Recent Publications
2021 April
Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity. Cheng X, Shihabudeen Haider Ali MS, Moran M, Viana MP, Schlichte SL, Zimmerman MC, Khalimonchuk O, Feinberg MW, Sun X. Redox Biol. 2021 Apr;40:101863. doi: 10.1016/j.redox.2021.101863. Epub 2021 Jan 19. PMID: 33508742 Free PMC article
2021 March
Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes. Chaurasia B, Ying L, Talbot CL, Maschek JA, Cox J, Schuchman EH, Hirabayashi Y, Holland WL, Summers SA. Mol Metab. 2021 Mar;45:101145. doi: 10.1016/j.molmet.2020.101145. Epub 2020 Dec 19. PMID: 33352310
Reconciling markedly discordant values of serum ferritin versus reticulocyte hemoglobin content. Bahr TM, Baer VL, Ohls RK, Christensen TR, Ward DM, Bennett ST, Christensen RD. J Perinatol. 2021 Mar;41(3):619-626. doi: 10.1038/s41372-020-00845-2. Epub 2020 Oct 4. PMID: 33012780
Red blood cell transfusions and potentially related morbidities in neonates under 32 weeks’ gestation. D’Amato G, Faienza MF, Palladino V, Bianchi FP, Natale MP, Christensen RD, Giordano P, Del Vecchio A. Blood Transfus. 2021 Mar;19(2):113-119. doi: 10.2450/2020.0092-20. Epub 2020 Oct 14. PMID: 33085599
Rationale and design of the Kidney Precision Medicine Project. de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP, Hacohen N, He Y, Hodgin JB, Jain S, Kellum JA, Kiryluk K, Knight R, Laszik ZG, Lienczewski C, Mariani LH, McClelland RL, Menez S, Moledina DG, Mooney SD, O’Toole JF, Palevsky PM, Parikh CR, Poggio ED, Rosas SE, Rosengart MR, Sarwal MM, Schaub JA, Sedor JR, Sharma K, Steck B, Toto RD, Troyanskaya OG, Tuttle KR, Vazquez MA, Waikar SS, Williams K, Wilson FP, Zhang K, Iyengar R, Kretzler M, Himmelfarb J; Kidney Precision Medicine Project. Kidney Int. 2021 Mar;99(3):498-510. doi: 10.1016/j.kint.2020.08.039. PMID: 33637194
Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type 1 diabetes. Kim H, Perovanovic J, Shakya A, Shen Z, German CN, Ibarra A, Jafek JL, Lin NP, Evavold BD, Chou DH, Jensen PE, He X, Tantin D. J Exp Med. 2021 Mar 1;218(3):e20200533. doi: 10.1084/jem.20200533. PMID: 33295943
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cluntun AA, Badolia R, Lettlova S, Parnell KM, Shankar TS, Diakos NA, Olson KA, Taleb I, Tatum SM, Berg JA, Cunningham CN, Van Ry T, Bott AJ, Krokidi AT, Fogarty S, Skedros S, Swiatek WI, Yu X, Luo B, Merx S, Navankasattusas S, Cox JE, Ducker GS, Holland WL, McKellar SH, Rutter J, Drakos SG. Cell Metab. 2021 Mar 2;33(3):629-648.e10. doi: 10.1016/j.cmet.2020.12.003. Epub 2020 Dec 16. PMID: 33333007
Commentary on the AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia. Kaunitz JD, Ganz T. Gastroenterology. 2021 Mar 3:S0016-5085(21)00470-4. doi: 10.1053/j.gastro.2021.03.001. Online ahead of print. PMID: 33675744 No abstract available.
Characterizing a common CERS2 polymorphism in a mouse model of metabolic disease and in subjects from the Utah CAD Study. Nicholson RJ, Poss AM, Maschek JA, Cox JE, Hopkins PN, Hunt SC, Playdon MC, Holland WL, Summers SA. J Clin Endocrinol Metab. 2021 Mar 11:dgab155. doi: 10.1210/clinem/dgab155. Online ahead of print. PMID: 33705551
Kidney injury biomarkers during exposure to tenofovir-based pre-exposure prophylaxis. Nickolas TL, Barasch J, Mugwanya KK, Branch AD, Heffron R, Wanga V, Mugo NR, Ronald A, Celum C, Donnell D, Baeten JM, Wyatt CM; Partners PrEP Study Team. AIDS. 2021 Mar 11. doi: 10.1097/QAD.0000000000002865. Online ahead of print. PMID: 33710023
2021 February
FGF23, Frailty, and Falls in SPRINT. Jovanovich A, Ginsberg C, You Z, Katz R, Ambrosius WT, Berlowitz D, Cheung AK, Cho M, Lee AK, Punzi H, Rehman S, Roumie C, Supiano MA, Wright CB, Shlipak M, Ix JH, Chonchol M. J Am Geriatr Soc. 2021 Feb;69(2):467-473. doi: 10.1111/jgs.16895. Epub 2020 Dec 1. PMID: 33289072
SARS-CoV-2 innate effector associations and viral load in early nasopharyngeal infection. Liou TG, Adler FR, Cahill BC, Cox DR, Cox JE, Grant GJ, Hanson KE, Hartsell SC, Hatton ND, Helms MN, Jensen JL, Kartsonaki C, Li Y, Leung DT, Marvin JE, Middleton EA, Osburn-Staker SM, Packer KA, Shakir SM, Sturrock AB, Tardif KD, Warren KJ, Waddoups LJ, Weaver LJ, Zimmerman E, Paine R 3rd. Physiol Rep. 2021 Feb;9(4):e14761. doi: 10.14814/phy2.14761. PMID: 33625796
Inflammatory, synaptic, motor, and behavioral alterations induced by gestational sepsis on the offspring at different stages of life. Granja MG, Alves LP, Leardini-Tristão M, Saul ME, Bortoni LC, de Moraes FM, Ferreira EC, de Moraes BPT, da Silva VZ, Dos Santos AFR, Silva AR, Gonçalves-de-Albuquerque CF, Bambini-Junior V, Weyrich AS, Rondina MT, Zimmerman GA, de Castro-Faria-Neto HC. J Neuroinflammation. 2021 Feb 25;18(1):60. doi: 10.1186/s12974-021-02106-1. PMID: 33632243
Layered immunity of the developing thymus. López DA, Beaudin AE. Blood. 2021 Feb 25;137(8):1003-1004. doi: 10.1182/blood.2020009207. PMID: 33630049 No abstract available.
Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in Candida albicans. Weissman Z, Pinsky M, Donegan RK, Reddi AR, Kornitzer D. Cell Microbiol. 2021 Feb;23(2):e13282. doi: 10.1111/cmi.13282. Epub 2020 Nov 9. PMID: 33104284
Emerimicins V-X, 15-Residue Peptaibols Discovered from an Acremonium sp. through Integrated Genomic and Chemical Approaches. Wu G, Dentinger BTM, Nielson JR, Peterson RT, Winter JM. J Nat Prod. 2021 Feb 22. doi: 10.1021/acs.jnatprod.0c01186. Online ahead of print. PMID: 33617244
Gams isolated from a soil sample collected from the University of Utah led to the isolation and characterization of six new linear pentadecapeptides, emerimicins V-X (1-6). …
Single-cell analysis of erythropoiesis in Rpl11 haploinsufficient mice reveals insight into the pathogenesis of Diamond Blackfan anemia. Doty RT, Yan X, Meng C, Lausted C, Tian Q, Abkowitz JL. Exp Hematol. 2021 Feb 22:S0301-472X(21)00092-8. doi: 10.1016/j.exphem.2021.02.010. Online ahead of print. PMID: 33631277
Expression Profiling Identifies TWIST2 Target Genes in Setleis Syndrome Patient Fibroblast and Lymphoblast Cells. Crespo NE, Torres-Bracero A, Renta JY, Desnick RJ, Cadilla CL. Int J Environ Res Public Health. 2021 Feb 19;18(4):1997. doi: 10.3390/ijerph18041997. PMID: 33669496
Increase of plasma erythroferrone levels during high-altitude exposure: A sub-analysis of the TOP OF HOMe study. Emrich IE, Scheuer A, Wagenpfeil S, Ganz T, Heine GH. Am J Hematol. 2021 Feb 19. doi: 10.1002/ajh.26130. Online ahead of print. PMID: 33606284 No abstract available.
Maestro of the SereNADe: SLC25A51 Orchestrates Mitochondrial NAD. Ouyang Y, Bott AJ, Rutter J. Trends Biochem Sci. 2021 Feb 19:S0968-0004(21)00029-3. doi: 10.1016/j.tibs.2021.02.001. Online ahead of print. PMID: 33618948
A mutation in the iron-responsive element of ALAS2 is a modifier of disease severity in a patient suffering from CLPX associated erythropoietic protoporphyria. Ducamp S, Luscieti S, Ferrer-Cortès X, Nicolas G, Manceau H, Peoc’h K, Yien YY, Kannengiesser C, Gouya L, Puy H, Sanchez M. Haematologica. 2021 Feb 18. doi: 10.3324/haematol.2020.272450. Online ahead of print. PMID: 33596641
A time to build and a time to burn: glucose metabolism for every season. McKean WB, Toshniwal AG, Rutter J. Mol Cell. 2021 Feb 18;81(4):642-644. doi: 10.1016/j.molcel.2021.02.003. PMID: 33606971
Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle. Ferrara PJ, Rong X, Maschek JA, Verkerke AR, Siripoksup P, Song H, Green TD, Krishnan KC, Johnson JM, Turk J, Houmard JA, Lusis AJ, Drummond MJ, McClung JM, Cox JE, Shaikh SR, Tontonoz P, Holland WL, Funai K. J Clin Invest. 2021 Feb 16:135963. doi: 10.1172/JCI135963. Online ahead of print. PMID: 3359195
Maternal obesity and impaired offspring neurodevelopment: could fetal iron deficiency be a pathogenic link? Bahr TM, Benson AE, Kling PJ, Ohls RK, Ward DM, Christensen RD. J Perinatol. 2021 Feb 16. doi: 10.1038/s41372-021-00951-9. Online ahead of print. PMID: 33594227 No abstract available.
Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes. Zhu X, Boulet A, Buckley KM, Phillips CB, Gammon MG, Oldfather LE, Moore SA, Leary SC, Cobine PA. Elife. 2021 Feb 16;10:e64690. doi: 10.7554/eLife.64690. PMID: 33591272
Heparanase expression and activity are increased in platelets during clinical sepsis. Eustes AS, Campbell RA, Middleton EA, Tolley ND, Manne BK, Montenont E, Rowley JW, Krauel K, Blair A, Guo L, Kosaka Y, Medeiros-de-Moraes IM, Lacerda M, Hottz ED, Neto HCF, Zimmerman GA, Weyrich AS, Petrey A, Rondina MT. J Thromb Haemost. 2021 Feb 15. doi: 10.1111/jth.15266. Online ahead of print. PMID: 33587773
Accidental massive platelet transfusion. Tsang HC, Gernsheimer TB, Abkowitz JL, Hess JR. Transfusion. 2021 Feb 11. doi: 10.1111/trf.16314. Online ahead of print. PMID: 33569795 No abstract available.
Novel mechanism of hereditary pyropoikilocytosis phenotype due to co-inheritance of β globin and α spectrin mutations. Kim SJ, Song J, Reading NS, Lautersztain J, Kutlar A, Agarwal AM, Coetzer TL, Prchal JT. Am J Hematol. 2021 Feb 8. doi: 10.1002/ajh.26121. Online ahead of print. PMID: 33556202
Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins. Goncalves Monteiro D, van Dijk JWA, Aliyanto R, Fung E, Nemeth E, Ganz T, Rosengren J, Clark RJ. Biomedicines. 2021 Feb 8;9(2):164. doi: 10.3390/biomedicines9020164. PMID: 33567510
Non-transferrin-bound iron in the spotlight: novel mechanistic insights into the vasculo-toxic and atherosclerotic effect of iron. Vinchi F. Antioxid Redox Signal. 2021 Feb 6. doi: 10.1089/ars.2020.8167. Online ahead of print. PMID: 33554718
Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens. Goldstein SA, Brown J, Pedersen BS, Quinlan AR, Elde NC. bioRxiv. 2021 Feb 4:2021.02.03.429646. doi: 10.1101/2021.02.03.429646. Preprint. PMID: 33564759
Diversification of CD1 molecules shapes lipid antigen selectivity. Paterson NM, Al-Zubieri H, Barber MF. Mol Biol Evol. 2021 Feb 2:msab022. doi: 10.1093/molbev/msab022. Online ahead of print. PMID: 33528563
Molecular studies of host-pathogen evolution have largely focused on the consequences of variation at protein-protein interaction surfaces. …These findings suggest that lipid-protein conflicts have shaped CD1 genetic variation during primate evolution. Consistent …
Maternal schistosomiasis impairs offspring Interleukin-4 production and B cell expansion. Cortés-Selva D, Gibbs L, Ready A, Ekiz HA, O’Connell R, Rajwa B, Fairfax KC. PLoS Pathog. 2021 Feb 1;17(2):e1009260. doi: 10.1371/journal.ppat.1009260. eCollection 2021 Feb. PMID: 33524040 Free PMC article.
miR-155 promotes T reg cell development by safeguarding medullary thymic epithelial cell maturation. Dong J, Warner LM, Lin LL, Chen MC, O’Connell RM, Lu LF. J Exp Med. 2021 Feb 1;218(2):e20192423. doi: 10.1084/jem.20192423. PMID: 33125052
2021 January
Chemical Genetics: Manipulating the Germline with Small Molecules. Jin YN, Peterson RT. Methods Mol Biol. 2021;2218:61-73. doi: 10.1007/978-1-0716-0970-5_6. PMID: 33606223
Isolation and thermal stabilization of mouse ferroportin. Deshpande CN, Azucenas CR, Qiao B, Nomura N, Xin V, Font J, Iwata S, Ganz T, Nemeth E, Mackenzie B, Jormakka M. FEBS Open Bio. 2021 Jan;11(1):26-34. doi: 10.1002/2211-5463.13039. Epub 2020 Dec 17. PMID: 3319042
One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers. Chambers IG, Willoughby MM, Hamza I, Reddi AR. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118881. doi: 10.1016/j.bbamcr.2020.118881. Epub 2020 Oct 3. PMID: 33022276
Parenteral iron therapy and phosphorus homeostasis: A review. Kalantar-Zadeh K, Ganz T, Trumbo H, Seid MH, Goodnough LT, Levine MA. Am J Hematol. 2021 Jan 20. doi: 10.1002/ajh.26100. Online ahead of print. PMID: 33471363 Review.
Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex. Viana MP, Levytskyy RM, Anand R, Reichert AS, Khalimonchuk O. iScience. 2021 Jan 29;24(2):102119. doi: 10.1016/j.isci.2021.102119. eCollection 2021 Feb 19. PMID: 33644718 Free PMC article.
ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway. Xiao T, Shakya VP, Hughes AL. Life Sci Alliance. 2021 Jan 21;4(3):e202000918. doi: 10.26508/lsa.202000918. Print 2021 Mar. PMID: 33479049
Reshaping Erythrophagocytosis and Iron Recycling by Reticuloendothelial Macrophages. Vinchi F, Vance SZ. Hemasphere. 2021 Jan 20;5(2):e525. doi: 10.1097/HS9.0000000000000525. eCollection 2021 Feb. PMID: 33490878
Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain. Bezerra GA, Holenstein A, Foster WR, Xie B, Hicks KG, Bürer C, Lutz S, Mukherjee A, Sarkar D, Bhattacharya D, Rutter J, Talukdar A, Brown PJ, Luo M, Shi L, Froese DS, Yue WW. Biochimie. 2021 Jan 18:S0300-9084(21)00009-2. doi: 10.1016/j.biochi.2021.01.007. Online ahead of print. PMID: 33476699
Metabolic reprogramming of the myeloid lineage by Schistosoma mansoni infection persists independently of antigen exposure. Cortes-Selva D, Gibbs L, Maschek JA, Nascimento M, Van Ry T, Cox JE, Amiel E, Fairfax KC. PLoS Pathog. 2021 Jan 8;17(1):e1009198. doi: 10.1371/journal.ppat.1009198. eCollection 2021 Jan. PMID: 33417618
Is the erythropoietin-erythroferrone-hepcidin axis intact in human neonates? Bahr TM, Ward DM, Jia X, Ohls RK, German KR, Christensen RD. Blood Cells Mol Dis. 2021 May;88:102536. doi: 10.1016/j.bcmd.2021.102536. Epub 2021 Jan 6. PMID: 33450539
2020 December
5-Aminolevulinate dehydratase porphyria: Update on hepatic 5-aminolevulinic acid synthase induction and long-term response to hemin. Lahiji AP, Anderson KE, Chan A, Simon A, Desnick RJ, Ramanujam VMS. Mol Genet Metab. 2020 Dec;131(4):418-423. doi: 10.1016/j.ymgme.2020.10.011. Epub 2020 Oct 26. PMID: 33199206
Questions and answers on iron deficiency treatment selection and the use of intravenous iron in routine clinical practice. Richards T, Breymann C, Brookes MJ, Lindgren S, Macdougall IC, McMahon LP, Munro MG, Nemeth E, Rosano GMC, Schiefke I, Weiss G. Ann Med. 2021 Dec;53(1):274-285. doi: 10.1080/07853890.2020.1867323. PMID: 33426933
Erythroferrone structure, function, and physiology: Iron homeostasis and beyond. Srole DN, Ganz T. J Cell Physiol. 2020 Dec 28. doi: 10.1002/jcp.30247. Online ahead of print. PMID: 33372284 Review.
Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network. Sorouri M, Chang T, Jesudhasan P, Pinkham C, Elde NC, Hancks DC. PLoS Biol. 2020 Dec 28;18(12):e3001045. doi: 10.1371/journal.pbio.3001045. eCollection 2020 Dec. PMID: 33370271
Differential translational control of 5′ IRE-containing mRNA in response to dietary iron deficiency and acute iron overload. Garza KR, Clarke SL, Ho YH, Bruss MD, Vasanthakumar A, Anderson SA, Eisenstein RS. Metallomics. 2020 Dec 23;12(12):2186-2198. doi: 10.1039/d0mt00192a. PMID: 33325950
Beta-adrenergic agonists increase maximal output of oxidative phosphorylation in bovine satellite cells. Sieck RL, Treffer LK, Ponte Viana M, Khalimonchuk O, Schmidt TB, Yates DT, Petersen JL. Transl Anim Sci. 2020 Dec 22;4(Suppl 1):S94-S97. doi: 10.1093/tas/txaa112. eCollection 2020 Dec. PMID: 33381728
Comparison of myeloid blast counts and variant allele frequencies of gene mutations in myelodysplastic syndrome with excess blasts and secondary acute myeloid leukemia. Chen X, Othus M, Wood BL, Walter RB, Becker PS, Percival ME, Abkowitz JL, Appelbaum FR, Estey EH. Leuk Lymphoma. 2020 Dec 19:1-7. doi: 10.1080/10428194.2020.1861267. Online ahead of print. PMID: 33345655
Platelet electrical resistance for measuring platelet activation and adhesion in human health and disease. Griffiths TM, Page L, Weyrich AS, Rondina MT, Campbell RA. Thromb Res. 2021 Feb;198:204-209. doi: 10.1016/j.thromres.2020.12.012. Epub 2020 Dec 18. PMID: 33360636
Physiological and pathophysiological mechanisms of hepcidin regulation: clinical implications for iron disorders. Xu Y, Alfaro-Magallanes VM, Babitt JL. Br J Haematol. 2020 Dec 14. doi: 10.1111/bjh.17252. Online ahead of print. PMID: 33316086
ER-mitochondria contacts promote mitochondrial-derived compartment biogenesis. English AM, Schuler MH, Xiao T, Kornmann B, Shaw JM, Hughes AL. J Cell Biol. 2020 Dec 7;219(12):e202002144. doi: 10.1083/jcb.202002144. PMID: 33090183
2020 November
Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity Okada, M, Guo, P, Nalder, S, Sigala, PA. Elife. November 2020. In press.
Lung Iron Overload Does Not Exacerbate the Fibrotic Response to Bleomycin in a Mouse Model of Pulmonary Fibrosis. Zhang V, Nemeth E, Kim A. Am J Respir Cell Mol Biol. 2020 Nov;63(5):713-716. doi: 10.1165/rcmb.2020-0192LE. PMID: 33124901 No abstract available.
Hepcidin Is Essential for Alveolar Macrophage Function and Is Disrupted by Smoke in a Murine Chronic Obstructive Pulmonary Disease Model. Perez E, Baker JR, Di Giandomenico S, Kermani P, Parker J, Kim K, Yang J, Barnes PJ, Vaulont S, Scandura JM, Donnelly LE, Stout-Delgado H, Cloonan SM. J Immunol. 2020 Nov 1;205(9):2489-2498. doi: 10.4049/jimmunol.1901284. Epub 2020 Sep 21. PMID: 32958690
2020 October
Wende AR, Schell JC, Ha CM, Pepin ME, Khalimonchuk O, Schwertz H, Pereira RO, Brahma MK, Tuinei J, Contreras-Ferrat A, Wang L, Andrizzi CA, Olsen CD, Bradley WE, Dell’Italia LJ, Dillmann WH, Litwin SE, Abel ED. Diabetes. 2020 Oct;69(10):2094-2111. doi: 10.2337/db19-1057. Epub 2020 May 4. PMID: 32366681
Human ribosomal G-quadruplexes regulate heme bioavailability. Mestre-Fos S, Ito C, Moore CM, Reddi AR, Williams LD. J Biol Chem. 2020 Oct 30;295(44):14855-14865. doi: 10.1074/jbc.RA120.014332. Epub 2020 Aug 13. PMID: 32817343
Mitochondrial pyruvate carriers are required for myocardial stress adaptation. Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED. Nat Metab. 2020 Oct 26. doi: 10.1038/s42255-020-00288-1. Online ahead of print. PMID: 33106689
Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in Candida albicans. Weissman Z, Pinsky M, Donegan RK, Reddi AR, Kornitzer D. Cell Microbiol. 2020 Oct 26:e13282. doi: 10.1111/cmi.13282. Online ahead of print. PMID: 33104284
Mutations in transcription factor CP2-like 1 may cause a novel syndrome with distal renal tubulopathy in humans. Klämbt V, Werth M, Onuchic-Whitford AC, Getwan M, Kitzler TM, Buerger F, Mao Y, Deutsch K, Mann N, Majmundar AJ, Kaminski MM, Shen T, Schmidt-Ott KM, Shalaby M, El Desoky S, Kari JA, Shril S, Lienkamp SS, Barasch J, Hildebrandt F. Nephrol Dial Transplant. 2020 Oct 23:gfaa215. doi: 10.1093/ndt/gfaa215. Online ahead of print. PMID: 33097957
Different glycoforms of alpha-1-acid glycoprotein contribute to its functional alterations in platelets and neutrophils. Sumanth MS, Jacob SP, Abhilasha KV, Manne BK, Basrur V, Lehoux S, Campbell RA, Yost CC, McIntyre TM, Cummings RD, Weyrich AS, Rondina MT, Marathe GK. J Leukoc Biol. 2020 Oct 18. doi: 10.1002/JLB.3A0720-422R. Online ahead of print. PMID: 33070381
Mitochondrial dysfunction in lung ageing and disease. Cloonan SM, Kim K, Esteves P, Trian T, Barnes PJ. Eur Respir Rev. 2020 Oct 15;29(157):200165. doi: 10.1183/16000617.0165-2020. Print 2020 Sep 30. PMID: 33060165
TRPswitch-A Step-Function Chemo-optogenetic Ligand for the Vertebrate TRPA1 Channel. Lam PY, Thawani AR, Balderas E, White AJP, Chaudhuri D, Fuchter MJ, Peterson RT. J Am Chem Soc. 2020 Oct 14;142(41):17457-17468. doi: 10.1021/jacs.0c06811. Epub 2020 Oct 5. PMID: 32966062
Red blood cell transfusions and potentially related morbidities in neonates under 32 weeks’ gestation. D’Amato G, Faienza MF, Palladino V, Bianchi FP, Natale MP, Christensen RD, Giordano P, Del Vecchio A. Blood Transfus. 2020 Oct 14. doi: 10.2450/2020.0092-20. Online ahead of print. PMID: 33085599
Chronic cold exposure enhances glucose oxidation in brown adipose tissue. Wang Z, Ning T, Song A, Rutter J, Wang QA, Jiang L. EMBO Rep. 2020 Oct 12:e50085. doi: 10.15252/embr.202050085. Online ahead of print. PMID: 33043581
Efficacy of Ciprofloxacin/Celecoxib combination in zebrafish models of amyotrophic lateral sclerosis. Goldshtein H, Muhire A, Petel Légaré V, Pushett A, Rotkopf R, Shefner JM, Peterson RT, Armstrong GAB, Russek-Blum N. Ann Clin Transl Neurol. 2020 Oct;7(10):1883-1897. doi: 10.1002/acn3.51174. Epub 2020 Sep 11. PMID: 32915525
miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin. Bhatlekar S, Manne BK, Basak I, Edelstein LC, Tugolukova E, Stoller ML, Cody MJ, Morley SC, Nagalla S, Weyrich AS, Rowley JW, O’Connell RM, Rondina MT, Campbell RA, Bray PF. Blood. 2020 Oct 8;136(15):1760-1772. doi: 10.1182/blood.2020005230. PMID: 32844999
Porphyric Neuropathy: Pathophysiology, Diagnosis, and Updated Management. Kazamel M, Desnick RJ, Quigley JG. Curr Neurol Neurosci Rep. 2020 Oct 7;20(12):56. doi: 10.1007/s11910-020-01078-8. PMID: 33026560 Review.
Reconciling markedly discordant values of serum ferritin versus reticulocyte hemoglobin content. Bahr TM, Baer VL, Ohls RK, Christensen TR, Ward DM, Bennett ST, Christensen RD. J Perinatol. 2020 Oct 4. doi: 10.1038/s41372-020-00845-2. Online ahead of print. PMID: 33012780
One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers. Chambers IG, Willoughby MM, Hamza I, Reddi AR. Biochim Biophys Acta Mol Cell Res. 2020 Oct 3;1868(1):118881. doi: 10.1016/j.bbamcr.2020.118881. Online ahead of print. PMID: 33022276
Getting out what you put in: Copper in mitochondria and its impacts on human disease. Cobine PA, Moore SA, Leary SC. Biochim Biophys Acta Mol Cell Res. 2020 Oct 2;1868(1):118867. doi: 10.1016/j.bbamcr.2020.118867. Online ahead of print. PMID: 32979421
2020 September
Bone morphogenic proteins in iron homeostasis. Xiao X, Alfaro-Magallanes VM, Babitt JL. Bone. 2020 Sep;138:115495. doi: 10.1016/j.bone.2020.115495. Epub 2020 Jun 23. PMID: 32585319
Kidney Biopsy Findings in Patients with COVID-19. Kudose S, Batal I, Santoriello D, Xu K, Barasch J, Peleg Y, Canetta P, Ratner LE, Marasa M, Gharavi AG, Stokes MB, Markowitz GS, D’Agati VD. J Am Soc Nephrol. 2020 Sep;31(9):1959-1968. doi: 10.1681/ASN.2020060802. Epub 2020 Jul 17. PMID: 32680910
Postmortem Kidney Pathology Findings in Patients with COVID-19. Santoriello D, Khairallah P, Bomback AS, Xu K, Kudose S, Batal I, Barasch J, Radhakrishnan J, D’Agati V, Markowitz G. J Am Soc Nephrol. 2020 Sep;31(9):2158-2167. doi: 10.1681/ASN.2020050744. Epub 2020 Jul 29. PMID: 32727719
Tumescent technique versus electrocautery mastectomy: A randomized controlled trial. Lautrup MD, Thomsen JB, Christensen RD, Kjaer C. Surg Oncol. 2020 Sep;34:276-282. doi: 10.1016/j.suronc.2020.05.003. Epub 2020 May 22. PMID: 32891342
Single-cell RNA sequencing reveals the diversity of the immunological landscape following CNS infection by a murine coronavirus. Syage AR, Ekiz HA, Skinner DD, Stone C, O’Connell RM, Lane TE. J Virol. 2020 Sep 30:JVI.01295-20. doi: 10.1128/JVI.01295-20. Online ahead of print. PMID: 32999036
A Novel Variant in G6PD (c.1375C>G) Identified from a Hispanic Neonate with Extreme Hyperbilirubinemia and Low G6PD Enzymatic Activity. Bahr TM, Lozano-Chinga M, Agarwal AM, Meznarich JA, Yost CC, Li P, Reading NS, Prchal JT, Christensen RD. Neonatology. 2020 Sep 28:1-4. doi: 10.1159/000510300. Online ahead of print. PMID: 32987391
The role of hepcidin in fetal iron homeostasis. Ganz T. Blood. 2020 Sep 24;136(13):1474-1475. doi: 10.1182/blood.2020007382. PMID: 32970808 No abstract available.
