in planning your career trajectory – both short-
    and long-term.

    • Input regarding application letters, CVs, research presentation and what to expect in
    interviews.

    Applicants should send a cover letter describing research background and career goals, curriculum
    vitae and three letters of reference to:
    Rick Eisenstein Ph.D.
    Dept. of Nutritional Sciences, University of Wisconsin 1415 Linden Drive, Madison, WI 53706
    Email contact: eisenstein@nutrisci.wisc.edu

    UW-Madison is an equal opportunity/affirmative action employer.
    We promote excellence through diversity and encourage all qualified individuals to apply.
    Positions are open only to U.S. citizens and non-citizen nationals per NIH policy.

     

     

    Tisch Cancer Institute Postdoctoral Position open 10/23/20

    Division of Hematology/Medical Oncology

    Job Title:                              Postdoctoral Fellow

    Job Class:                            TR04

    Pay frequency: Biweekly

    Exempt status: Exempt

    Job Description:

    A Postdoctoral position is currently available within the lab of Dr. Yelena Ginzburg at the Tisch Cancer Institute at the Icahn School of Medicine of Mount Sinai. The lab focuses on iron metabolism and erythropoiesis in health and disease, using mouse models and human samples ex vivo to ask questions about basic biology, physiology, and pathophysiology.

    The candidate PhD or MD/PhD in biochemistry, physiology, or molecular biology will have an opportunity to contribute to and shape several ongoing projects within the lab.

    The Ginzburg laboratory is a team of scientists and student scientists with deep interest in understanding the crosstalk between erythropoiesis and iron metabolism. We recently also generated preliminary data focused on understanding the crosstalk with bone homeostasis. We are looking for a highly motivated postdoctoral fellow to lead a research project aimed at understanding in detail how iron transport influences erythropoiesis, how the erythron communicates iron requirements to the liver, the main organ involved in hepcidin production, and how the known regulatory nodes influence bone homeostasis.

    To accomplish these goals, we aim to utilize standard molecular biology techniques, novel mouse models with mutations in erythropoiesis- and iron-related genes, and state-of-the-art genetic manipulation tools.

    Iron transport for erythropoiesis, crosstalk between them, and erythroid regulation of iron metabolism are central tenets in recovery during stress erythropoiesis and are dysregulated in multiple hematological disorders and thus of great interest to the hematology field. Coordination with bone homeostasis is critically important given the proximal physical relationship between bone marrow and bone. The successful completion of this work will provide insight into the pathophysiology of human diseases in which erythropoiesis is disturbed (e.g. β-thalassemia, polycythemia vera, and MDS), extend current knowledge in iron metabolism and bone homeostasis, and add new paradigms for further exploring erythroid regulation of hepcidin in health and disease.

    Candidate profile:

    We are looking for a scientist with a solid background in biochemistry, physiology, and molecular biology. Skills in microscopy, flow cytometry, ex vivo hematopoietic stem cell proliferation and differentiation, immunoprecipitation, western blot, ELISA, RT-PCR, transfection using plasmid for knockdown and overexpression, and cell sorting techniques as well as mouse husbandry (i.e. breeding and handling)) are advantageous. The candidate should be able to work independently, in a collaborative manner. A track record of publications in peer-reviewed journals is required.

    Duties/responsibilities:

    1. Conduct and design experiments under the direction of lab PI.
    2. Report to PI research progress and maintain a current knowledge of literature in relevant fields.
    3. Maintain good records and contact with collaborators.
    4. Nurture collaborative relationships with fellow scientists within the institution, locally, nationally and internationally.
    5. Summarize experimental data timely and assist in drafting publications under the direction of the PI.
    6. Master computer and technical skills necessary for experimental execution as well as data input and analysis.
    7. Performs other related duties as assigned.

    Qualifications:

    • A Ph.D. in molecular or cellular biology, biochemistry, genetics, or immunology.
    • Previous experience in basic molecular and cellular biology methods including DNA and RNA isolation, siRNA methods, construct engineering, tissue culture and preparation and analysis of samples through flow cytometry.
    • Previous experience with biochemistry techniques including Western blots and immuno-precipitations among others.
    • Expertise in code writing and/or bioinformatics will be weighed as a plus.
    • The candidate is also expected to be self-motivated, creative and capable of contributing productively in a team environment.
    • Excellent communication skills in written and oral English are essential.

    Contact information:

    Yelena Ginzburg, MD

    Office Tel: 212-241-0579

    Email: Yelena.ginzburg@mssm.edu

    Website: https://labs.icahn.mssm.edu/ginzburglab/

    Ginzburg Lab

    Area of Interest:

    The Ginzburg Lab has been continuously funded for the last 15 years to focus on molecular mechanisms involved in the crosstalk between erythropoiesis and iron metabolism in multiple diseases.

    Current Research:

    The goals of our multiple projects are to elucidate a mechanistic understanding of the crosstalk between erythropoiesis and iron metabolism. We focus on diseases such as β-thalassemia, sickle cell anemia, iron deficiency anemia, anemia of renal failure, myelodysplastic syndrome, and most recently polycythemia vera. We have generated and analyzed mouse models and human cells in culture with the ultimate goal of developing novel therapeutics for diseases of disordered erythropoiesis and or iron metabolism. Clinical trials are on-going as a consequence of the research done in our lab and that of our collaborators. Most recently, we have focused also on the crosstalk of iron metabolism and inflammation and with bone homeostasis.

    Specifically, the current projects in the laboratory involve:

    • analyzing the role of transferrin and its receptor partners, hepcidin, and erythroferrone in ineffective erythropoiesis in a mouse model of β-thalassemia;
    • exploring the role of erythroferrone in coordinating erythropoiesis, iron metabolism, and bone homeostasis using mice models in vivo and in vitro;
    • evaluating the mechanisms leading to persistent erythropoiesis in polycythemia vera despite iron deficiency in vivo and in vitro; and
    • determining the effect of iron overload and iron chelation on erythropoiesis in a mouse model of myelodysplastic syndrome.

    We are also engaged in several collaborative clinical projects in various stages, including using macrophage iron status in sputum of sickle cell patients to predict acute chest syndrome, evaluating the effect of iron chelation on survival in patients with myelofibrosis, and eliminating phlebotomy requirements in patients with polycythemia vera treated with hepcidin mimetics. We are always looking for hard-working and passionate junior physician scientists interested in engaging on topics of mutual interest.

     

    UCLA Postdoctoral Position open 7/23/20

    UCLA Center for Iron Disorders is looking for a postdoctoral fellow for a project studying the interaction between iron and phosphate homeostasis. We are focusing on the hormone FGF23, a physiological regulator of phosphate homeostasis, which likely plays a pathogenic role in cardiovascular complications in chronic kidney disease. The project will explore the regulation of FGF23 production and processing (including by iron and erythropoiesis), and the mechanism by which FGF23 mediates its pathogenic effects in CKD. The project is led by Mark Hanudel, pediatric nephrologist and a junior faculty at the Center. The senior mentors will be Tomas Ganz and Elizabeta Nemeth. The position is available now. Please send inquiries to enemeth@mednet.ucla.edu.

     

    Student/Postdoctoral Fellow Exchange Program

    Postdoc/Student Exchange March 30-April 2, 2020 postponed

    application link

     

     

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