Recent Publications

2021 July

A computational study of structural differences of binding of NADP+ and G6P substrates to G6PD Mediterraneanc.563T, G6PD A-c.202A/c.376G, G6PD Cairoc.404C and G6PD Gazac.536A mutations. Sirdah M, Reading NS, Vankayalapati H, Prchal JT. Blood Cells Mol Dis. 2021 Jul;89:102572. doi: 10.1016/j.bcmd.2021.102572. Epub 2021 Apr 27. PMID: 33957359

Amelioration of chronic kidney disease-associated anemia by vadadustat in mice is not dependent on erythroferrone. Hanudel MR, Wong S, Jung G, Qiao B, Gabayan V, Zuk A, Ganz T. Kidney Int. 2021 Jul;100(1):79-89. doi: 10.1016/j.kint.2021.03.019. Epub 2021 Mar 31. PMID: 33811979

A mutation in the iron-responsive element of ALAS2 is a modifier of disease severity in a patient suffering from CLPX associated erythropoietic protoporphyria. Ducamp S, Luscieti S, Ferrer-Cortès X, Nicolas G, Manceau H, Peoc’h K, Yien YY, Kannengiesser C, Gouya L, Puy H, Sanchez M. Haematologica. 2021 Jul 1;106(7):2030-2033. doi: 10.3324/haematol.2020.272450. PMID: 33596641

Glycerol-3-phosphate and fibroblast growth factor 23 regulation. Simic P, Babitt JL, Rhee EP. Curr Opin Nephrol Hypertens. 2021 Jul 1;30(4):397-403. doi: 10.1097/MNH.0000000000000715. PMID: 33901058

Serum Erythroferrone During Pregnancy Is Related to Erythropoietin but Does Not Predict the Risk of Anemia.  Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O’Brien KO. J Nutr. 2021 Jul 1;151(7):1824-1833. doi: 10.1093/jn/nxab093. PMID: 33982118

Does neocytolysis exist after descent from high altitude?  Song J, Christensen RD, Thiagarajan P, Prchal JT. Acta Physiol (Oxf). 2021 Jul 6:e13713. doi: 10.1111/apha.13713. Online ahead of print. PMID: 34228882

Autoimmune- and complement-mediated hematologic condition recrudescence following SARS-CoV-2 vaccination.  Portuguese AJ, Sunga C, Kruse-Jarres R, Gernsheimer T, Abkowitz J. Blood Adv. 2021 Jul 13;5(13):2794-2798. doi: 10.1182/bloodadvances.2021004957. PMID: 34255033

Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study.  Nicholson RJ, Poss AM, Maschek JA, Cox JE, Hopkins PN, Hunt SC, Playdon MC, Holland WL, Summers SA. J Clin Endocrinol Metab. 2021 Jul 13;106(8):e3098-e3109. doi: 10.1210/clinem/dgab155. PMID: 33705551

The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover.  Rondelli CM, Perfetto M, Danoff A, Bergonia H, Gillis S, O’Neill L, Jackson L, Nicolas G, Puy H, West R, Phillips JD, Yien YY. J Biol Chem. 2021 Jul 16:100972. doi: 10.1016/j.jbc.2021.100972. Online ahead of print. PMID: 34280433

Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage.  Zhao S, Wang X, Zheng X, Liang X, Wang Z, Zhang J, Zhao X, Zhuang S, Pan Q, Sun F, Shang W, Barasch J, Qiu A. Free Radic Biol Med. 2021 Jul 21;173:81-96. doi: 10.1016/j.freeradbiomed.2021.07.025. Online ahead of print. PMID: 34298093

New regulators of systemic iron homeostasis.  Ganz T. Signal Transduct Target Ther. 2021 Jul 21;6(1):280. doi: 10.1038/s41392-021-00696-z. PMID: 34290226

Nicotinic Acetylcholine Receptor Partial Antagonist Polyamides from Tunicates and Their Predatory Sea Slugs.  Paguigan ND, Tun JO, Leavitt LS, Lin Z, Chase K, Dowell C, Deering-Rice CE, Lim AL, Karthikeyan M, Hughen RW, Zhang J, Peterson RT, Reilly CA, Light AR, Raghuraman S, McIntosh JM, Olivera BM, Schmidt EW. ACS Chem Neurosci. 2021 Jul 21;12(14):2693-2704. doi: 10.1021/acschemneuro.1c00345. Epub 2021 Jul 2. PMID: 34213884


2021 June

Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference.  Babitt JL, Eisenga MF, Haase VH, Kshirsagar AV, Levin A, Locatelli F, Małyszko J, Swinkels DW, Tarng DC, Cheung M, Jadoul M, Winkelmayer WC, Drüeke TB; Conference Participants. Kidney Int. 2021 Jun;99(6):1280-1295. doi: 10.1016/j.kint.2021.03.020. Epub 2021 Apr 8. PMID: 33839163

Gain-of-function Tibetan PHD2D4E;C127S variant suppresses monocyte function: A lesson in inflammatory response to inspired hypoxia.  Bhattacharya S, Shrimali NM, Mohammad G, Koul PA, Prchal JT, Guchhait P. EBioMedicine. 2021 Jun;68:103418. doi: 10.1016/j.ebiom.2021.103418. Epub 2021 Jun 5. PMID: 34102396

Physiological and pathophysiological mechanisms of hepcidin regulation: clinical implications for iron disorders.  Xu Y, Alfaro-Magallanes VM, Babitt JL. Br J Haematol. 2021 Jun;193(5):882-893. doi: 10.1111/bjh.17252. Epub 2020 Dec 14. PMID: 33316086 Review.

Umbilical Cord Erythroferrone Is Inversely Associated with Hepcidin, but Does Not Capture the Most Variability in Iron Status of Neonates Born to Teens Carrying Singletons and Women Carrying Multiples.  Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O’Brien KO. J Nutr. 2021 Jun 3:nxab156. doi: 10.1093/jn/nxab156. Online ahead of print. PMID: 34236433

No small matter: emerging roles for exosomal miRNAs in the immune system.  Bauer KM, Round JL, O’Connell RM. FEBS J. 2021 Jun 4. doi: 10.1111/febs.16052. Online ahead of print. PMID: 34087046

Sugar phosphate activation of the stress sensor eIF2B.  Hao Q, Heo JM, Nocek BP, Hicks KG, Stoll VS, Remarcik C, Hackett S, LeBon L, Jain R, Eaton D, Rutter J, Wong YL, Sidrauski C. Nat Commun. 2021 Jun 8;12(1):3440. doi: 10.1038/s41467-021-23836-z. PMID: 34103529

Prepregnancy Obesity Does Not Impact Placental Iron Trafficking.  Tussing-Humphreys L, LaBomascus B, O’Brien K, Nemeth E, Sangkhae V, Steffen AD, Castellanos K, DeMartelly V, Ruchob R, Welke L, Hemphill NO, Pezley L, McLeod A, Hirsch B, Elam G, Ferrans CE, Koenig MD. J Nutr. 2021 Jun 16:nxab191. doi: 10.1093/jn/nxab191. Online ahead of print. PMID: 34132349

Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis.  Nemeth E, Ganz T. Int J Mol Sci. 2021 Jun 17;22(12):6493. doi: 10.3390/ijms22126493. PMID: 34204327

The iron chaperone and nucleic acid-binding activities of poly(rC)-binding protein 1 are separable and independently essential.  Patel SJ, Protchenko O, Shakoury-Elizeh M, Baratz E, Jadhav S, Philpott CC. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2104666118. doi: 10.1073/pnas.2104666118. PMID: 34161287

Effects of altitude and recombinant human erythropoietin on iron metabolism: a randomized controlled trial.  Breenfeldt Andersen A, Bonne TC, Bejder J, Jung G, Ganz T, Nemeth E, Olsen NV, Rodriguez Huertas J, Nordsborg NB. Am J Physiol Regul Integr Comp Physiol. 2021 Jun 23. doi: 10.1152/ajpregu.00070.2021. Online ahead of print. PMID: 34160288

Screening out the Exposome to Improve Transfusion Quality.  DeSimone RA, Vinchi F. Hemasphere. 2021 Jun 25;5(7):e605. doi: 10.1097/HS9.0000000000000605. eCollection 2021 Jul. PMID: 34235402

Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy.  Fisher AL, Sangkhae V, Balušíková K, Palaskas NJ, Ganz T, Nemeth E. Nat Commun. 2021 Jun 29;12(1):4026. doi: 10.1038/s41467-021-24333-z. PMID: 34188052


2021 May

Iron Toxicity and Chelation Therapy in Hematopoietic Stem Cell Transplant.  Isidori A, Loscocco F, Visani G, Chiarucci M, Musto P, Kubasch AS, Platzbecker U, Vinchi F. Transplant Cell Ther. 2021 May;27(5):371-379. doi: 10.1016/j.jtct.2020.11.007. Epub 2020 Dec 11. PMID: 33969823 Free article. Review.

Single-cell analysis of erythropoiesis in Rpl11 haploinsufficient mice reveals insight into the pathogenesis of Diamond-Blackfan anemia.  Doty RT, Yan X, Meng C, Lausted C, Tian Q, Abkowitz JL. Exp Hematol. 2021 May;97:66-78.e6. doi: 10.1016/j.exphem.2021.02.010. Epub 2021 Feb 22. PMID: 33631277

SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA.  Yan D, Franzini A, Pomicter AD, Halverson BJ, Antelope O, Mason CC, Ahmann JM, Senina AV, Vellore NA, Jones CL, Zabriskie MS, Than H, Xiao MJ, van Scoyk A, Patel AB, Clair PM, Heaton WL, Owen SC, Andersen JL, Egbert CM, Reisz JA, D’Alessandro A, Cox JE, Gantz KC, Redwine HM, Iyer SM, Khorashad JS, Rajabi N, Olsen CA, O’Hare T, Deininger MW. Blood Cancer Discov. 2021 May;2(3):266-287. doi: 10.1158/2643-3230.bcd-20-0168. Epub 2019 Dec 2. PMID: 34027418 Free PMC article.

Vasculo-toxic and pro-inflammatory action of unbound haemoglobin, haem and iron in transfusion-dependent patients with haemolytic anaemias.  Vinchi F, Sparla R, Passos ST, Sharma R, Vance SZ, Zreid HS, Juaidi H, Manwani D, Yazdanbakhsh K, Nandi V, Silva AMN, Agarvas AR, Fibach E, Belcher JD, Vercellotti GM, Ghoti H, Muckenthaler MU. Br J Haematol. 2021 May;193(3):637-658. doi: 10.1111/bjh.17361. Epub 2021 Mar 15. PMID: 3372386

Erythropoietic protoporphyria: time to prodrome, the warning signal to exit sun exposure without pain-a patient-reported outcome efficacy measure.  Wensink D, Langendonk JG, Overbey JR, Balwani M, Van Broekhoven EJE, Wagenmakers MAEM, Wilson JHP, Wheeden K, Naik H, Desnick RJ. Genet Med. 2021 May 3. doi: 10.1038/s41436-021-01176-z. Online ahead of print. PMID: 33941881

Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency.  Bahr TM, Carr NR, Christensen TR, Wilkes J, O’Brien EA, German KR, Ohls RK, Ward DM, Christensen RD. Blood Cells Mol Dis. 2021 May 6;90:102575. doi: 10.1016/j.bcmd.2021.102575. Online ahead of print. PMID: 33989937

HIF-2 inhibitor, erythrocytosis, and pulmonary hypertension.  Prchal JT, Gordeuk VR. Blood. 2021 May 6;137(18):2424-2425. doi: 10.1182/blood.2020010323. PMID: 33956067

A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages.  Huffaker TB, Ekiz HA, Barba C, Lee SH, Runtsch MC, Nelson MC, Bauer KM, Tang WW, Mosbruger TL, Cox JE, Round JL, Voth WP, O’Connell RM. Nat Commun. 2021 May 11;12(1):2620. doi: 10.1038/s41467-021-22923-5. PMID: 33976173 Free PMC article.