ACVR1/JAK1/JAK2 inhibitor momelotinib reverses transfusion dependency and suppresses hepcidin in myelofibrosis phase 2 trial. Oh ST, Talpaz M, Gerds AT, Gupta V, Verstovsek S, Mesa R, Miller CB, Rivera CE, Fleischman AG, Goel S, Heaney ML, O’Connell C, Arcasoy MO, Zhang Y, Kawashima J, Ganz T, Kowalski M, Brachmann CB. Blood Adv. 2020 Sep 22;4(18):4282-4291. doi: 10.1182/bloodadvances.2020002662. PMID: 32915978
Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia. Xu G, van Bruggen R, Gualtieri CO, Moradin N, Fois A, Vallerand D, De Sa Tavares Russo M, Bassenden A, Lu W, Tam M, Lesage S, Girouard H, Avizonis DZ, Deblois G, Prchal JT, Stevenson M, Berghuis A, Muir T, Rabinowitz J, Vidal SM, Fodil N, Gros P. Cell Rep. 2020 Sep 22;32(12):108170. doi: 10.1016/j.celrep.2020.108170. PMID: 32966787
Prognostic associations of plasma hepcidin in women with early breast cancer. Jerzak KJ, Lohmann AE, Ennis M, Nemeth E, Ganz T, Goodwin PJ. Breast Cancer Res Treat. 2020 Sep 22. doi: 10.1007/s10549-020-05903-z. Online ahead of print. PMID: 32960376
Does heterozygosity for UGT1A1 *28 convey increased risk for severe neonatal jaundice? Bahr TM, Agarwal AM, Christensen RD. J Perinatol. 2020 Sep 21. doi: 10.1038/s41372-020-00826-5. Online ahead of print. PMID: 32958836
Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer. Cowman SJ, Fuja DG, Liu XD, Tidwell RSS, Kandula N, Sirohi D, Agarwal AM, Emerson LL, Tripp SR, Mohlman JS, Stonhill M, Garcia G, Conley CJ, Olalde AA, Sargis T, Ramirez-Torres A, Karam JA, Wood CG, Sircar K, Tamboli P, Boucher K, Maughan B, Spike BT, Ho TH, Agarwal N, Jonasch E, Koh MY. Clin Cancer Res. 2020 Sep 15;26(18):4970-4982. doi: 10.1158/1078-0432.CCR-19-3890. Epub 2020 Jun 25. PMID: 32586940
Battlefronts of evolutionary conflict between bacteria and animal hosts. Aleru O, Barber MF. PLoS Pathog. 2020 Sep 17;16(9):e1008797. doi: 10.1371/journal.ppat.1008797. eCollection 2020 Sep. PMID: 32941529
Diagnostic yield and clinical utility of whole exome sequencing using an automated variant prioritization system, EVIDENCE. Seo GH, Kim T, Choi IH, Park JY, Lee J, Kim S, Won DG, Oh A, Lee Y, Choi J, Lee H, Kang HG, Cho HY, Cho MH, Kim YJ, Yoon YH, Eun BL, Desnick RJ, Keum C, Lee BH. Clin Genet. 2020 Sep 9. doi: 10.1111/cge.13848. Online ahead of print. PMID: 32901917
Cutting in-line with iron: ribosomal function and non-oxidative RNA cleavage. Guth-Metzler R, Bray MS, Frenkel-Pinter M, Suttapitugsakul S, Montllor-Albalate C, Bowman JC, Wu R, Reddi AR, Okafor CD, Glass JB, Williams LD. Nucleic Acids Res. 2020 Sep 4;48(15):8663-8674. doi: 10.1093/nar/gkaa586. PMID: 32663277
Improving thermoregulation in transported preterm infants. Bahr TM, Kerry BB, Baserga MC, Christensen RD. J Perinatol. 2020 Sep 3. doi: 10.1038/s41372-020-00812-x. Online ahead of print. PMID: 32884103
Decision Accuracy and Safety of Transcutaneous Bilirubin Screening at Intermountain Healthcare. Konana OS, Bahr TM, Strike HR, Coleman J, Snow GL, Christensen RD. J Pediatr. 2020 Sep 2:S0022-3476(20)31115-X. doi: 10.1016/j.jpeds.2020.08.079. Online ahead of print. PMID: 3289057
Clinical Immunoassay for Human Hepcidin Predicts Iron Deficiency in First-Time Blood Donors. Gutschow P, Han H, Olbina G, Westerman K, Nemeth E, Ganz T, Copeland K, Westerman M, Ostland V. J Appl Lab Med. 2020 Sep 1;5(5):943-953. doi: 10.1093/jalm/jfaa038. PMID: 32674118
2020 August
Challenging the Erythropoiesis Paradigm in β-Thalassemia. Vinchi F, Vance SZ. Hemasphere. 2020 Aug 27;4(5):e475. doi: 10.1097/HS9.0000000000000475. eCollection 2020 Oct. PMID: 32923985
Sestrin2 Phosphorylation by ULK1 Induces Autophagic Degradation of Mitochondria Damaged by Copper-Induced Oxidative Stress. Kim H, Jeon BT, Kim IM, Bennett SJ, Lorch CM, Viana MP, Myers JF, Trupp CJ, Whipps ZT, Kundu M, Chung S, Sun X, Khalimonchuk O, Lee J, Ro SH. Int J Mol Sci. 2020 Aug 25;21(17):6130. doi: 10.3390/ijms21176130. PMID: 32854424
Management versus miscues in the cytosolic labile iron pool: The varied functions of iron chaperones. Philpott CC, Patel SJ, Protchenko O. Biochim Biophys Acta Mol Cell Res. 2020 Nov;1867(11):118830. doi: 10.1016/j.bbamcr.2020.118830. Epub 2020 Aug 21. PMID: 32835748
Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria. Nowinski SM, Solmonson A, Rusin SF, Maschek JA, Bensard CL, Fogarty S, Jeong MY, Lettlova S, Berg JA, Morgan JT, Ouyang Y, Naylor BC, Paulo JA, Funai K, Cox JE, Gygi SP, Winge DR, DeBerardinis RJ, Rutter J. Elife. 2020 Aug 17;9:e58041. doi: 10.7554/eLife.58041. PMID: 32804083
MicroRNAs: At the Interface of Metabolic Pathways and Inflammatory Responses by Macrophages. Nelson MC, O’Connell RM. Front Immunol. 2020 Aug 14;11:1797. doi: 10.3389/fimmu.2020.01797. eCollection 2020. PMID: 32922393.
