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Welcome to the new Protein-Metabolite Discovery Core. More details soon . . .

The Protein-metabolite Discovery Core

2021 Rates

Service CIHD Internal CIHD External University of Utah External Academic Commercial
 

Kevin Hicks

15 N Medical Drive East

Room 4100

Salt Lake City UT 84112

Hours of Operation

Monday-Friday 9am-5pm

Location

Emma Eccles Jones Medical Science Building (EEJ) Room 4100
15 N Medical Dr East
Salt Lake City, UT 84112

Access is through the North or South stairwell as well as the service elevator.

Staff

Kevin Hicks Ph.D.

Kevin Hicks, Ph.D. , Director
Phone: 801-581-8718
kevin.hicks@biochem.utah.edu


Oversight Committee

Agilent 7200 GC-QTOF with EI and CI capabilities

This new, state of the art gas chromatograph-mass spectrometer is a high resolution/high mass accuracy quadrupole time-of-flight instrument. It is fitted with a CTC MPS auto sampler that automates sample preparation for high throughput sample analysis. This workhorse instrument is primary used for the analysis of the low molecular weight metabolome and for flux analysis.

Agilent 6550

An Agilent 6550 Quadrupole-Time-of-Flight (QToF) mass spectrometer coupled to an Agilent 1290 Ultra Pressure Liquid Chromatograph (UPLC) is used as our primary instrument for higher molecular weight metabolite analysis and for the profiling of metabolites not amenable to gas chromatography-mass spectrometry. Hydrophilic Liquid Chromatography (HILIC) is employed for metabolite separation prior to analysis. This instrument was purchased through NIH S10OD016232-01

Agilent 6530

An Agilent 6530 UPLC-QToF mass spectrometer is used as our primary instrument for non-targeted lipidomics analysis. Ultra pressure reversed phase liquid chromatography is employed for lipid separation prior to analysis. This instrument was purchased through a University of Utah Request for Instrumentation grant.

Agilent 6490

An Agilent 6490 Triple Quadrupole (QQQ) mass spectrometer coupled to an Agilent 1290 Ultra Pressure Liquid Chromatograph (UPLC) is used as our primary instrument for the targeted quantification of metabolites and drug molecules. Ultra-pressure reversed phase liquid chromatography is employed for rapid chromatographic fractionation prior to analysis. This instrument was purchased through a RIF grant.

Waters GCT Premier

A Waters GCT Premier is used for profiling the low molecular weight metabolome and is especially proficient at low molecular weight acids such as lactate, pyruvate, amino acids, TCA cycle intermediates, free fatty acids, and phosphorylated sugars. This is a Gas Chromatograph Time-of-Flight Mass Spectrometer (GC-ToF-MS) and was purchased through NIDDK grant P30DK072437.