A tale of two receptors: Bmp heterodimers recruit two type I receptors but use the kinase activity of only one.  Christian J. Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2104745118. doi: 10.1073/pnas.2104745118. PMID: 33893177

Coordination of iron homeostasis by bone morphogenetic proteins: Current understanding and unanswered questions.  Fisher AL, Babitt JL. Dev Dyn. 2021 May 16. doi: 10.1002/dvdy.372. Online ahead of print. PMID: 33993583

Measurement of Immature Reticulocytes in Dried Blood Spots by Mass Spectrometry.  Cox HD, Miller GD, Manandhar A, Husk JD, Jia X, Marvin J, Ward DM, Phillips J, Eichner D. Clin Chem. 2021 May 16:hvab058. doi: 10.1093/clinchem/hvab058. Online ahead of print. PMID: 33993255

The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model.  Matte A, Federti E, Kung C, Kosinski PA, Narayanaswamy R, Russo R, Federico G, Carlomagno F, Desbats MA, Salviati L, Leboeuf C, Valenti MT, Turrini F, Janin A, Yu S, Beneduce E, Ronseaux S, Iatcenko I, Dang L, Ganz T, Jung CL, Iolascon A, Brugnara C, De Franceschi L. J Clin Invest. 2021 May 17;131(10):e144206. doi: 10.1172/JCI144206. PMID: 33822774

The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder.  Bosse GD, Cadeddu R, Floris G, Farero RD, Vigato E, Lee SJ, Zhang T, Gaikwad NW, Keefe KA, Phillips PE, Bortolato M, Peterson RT. J Clin Invest. 2021 May 17;131(10):e143990. doi: 10.1172/JCI143990. PMID: 33848264

The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry.  Castro-Mollo M, Gera S, Ruiz-Martinez M, Feola M, Gumerova A, Planoutene M, Clementelli C, Sangkhae V, Casu C, Kim SM, Ostland V, Han H, Nemeth E, Fleming R, Rivella S, Lizneva D, Yuen T, Zaidi M, Ginzburg Y. Elife. 2021 May 18;10:e68217. doi: 10.7554/eLife.68217. PMID: 34002695

Diversification of CD1 Molecules Shapes Lipid Antigen Selectivity.  Paterson NM, Al-Zubieri H, Barber MF. Mol Biol Evol. 2021 May 19;38(6):2273-2284. doi: 10.1093/molbev/msab022. PMID: 33528563

A New Hour-Specific Serum Bilirubin Nomogram for Neonates ≥35 Weeks of Gestation.  Bahr TM, Henry E, Christensen RD, Minton SD, Bhutani VK. J Pediatr. 2021 May 21:S0022-3476(21)00489-3. doi: 10.1016/j.jpeds.2021.05.039. Online ahead of print. PMID: 34023346

Inflammation drives alternative first exon usage to regulate immune genes including a novel iron-regulated isoform of Aim2.  Robinson EK, Jagannatha P, Covarrubias S, Cattle M, Smaliy V, Safavi R, Shapleigh B, Abu-Shumays R, Jain M, Cloonan SM, Akeson M, Brooks AN, Carpenter S. Elife. 2021 May 28;10:e69431. doi: 10.7554/eLife.69431. PMID: 34047695


2021 April

Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity.  Cheng X, Shihabudeen Haider Ali MS, Moran M, Viana MP, Schlichte SL, Zimmerman MC, Khalimonchuk O, Feinberg MW, Sun X. Redox Biol. 2021 Apr;40:101863. doi: 10.1016/j.redox.2021.101863. Epub 2021 Jan 19. PMID: 33508742 Free PMC article

2021 March

Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes.  Chaurasia B, Ying L, Talbot CL, Maschek JA, Cox J, Schuchman EH, Hirabayashi Y, Holland WL, Summers SA. Mol Metab. 2021 Mar;45:101145. doi: 10.1016/j.molmet.2020.101145. Epub 2020 Dec 19. PMID: 33352310

Reconciling markedly discordant values of serum ferritin versus reticulocyte hemoglobin content.  Bahr TM, Baer VL, Ohls RK, Christensen TR, Ward DM, Bennett ST, Christensen RD. J Perinatol. 2021 Mar;41(3):619-626. doi: 10.1038/s41372-020-00845-2. Epub 2020 Oct 4. PMID: 33012780

Red blood cell transfusions and potentially related morbidities in neonates under 32 weeks’ gestation.  D’Amato G, Faienza MF, Palladino V, Bianchi FP, Natale MP, Christensen RD, Giordano P, Del Vecchio A. Blood Transfus. 2021 Mar;19(2):113-119. doi: 10.2450/2020.0092-20. Epub 2020 Oct 14. PMID: 33085599

Rationale and design of the Kidney Precision Medicine Project. de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP, Hacohen N, He Y, Hodgin JB, Jain S, Kellum JA, Kiryluk K, Knight R, Laszik ZG, Lienczewski C, Mariani LH, McClelland RL, Menez S, Moledina DG, Mooney SD, O’Toole JF, Palevsky PM, Parikh CR, Poggio ED, Rosas SE, Rosengart MR, Sarwal MM, Schaub JA, Sedor JR, Sharma K, Steck B, Toto RD, Troyanskaya OG, Tuttle KR, Vazquez MA, Waikar SS, Williams K, Wilson FP, Zhang K, Iyengar R, Kretzler M, Himmelfarb J; Kidney Precision Medicine Project. Kidney Int. 2021 Mar;99(3):498-510. doi: 10.1016/j.kint.2020.08.039. PMID: 33637194

Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type 1 diabetes.  Kim H, Perovanovic J, Shakya A, Shen Z, German CN, Ibarra A, Jafek JL, Lin NP, Evavold BD, Chou DH, Jensen PE, He X, Tantin D. J Exp Med. 2021 Mar 1;218(3):e20200533. doi: 10.1084/jem.20200533. PMID: 33295943

The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure.  Cluntun AA, Badolia R, Lettlova S, Parnell KM, Shankar TS, Diakos NA, Olson KA, Taleb I, Tatum SM, Berg JA, Cunningham CN, Van Ry T, Bott AJ, Krokidi AT, Fogarty S, Skedros S, Swiatek WI, Yu X, Luo B, Merx S, Navankasattusas S, Cox JE, Ducker GS, Holland WL, McKellar SH, Rutter J, Drakos SG. Cell Metab. 2021 Mar 2;33(3):629-648.e10. doi: 10.1016/j.cmet.2020.12.003. Epub 2020 Dec 16. PMID: 33333007

Commentary on the AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia.  Kaunitz JD, Ganz T. Gastroenterology. 2021 Mar 3:S0016-5085(21)00470-4. doi: 10.1053/j.gastro.2021.03.001. Online ahead of print. PMID: 33675744 No abstract available.

Characterizing a common CERS2 polymorphism in a mouse model of metabolic disease and in subjects from the Utah CAD Study.  Nicholson RJ, Poss AM, Maschek JA, Cox JE, Hopkins PN, Hunt SC, Playdon MC, Holland WL, Summers SA. J Clin Endocrinol Metab. 2021 Mar 11:dgab155. doi: 10.1210/clinem/dgab155. Online ahead of print. PMID: 33705551

Kidney injury biomarkers during exposure to tenofovir-based pre-exposure prophylaxis.  Nickolas TL, Barasch J, Mugwanya KK, Branch AD, Heffron R, Wanga V, Mugo NR, Ronald A, Celum C, Donnell D, Baeten JM, Wyatt CM; Partners PrEP Study Team. AIDS. 2021 Mar 11. doi: 10.1097/QAD.0000000000002865. Online ahead of print. PMID: 33710023


2021 February

FGF23, Frailty, and Falls in SPRINT.  Jovanovich A, Ginsberg C, You Z, Katz R, Ambrosius WT, Berlowitz D, Cheung AK, Cho M, Lee AK, Punzi H, Rehman S, Roumie C, Supiano MA, Wright CB, Shlipak M, Ix JH, Chonchol M. J Am Geriatr Soc. 2021 Feb;69(2):467-473. doi: 10.1111/jgs.16895. Epub 2020 Dec 1. PMID: 33289072

SARS-CoV-2 innate effector associations and viral load in early nasopharyngeal infection.  Liou TG, Adler FR, Cahill BC, Cox DR, Cox JE, Grant GJ, Hanson KE, Hartsell SC, Hatton ND, Helms MN, Jensen JL, Kartsonaki C, Li Y, Leung DT, Marvin JE, Middleton EA, Osburn-Staker SM, Packer KA, Shakir SM, Sturrock AB, Tardif KD, Warren KJ, Waddoups LJ, Weaver LJ, Zimmerman E, Paine R 3rd. Physiol Rep. 2021 Feb;9(4):e14761. doi: 10.14814/phy2.14761. PMID: 33625796

Inflammatory, synaptic, motor, and behavioral alterations induced by gestational sepsis on the offspring at different stages of life.  Granja MG, Alves LP, Leardini-Tristão M, Saul ME, Bortoni LC, de Moraes FM, Ferreira EC, de Moraes BPT, da Silva VZ, Dos Santos AFR, Silva AR, Gonçalves-de-Albuquerque CF, Bambini-Junior V, Weyrich AS, Rondina MT, Zimmerman GA, de Castro-Faria-Neto HC. J Neuroinflammation. 2021 Feb 25;18(1):60. doi: 10.1186/s12974-021-02106-1. PMID: 33632243

Layered immunity of the developing thymus.  López DA, Beaudin AE. Blood. 2021 Feb 25;137(8):1003-1004. doi: 10.1182/blood.2020009207. PMID: 33630049 No abstract available.

Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in Candida albicans.  Weissman Z, Pinsky M, Donegan RK, Reddi AR, Kornitzer D. Cell Microbiol. 2021 Feb;23(2):e13282. doi: 10.1111/cmi.13282. Epub 2020 Nov 9. PMID: 33104284

Emerimicins V-X, 15-Residue Peptaibols Discovered from an Acremonium sp. through Integrated Genomic and Chemical Approaches.  Wu G, Dentinger BTM, Nielson JR, Peterson RT, Winter JM. J Nat Prod. 2021 Feb 22. doi: 10.1021/acs.jnatprod.0c01186. Online ahead of print. PMID: 33617244
Gams isolated from a soil sample collected from the University of Utah led to the isolation and characterization of six new linear pentadecapeptides, emerimicins V-X (1-6). …

Single-cell analysis of erythropoiesis in Rpl11 haploinsufficient mice reveals insight into the pathogenesis of Diamond Blackfan anemia.  Doty RT, Yan X, Meng C, Lausted C, Tian Q, Abkowitz JL. Exp Hematol. 2021 Feb 22:S0301-472X(21)00092-8. doi: 10.1016/j.exphem.2021.02.010. Online ahead of print. PMID: 33631277

Expression Profiling Identifies TWIST2 Target Genes in Setleis Syndrome Patient Fibroblast and Lymphoblast Cells.  Crespo NE, Torres-Bracero A, Renta JY, Desnick RJ, Cadilla CL. Int J Environ Res Public Health. 2021 Feb 19;18(4):1997. doi: 10.3390/ijerph18041997. PMID: 33669496

Increase of plasma erythroferrone levels during high-altitude exposure: A sub-analysis of the TOP OF HOMe study.  Emrich IE, Scheuer A, Wagenpfeil S, Ganz T, Heine GH. Am J Hematol. 2021 Feb 19. doi: 10.1002/ajh.26130. Online ahead of print. PMID: 33606284 No abstract available.

Maestro of the SereNADe: SLC25A51 Orchestrates Mitochondrial NAD.  Ouyang Y, Bott AJ, Rutter J. Trends Biochem Sci. 2021 Feb 19:S0968-0004(21)00029-3. doi: 10.1016/j.tibs.2021.02.001. Online ahead of print. PMID: 33618948

A mutation in the iron-responsive element of ALAS2 is a modifier of disease severity in a patient suffering from CLPX associated erythropoietic protoporphyria.  Ducamp S, Luscieti S, Ferrer-Cortès X, Nicolas G, Manceau H, Peoc’h K, Yien YY, Kannengiesser C, Gouya L, Puy H, Sanchez M. Haematologica. 2021 Feb 18. doi: 10.3324/haematol.2020.272450. Online ahead of print. PMID: 33596641

A time to build and a time to burn: glucose metabolism for every season.  McKean WB, Toshniwal AG, Rutter J. Mol Cell. 2021 Feb 18;81(4):642-644. doi: 10.1016/j.molcel.2021.02.003. PMID: 33606971

Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle.  Ferrara PJ, Rong X, Maschek JA, Verkerke AR, Siripoksup P, Song H, Green TD, Krishnan KC, Johnson JM, Turk J, Houmard JA, Lusis AJ, Drummond MJ, McClung JM, Cox JE, Shaikh SR, Tontonoz P, Holland WL, Funai K. J Clin Invest. 2021 Feb 16:135963. doi: 10.1172/JCI135963. Online ahead of print. PMID: 3359195

Maternal obesity and impaired offspring neurodevelopment: could fetal iron deficiency be a pathogenic link?  Bahr TM, Benson AE, Kling PJ, Ohls RK, Ward DM, Christensen RD. J Perinatol. 2021 Feb 16. doi: 10.1038/s41372-021-00951-9. Online ahead of print. PMID: 33594227 No abstract available.

Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes.  Zhu X, Boulet A, Buckley KM, Phillips CB, Gammon MG, Oldfather LE, Moore SA, Leary SC, Cobine PA. Elife. 2021 Feb 16;10:e64690. doi: 10.7554/eLife.64690. PMID: 33591272

Heparanase expression and activity are increased in platelets during clinical sepsis.  Eustes AS, Campbell RA, Middleton EA, Tolley ND, Manne BK, Montenont E, Rowley JW, Krauel K, Blair A, Guo L, Kosaka Y, Medeiros-de-Moraes IM, Lacerda M, Hottz ED, Neto HCF, Zimmerman GA, Weyrich AS, Petrey A, Rondina MT. J Thromb Haemost. 2021 Feb 15. doi: 10.1111/jth.15266. Online ahead of print. PMID: 33587773

Accidental massive platelet transfusion.  Tsang HC, Gernsheimer TB, Abkowitz JL, Hess JR. Transfusion. 2021 Feb 11. doi: 10.1111/trf.16314. Online ahead of print. PMID: 33569795 No abstract available.

Novel mechanism of hereditary pyropoikilocytosis phenotype due to co-inheritance of β globin and α spectrin mutations.  Kim SJ, Song J, Reading NS, Lautersztain J, Kutlar A, Agarwal AM, Coetzer TL, Prchal JT. Am J Hematol. 2021 Feb 8. doi: 10.1002/ajh.26121. Online ahead of print. PMID: 33556202

Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins.  Goncalves Monteiro D, van Dijk JWA, Aliyanto R, Fung E, Nemeth E, Ganz T, Rosengren J, Clark RJ. Biomedicines. 2021 Feb 8;9(2):164. doi: 10.3390/biomedicines9020164. PMID: 33567510

Non-transferrin-bound iron in the spotlight: novel mechanistic insights into the vasculo-toxic and atherosclerotic effect of iron.  Vinchi F. Antioxid Redox Signal. 2021 Feb 6. doi: 10.1089/ars.2020.8167. Online ahead of print. PMID: 33554718

Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens.  Goldstein SA, Brown J, Pedersen BS, Quinlan AR, Elde NC. bioRxiv. 2021 Feb 4:2021.02.03.429646. doi: 10.1101/2021.02.03.429646. Preprint. PMID: 33564759

Diversification of CD1 molecules shapes lipid antigen selectivity.  Paterson NM, Al-Zubieri H, Barber MF. Mol Biol Evol. 2021 Feb 2:msab022. doi: 10.1093/molbev/msab022. Online ahead of print. PMID: 33528563
Molecular studies of host-pathogen evolution have largely focused on the consequences of variation at protein-protein interaction surfaces. …These findings suggest that lipid-protein conflicts have shaped CD1 genetic variation during primate evolution. Consistent …

Maternal schistosomiasis impairs offspring Interleukin-4 production and B cell expansion.  Cortés-Selva D, Gibbs L, Ready A, Ekiz HA, O’Connell R, Rajwa B, Fairfax KC. PLoS Pathog. 2021 Feb 1;17(2):e1009260. doi: 10.1371/journal.ppat.1009260. eCollection 2021 Feb. PMID: 33524040 Free PMC article.

miR-155 promotes T reg cell development by safeguarding medullary thymic epithelial cell maturation.  Dong J, Warner LM, Lin LL, Chen MC, O’Connell RM, Lu LF. J Exp Med. 2021 Feb 1;218(2):e20192423. doi: 10.1084/jem.20192423. PMID: 33125052


2021 January

Chemical Genetics: Manipulating the Germline with Small Molecules.  Jin YN, Peterson RT. Methods Mol Biol. 2021;2218:61-73. doi: 10.1007/978-1-0716-0970-5_6. PMID: 33606223

Isolation and thermal stabilization of mouse ferroportin.  Deshpande CN, Azucenas CR, Qiao B, Nomura N, Xin V, Font J, Iwata S, Ganz T, Nemeth E, Mackenzie B, Jormakka M. FEBS Open Bio. 2021 Jan;11(1):26-34. doi: 10.1002/2211-5463.13039. Epub 2020 Dec 17. PMID: 3319042

One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers.  Chambers IG, Willoughby MM, Hamza I, Reddi AR. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118881. doi: 10.1016/j.bbamcr.2020.118881. Epub 2020 Oct 3. PMID: 33022276

Parenteral iron therapy and phosphorus homeostasis: A review.  Kalantar-Zadeh K, Ganz T, Trumbo H, Seid MH, Goodnough LT, Levine MA. Am J Hematol. 2021 Jan 20. doi: 10.1002/ajh.26100. Online ahead of print. PMID: 33471363 Review.

Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex.  Viana MP, Levytskyy RM, Anand R, Reichert AS, Khalimonchuk O. iScience. 2021 Jan 29;24(2):102119. doi: 10.1016/j.isci.2021.102119. eCollection 2021 Feb 19. PMID: 33644718 Free PMC article.

ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway.  Xiao T, Shakya VP, Hughes AL. Life Sci Alliance. 2021 Jan 21;4(3):e202000918. doi: 10.26508/lsa.202000918. Print 2021 Mar. PMID: 33479049

Reshaping Erythrophagocytosis and Iron Recycling by Reticuloendothelial Macrophages.  Vinchi F, Vance SZ. Hemasphere. 2021 Jan 20;5(2):e525. doi: 10.1097/HS9.0000000000000525. eCollection 2021 Feb. PMID: 33490878

Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain.  Bezerra GA, Holenstein A, Foster WR, Xie B, Hicks KG, Bürer C, Lutz S, Mukherjee A, Sarkar D, Bhattacharya D, Rutter J, Talukdar A, Brown PJ, Luo M, Shi L, Froese DS, Yue WW. Biochimie. 2021 Jan 18:S0300-9084(21)00009-2. doi: 10.1016/j.biochi.2021.01.007. Online ahead of print. PMID: 33476699

Metabolic reprogramming of the myeloid lineage by Schistosoma mansoni infection persists independently of antigen exposure.  Cortes-Selva D, Gibbs L, Maschek JA, Nascimento M, Van Ry T, Cox JE, Amiel E, Fairfax KC. PLoS Pathog. 2021 Jan 8;17(1):e1009198. doi: 10.1371/journal.ppat.1009198. eCollection 2021 Jan. PMID: 33417618

Is the erythropoietin-erythroferrone-hepcidin axis intact in human neonates?  Bahr TM, Ward DM, Jia X, Ohls RK, German KR, Christensen RD. Blood Cells Mol Dis. 2021 May;88:102536. doi: 10.1016/j.bcmd.2021.102536. Epub 2021 Jan 6. PMID: 33450539


2020 December

5-Aminolevulinate dehydratase porphyria: Update on hepatic 5-aminolevulinic acid synthase induction and long-term response to hemin.  Lahiji AP, Anderson KE, Chan A, Simon A, Desnick RJ, Ramanujam VMS. Mol Genet Metab. 2020 Dec;131(4):418-423. doi: 10.1016/j.ymgme.2020.10.011. Epub 2020 Oct 26. PMID: 33199206

Questions and answers on iron deficiency treatment selection and the use of intravenous iron in routine clinical practice.  Richards T, Breymann C, Brookes MJ, Lindgren S, Macdougall IC, McMahon LP, Munro MG, Nemeth E, Rosano GMC, Schiefke I, Weiss G. Ann Med. 2021 Dec;53(1):274-285. doi: 10.1080/07853890.2020.1867323. PMID: 33426933

Erythroferrone structure, function, and physiology: Iron homeostasis and beyond.  Srole DN, Ganz T. J Cell Physiol. 2020 Dec 28. doi: 10.1002/jcp.30247. Online ahead of print. PMID: 33372284 Review.

Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network.  Sorouri M, Chang T, Jesudhasan P, Pinkham C, Elde NC, Hancks DC. PLoS Biol. 2020 Dec 28;18(12):e3001045. doi: 10.1371/journal.pbio.3001045. eCollection 2020 Dec. PMID: 33370271

Differential translational control of 5′ IRE-containing mRNA in response to dietary iron deficiency and acute iron overload.  Garza KR, Clarke SL, Ho YH, Bruss MD, Vasanthakumar A, Anderson SA, Eisenstein RS. Metallomics. 2020 Dec 23;12(12):2186-2198. doi: 10.1039/d0mt00192a. PMID: 33325950

Beta-adrenergic agonists increase maximal output of oxidative phosphorylation in bovine satellite cells.  Sieck RL, Treffer LK, Ponte Viana M, Khalimonchuk O, Schmidt TB, Yates DT, Petersen JL. Transl Anim Sci. 2020 Dec 22;4(Suppl 1):S94-S97. doi: 10.1093/tas/txaa112. eCollection 2020 Dec. PMID: 33381728

Comparison of myeloid blast counts and variant allele frequencies of gene mutations in myelodysplastic syndrome with excess blasts and secondary acute myeloid leukemia.  Chen X, Othus M, Wood BL, Walter RB, Becker PS, Percival ME, Abkowitz JL, Appelbaum FR, Estey EH. Leuk Lymphoma. 2020 Dec 19:1-7. doi: 10.1080/10428194.2020.1861267. Online ahead of print. PMID: 33345655

Platelet electrical resistance for measuring platelet activation and adhesion in human health and disease.  Griffiths TM, Page L, Weyrich AS, Rondina MT, Campbell RA. Thromb Res. 2021 Feb;198:204-209. doi: 10.1016/j.thromres.2020.12.012. Epub 2020 Dec 18. PMID: 33360636

Physiological and pathophysiological mechanisms of hepcidin regulation: clinical implications for iron disorders.  Xu Y, Alfaro-Magallanes VM, Babitt JL. Br J Haematol. 2020 Dec 14. doi: 10.1111/bjh.17252. Online ahead of print. PMID: 33316086

ER-mitochondria contacts promote mitochondrial-derived compartment biogenesis.  English AM, Schuler MH, Xiao T, Kornmann B, Shaw JM, Hughes AL. J Cell Biol. 2020 Dec 7;219(12):e202002144. doi: 10.1083/jcb.202002144. PMID: 33090183


2020 November

Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity Okada, M, Guo, P, Nalder, S, Sigala, PA. Elife.  November 2020. In press.

Lung Iron Overload Does Not Exacerbate the Fibrotic Response to Bleomycin in a Mouse Model of Pulmonary Fibrosis.  Zhang V, Nemeth E, Kim A. Am J Respir Cell Mol Biol. 2020 Nov;63(5):713-716. doi: 10.1165/rcmb.2020-0192LE. PMID: 33124901 No abstract available.

Hepcidin Is Essential for Alveolar Macrophage Function and Is Disrupted by Smoke in a Murine Chronic Obstructive Pulmonary Disease Model.  Perez E, Baker JR, Di Giandomenico S, Kermani P, Parker J, Kim K, Yang J, Barnes PJ, Vaulont S, Scandura JM, Donnelly LE, Stout-Delgado H, Cloonan SM. J Immunol. 2020 Nov 1;205(9):2489-2498. doi: 10.4049/jimmunol.1901284. Epub 2020 Sep 21. PMID: 32958690


2020 October

Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction.

Wende AR, Schell JC, Ha CM, Pepin ME, Khalimonchuk O, Schwertz H, Pereira RO, Brahma MK, Tuinei J, Contreras-Ferrat A, Wang L, Andrizzi CA, Olsen CD, Bradley WE, Dell’Italia LJ, Dillmann WH, Litwin SE, Abel ED. Diabetes. 2020 Oct;69(10):2094-2111. doi: 10.2337/db19-1057. Epub 2020 May 4. PMID: 32366681

Human ribosomal G-quadruplexes regulate heme bioavailability.  Mestre-Fos S, Ito C, Moore CM, Reddi AR, Williams LD. J Biol Chem. 2020 Oct 30;295(44):14855-14865. doi: 10.1074/jbc.RA120.014332. Epub 2020 Aug 13. PMID: 32817343

Mitochondrial pyruvate carriers are required for myocardial stress adaptation.  Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED. Nat Metab. 2020 Oct 26. doi: 10.1038/s42255-020-00288-1. Online ahead of print. PMID: 33106689

Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in Candida albicans.  Weissman Z, Pinsky M, Donegan RK, Reddi AR, Kornitzer D. Cell Microbiol. 2020 Oct 26:e13282. doi: 10.1111/cmi.13282. Online ahead of print. PMID: 33104284

Mutations in transcription factor CP2-like 1 may cause a novel syndrome with distal renal tubulopathy in humans.  Klämbt V, Werth M, Onuchic-Whitford AC, Getwan M, Kitzler TM, Buerger F, Mao Y, Deutsch K, Mann N, Majmundar AJ, Kaminski MM, Shen T, Schmidt-Ott KM, Shalaby M, El Desoky S, Kari JA, Shril S, Lienkamp SS, Barasch J, Hildebrandt F. Nephrol Dial Transplant. 2020 Oct 23:gfaa215. doi: 10.1093/ndt/gfaa215. Online ahead of print. PMID: 33097957

Different glycoforms of alpha-1-acid glycoprotein contribute to its functional alterations in platelets and neutrophils.  Sumanth MS, Jacob SP, Abhilasha KV, Manne BK, Basrur V, Lehoux S, Campbell RA, Yost CC, McIntyre TM, Cummings RD, Weyrich AS, Rondina MT, Marathe GK. J Leukoc Biol. 2020 Oct 18. doi: 10.1002/JLB.3A0720-422R. Online ahead of print. PMID: 33070381

Mitochondrial dysfunction in lung ageing and disease.  Cloonan SM, Kim K, Esteves P, Trian T, Barnes PJ. Eur Respir Rev. 2020 Oct 15;29(157):200165. doi: 10.1183/16000617.0165-2020. Print 2020 Sep 30. PMID: 33060165

TRPswitch-A Step-Function Chemo-optogenetic Ligand for the Vertebrate TRPA1 Channel.  Lam PY, Thawani AR, Balderas E, White AJP, Chaudhuri D, Fuchter MJ, Peterson RT. J Am Chem Soc. 2020 Oct 14;142(41):17457-17468. doi: 10.1021/jacs.0c06811. Epub 2020 Oct 5. PMID: 32966062

Red blood cell transfusions and potentially related morbidities in neonates under 32 weeks’ gestation.  D’Amato G, Faienza MF, Palladino V, Bianchi FP, Natale MP, Christensen RD, Giordano P, Del Vecchio A. Blood Transfus. 2020 Oct 14. doi: 10.2450/2020.0092-20. Online ahead of print. PMID: 33085599

Chronic cold exposure enhances glucose oxidation in brown adipose tissue.  Wang Z, Ning T, Song A, Rutter J, Wang QA, Jiang L. EMBO Rep. 2020 Oct 12:e50085. doi: 10.15252/embr.202050085. Online ahead of print. PMID: 33043581

Efficacy of Ciprofloxacin/Celecoxib combination in zebrafish models of amyotrophic lateral sclerosis.  Goldshtein H, Muhire A, Petel Légaré V, Pushett A, Rotkopf R, Shefner JM, Peterson RT, Armstrong GAB, Russek-Blum N. Ann Clin Transl Neurol. 2020 Oct;7(10):1883-1897. doi: 10.1002/acn3.51174. Epub 2020 Sep 11. PMID: 32915525

miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin.  Bhatlekar S, Manne BK, Basak I, Edelstein LC, Tugolukova E, Stoller ML, Cody MJ, Morley SC, Nagalla S, Weyrich AS, Rowley JW, O’Connell RM, Rondina MT, Campbell RA, Bray PF. Blood. 2020 Oct 8;136(15):1760-1772. doi: 10.1182/blood.2020005230. PMID: 32844999

Porphyric Neuropathy: Pathophysiology, Diagnosis, and Updated Management.  Kazamel M, Desnick RJ, Quigley JG. Curr Neurol Neurosci Rep. 2020 Oct 7;20(12):56. doi: 10.1007/s11910-020-01078-8. PMID: 33026560 Review.

Reconciling markedly discordant values of serum ferritin versus reticulocyte hemoglobin content.  Bahr TM, Baer VL, Ohls RK, Christensen TR, Ward DM, Bennett ST, Christensen RD. J Perinatol. 2020 Oct 4. doi: 10.1038/s41372-020-00845-2. Online ahead of print. PMID: 33012780

One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers.  Chambers IG, Willoughby MM, Hamza I, Reddi AR. Biochim Biophys Acta Mol Cell Res. 2020 Oct 3;1868(1):118881. doi: 10.1016/j.bbamcr.2020.118881. Online ahead of print. PMID: 33022276

Getting out what you put in: Copper in mitochondria and its impacts on human disease.  Cobine PA, Moore SA, Leary SC. Biochim Biophys Acta Mol Cell Res. 2020 Oct 2;1868(1):118867. doi: 10.1016/j.bbamcr.2020.118867. Online ahead of print. PMID: 32979421


2020 September

Bone morphogenic proteins in iron homeostasis.  Xiao X, Alfaro-Magallanes VM, Babitt JL. Bone. 2020 Sep;138:115495. doi: 10.1016/j.bone.2020.115495. Epub 2020 Jun 23. PMID: 32585319

Kidney Biopsy Findings in Patients with COVID-19.  Kudose S, Batal I, Santoriello D, Xu K, Barasch J, Peleg Y, Canetta P, Ratner LE, Marasa M, Gharavi AG, Stokes MB, Markowitz GS, D’Agati VD. J Am Soc Nephrol. 2020 Sep;31(9):1959-1968. doi: 10.1681/ASN.2020060802. Epub 2020 Jul 17. PMID: 32680910

Postmortem Kidney Pathology Findings in Patients with COVID-19.  Santoriello D, Khairallah P, Bomback AS, Xu K, Kudose S, Batal I, Barasch J, Radhakrishnan J, D’Agati V, Markowitz G. J Am Soc Nephrol. 2020 Sep;31(9):2158-2167. doi: 10.1681/ASN.2020050744. Epub 2020 Jul 29. PMID: 32727719

Tumescent technique versus electrocautery mastectomy: A randomized controlled trial.  Lautrup MD, Thomsen JB, Christensen RD, Kjaer C. Surg Oncol. 2020 Sep;34:276-282. doi: 10.1016/j.suronc.2020.05.003. Epub 2020 May 22. PMID: 32891342

Single-cell RNA sequencing reveals the diversity of the immunological landscape following CNS infection by a murine coronavirus.  Syage AR, Ekiz HA, Skinner DD, Stone C, O’Connell RM, Lane TE. J Virol. 2020 Sep 30:JVI.01295-20. doi: 10.1128/JVI.01295-20. Online ahead of print. PMID: 32999036

A Novel Variant in G6PD (c.1375C>G) Identified from a Hispanic Neonate with Extreme Hyperbilirubinemia and Low G6PD Enzymatic Activity.  Bahr TM, Lozano-Chinga M, Agarwal AM, Meznarich JA, Yost CC, Li P, Reading NS, Prchal JT, Christensen RD. Neonatology. 2020 Sep 28:1-4. doi: 10.1159/000510300. Online ahead of print. PMID: 32987391

The role of hepcidin in fetal iron homeostasis.  Ganz T. Blood. 2020 Sep 24;136(13):1474-1475. doi: 10.1182/blood.2020007382. PMID: 32970808 No abstract available.