Expression of Iron-Regulatory Hormone Hepcidin and Iron Transporters Ferroportin and ZIP8 in Patients With and Without Chronic Rhinosinusitis. Hsu D, Kim A, Ganz T, Suh JD, Wang M, Wu TJ, Lee JT. Otolaryngol Head Neck Surg. 2020 Aug 4:194599820939910. doi: 10.1177/0194599820939910. Online ahead of print. PMID: 32746765
2020 July
Urinary ferritin; a potential noninvasive way to screen NICU patients for iron deficiency. Gerday E, Brereton JB, Bahr TM, Elmont JO, Fullmer S, Middleton BA, Ward DM, Ohls RK, Christensen RD. J Perinatol. 2020 Jul 24. doi: 10.1038/s41372-020-0746-6. Online ahead of print. PMID: 32709979
Hepatocellular Carcinoma in Acute Hepatic Porphyrias: Results from the Longitudinal Study of the U.S. Porphyrias Consortium. Saberi B, Naik H, Overbey JR, Erwin AL, Anderson KE, Bissell DM, Bonkovsky HL, Phillips JD, Wang B, K Singal A, M McGuire B, Desnick RJ, Balwani M. Hepatology. 2020 Jul 18. doi: 10.1002/hep.31460. Online ahead of print. PMID: 32681675
Exchange transfusion for hemolytic hyperbilirubinemia: could some be averted by emergent administration of an inhibitor of bilirubin production? Wiedmeier SE, Bahr TM, Ohls RK, Christensen TR, Baer VL, Ilstrup SJ, Cail K, Christensen RD. J Perinatol. 2020 Jul 15. doi: 10.1038/s41372-020-0736-8. Online ahead of print. PMID: 32669646
Peripheral blood mononuclear cells show prominent gene expression by erythroid progenitors in diseases characterized by heightened erythropoiesis. Zhang X, Song J, Shah BN, Nekhai S, Miasnikova G, Sergueeva A, Prchal JT, Gordeuk VR. Br J Haematol. 2020 Jul;190(1):e42-e45. doi: 10.1111/bjh.16696. Epub 2020 May 12. PMID: 32399971
Cutting in-line with iron: ribosomal function and non-oxidative RNA cleavage. Guth-Metzler R, Bray MS, Frenkel-Pinter M, Suttapitugsakul S, Montllor-Albalate C, Bowman JC, Wu R, Reddi AR, Okafor CD, Glass JB, Williams LD. Nucleic Acids Res. 2020 Jul 14:gkaa586. doi: 10.1093/nar/gkaa586. Online ahead of print. PMID: 32663277
2020 June
Dizygotic twins prolonged jaundice and microcytic, hypochromic, hemolytic anemia with pyropoikilocytosis. Bahr TM, Lozano-Chinga M, Agarwal AM, Meznarich JA, Gerday E, Smoot JL, Taylor A, Christensen RD. Blood Cells Mol Dis. 2020 Jun 25;85:102462. doi: 10.1016/j.bcmd.2020.102462. Online ahead of print. PMID: 32623341
Pediatric Hematology Normal Ranges Derived From Pediatric Primary Care Patients. Staffa SJ, Joerger JD, Henry E, Christensen RD, Brugnara C, Zurakowski D. Am J Hematol. 2020 Jun 12. doi: 10.1002/ajh.25904. Online ahead of print. PMID: 32530536
QSRR Automator: A Tool for Automating Retention Time Prediction in Lipidomics and Metabolomics. Naylor BC, Catrow JL, Maschek JA, Cox JE. Metabolites. 2020 Jun 9;10(6):237. doi: 10.3390/metabo10060237. PMID: 32526851
Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release. Bailey HJ, Bezerra GA, Marcero JR, Padhi S, Foster WR, Rembeza E, Roy A, Bishop DF, Desnick RJ, Bulusu G, Dailey HA Jr, Yue WW. Nat Commun. 2020 Jun 4;11(1):2813. doi: 10.1038/s41467-020-16586-x.
Macrophage HIF-1α is an independent prognostic indicator in kidney cancer. Cowman S, Fuja DG, Liu XD, Tidwell RSS, Kandula N, Sirohi D, Agarwal AM, Emerson LL, Tripp SR, Mohlman JS, Stonhill M, Garcia G, Conley CJ, Olalde AA, Sargis T, Ramirez-Torres A, Karam JA, Wood CG, Sircar K, Tamboli P, Boucher KM, Maughan BL, Spike BT, Ho TH, Agarwal N, Jonasch E, Koh MY. Clin Cancer Res. 2020 Jun 25:clincanres.3890.2019. doi: 10.1158/1078-0432.CCR-19-3890. Online ahead of print. PMID: 32586940
Iron overload causes a mild and transient increase in acute lung injury. Zhang V, Ganz T, Nemeth E, Kim A. Physiol Rep. 2020 Jun;8(12):e14470. doi: 10.14814/phy2.14470. PMID: 32596989
Maternal Hepcidin Determines Embryo Iron Homeostasis. Sangkhae V, Fisher AL, Chua KJ, Ruchala P, Ganz T, Nemeth E. Blood. 2020 Jun 25:blood.2020005745. doi: 10.1182/blood.2020005745. Online ahead of print. PMID: 32584957
The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice. Seguin A, Jia X, Earl AM, Li L, Wallace J, Qiu A, Bradley T, Shrestha R, Troadec MB, Hockin M, Titen S, Warner DE, Dowdle PT, Wohlfahrt ME, Hillas E, Firpo MA, Phillips JD, Kaplan J, Paw BH, Barasch J, Ward DM. J Biol Chem. 2020 Jun 9:jbc.RA120.013229. doi: 10.1074/jbc.RA120.013229. Online ahead of print. PMID: 32518166
2020 May
Iron chaperone PCBP1 protects murine liver from lipid peroxidation and steatosis. Protchenko O, Baratz E, Jadhav S, Li F, Shakoury-Elizeh M, Gavrilova O, Ghosh MC, Cox JE, Maschek JA, Tyurin VA, Tyurina YY, Bayir H, Aron AT, Chang CJ, Kagan VE, Philpott CC. Hepatology. 2020 May 21. doi: 10.1002/hep.31328. Online ahead of print. PMID: 32438524
Toxoplasma gondii requires its plant-like heme biosynthesis pathway for infection. Bergmann A, Floyd K, Key M, Dameron C, Rees KC, Thornton LB, Whitehead DC, Hamza I, Dou Z.PLoS Pathog. 2020 May 14;16(5):e1008499. doi: 10.1371/journal.ppat.1008499. eCollection 2020 May. PMID: 32407406Free PMC article.
Increased iron stores influence glucose metabolism in sickle cell anaemia. Shah BN, Hassan TO, Zhang X, McClain DA, Gordeuk VR. Br J Haematol. 2020 May;189(4):e184-e187. doi: 10.1111/bjh.16596. Epub 2020 Mar 30. PMID: 32232834
2020 Apr
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing. Bessman NJ, Mathieu JRR, Renassia C, Zhou L, Fung TC, Fernandez KC, Austin C, Moeller JB, Zumerle S, Louis S, Vaulont S, Ajami NJ, Sokol H, Putzel GG, Arvedson T, Sockolow RE, Lakhal-Littleton S, Cloonan SM, Arora M, Peyssonnaux C, Sonnenberg GF. Science. 2020 Apr 10;368(6487):186-189. doi: 10.1126/science.aau6481.PMID:32273468
Mitochondrial-nuclear heme trafficking is regulated by GTPases in control of mitochondrial dynamics and ER contact sites. Martinez-Guzman O, Willoughby MM, Saini A, Dietz JV, Bohovych I, Medlock AE, Khalimonchuk O, Reddi AR. J Cell Sci. 2020 Apr 7. pii: jcs.237917. doi: 10.1242/jcs.237917. [Epub ahead of print] PMID:32265272
2020 Mar
Exploiting species specificity to understand the tropism of a human-specific toxin. Boguslawski KM, McKeown AN, Day CJ, Lacey KA, Tam K, Vozhilla N, Kim SY, Jennings MP, Koralov SB, Elde NC, Torres VJ. Sci Adv. 2020 Mar 11;6(11):eaax7515. doi: 10.1126/sciadv.aax7515. eCollection 2020 Mar. PMID:32195339
2020 Feb
Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Crowther MD, Dolton G, Legut M, Caillaud ME, Lloyd A, Attaf M, Galloway SAE, Rius C, Farrell CP, Szomolay B, Ager A, Parker AL, Fuller A, Donia M, McCluskey J, Rossjohn J, Svane IM, Phillips JD, Sewell AK. Nat Immunol. 2020 Feb;21(2):178-185. doi: 10.1038/s41590-019-0578-8. Epub 2020 Jan 20. PMID:31959982
Dexmedetomidine pretreatment improves lipopolysaccharide-induced iron homeostasis disorder in aged mice. Guo F, Kang J, Tan J, Wang Y, Jia L, Xu H. Curr Neurovasc Res. 2020 Feb 16. doi: 10.2174/1567202617666200217105109. [Epub ahead of print]
PMID:32065090
2020 Jan
Alternative splicing of UCP1 by non-cell-autonomous action of PEMT. Johnson JM, Verkerke ARP, Maschek JA, Ferrara PJ, Lin CT, Kew KA, Neufer PD, Lodhi IJ, Cox JE, Funai K. Mol Metab. 2020 Jan;31:55-66. doi: 10.1016/j.molmet.2019.10.007. Epub 2019 Nov 8.PMID:31918922
Iron and Heme Metabolism at the Leishmania-Host Interface. Laranjeira-Silva MF, Hamza I, Pérez-Victoria JM. Trends Parasitol. 2020 Mar;36(3):279-289. doi: 10.1016/j.pt.2019.12.010. Epub 2020 Jan 28. PMID: 32005611
Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis. Hughes C.E. Coody T.K. , Jeong M.-Y. ,Berg J.A. , Winge D.R., Hughes A.L. Cell. 2020; 180: 296-310
Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish. Nath AK, Ma J, Chen ZZ, Li Z, Vitery MDC, Kelley ML, Peterson RT, Gerszten RE, Yeh JJ. FASEB J. 2020 Jan;34(1):1546-1557. doi: 10.1096/fj.201901466R. Epub 2019 Dec 2. PMID:31914600
XPRESSyourself: Enhancing, standardizing, and automating ribosome profiling computational analyses yields improved insight into data. Berg JA, Belyeu JR, Morgan JT, Ouyang Y, Bott AJ, Quinlan AR, Gertz J, Rutter J. PLoS Comput Biol. 2020 Jan 31;16(1):e1007625. doi: 10.1371/journal.pcbi.1007625. [Epub ahead of print] PMID:32004313
Machine learning reveals serum sphingolipids as cholesterol-independent biomarkers of coronary artery disease. Poss AM, Maschek JA, Cox JE, Hauner BJ, Hopkins PN, Hunt SC, Holland WL, Summers SA, Playdon MC. J Clin Invest. 2020 Jan 27. pii: 131838. doi: 10.1172/JCI131838. [Epub ahead of print] PMID:31743112
PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3′ UTR. Yabe-Wada T, Philpott CC, Onai N. FEBS Open Bio. 2020 Jan 21. doi: 10.1002/2211-5463.12794. [Epub ahead of print] PMID:3196107
Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification. Santos MCFD, Anderson CP, Neschen S, Zumbrennen-Bullough KB, Romney SJ, Kahle-Stephan M, Rathkolb B, Gailus-Durner V, Fuchs H, Wolf E, Rozman J, de Angelis MH, Cai WM, Rajan M, Hu J, Dedon PC, Leibold EA. Nat Commun. 2020 Jan 15;11(1):296. doi: 10.1038/s41467-019-14004-5. PMID:31941883
Editorial: Special Issue on mitochondrial fidelity. Khalimonchuk O. Mitochondrion. 2020 Jan 7;51:104. doi: 10.1016/j.mito.2019.12.007. [Epub ahead of print] No abstract available. PMID:31917323
Maternal Tobacco Smoke Exposure Causes Sex-Divergent Changes in Placental Lipid Metabolism in the Rat. Weinheimer C, Wang H, Comstock JM, Singh P, Wang Z, Locklear BA, Goodwin KL, Maschek JA, Cox JE, Baack ML, Joss-Moore LA. Reprod Sci. 2020 Jan 6. doi: 10.1007/s43032-019-00065-w. [Epub ahead of print] PMID:32046449
ASA Suppresses PGE2 in Plasma and Melanocytic Nevi of Human Subjects at Increased Risk for Melanoma. Varedi A, Rahman H, Kumar D, Catrow JL, Cox JE, Liu T, Florell SR, Boucher KM, Okwundu N, Burnett WJ, VanBrocklin MW, Grossman D. Pharmaceuticals (Basel). 2020 Jan 2;13(1). pii: E7. doi: 10.3390/ph13010007. PMID:31906519
The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1. Li L, Bertram S, Kaplan J, Jia X, Ward DM.J Biol Chem. 2020 Jan 2. pii: jbc.RA119.011154. doi: 10.1074/jbc.RA119.011154. [Epub ahead of print] PMID:31896574
Compartment and hub definitions tune metabolic networks for metabolomic interpretations. Waller TC, Berg JA, Lex A, Chapman BE, Rutter J. Gigascience. 2020 Jan 1;9(1). pii: giz137. doi: 10.1093/gigascience/giz137. PMID:31972021
2019 Dec
Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish. Zhang T, Trauger SA, Vidoudez C, Doane KP, Pluimer BR, Peterson RT. Sci Rep. 2019 Dec 27;9(1):19939. doi: 10.1038/s41598-019-56466-z.
A prospective evaluation of pegylated interferon alfa-2a therapy in patients with polycythemia vera and essential thrombocythemia with a prior splanchnic vein thrombosis. Mascarenhas J, Kosiorek H, Prchal J, Yacoub A, Berenzon D, Baer MR, Ritchie E, Silver RT, Kessler C, Winton E, Finazzi MC, Rambaldi A, Vannucchi AM, Leibowitz D, Rondelli D, Arcasoy MO, Catchatourian R, Vadakara J, Rosti V, Hexner E, Kremyanskaya M, Sandy L, Tripodi J, Najfeld V, Farnoud N, Salama ME, Weinberg RS, Rampal R, Goldberg JD, Mesa R, Dueck AC, Hoffman R. Leukemia. 2019 Dec;33(12):2974-2978. doi: 10.1038/s41375-019-0524-7. Epub 2019 Jul 30. No abstract available. PMID:31363161
JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera. Patel AB, Franzini A, Leroy E, Kim SJ, Pomicter AD, Genet L, Xiao M, Yan D, Ahmann JM, Agarwal AM, Clair P, Addada J, Lambert J, Salmon M, Gleich GJ, Cross NCP, Constantinescu SN, O’Hare T, Prchal JT, Deininger MW. Blood. 2019 Dec 26;134(26):2388-2398. doi: 10.1182/blood.2019001385. PMID:31697804
Universal Principled Review: A Community-Driven Method to Improve Peer Review. Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, Chi H, O’Connell R, Wherry EJ, Pepper M; Future Immunology Consortium. Cell. 2019 Dec 12;179(7):1441-1445. doi: 10.1016/j.cell.2019.11.029. PMID:31835023
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier. Bensard CL, Wisidagama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, Earl CS, Namnath DF, Vázquez-Arreguín K, Villanueva CJ, Tantin D, Murtaugh LC, Evason KJ, Ducker GS, Thummel CS, Rutter J. Cell Metab. 2019 Dec 5. pii: S1550-4131(19)30609-6. doi: 10.1016/j.cmet.2019.11.002. [Epub ahead of print] PMID:31813825
Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3. Wang CY, Xu Y, Traeger L, Dogan DY, Xiao X, Steinbicker AU, Babitt JL. Blood. 2019 Dec 4. pii: blood.2019002620. doi: 10.1182/blood.2019002620. [Epub ahead of print] No abstract available. PMID:31800957
Absence of severe neonatal ABO hemolytic disease at Intermountain Healthcare. Why? Baer VL, Hulse W, Bahr TM, Ilstrup SJ, Christensen RD. J Perinatol. 2019 Dec 3. doi: 10.1038/s41372-019-0553-0. [Epub ahead of print] No abstract available. PMID:31796840
Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p. Chalermwat C, Thosapornvichai T, Wongkittichote P, Phillips JD, Cox JE, Jensen AN, Wattanasirichaigoon D, Jensen LT. FEMS Yeast Res. 2019 Dec 1;19(8). pii: foz078. doi: 10.1093/femsyr/foz078.PMID:31711143
2019 Nov
Heme biosynthesis and the porphyrias. Phillips JD. Mol Genet Metab. 2019 Nov;128(3):164-177. doi: 10.1016/j.ymgme.2019.04.008. Epub 2019 Apr 22. Review.PMID:31326287
Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice. Xiao X, Dev S, Canali S, Bayer A, Xu Y, Agarwal A, Wang CY, Babitt JL. Hepatology. 2019 Nov 28. doi: 10.1002/hep.31048. [Epub ahead of print] PMID:31778583
Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma’s cyclin D1. Babosova O, Kapralova K, Raskova Kafkova L, Korinek V, Divoky V, Prchal JT, Lanikova L. J Cell Mol Med. 2019 Nov;23(11):7785-7795. doi: 10.1111/jcmm.14655. Epub 2019 Sep 13. PMID:31517438
Neonates with suspected microangiopathic disorders: performance of standard manual schistocyte enumeration vs. the automated fragmented red cell count. Bahr TM, Judkins AJ, Christensen RD, Baer VL, Henry E, Minton SD, Gerday E, Bennett ST. J Perinatol. 2019 Nov;39(11):1555-1561. doi: 10.1038/s41372-019-0482-y. Epub 2019 Aug 28. PMID:31462723
Results of a pilot study of isoniazid in patients with erythropoietic protoporphyria.Parker CJ, Desnick RJ, Bissel MD, Bloomer JR, Singal A, Gouya L, Puy H, Anderson KE, Balwani M, Phillips JD. Mol Genet Metab. 2019 Nov;128(3):309-313. doi: 10.1016/j.ymgme.2019.07.017. Epub 2019 Jul 31.PMID:31395332
Mitoferrin-1 is required for brain energy metabolism and hippocampus-dependent memory. Baldauf L, Endres T, Scholz J, Kirches E, Ward DM, Lessmann V, Borucki K, Mawrin C.Neurosci Lett. 2019 Nov 20;713:134521. doi: 10.1016/j.neulet.2019.134521. Epub 2019 Sep 26. PMID:31563673
Absence of HIF1A Leads to Glycogen Accumulation and an Inflammatory Response That Enables Pancreatic Tumor Growth. Maruggi M, Layng FI, Lemos R Jr, Garcia G, James BP, Sevilla M, Soldevilla F, Baaten BJ, de Jong PR, Koh MY, Powis G. Cancer Res. 2019 Nov 15;79(22):5839-5848. doi: 10.1158/0008-5472.CAN-18-2994. Epub 2019 Oct 4. PMID:31585939
