Available postdoctoral positions in stem cells and immunology 9/30/21
Up to two full-time postdoctoral fellowship positions are available (open until filled) at the University of Utah School of Medicine and Huntsman Cancer Institute in Salt Lake City, UT, to investigate gene regulatory circuitries underlying adaptive immunity. Talented and motivated candidates with a track record of success in gene regulation and immunology will be considered. Experience with basic molecular biological methods and cell culture is required. Experience with mouse models and bioinformatic analysis is ideal. Candidates must have PhD or equivalent training. The successful candidate will be able to work independently as well as in a collaborative setting. Starting salaries will be based on the NIH postdoc scale. Send cover letter, current CV and contact information for three potential references to Dr. Dean Tantin, email@example.com. Be sure to include “PD position 1” in the subject line.
The Tantin laboratory is committed to creating an inclusive work environment. All qualified individuals, including minorities, women, individuals with disabilities, and veterans are encouraged to apply.
Dean Tantin, PhD
Professor of Pathology
Division of Microbiology&Immunology
University of Utah School of Medicine
Huntsman Cancer Institute
2000 Circle of Hope, Research South 3707
Salt Lake City, UT 84112-5550
1 Postdoctoral Training Position Available 9/16/21
Postdoctoral Position Available at the National Institutes of Health
Iron Chaperones and the Distribution of Iron Cofactors within Cells
Caroline C. Philpott, M. D.
Genetics and Metabolism Section, LDB, NIDDK, NIH
Postdoctoral position available to study the distribution and utilization of iron cofactors within mammalian cells and tissues. Iron is an essential nutrient for every cell in the human body, yet it can also be a potent cellular toxin. Iron is essential because enzymes that require iron co-factors (namely, heme, iron-sulfur clusters, mononuclear and diiron centers) are involved in virtually every major metabolic process in the cell. Iron deficiency continues to be the most common nutritional deficiency in the world, especially among children and women of childbearing age, where it causes anemia and impairs neurological development and function. Although the pathogenesis of anemia in iron deficiency is well understood, other manifestations of iron deficiency are not understood at the cellular or metabolic level. Iron overload is a feature of an increasing number of human diseases, including genetic disorders such as hereditary hemochromatosis, thalassemias, and Friedreich ataxia, as well as chronic inflammatory diseases of the liver, such as hepatitis C. Hundreds of iron, zinc, copper, and manganese proteins are expressed in human cells, yet little is known about the mechanisms by which these metalloproteins acquire their native metal ligands and avoid mis-metallation. We have made significant advances in understanding the delivery of iron to iron-dependent enzymes in the cytosol.
We identified Poly rC-Binding Protein 1 (PCBP1) as an iron-binding protein that delivers iron to ferritin in human cells (Shi, et al. 2008, Science 320, 1207-10). This was the first description of a cytosolic iron chaperone – a protein that specifically binds iron ions and delivers them to target proteins through direct protein-protein interactions. PCBP1 and its human paralogs are multifunctional adaptor proteins that also bind single-stranded DNA and RNA in a sequence-specific manner to regulate the fate of the nucleic acid. PCBP2, a human paralog of PCBP1, is independently required for the delivery of iron to ferritin. PCBP1 and PCBP2 deliver iron to additional families of target enzymes: the prolyl hydroxylases (PHDs) that regulate the degradation of hypoxia inducible factor 1 (HIF1) and deoxyhypusine hydroxylase (DOHH). Projects currently underway explore the roles of PCBPs in erythroid cell development, duodenal iron absorption, macrophage iron recycling, and the intersection of iron ion chaperones with the Fe-S cluster machinery. Mouse models of PCBP1 and PCBP2 deficiency have been developed and are revealing new functions of these proteins in maintaining iron homeostasis in mammals.
We use the tools of cell biology, genetics and biochemistry to address questions about how cells and animals use iron. The postdoctoral position is fully funded, available immediately, and open to any motivated Ph.D./M.D. with less than five years of postdoctoral experience. NIH is an equal opportunity employer.