ACVR1/JAK1/JAK2 inhibitor momelotinib reverses transfusion dependency and suppresses hepcidin in myelofibrosis phase 2 trial.  Oh ST, Talpaz M, Gerds AT, Gupta V, Verstovsek S, Mesa R, Miller CB, Rivera CE, Fleischman AG, Goel S, Heaney ML, O’Connell C, Arcasoy MO, Zhang Y, Kawashima J, Ganz T, Kowalski M, Brachmann CB. Blood Adv. 2020 Sep 22;4(18):4282-4291. doi: 10.1182/bloodadvances.2020002662. PMID: 32915978

Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.  Xu G, van Bruggen R, Gualtieri CO, Moradin N, Fois A, Vallerand D, De Sa Tavares Russo M, Bassenden A, Lu W, Tam M, Lesage S, Girouard H, Avizonis DZ, Deblois G, Prchal JT, Stevenson M, Berghuis A, Muir T, Rabinowitz J, Vidal SM, Fodil N, Gros P. Cell Rep. 2020 Sep 22;32(12):108170. doi: 10.1016/j.celrep.2020.108170. PMID: 32966787

Prognostic associations of plasma hepcidin in women with early breast cancer.  Jerzak KJ, Lohmann AE, Ennis M, Nemeth E, Ganz T, Goodwin PJ. Breast Cancer Res Treat. 2020 Sep 22. doi: 10.1007/s10549-020-05903-z. Online ahead of print. PMID: 32960376

Does heterozygosity for UGT1A1 *28 convey increased risk for severe neonatal jaundice?  Bahr TM, Agarwal AM, Christensen RD. J Perinatol. 2020 Sep 21. doi: 10.1038/s41372-020-00826-5. Online ahead of print. PMID: 32958836

Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer.  Cowman SJ, Fuja DG, Liu XD, Tidwell RSS, Kandula N, Sirohi D, Agarwal AM, Emerson LL, Tripp SR, Mohlman JS, Stonhill M, Garcia G, Conley CJ, Olalde AA, Sargis T, Ramirez-Torres A, Karam JA, Wood CG, Sircar K, Tamboli P, Boucher K, Maughan B, Spike BT, Ho TH, Agarwal N, Jonasch E, Koh MY. Clin Cancer Res. 2020 Sep 15;26(18):4970-4982. doi: 10.1158/1078-0432.CCR-19-3890. Epub 2020 Jun 25. PMID: 32586940

Battlefronts of evolutionary conflict between bacteria and animal hosts.  Aleru O, Barber MF. PLoS Pathog. 2020 Sep 17;16(9):e1008797. doi: 10.1371/journal.ppat.1008797. eCollection 2020 Sep. PMID: 32941529

Diagnostic yield and clinical utility of whole exome sequencing using an automated variant prioritization system, EVIDENCE.  Seo GH, Kim T, Choi IH, Park JY, Lee J, Kim S, Won DG, Oh A, Lee Y, Choi J, Lee H, Kang HG, Cho HY, Cho MH, Kim YJ, Yoon YH, Eun BL, Desnick RJ, Keum C, Lee BH. Clin Genet. 2020 Sep 9. doi: 10.1111/cge.13848. Online ahead of print. PMID: 32901917

Cutting in-line with iron: ribosomal function and non-oxidative RNA cleavage.  Guth-Metzler R, Bray MS, Frenkel-Pinter M, Suttapitugsakul S, Montllor-Albalate C, Bowman JC, Wu R, Reddi AR, Okafor CD, Glass JB, Williams LD. Nucleic Acids Res. 2020 Sep 4;48(15):8663-8674. doi: 10.1093/nar/gkaa586. PMID: 32663277

Improving thermoregulation in transported preterm infants.  Bahr TM, Kerry BB, Baserga MC, Christensen RD. J Perinatol. 2020 Sep 3. doi: 10.1038/s41372-020-00812-x. Online ahead of print. PMID: 32884103

Decision Accuracy and Safety of Transcutaneous Bilirubin Screening at Intermountain Healthcare.  Konana OS, Bahr TM, Strike HR, Coleman J, Snow GL, Christensen RD. J Pediatr. 2020 Sep 2:S0022-3476(20)31115-X. doi: 10.1016/j.jpeds.2020.08.079. Online ahead of print. PMID: 3289057

Clinical Immunoassay for Human Hepcidin Predicts Iron Deficiency in First-Time Blood Donors.  Gutschow P, Han H, Olbina G, Westerman K, Nemeth E, Ganz T, Copeland K, Westerman M, Ostland V. J Appl Lab Med. 2020 Sep 1;5(5):943-953. doi: 10.1093/jalm/jfaa038. PMID: 32674118


2020 August

Challenging the Erythropoiesis Paradigm in β-Thalassemia.  Vinchi F, Vance SZ. Hemasphere. 2020 Aug 27;4(5):e475. doi: 10.1097/HS9.0000000000000475. eCollection 2020 Oct. PMID: 32923985

Sestrin2 Phosphorylation by ULK1 Induces Autophagic Degradation of Mitochondria Damaged by Copper-Induced Oxidative Stress. Kim H, Jeon BT, Kim IM, Bennett SJ, Lorch CM, Viana MP, Myers JF, Trupp CJ, Whipps ZT, Kundu M, Chung S, Sun X, Khalimonchuk O, Lee J, Ro SH. Int J Mol Sci. 2020 Aug 25;21(17):6130. doi: 10.3390/ijms21176130. PMID: 32854424

Management versus miscues in the cytosolic labile iron pool: The varied functions of iron chaperones.  Philpott CC, Patel SJ, Protchenko O. Biochim Biophys Acta Mol Cell Res. 2020 Nov;1867(11):118830. doi: 10.1016/j.bbamcr.2020.118830. Epub 2020 Aug 21. PMID: 32835748

Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria.  Nowinski SM, Solmonson A, Rusin SF, Maschek JA, Bensard CL, Fogarty S, Jeong MY, Lettlova S, Berg JA, Morgan JT, Ouyang Y, Naylor BC, Paulo JA, Funai K, Cox JE, Gygi SP, Winge DR, DeBerardinis RJ, Rutter J. Elife. 2020 Aug 17;9:e58041. doi: 10.7554/eLife.58041. PMID: 32804083

MicroRNAs: At the Interface of Metabolic Pathways and Inflammatory Responses by Macrophages.  Nelson MC, O’Connell RM. Front Immunol. 2020 Aug 14;11:1797. doi: 10.3389/fimmu.2020.01797. eCollection 2020. PMID: 32922393.

Expression of Iron-Regulatory Hormone Hepcidin and Iron Transporters Ferroportin and ZIP8 in Patients With and Without Chronic Rhinosinusitis.  Hsu D, Kim A, Ganz T, Suh JD, Wang M, Wu TJ, Lee JT. Otolaryngol Head Neck Surg. 2020 Aug 4:194599820939910. doi: 10.1177/0194599820939910. Online ahead of print. PMID: 32746765


2020 July

Urinary ferritin; a potential noninvasive way to screen NICU patients for iron deficiency.  Gerday E, Brereton JB, Bahr TM, Elmont JO, Fullmer S, Middleton BA, Ward DM, Ohls RK, Christensen RD. J Perinatol. 2020 Jul 24. doi: 10.1038/s41372-020-0746-6. Online ahead of print. PMID: 32709979

Hepatocellular Carcinoma in Acute Hepatic Porphyrias: Results from the Longitudinal Study of the U.S. Porphyrias Consortium.  Saberi B, Naik H, Overbey JR, Erwin AL, Anderson KE, Bissell DM, Bonkovsky HL, Phillips JD, Wang B, K Singal A, M McGuire B, Desnick RJ, Balwani M. Hepatology. 2020 Jul 18. doi: 10.1002/hep.31460. Online ahead of print. PMID: 32681675

Exchange transfusion for hemolytic hyperbilirubinemia: could some be averted by emergent administration of an inhibitor of bilirubin production?  Wiedmeier SE, Bahr TM, Ohls RK, Christensen TR, Baer VL, Ilstrup SJ, Cail K, Christensen RD. J Perinatol. 2020 Jul 15. doi: 10.1038/s41372-020-0736-8. Online ahead of print. PMID: 32669646

Peripheral blood mononuclear cells show prominent gene expression by erythroid progenitors in diseases characterized by heightened erythropoiesis.  Zhang X, Song J, Shah BN, Nekhai S, Miasnikova G, Sergueeva A, Prchal JT, Gordeuk VR. Br J Haematol. 2020 Jul;190(1):e42-e45. doi: 10.1111/bjh.16696. Epub 2020 May 12. PMID: 32399971

Cutting in-line with iron: ribosomal function and non-oxidative RNA cleavage.  Guth-Metzler R, Bray MS, Frenkel-Pinter M, Suttapitugsakul S, Montllor-Albalate C, Bowman JC, Wu R, Reddi AR, Okafor CD, Glass JB, Williams LD. Nucleic Acids Res. 2020 Jul 14:gkaa586. doi: 10.1093/nar/gkaa586. Online ahead of print. PMID: 32663277

2020 June

Dizygotic twins prolonged jaundice and microcytic, hypochromic, hemolytic anemia with pyropoikilocytosis.  Bahr TM, Lozano-Chinga M, Agarwal AM, Meznarich JA, Gerday E, Smoot JL, Taylor A, Christensen RD. Blood Cells Mol Dis. 2020 Jun 25;85:102462. doi: 10.1016/j.bcmd.2020.102462. Online ahead of print. PMID: 32623341

Pediatric Hematology Normal Ranges Derived From Pediatric Primary Care Patients.  Staffa SJ, Joerger JD, Henry E, Christensen RD, Brugnara C, Zurakowski D. Am J Hematol. 2020 Jun 12. doi: 10.1002/ajh.25904. Online ahead of print. PMID: 32530536

QSRR Automator: A Tool for Automating Retention Time Prediction in Lipidomics and Metabolomics.  Naylor BC, Catrow JL, Maschek JA, Cox JE. Metabolites. 2020 Jun 9;10(6):237. doi: 10.3390/metabo10060237. PMID: 32526851

Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release.  Bailey HJ, Bezerra GA, Marcero JR, Padhi S, Foster WR, Rembeza E, Roy A, Bishop DF, Desnick RJ, Bulusu G, Dailey HA Jr, Yue WW. Nat Commun. 2020 Jun 4;11(1):2813. doi: 10.1038/s41467-020-16586-x.