Structural insights into heme binding to IL-36α proinflammatory cytokine. Wißbrock A, Goradia NB, Kumar A, Paul George AA, Kühl T, Bellstedt P, Ramachandran R, Hoffmann P, Galler K, Popp J, Neugebauer U, Hampel K, Zimmermann B, Adam S, Wiendl M, Krönke G, Hamza I, Heinemann SH, Frey S, Hueber AJ, Ohlenschläger O, Imhof D. Sci Rep. 2019 Nov 15;9(1):16893. doi: 10.1038/s41598-019-53231-0. PMID:31729440
The Human-Specific BOLA2 Duplication Modifies Iron Homeostasis and Anemia Predisposition in Chromosome 16p11.2 Autism Individuals. Giannuzzi G, Schmidt PJ, Porcu E, Willemin G, Munson KM, Nuttle X, Earl R, Chrast J, Hoekzema K, Risso D, Männik K, De Nittis P, Baratz ED; 16p11.2 Consortium, Herault Y, Gao X, Philpott CC, Bernier RA, Kutalik Z, Fleming MD, Eichler EE, Reymond A.Am J Hum Genet. 2019 Nov 7;105(5):947-958. doi: 10.1016/j.ajhg.2019.09.023. Epub 2019 Oct 24. PMID:31668704
Evaluating the Patient-Reported Outcomes Measurement Information System scales in acute intermittent porphyria. Naik H, Overbey JR, Montgomery GH, Winkel G, Balwani M, Anderson KE, Bissell DM, Bonkovsky HL, Phillips JD, Wang B, McGuire B, Keel S, Levy C, Erwin A, Desnick RJ. Genet Med. 2019 Nov 6. doi: 10.1038/s41436-019-0683-y. [Epub ahead of print]PMID:31690837
The fragmented red cell count can support the diagnosis of a microangiopathic neonatal condition. Bahr TM, Judkins AJ, Baer VL, Henry E, Grubb PH, Hulse W, Pysher TJ, Bennett ST, Christensen RD. J Perinatol. 2019 Nov 6. doi: 10.1038/s41372-019-0552-1. [Epub ahead of print] No abstract available. PMID:31695135
Response to interferon treatment in essential thrombocythemia with inv(3)(q21q26). Gangaraju R, Carroll AJ, Prchal JT. Ann Hematol. 2019 Nov 1. doi: 10.1007/s00277-019-03805-9. [Epub ahead of print] No abstract available. PMID:31676985
2019 Oct
Evaluating emergency-release blood transfusion of newborn infants at the Intermountain Healthcare hospitals. Bahr TM, DuPont TL, Christensen TR, Rees T, O’Brien EA, Ilstrup SJ, Christensen RD. Transfusion. 2019 Oct;59(10):3113-3119. doi: 10.1111/trf.15495. Epub 2019 Sep 3. PMID:31479169
First report of using low-titer cold-stored type O whole blood in massive postpartum hemorrhage. Bahr TM, DuPont TL, Morris DS, Pierson SE, Esplin MS, Brown SM, O’Brien EA, Ilstrup SJ, Christensen RD. Transfusion. 2019 Oct;59(10):3089-3092. doi: 10.1111/trf.15492. Epub 2019 Aug 30. PMID:31469450
Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea. Yacoub A, Mascarenhas J, Kosiorek H, Prchal JT, Berenzon D, Baer MR, Ritchie E, Silver RT, Kessler C, Winton E, Finazzi MC, Rambaldi A, Vannucchi AM, Leibowitz D, Rondelli D, Arcasoy MO, Catchatourian R, Vadakara J, Rosti V, Hexner E, Kremyanskaya M, Sandy L, Tripodi J, Najfeld V, Farnoud N, Papaemmanuil E, Salama M, Singer-Weinberg R, Rampal R, Goldberg JD, Barbui T, Mesa R, Dueck AC, Hoffman R. Blood. 2019 Oct 31;134(18):1498-1509. doi: 10.1182/blood.2019000428. PMID:31515250
Experimental Modeling of Myeloproliferative Neoplasms. Lanikova L, Babosova O, Prchal JT. Genes (Basel). 2019 Oct 15;10(10). pii: E813. doi: 10.3390/genes10100813. Review. PMID:31618985
2019 Sep
Proteolytic Activation of Bmps: Analysis of Cleavage in Xenopus Oocytes and Embryos. Kim HS, McKnite A, Christian JL. Methods Mol Biol. 2019;1891:115-133. doi: 10.1007/978-1-4939-8904-1_9. PMID: 30414129
BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis. Kim HS, Neugebauer J, McKnite A, Tilak A, Christian JL. Elife. 2019 Sep 30;8:e48872. doi: 10.7554/eLife.48872. PMID: 31566563
A PCBP1-BolA2 chaperone complex delivers iron for cytosolic [2Fe-2S] cluster assembly. Patel SJ, Frey AG, Palenchar DJ, Achar S, Bullough KZ, Vashisht A, Wohlschlegel JA, Philpott CC. Nat Chem Biol. 2019 Sep;15(9):872-881. doi: 10.1038/s41589-019-0330-6. Epub 2019 Aug 12.PMID:31406370
NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling. Rajan M, Anderson CP, Rindler PM, Romney SJ, Ferreira Dos Santos MC, Gertz J, Leibold EA. Elife. 2019 Sep 18;8. pii: e44674. doi: 10.7554/eLife.44674. PMID:31532389
EXPLORE: A Prospective, Multinational, Natural History Study of Patients with Acute Hepatic Porphyria with Recurrent Attacks. Gouya L, Ventura P, Balwani M, Bissell DM, Rees DC, Stölzel U, Phillips JD, Kauppinen R, Langendonk JG, Desnick RJ, Deybach JC, Bonkovsky HL, Parker C, Naik H, Badminton M, Stein PE, Minder E, Windyga J, Bruha R, Cappellini MD, Sardh E, Harper P, Sandberg S, Aarsand AK, Andersen J, Alegre F, Ivanova A, Talbi N, Chan A, Querbes W, Ko J, Penz C, Liu S, Lin T, Simon A, Anderson KE. Hepatology. 2019 Sep 12. doi: 10.1002/hep.30936. [Epub ahead of print]PMID:31512765
Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K. Sci Adv. 2019 Sep 11;5(9):eaax8352. doi: 10.1126/sciadv.aax8352. eCollection 2019 Sep. PMID:31535029
A Low Iron Diet Protects from Steatohepatitis in a Mouse Model. Salaye L, Bychkova I, Sink S, Kovalic AJ, Bharadwaj MS, Lorenzo F, Jain S, Harrison AV, Davis AT, Turnbull K, Meegalla NT, Lee SH, Cooksey R, Donati GL, Kavanagh K, Bonkovsky HL, McClain DA. Nutrients. 2019 Sep 10;11(9). pii: E2172. doi: 10.3390/nu11092172. PMID:31510077
2019 Aug
Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia. Jafek JL, Shakya A, Tai PY, Ibarra A, Kim H, Maddox J, Chumley J, Spangrude GJ, Miles RR, Kelley TW, Tantin D. Exp Hematol. 2019 Aug;76:38-48.e2. doi: 10.1016/j.exphem.2019.07.002. Epub 2019 Jul 8. PMID:31295506
Knowing When to Let Go: Lysosomes Regulate Inter-Mitochondrial Tethering. English AM, Hughes AL. Dev Cell. 2019 Aug 5;50(3):259-260. doi: 10.1016/j.devcel.2019.07.019. PMID:31386859
Rsp5 and Mdm30 reshape the mitochondrial network in response to age-induced vacuole stress. Goodrum JM, Lever AR, Coody TK, Gottschling DE, Hughes AL. Mol Biol Cell. 2019 Aug 1;30(17):2141-2154. doi: 10.1091/mbc.E19-02-0094. Epub 2019 May 29. PMID:31141470
2019 July
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis. Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA.Science. 2019 Jul 26;365(6451):386-392. doi: 10.1126/science.aav3722. Epub 2019 Jul 4.PMID:31273070
T cell-mediated regulation of the microbiota protects against obesity. Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O’Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL. Science. 2019 Jul 26;365(6451). pii: eaat9351. doi: 10.1126/science.aat9351. PMID:31346040
Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness. Sharma A, Oonthonpan L, Sheldon RD, Rauckhorst AJ, Zhu Z, Tompkins SC, Cho K, Grzesik WJ, Gray LR, Scerbo DA, Pewa AD, Cushing EM, Dyle MC, Cox JE, Adams C, Davies BS, Shields RK, Norris AW, Patti G, Zingman LV, Taylor EB. Elife. 2019 Jul 18;8. pii: e45873. doi: 10.7554/eLife.45873. PMID:31305240
Thrombotic risk in congenital erythrocytosis due to up-regulated hypoxia sensing is not associated with elevated hematocrit. Gordeuk VR, Miasnikova GY, Sergueeva AI, Lorenzo FR, Zhang X, Song J, Stockton DW, Prchal JT. Haematologica. 2019 Jul 9. pii: haematol.2019.216267. doi: 10.3324/haematol.2019.216267. [Epub ahead of print]PMID:31289208
2019 June
Redox Regulation of the Mitochondrial Quality Control Protease Oma1. Bohovych I, Dietz JV, Swenson S, Zahayko N, Khalimonchuk O. Antioxid Redox Signal. 2019 Jun 18. doi: 10.1089/ars.2018.7642. [Epub ahead of print] PMID:31011300
Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex. McClellan D, Casey MJ, Bareyan D, Lucente H, Ours C, Velinder M, Singer J, Lone MD, Sun W, Coria Y, Mason CC, Engel ME. Mol Cell Biol. 2019 Jun 13;39(13). pii: e00020-19. doi: 10.1128/MCB.00020-19. Print 2019 Jul 1.PMID:30988160
2019 May