Caroline C. Philpott, M. D.Chief, Genetics and Metabolism Section
Liver Diseases Branch, NIDDK, NIH
Bldg 10, Rm 9B-16
10 Center Drive
Bethesda, MD 20892-1800
2 Postdoctoral Training Positions Available 5/14/21
Postdoctoral positions in the
Enns/Zhang Labs in the Department
of Cell, Developmental, and Cancer Biology at Oregon Health &
Science University, Portland, OR USA. Detail link
Postdoctoral Training Position Available Fellowship 5/7/21
Bone Marrow Spatial Transcriptomics to Enhance In Vitro Platelet Production:
The Moffitt and Cantor Laboratories at Boston Children’s Hospital/Harvard Medical School (HMS) are currently
accepting applications for an entry-level joint post-doctoral training position. The Moffitt lab focuses on
development and utilization of in situ single-molecule imaging methods to further understand tissue
architecture, developmental signaling, and novel cell type identification. The Cantor lab specializes in
hematopoiesis and platelet production. This joint project will develop and apply Multiplexed Error-robust
Fluorescence In Situ Hybridization (MERFISH) to the mouse and human bone marrow to further understand
how megakaryocytes generate platelets in the context of their native microenvironment. This knowledge will
then be applied to enhance in vitro platelet production from induced pluripotent stem cells (hIPSCs) for
transfusion purposes. The candidate will also interact with the Allon Klein’s laboratory at HMS to develop and
correlate scRNA-seq and in situ transcriptomic datasets. The candidate will be jointly advised by Dr. Moffitt and
Dr. Cantor and will have the opportunity to learn and develop a cutting-edge spatial transcriptomics tool while
substantially advancing our understanding of bone micro-environment and its critical role in the important
process of platelet production and stem cell biology.
Candidates should have recently (within ~1 year) obtained a PhD or an MD/PhD degree in the fields of
Computational Biology, Genomics, Molecular Biology, Cellular Biology, Biochemistry, Development, or
Genetics. The candidate should have evidence of prior productive scientific work in the form of publications in
peer-reviewed journals. Prior experience in computational biology, scRNAseq, and/or other “-omics” type
approaches is strongly preferred. U.S. citizenship or Permanent Resident status (i.e., “Green Card” holders) is
not necessary, but is favored.
Interested candidates should send their Curriculum Vitae and a cover letter describing their background and
research interests to firstname.lastname@example.org and email@example.com.
Candidates should also arrange for two letters of recommendation, which may be requested. Jeffrey Moffitt, PhD
Alan Cantor, MD, PhD
Assistant Professor of Pediatrics Associate Professor of Pediatrics
Program in Cellular and Molecular Medicine Division of Pediatric Hematology/Oncology
Office: 617-713-8902 Office:617-919-2026
Boston Children’s Hospital is an equal opportunity employer. Women and members of under-represented
minorities are encouraged to apply
Postdoc Fellow/Staff Scientist 5/6/21
Location: Boston Children’s Hospital, Harvard Medical School
The Bauer laboratory seeks highly motivated post-doctoral research fellows and staff scientists to investigate
therapeutic gene editing to address human diseases with unmet clinical needs and to explore the functional
genomics of human hematopoiesis. We conduct studies ranging from technology development, target discovery,
preclinical validation and first-in-human clinical application.
We have identified regulatory elements that are subject to naturally occurring disease associated genetic variation
and are critical determinants of fetal hemoglobin level and hemoglobin disorder clinical severity. We have
developed methodologies for high-throughput and high-resolution functional evaluation of coding and noncoding
genetic elements. We have demonstrated highly efficient and specific methods for nuclease and base editing of
human hematopoietic stem and progenitor cells. We use molecular genetic, biochemical, and genome editing
methodologies to perturb and observe blood cells. Our studies are meant to elucidate fundamental mechanisms
of gene regulatory elements in their endogenous chromosomal environment, to explore determinants of blood cell
development, homeostasis, and disease, and to define structure-function relationships of disease relevant protein
complexes. A major motivation of our work is to translate findings into novel therapies for patients with blood
disorders. We are advancing therapeutic gene editing from preclinical studies to first-in-human trials.
Prior experience in gene editing/gene therapy, protein engineering, hematopoiesis, molecular and cell biology,
genetics, biochemistry, systems biology, structural/chemical biology, and/or bioinformatics/computational biology
is highly desirable. The candidate must be independent in scientific research and writing, self-motivated, ethical,
team spirited, and must have exceptional laboratory, communication, organizational, and writing skills.
Interested applicants should send a CV, cover letter, statement of research interest and contact information for
three references via email to
Daniel Bauer, MD PhD (firstname.lastname@example.org), Division of
Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA. Boston Children’s
Hospital is one of the top pediatric research centers in the world, and a major research and teaching affiliate of
Harvard Medical School. The Bauer Laboratory is also affiliated with the Dana-Farber Cancer Institute, Harvard
Stem Cell Institute, and Broad Institute of Harvard and MIT.