Macrophage HIF-1α is an independent prognostic indicator in kidney cancer.  Cowman S, Fuja DG, Liu XD, Tidwell RSS, Kandula N, Sirohi D, Agarwal AM, Emerson LL, Tripp SR, Mohlman JS, Stonhill M, Garcia G, Conley CJ, Olalde AA, Sargis T, Ramirez-Torres A, Karam JA, Wood CG, Sircar K, Tamboli P, Boucher KM, Maughan BL, Spike BT, Ho TH, Agarwal N, Jonasch E, Koh MY. Clin Cancer Res. 2020 Jun 25:clincanres.3890.2019. doi: 10.1158/1078-0432.CCR-19-3890. Online ahead of print. PMID: 32586940

Iron overload causes a mild and transient increase in acute lung injury.  Zhang V, Ganz T, Nemeth E, Kim A. Physiol Rep. 2020 Jun;8(12):e14470. doi: 10.14814/phy2.14470. PMID: 32596989

Maternal Hepcidin Determines Embryo Iron Homeostasis.  Sangkhae V, Fisher AL, Chua KJ, Ruchala P, Ganz T, Nemeth E. Blood. 2020 Jun 25:blood.2020005745. doi: 10.1182/blood.2020005745. Online ahead of print. PMID: 32584957

The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice.  Seguin A, Jia X, Earl AM, Li L, Wallace J, Qiu A, Bradley T, Shrestha R, Troadec MB, Hockin M, Titen S, Warner DE, Dowdle PT, Wohlfahrt ME, Hillas E, Firpo MA, Phillips JD, Kaplan J, Paw BH, Barasch J, Ward DM. J Biol Chem. 2020 Jun 9:jbc.RA120.013229. doi: 10.1074/jbc.RA120.013229. Online ahead of print. PMID: 32518166

2020 May

Iron chaperone PCBP1 protects murine liver from lipid peroxidation and steatosis.  Protchenko O, Baratz E, Jadhav S, Li F, Shakoury-Elizeh M, Gavrilova O, Ghosh MC, Cox JE, Maschek JA, Tyurin VA, Tyurina YY, Bayir H, Aron AT, Chang CJ, Kagan VE, Philpott CC. Hepatology. 2020 May 21. doi: 10.1002/hep.31328. Online ahead of print. PMID: 32438524

Toxoplasma gondii requires its plant-like heme biosynthesis pathway for infection.  Bergmann A, Floyd K, Key M, Dameron C, Rees KC, Thornton LB, Whitehead DC, Hamza I, Dou Z.PLoS Pathog. 2020 May 14;16(5):e1008499. doi: 10.1371/journal.ppat.1008499. eCollection 2020 May. PMID: 32407406Free PMC article.

Increased iron stores influence glucose metabolism in sickle cell anaemia.  Shah BN, Hassan TO, Zhang X, McClain DA, Gordeuk VR. Br J Haematol. 2020 May;189(4):e184-e187. doi: 10.1111/bjh.16596. Epub 2020 Mar 30. PMID: 32232834

2020 Apr

Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing. Bessman NJ, Mathieu JRR, Renassia C, Zhou L, Fung TC, Fernandez KC, Austin C, Moeller JB, Zumerle S, Louis S, Vaulont S, Ajami NJ, Sokol H, Putzel GG, Arvedson T, Sockolow RE, Lakhal-Littleton S, Cloonan SM, Arora M, Peyssonnaux C, Sonnenberg GF. Science. 2020 Apr 10;368(6487):186-189. doi: 10.1126/science.aau6481.PMID:32273468

Mitochondrial-nuclear heme trafficking is regulated by GTPases in control of mitochondrial dynamics and ER contact sites. Martinez-Guzman O, Willoughby MM, Saini A, Dietz JV, Bohovych I, Medlock AE, Khalimonchuk O, Reddi AR. J Cell Sci. 2020 Apr 7. pii: jcs.237917. doi: 10.1242/jcs.237917. [Epub ahead of print] PMID:32265272

2020 Mar

Exploiting species specificity to understand the tropism of a human-specific toxin. Boguslawski KM, McKeown AN, Day CJ, Lacey KA, Tam K, Vozhilla N, Kim SY, Jennings MP, Koralov SB, Elde NC, Torres VJ. Sci Adv. 2020 Mar 11;6(11):eaax7515. doi: 10.1126/sciadv.aax7515. eCollection 2020 Mar. PMID:32195339

2020 Feb

Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Crowther MD, Dolton G, Legut M, Caillaud ME, Lloyd A, Attaf M, Galloway SAE, Rius C, Farrell CP, Szomolay B, Ager A, Parker AL, Fuller A, Donia M, McCluskey J, Rossjohn J, Svane IM, Phillips JD, Sewell AK. Nat Immunol. 2020 Feb;21(2):178-185. doi: 10.1038/s41590-019-0578-8. Epub 2020 Jan 20. PMID:31959982

Dexmedetomidine pretreatment improves lipopolysaccharide-induced iron homeostasis disorder in aged mice. Guo F, Kang J, Tan J, Wang Y, Jia L, Xu H. Curr Neurovasc Res. 2020 Feb 16. doi: 10.2174/1567202617666200217105109. [Epub ahead of print]


2020 Jan

Alternative splicing of UCP1 by non-cell-autonomous action of PEMT. Johnson JM, Verkerke ARP, Maschek JA, Ferrara PJ, Lin CT, Kew KA, Neufer PD, Lodhi IJ, Cox JE, Funai K. Mol Metab. 2020 Jan;31:55-66. doi: 10.1016/j.molmet.2019.10.007. Epub 2019 Nov 8.PMID:31918922

Iron and Heme Metabolism at the Leishmania-Host Interface.  Laranjeira-Silva MF, Hamza I, Pérez-Victoria JM. Trends Parasitol. 2020 Mar;36(3):279-289. doi: 10.1016/ Epub 2020 Jan 28. PMID: 32005611

Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis. Hughes C.E. Coody T.K. , Jeong M.-Y. ,Berg J.A. , Winge D.R., Hughes A.L. Cell. 2020; 180: 296-310

Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish. Nath AK, Ma J, Chen ZZ, Li Z, Vitery MDC, Kelley ML, Peterson RT, Gerszten RE, Yeh JJ. FASEB J. 2020 Jan;34(1):1546-1557. doi: 10.1096/fj.201901466R. Epub 2019 Dec 2. PMID:31914600

XPRESSyourself: Enhancing, standardizing, and automating ribosome profiling computational analyses yields improved insight into data. Berg JA, Belyeu JR, Morgan JT, Ouyang Y, Bott AJ, Quinlan AR, Gertz J, Rutter J. PLoS Comput Biol. 2020 Jan 31;16(1):e1007625. doi: 10.1371/journal.pcbi.1007625. [Epub ahead of print] PMID:32004313

Machine learning reveals serum sphingolipids as cholesterol-independent biomarkers of coronary artery disease. Poss AM, Maschek JA, Cox JE, Hauner BJ, Hopkins PN, Hunt SC, Holland WL, Summers SA, Playdon MC. J Clin Invest. 2020 Jan 27. pii: 131838. doi: 10.1172/JCI131838. [Epub ahead of print] PMID:31743112

PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3′ UTR. Yabe-Wada T, Philpott CC, Onai N. FEBS Open Bio. 2020 Jan 21. doi: 10.1002/2211-5463.12794. [Epub ahead of print] PMID:3196107

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification. Santos MCFD, Anderson CP, Neschen S, Zumbrennen-Bullough KB, Romney SJ, Kahle-Stephan M, Rathkolb B, Gailus-Durner V, Fuchs H, Wolf E, Rozman J, de Angelis MH, Cai WM, Rajan M, Hu J, Dedon PC, Leibold EA. Nat Commun. 2020 Jan 15;11(1):296. doi: 10.1038/s41467-019-14004-5. PMID:31941883

Editorial: Special Issue on mitochondrial fidelity. Khalimonchuk O. Mitochondrion. 2020 Jan 7;51:104. doi: 10.1016/j.mito.2019.12.007. [Epub ahead of print] No abstract available. PMID:31917323

Maternal Tobacco Smoke Exposure Causes Sex-Divergent Changes in Placental Lipid Metabolism in the Rat. Weinheimer C, Wang H, Comstock JM, Singh P, Wang Z, Locklear BA, Goodwin KL, Maschek JA, Cox JE, Baack ML, Joss-Moore LA. Reprod Sci. 2020 Jan 6. doi: 10.1007/s43032-019-00065-w. [Epub ahead of print] PMID:32046449

ASA Suppresses PGE2 in Plasma and Melanocytic Nevi of Human Subjects at Increased Risk for Melanoma. Varedi A, Rahman H, Kumar D, Catrow JL, Cox JE, Liu T, Florell SR, Boucher KM, Okwundu N, Burnett WJ, VanBrocklin MW, Grossman D. Pharmaceuticals (Basel). 2020 Jan 2;13(1). pii: E7. doi: 10.3390/ph13010007. PMID:31906519

The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1. Li L, Bertram S, Kaplan J, Jia X, Ward DM.J Biol Chem. 2020 Jan 2. pii: jbc.RA119.011154. doi: 10.1074/jbc.RA119.011154. [Epub ahead of print] PMID:31896574

Compartment and hub definitions tune metabolic networks for metabolomic interpretations. Waller TC, Berg JA, Lex A, Chapman BE, Rutter J. Gigascience. 2020 Jan 1;9(1). pii: giz137. doi: 10.1093/gigascience/giz137. PMID:31972021


2019 Dec

Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish. Zhang T, Trauger SA, Vidoudez C, Doane KP, Pluimer BR, Peterson RT. Sci Rep. 2019 Dec 27;9(1):19939. doi: 10.1038/s41598-019-56466-z.

A prospective evaluation of pegylated interferon alfa-2a therapy in patients with polycythemia vera and essential thrombocythemia with a prior splanchnic vein thrombosis. Mascarenhas J, Kosiorek H, Prchal J, Yacoub A, Berenzon D, Baer MR, Ritchie E, Silver RT, Kessler C, Winton E, Finazzi MC, Rambaldi A, Vannucchi AM, Leibowitz D, Rondelli D, Arcasoy MO, Catchatourian R, Vadakara J, Rosti V, Hexner E, Kremyanskaya M, Sandy L, Tripodi J, Najfeld V, Farnoud N, Salama ME, Weinberg RS, Rampal R, Goldberg JD, Mesa R, Dueck AC, Hoffman R. Leukemia. 2019 Dec;33(12):2974-2978. doi: 10.1038/s41375-019-0524-7. Epub 2019 Jul 30. No abstract available. PMID:31363161

JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera. Patel AB, Franzini A, Leroy E, Kim SJ, Pomicter AD, Genet L, Xiao M, Yan D, Ahmann JM, Agarwal AM, Clair P, Addada J, Lambert J, Salmon M, Gleich GJ, Cross NCP, Constantinescu SN, O’Hare T, Prchal JT, Deininger MW. Blood. 2019 Dec 26;134(26):2388-2398. doi: 10.1182/blood.2019001385. PMID:31697804

Universal Principled Review: A Community-Driven Method to Improve Peer Review. Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, Chi H, O’Connell R, Wherry EJ, Pepper M; Future Immunology Consortium. Cell. 2019 Dec 12;179(7):1441-1445. doi: 10.1016/j.cell.2019.11.029. PMID:31835023

Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier. Bensard CL, Wisidagama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, Earl CS, Namnath DF, Vázquez-Arreguín K, Villanueva CJ, Tantin D, Murtaugh LC, Evason KJ, Ducker GS, Thummel CS, Rutter J. Cell Metab. 2019 Dec 5. pii: S1550-4131(19)30609-6. doi: 10.1016/j.cmet.2019.11.002. [Epub ahead of print] PMID:31813825

Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3. Wang CY, Xu Y, Traeger L, Dogan DY, Xiao X, Steinbicker AU, Babitt JL. Blood. 2019 Dec 4. pii: blood.2019002620. doi: 10.1182/blood.2019002620. [Epub ahead of print] No abstract available. PMID:31800957