Ferritin in serum and urine: A pilot study. Bahr TM, Christensen RD, Ward DM, Meng F, Jackson LK, Doyle K, Christensen DR, Harvey AG, Yaish HM. Blood Cells Mol Dis. 2019 May;76:59-62. doi: 10.1016/j.bcmd.2019.02.001. Epub 2019 Feb 8. PMID;30777730
Phase evolution of conversion-type electrode for lithium ion batteries. Li J, Hwang S, Guo F, Li S, Chen Z, Kou R, Sun K, Sun CJ, Gan H, Yu A, Stach EA, Zhou H, Su D. Nat Commun. 2019 May 20;10(1):2224. doi: 10.1038/s41467-019-09931-2. PMID:31110173
Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program. Kikani CK, Wu X, Fogarty S, Kang SAW, Dephoure N, Gygi SP, Sabatini DM, Rutter J. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10382-10391. doi: 10.1073/pnas.1804013116. Epub 2019 May 9. PMID:31072927
Hypoxia-Associated Factor (HAF) Mediates Neurofibromin Ubiquitination and Degradation Leading to Ras-ERK Pathway Activation in Hypoxia. Green YS, Sargis T, Reichert EC, Rudasi E, Fuja D, Jonasch E, Koh MY. Mol Cancer Res. 2019 May;17(5):1220-1232. doi: 10.1158/1541-7786.MCR-18-1080. Epub 2019 Jan 31. PMID:30705246
International Porphyria Molecular Diagnostic Collaborative: an evidence-based database of verified pathogenic and benign variants for the porphyrias. Chen B, Whatley S, Badminton M, Aarsand AK, Anderson KE, Bissell DM, Bonkovsky HL, Cappellini MD, Floderus Y, Friesema ECH, Gouya L, Harper P, Kauppinen R, Loskove Y, Martásek P, Phillips JD, Puy H, Sandberg S, Schmitt C, To-Figueras J, Weiss Y, Yasuda M, Deybach JC, Desnick RJ. Genet Med. 2019 May 10. doi: 10.1038/s41436-019-0537-7. [Epub ahead of print] PMID:31073229
Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, Li H, Sadoshima J. Cell Metab. 2019 May 7;29(5):1119-1134.e12. doi: 10.1016/j.cmet.2019.01.005. Epub 2019 Feb 7. PMID:30745182
Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy.Vazquez-Arreguin K, Bensard C, Schell JC, Swanson E, Chen X, Rutter J, Tantin D. (2019) PLoS Genetics. 2019 May 6;15(5):e1007687. PMID:31059499
2019 Apr
Re-evaluation of hematocrit as a determinant of thrombotic risk in erythrocytosis. Gordeuk VR, Key NS, Prchal JT. Haematologica. 2019 Apr;104(4):653-658. doi: 10.3324/haematol.2018.210732. Epub 2019 Mar 14. PMID:30872370
Proteolytic regulation of mitochondrial dynamics. Dietz JV, Bohovych I, Viana MP, Khalimonchuk O. Mitochondrion. 2019 Apr 25. pii: S1567-7249(19)30047-9. doi: 10.1016/j.mito.2019.04.008. [Epub ahead of print] Review. PMID:31029640
Development of a symptom assessment in patients with myelofibrosis: qualitative study findings. Mesa RA, Su Y, Woolfson A, Prchal JT, Turnbull K, Jabbour E, Scherber R, Shields AL, Krohe M, Ojo F, Pompilus F, Cappelleri JC, Harrison C. Health Qual Life Outcomes. 2019 Apr 11;17(1):61. doi: 10.1186/s12955-019-1121-1. PMID:30975150
Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance. Ganeshan K, Nikkanen J, Man K, Leong YA, Sogawa Y, Maschek JA, Van Ry T, Chagwedera DN, Cox JE, Chawla A. Cell. 2019 Apr 4;177(2):399-413.e12. doi: 10.1016/j.cell.2019.01.050. Epub 2019 Mar 7. PMID:30853215
2019 Feb
An extracellular histidine-containing motif in the zinc transporter ZIP4 plays a role in zinc sensing and zinc-induced endocytosis in mammalian cells. Chun H, Korolnek T, Lee CJ, Coyne HJ 3rd, Winge DR, Kim BE, Petris MJ. J Biol Chem. 2019 Feb 22;294(8):2815-2826. doi: 10.1074/jbc.RA118.005203. Epub 2018 Dec 28. PMID:30593504
Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.Yao X, Jing X, Guo J, Sun K, Deng Y, Zhang Y, Guo F, Ye Y. Front Pharmacol. 2019 Feb 28;10:163. doi: 10.3389/fphar.2019.00163. eCollection 2019. PMID:30873034
Harderoporphyria: Case of lifelong photosensitivity associated with compound heterozygous coproporphyrinogen oxidase (CPOX) mutations. Moghe A, Ramanujam VMS, Phillips JD, Desnick RJ, Anderson KE. Mol Genet Metab Rep. 2019 Feb 19;19:100457. doi: 10.1016/j.ymgmr.2019.100457. eCollection 2019 Jun. PMID:30828546
2019 Jan
Screening umbilical cord blood for congenital Iron deficiency. MacQueen, BC, Christensen, RD, Baer VL, Ward, DM, Snow GL. (2019). Blood Cells Mol Dis. 77:95-100 PMID: 31005753
Diagnosing or ruling out polycythemia vera in patients with erythrocytosis. Prchal JT. Clin Adv Hematol Oncol. 2019 Jan;17(1):24-27. PMID:30843892
Identification and characterization of 40 novel hydroxymethylbilane synthase mutations that cause acute intermittent porphyria. Chen B, Solis-Villa C, Erwin AL, Balwani M, Nazarenko I, Phillips JD, Desnick RJ, Yasuda M. J Inherit Metab Dis. 2019 Jan;42(1):186-194. doi: 10.1002/jimd.12040. PMID: 30740734
Pilot Study of Novel Intermittent Fasting Effects on Metabolomic and Trimethylamine N-oxide Changes During 24-hour Water-Only Fasting in the FEELGOOD Trial. Washburn RL, Cox JE, Muhlestein JB, May HT, Carlquist JF, Le VT, Anderson JL, Horne BD. Nutrients. 2019 Jan 23;11(2). pii: E246. doi: 10.3390/nu11020246. PMID:30678028
The mitochondrial heme metabolon: Insights into the complex(ity) of heme synthesis and distribution. Piel RB 3rd, Dailey HA Jr, Medlock AE. Mol Genet Metab. 2019 Jan 17. pii: S1096-7192(18)30634-6. doi: 10.1016/j.ymgme.2019.01.006. [Epub ahead of print] Review. PMID:30709775
Imbalanced sphingolipid signaling is maintained as a core proponent of a cancerous phenotype in spite of metabolic pressure and epigenetic drift. Speirs MMP, Swensen AC, Chan TY, Jones PM, Holman JC, Harris MB, Maschek JA, Cox JE, Carson RH, Hill JT, Andersen JL, Prince JT, Price JC. Oncotarget. 2019 Jan 11;10(4):449-479. doi: 10.18632/oncotarget.26533. eCollection 2019 Jan 11. PMID:30728898
Homozygous hydroxymethylbilane synthase knock-in mice provide pathogenic insights into the severe neurological impairments present in human homozygous dominant acute intermittent porphyria. Yasuda M, Gan L, Chen B, Yu C, Zhang J, Gama-Sosa MA, Pollak DD, Berger S, Phillips JD, Edelmann W, Desnick RJ. Hum Mol Genet. 2019 Jan 7. doi: 10.1093/hmg/ddz003. [Epub ahead of print] PMID:30615115
2018
FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.Yien YY, Shi J, Chen C, Cheung JTM, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon LI, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH. J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26.PMID:30366982
The AAA ATPase Afg1 preserves mitochondrial fidelity and cellular health by maintaining mitochondrial matrix proteostasis. Germany EM, Zahayko N, Huebsch ML, Fox JL, Prahlad V, Khalimonchuk O. J Cell Sci. 2018 Nov 21;131(22). pii: jcs219956. doi: 10.1242/jcs.219956. PMID:30301782
Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus. Choby JE, Buechi HB, Farrand AJ, Skaar EP, Barber MF. MBio. 2018 Nov 20;9(6). pii: e01524-18. doi: 10.1128/mBio.01524-18. PMID:30459189
Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis. Burch JS, Marcero JR, Maschek JA, Cox JE, Jackson LK, Medlock AE, Phillips JD, Dailey HA Jr. Blood. 2018 Sep 6;132(10):987-998. doi: 10.1182/blood-2018-01-829036. Epub 2018 Jul 10. PMID:29991557
Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes. Barton JC, McLaren CE, Chen WP, Ramm GA, Anderson GJ, Powell LW, Subramaniam VN, Adams PC, Phatak PD, Gurrin LC, Phillips JD, Parker CJ, Emond MJ, McLaren GD. Ann Hepatol. 2018 Aug 24;17(5):871-879. doi: 10.5604/01.3001.0012.3169.PMID:30145563
ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly. Van Vranken JG, Nowinski SM, Clowers KJ, Jeong MY, Ouyang Y, Berg JA, Gygi JP, Gygi SP, Winge DR, Rutter J. Mol Cell. 2018 Aug 16;71(4):567-580.e4. doi: 10.1016/j.molcel.2018.06.039.PMID:30118679