Absence of severe neonatal ABO hemolytic disease at Intermountain Healthcare. Why? Baer VL, Hulse W, Bahr TM, Ilstrup SJ, Christensen RD. J Perinatol. 2019 Dec 3. doi: 10.1038/s41372-019-0553-0. [Epub ahead of print] No abstract available. PMID:31796840

Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p.  Chalermwat C, Thosapornvichai T, Wongkittichote P, Phillips JD, Cox JE, Jensen AN, Wattanasirichaigoon D, Jensen LT. FEMS Yeast Res. 2019 Dec 1;19(8). pii: foz078. doi: 10.1093/femsyr/foz078.PMID:31711143


2019 Nov

Heme biosynthesis and the porphyrias. Phillips JD. Mol Genet Metab. 2019 Nov;128(3):164-177. doi: 10.1016/j.ymgme.2019.04.008. Epub 2019 Apr 22. Review.PMID:31326287

Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice. Xiao X, Dev S, Canali S, Bayer A, Xu Y, Agarwal A, Wang CY, Babitt JL. Hepatology. 2019 Nov 28. doi: 10.1002/hep.31048. [Epub ahead of print] PMID:31778583

Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma’s cyclin D1. Babosova O, Kapralova K, Raskova Kafkova L, Korinek V, Divoky V, Prchal JT, Lanikova L. J Cell Mol Med. 2019 Nov;23(11):7785-7795. doi: 10.1111/jcmm.14655. Epub 2019 Sep 13. PMID:31517438

Neonates with suspected microangiopathic disorders: performance of standard manual schistocyte enumeration vs. the automated fragmented red cell count. Bahr TM, Judkins AJ, Christensen RD, Baer VL, Henry E, Minton SD, Gerday E, Bennett ST. J Perinatol. 2019 Nov;39(11):1555-1561. doi: 10.1038/s41372-019-0482-y. Epub 2019 Aug 28. PMID:31462723

Results of a pilot study of isoniazid in patients with erythropoietic protoporphyria.Parker CJ, Desnick RJ, Bissel MD, Bloomer JR, Singal A, Gouya L, Puy H, Anderson KE, Balwani M, Phillips JD. Mol Genet Metab. 2019 Nov;128(3):309-313. doi: 10.1016/j.ymgme.2019.07.017. Epub 2019 Jul 31.PMID:31395332

Mitoferrin-1 is required for brain energy metabolism and hippocampus-dependent memory. Baldauf L, Endres T, Scholz J, Kirches E, Ward DM, Lessmann V, Borucki K, Mawrin C.Neurosci Lett. 2019 Nov 20;713:134521. doi: 10.1016/j.neulet.2019.134521. Epub 2019 Sep 26. PMID:31563673

Absence of HIF1A Leads to Glycogen Accumulation and an Inflammatory Response That Enables Pancreatic Tumor Growth. Maruggi M, Layng FI, Lemos R Jr, Garcia G, James BP, Sevilla M, Soldevilla F, Baaten BJ, de Jong PR, Koh MY, Powis G. Cancer Res. 2019 Nov 15;79(22):5839-5848. doi: 10.1158/0008-5472.CAN-18-2994. Epub 2019 Oct 4. PMID:31585939

Structural insights into heme binding to IL-36α proinflammatory cytokine. Wißbrock A, Goradia NB, Kumar A, Paul George AA, Kühl T, Bellstedt P, Ramachandran R, Hoffmann P, Galler K, Popp J, Neugebauer U, Hampel K, Zimmermann B, Adam S, Wiendl M, Krönke G, Hamza I, Heinemann SH, Frey S, Hueber AJ, Ohlenschläger O, Imhof D. Sci Rep. 2019 Nov 15;9(1):16893. doi: 10.1038/s41598-019-53231-0. PMID:31729440

The Human-Specific BOLA2 Duplication Modifies Iron Homeostasis and Anemia Predisposition in Chromosome 16p11.2 Autism Individuals. Giannuzzi G, Schmidt PJ, Porcu E, Willemin G, Munson KM, Nuttle X, Earl R, Chrast J, Hoekzema K, Risso D, Männik K, De Nittis P, Baratz ED; 16p11.2 Consortium, Herault Y, Gao X, Philpott CC, Bernier RA, Kutalik Z, Fleming MD, Eichler EE, Reymond A.Am J Hum Genet. 2019 Nov 7;105(5):947-958. doi: 10.1016/j.ajhg.2019.09.023. Epub 2019 Oct 24. PMID:31668704

Evaluating the Patient-Reported Outcomes Measurement Information System scales in acute intermittent porphyria. Naik H, Overbey JR, Montgomery GH, Winkel G, Balwani M, Anderson KE, Bissell DM, Bonkovsky HL, Phillips JD, Wang B, McGuire B, Keel S, Levy C, Erwin A, Desnick RJ. Genet Med. 2019 Nov 6. doi: 10.1038/s41436-019-0683-y. [Epub ahead of print]PMID:31690837

The fragmented red cell count can support the diagnosis of a microangiopathic neonatal condition. Bahr TM, Judkins AJ, Baer VL, Henry E, Grubb PH, Hulse W, Pysher TJ, Bennett ST, Christensen RD. J Perinatol. 2019 Nov 6. doi: 10.1038/s41372-019-0552-1. [Epub ahead of print] No abstract available. PMID:31695135

Response to interferon treatment in essential thrombocythemia with inv(3)(q21q26). Gangaraju R, Carroll AJ, Prchal JT. Ann Hematol. 2019 Nov 1. doi: 10.1007/s00277-019-03805-9. [Epub ahead of print] No abstract available. PMID:31676985


2019 Oct

Evaluating emergency-release blood transfusion of newborn infants at the Intermountain Healthcare hospitals. Bahr TM, DuPont TL, Christensen TR, Rees T, O’Brien EA, Ilstrup SJ, Christensen RD. Transfusion. 2019 Oct;59(10):3113-3119. doi: 10.1111/trf.15495. Epub 2019 Sep 3. PMID:31479169

First report of using low-titer cold-stored type O whole blood in massive postpartum hemorrhage. Bahr TM, DuPont TL, Morris DS, Pierson SE, Esplin MS, Brown SM, O’Brien EA, Ilstrup SJ, Christensen RD. Transfusion. 2019 Oct;59(10):3089-3092. doi: 10.1111/trf.15492. Epub 2019 Aug 30. PMID:31469450

Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea. Yacoub A, Mascarenhas J, Kosiorek H, Prchal JT, Berenzon D, Baer MR, Ritchie E, Silver RT, Kessler C, Winton E, Finazzi MC, Rambaldi A, Vannucchi AM, Leibowitz D, Rondelli D, Arcasoy MO, Catchatourian R, Vadakara J, Rosti V, Hexner E, Kremyanskaya M, Sandy L, Tripodi J, Najfeld V, Farnoud N, Papaemmanuil E, Salama M, Singer-Weinberg R, Rampal R, Goldberg JD, Barbui T, Mesa R, Dueck AC, Hoffman R. Blood. 2019 Oct 31;134(18):1498-1509. doi: 10.1182/blood.2019000428. PMID:31515250

Experimental Modeling of Myeloproliferative Neoplasms. Lanikova L, Babosova O, Prchal JT. Genes (Basel). 2019 Oct 15;10(10). pii: E813. doi: 10.3390/genes10100813. Review. PMID:31618985


2019 Sep

Proteolytic Activation of Bmps: Analysis of Cleavage in Xenopus Oocytes and Embryos.  Kim HS, McKnite A, Christian JL. Methods Mol Biol. 2019;1891:115-133. doi: 10.1007/978-1-4939-8904-1_9.  PMID: 30414129

BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis.  Kim HS, Neugebauer J, McKnite A, Tilak A, Christian JL. Elife. 2019 Sep 30;8:e48872. doi: 10.7554/eLife.48872.  PMID: 31566563

A PCBP1-BolA2 chaperone complex delivers iron for cytosolic [2Fe-2S] cluster assembly. Patel SJ, Frey AG, Palenchar DJ, Achar S, Bullough KZ, Vashisht A, Wohlschlegel JA, Philpott CC. Nat Chem Biol. 2019 Sep;15(9):872-881. doi: 10.1038/s41589-019-0330-6. Epub 2019 Aug 12.PMID:31406370

NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling. Rajan M, Anderson CP, Rindler PM, Romney SJ, Ferreira Dos Santos MC, Gertz J, Leibold EA. Elife. 2019 Sep 18;8. pii: e44674. doi: 10.7554/eLife.44674. PMID:31532389

EXPLORE: A Prospective, Multinational, Natural History Study of Patients with Acute Hepatic Porphyria with Recurrent Attacks. Gouya L, Ventura P, Balwani M, Bissell DM, Rees DC, Stölzel U, Phillips JD, Kauppinen R, Langendonk JG, Desnick RJ, Deybach JC, Bonkovsky HL, Parker C, Naik H, Badminton M, Stein PE, Minder E, Windyga J, Bruha R, Cappellini MD, Sardh E, Harper P, Sandberg S, Aarsand AK, Andersen J, Alegre F, Ivanova A, Talbi N, Chan A, Querbes W, Ko J, Penz C, Liu S, Lin T, Simon A, Anderson KE. Hepatology. 2019 Sep 12. doi: 10.1002/hep.30936. [Epub ahead of print]PMID:31512765

Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K. Sci Adv. 2019 Sep 11;5(9):eaax8352. doi: 10.1126/sciadv.aax8352. eCollection 2019 Sep. PMID:31535029

A Low Iron Diet Protects from Steatohepatitis in a Mouse Model. Salaye L, Bychkova I, Sink S, Kovalic AJ, Bharadwaj MS, Lorenzo F, Jain S, Harrison AV, Davis AT, Turnbull K, Meegalla NT, Lee SH, Cooksey R, Donati GL, Kavanagh K, Bonkovsky HL, McClain DA. Nutrients. 2019 Sep 10;11(9). pii: E2172. doi: 10.3390/nu11092172. PMID:31510077


2019 Aug

Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia. Jafek JL, Shakya A, Tai PY, Ibarra A, Kim H, Maddox J, Chumley J, Spangrude GJ, Miles RR, Kelley TW, Tantin D. Exp Hematol. 2019 Aug;76:38-48.e2. doi: 10.1016/j.exphem.2019.07.002. Epub 2019 Jul 8. PMID:31295506

Knowing When to Let Go: Lysosomes Regulate Inter-Mitochondrial Tethering. English AM, Hughes AL. Dev Cell. 2019 Aug 5;50(3):259-260. doi: 10.1016/j.devcel.2019.07.019. PMID:31386859

Rsp5 and Mdm30 reshape the mitochondrial network in response to age-induced vacuole stress. Goodrum JM, Lever AR, Coody TK, Gottschling DE, Hughes AL. Mol Biol Cell. 2019 Aug 1;30(17):2141-2154. doi: 10.1091/mbc.E19-02-0094. Epub 2019 May 29. PMID:31141470


2019 July

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis. Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA.Science. 2019 Jul 26;365(6451):386-392. doi: 10.1126/science.aav3722. Epub 2019 Jul 4.PMID:31273070

T cell-mediated regulation of the microbiota protects against obesity. Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O’Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL. Science. 2019 Jul 26;365(6451). pii: eaat9351. doi: 10.1126/science.aat9351. PMID:31346040

Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness. Sharma A, Oonthonpan L, Sheldon RD, Rauckhorst AJ, Zhu Z, Tompkins SC, Cho K, Grzesik WJ, Gray LR, Scerbo DA, Pewa AD, Cushing EM, Dyle MC, Cox JE, Adams C, Davies BS, Shields RK, Norris AW, Patti G, Zingman LV, Taylor EB. Elife. 2019 Jul 18;8. pii: e45873. doi: 10.7554/eLife.45873. PMID:31305240

Thrombotic risk in congenital erythrocytosis due to up-regulated hypoxia sensing is not associated with elevated hematocrit. Gordeuk VR, Miasnikova GY, Sergueeva AI, Lorenzo FR, Zhang X, Song J, Stockton DW, Prchal JT. Haematologica. 2019 Jul 9. pii: haematol.2019.216267. doi: 10.3324/haematol.2019.216267. [Epub ahead of print]PMID:31289208


2019 June

Redox Regulation of the Mitochondrial Quality Control Protease Oma1. Bohovych I, Dietz JV, Swenson S, Zahayko N, Khalimonchuk O. Antioxid Redox Signal. 2019 Jun 18. doi: 10.1089/ars.2018.7642. [Epub ahead of print] PMID:31011300

Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex. McClellan D, Casey MJ, Bareyan D, Lucente H, Ours C, Velinder M, Singer J, Lone MD, Sun W, Coria Y, Mason CC, Engel ME. Mol Cell Biol. 2019 Jun 13;39(13). pii: e00020-19. doi: 10.1128/MCB.00020-19. Print 2019 Jul 1.PMID:30988160


2019 May

Ferritin in serum and urine: A pilot study. Bahr TM, Christensen RD, Ward DM, Meng F, Jackson LK, Doyle K, Christensen DR, Harvey AG, Yaish HM. Blood Cells Mol Dis. 2019 May;76:59-62. doi: 10.1016/j.bcmd.2019.02.001. Epub 2019 Feb 8. PMID;30777730

Phase evolution of conversion-type electrode for lithium ion batteries. Li J, Hwang S, Guo F, Li S, Chen Z, Kou R, Sun K, Sun CJ, Gan H, Yu A, Stach EA, Zhou H, Su D. Nat Commun. 2019 May 20;10(1):2224. doi: 10.1038/s41467-019-09931-2. PMID:31110173

Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program. Kikani CK, Wu X, Fogarty S, Kang SAW, Dephoure N, Gygi SP, Sabatini DM, Rutter J. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10382-10391. doi: 10.1073/pnas.1804013116. Epub 2019 May 9. PMID:31072927

Hypoxia-Associated Factor (HAF) Mediates Neurofibromin Ubiquitination and Degradation Leading to Ras-ERK Pathway Activation in Hypoxia. Green YS, Sargis T, Reichert EC, Rudasi E, Fuja D, Jonasch E, Koh MY. Mol Cancer Res. 2019 May;17(5):1220-1232. doi: 10.1158/1541-7786.MCR-18-1080. Epub 2019 Jan 31. PMID:30705246

International Porphyria Molecular Diagnostic Collaborative: an evidence-based database of verified pathogenic and benign variants for the porphyrias. Chen B, Whatley S, Badminton M, Aarsand AK, Anderson KE, Bissell DM, Bonkovsky HL, Cappellini MD, Floderus Y, Friesema ECH, Gouya L, Harper P, Kauppinen R, Loskove Y, Martásek P, Phillips JD, Puy H, Sandberg S, Schmitt C, To-Figueras J, Weiss Y, Yasuda M, Deybach JC, Desnick RJ. Genet Med. 2019 May 10. doi: 10.1038/s41436-019-0537-7. [Epub ahead of print] PMID:31073229

Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, Li H, Sadoshima J. Cell Metab. 2019 May 7;29(5):1119-1134.e12. doi: 10.1016/j.cmet.2019.01.005. Epub 2019 Feb 7. PMID:30745182

Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy.Vazquez-Arreguin K, Bensard C, Schell JC, Swanson E, Chen X, Rutter J, Tantin D. (2019)  PLoS Genetics. 2019 May 6;15(5):e1007687. PMID:31059499  


2019 Apr

Re-evaluation of hematocrit as a determinant of thrombotic risk in erythrocytosis. Gordeuk VR, Key NS, Prchal JT. Haematologica. 2019 Apr;104(4):653-658. doi: 10.3324/haematol.2018.210732. Epub 2019 Mar 14. PMID:30872370

Proteolytic regulation of mitochondrial dynamics. Dietz JV, Bohovych I, Viana MP, Khalimonchuk O. Mitochondrion. 2019 Apr 25. pii: S1567-7249(19)30047-9. doi: 10.1016/j.mito.2019.04.008. [Epub ahead of print] Review. PMID:31029640

Development of a symptom assessment in patients with myelofibrosis: qualitative study findings. Mesa RA, Su Y, Woolfson A, Prchal JT, Turnbull K, Jabbour E, Scherber R, Shields AL, Krohe M, Ojo F, Pompilus F, Cappelleri JC, Harrison C. Health Qual Life Outcomes. 2019 Apr 11;17(1):61. doi: 10.1186/s12955-019-1121-1. PMID:30975150

Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance. Ganeshan K, Nikkanen J, Man K, Leong YA, Sogawa Y, Maschek JA, Van Ry T, Chagwedera DN, Cox JE, Chawla A. Cell. 2019 Apr 4;177(2):399-413.e12. doi: 10.1016/j.cell.2019.01.050. Epub 2019 Mar 7. PMID:30853215


2019 Feb

An extracellular histidine-containing motif in the zinc transporter ZIP4 plays a role in zinc sensing and zinc-induced endocytosis in mammalian cells. Chun H, Korolnek T, Lee CJ, Coyne HJ 3rd, Winge DR, Kim BE, Petris MJ. J Biol Chem. 2019 Feb 22;294(8):2815-2826. doi: 10.1074/jbc.RA118.005203. Epub 2018 Dec 28. PMID:30593504

Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.Yao X, Jing X, Guo J, Sun K, Deng Y, Zhang Y, Guo F, Ye Y. Front Pharmacol. 2019 Feb 28;10:163. doi: 10.3389/fphar.2019.00163. eCollection 2019. PMID:30873034

Harderoporphyria: Case of lifelong photosensitivity associated with compound heterozygous coproporphyrinogen oxidase (CPOX) mutations. Moghe A, Ramanujam VMS, Phillips JD, Desnick RJ, Anderson KE. Mol Genet Metab Rep. 2019 Feb 19;19:100457. doi: 10.1016/j.ymgmr.2019.100457. eCollection 2019 Jun. PMID:30828546


2019 Jan

Screening umbilical cord blood for congenital Iron deficiency. MacQueen, BC, Christensen, RD, Baer VL, Ward, DM, Snow GL.  (2019). Blood Cells Mol Dis. 77:95-100 PMID: 31005753

Diagnosing or ruling out polycythemia vera in patients with erythrocytosis. Prchal JT. Clin Adv Hematol Oncol. 2019 Jan;17(1):24-27. PMID:30843892

Identification and characterization of 40 novel hydroxymethylbilane synthase mutations that cause acute intermittent porphyria. Chen B, Solis-Villa C, Erwin AL, Balwani M, Nazarenko I, Phillips JD, Desnick RJ, Yasuda M. J Inherit Metab Dis. 2019 Jan;42(1):186-194. doi: 10.1002/jimd.12040. PMID: 30740734

Pilot Study of Novel Intermittent Fasting Effects on Metabolomic and Trimethylamine N-oxide Changes During 24-hour Water-Only Fasting in the FEELGOOD Trial. Washburn RL, Cox JE, Muhlestein JB, May HT, Carlquist JF, Le VT, Anderson JL, Horne BD. Nutrients. 2019 Jan 23;11(2). pii: E246. doi: 10.3390/nu11020246. PMID:30678028

The mitochondrial heme metabolon: Insights into the complex(ity) of heme synthesis and distribution. Piel RB 3rd, Dailey HA Jr, Medlock AE. Mol Genet Metab. 2019 Jan 17. pii: S1096-7192(18)30634-6. doi: 10.1016/j.ymgme.2019.01.006. [Epub ahead of print] Review. PMID:30709775

Imbalanced sphingolipid signaling is maintained as a core proponent of a cancerous phenotype in spite of metabolic pressure and epigenetic drift. Speirs MMP, Swensen AC, Chan TY, Jones PM, Holman JC, Harris MB, Maschek JA, Cox JE, Carson RH, Hill JT, Andersen JL, Prince JT, Price JC. Oncotarget. 2019 Jan 11;10(4):449-479. doi: 10.18632/oncotarget.26533. eCollection 2019 Jan 11. PMID:30728898

Homozygous hydroxymethylbilane synthase knock-in mice provide pathogenic insights into the severe neurological impairments present in human homozygous dominant acute intermittent porphyria. Yasuda M, Gan L, Chen B, Yu C, Zhang J, Gama-Sosa MA, Pollak DD, Berger S, Phillips JD, Edelmann W, Desnick RJ. Hum Mol Genet. 2019 Jan 7. doi: 10.1093/hmg/ddz003. [Epub ahead of print] PMID:30615115



FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.Yien YY, Shi J, Chen C, Cheung JTM, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon LI, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH. J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26.PMID:30366982

The AAA ATPase Afg1 preserves mitochondrial fidelity and cellular health by maintaining mitochondrial matrix proteostasis. Germany EM, Zahayko N, Huebsch ML, Fox JL, Prahlad V, Khalimonchuk O. J Cell Sci. 2018 Nov 21;131(22). pii: jcs219956. doi: 10.1242/jcs.219956. PMID:30301782

Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus. Choby JE, Buechi HB, Farrand AJ, Skaar EP, Barber MF. MBio. 2018 Nov 20;9(6). pii: e01524-18. doi: 10.1128/mBio.01524-18. PMID:30459189

Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis. Burch JS, Marcero JR, Maschek JA, Cox JE, Jackson LK, Medlock AE, Phillips JD, Dailey HA Jr. Blood. 2018 Sep 6;132(10):987-998. doi: 10.1182/blood-2018-01-829036. Epub 2018 Jul 10. PMID:29991557

Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes. Barton JC, McLaren CE, Chen WP, Ramm GA, Anderson GJ, Powell LW, Subramaniam VN, Adams PC, Phatak PD, Gurrin LC, Phillips JD, Parker CJ, Emond MJ, McLaren GD. Ann Hepatol. 2018 Aug 24;17(5):871-879. doi: 10.5604/01.3001.0012.3169.PMID:30145563

ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly. Van Vranken JG, Nowinski SM, Clowers KJ, Jeong MY, Ouyang Y, Berg JA, Gygi JP, Gygi SP, Winge DR, Rutter J. Mol Cell. 2018 Aug 16;71(4):567-580.e4. doi: 10.1016/j.molcel.2018.06.039.PMID:30118679