Dean Tantin, PhD, University of Utah: Role of Oct1/Pou2f1 in blood cell development
Anna Beaudin, PhD and Amandine Chaix, PhD, University of Utah: “Delaying age and obesity-mediated hematopoietic dysfunction with time-restricted feeding
Iqbal Hamza, PhD University of Maryland, College Park: Interactors of HRG1 heme transporter in reticuloendothelial macrophages.
Paul Sigala, PhD, University of Utah: Unraveling the Mechanism and Biological Significance of Hemozoin Motion in Malaria Parasites
Diane Ward, PhD, University of Utah: The role of macrophage Cyb561a3/Lcytb in lysosomal iron recycling for erythropoiesis
Timothy M Bahr, MS MD, University of Utah: Iron deficiency in preterm neonates: prevalence, surveillance, contributing factors
Makiko Yasuda, MD PhD, Icahn School of Medicine at Mt Sinai: Investigations of hepatic heme homeostatic mechanisms using ALAS-deficient mice
Robert Christensen, MD, University of Utah: Neonatal iron deficiency; defining pathogenic mechanisms & improving detection
Tomas Ganz, MD, UCLA: Metabolic Effects of Pathologically Increased Erythroferrone in Anemias with Ineffective Erythropoiesis
Adam Hughes, PhD, University of Utah: Elucidating the role of the LON protease in the regulation of cellular iron metabolism
Paul Sigala, PhD, University of Utah: Mechanism of Iron Acquisition by Malaria Parasites
Ryan O’Connell, PhD, University of Utah: The role of Rab27a/b during mitochondria release from maturing erythroblasts
Paul Sigala, PhD, University of Utah: Mechanism of Iron Acquisition by Malaria Parasites 3.
Diane Ward, PhD, University of Utah: The role of the reductases Lcytb and Steap3 in lysosomal iron recycling in macrophages
Richard Eisenstein, PhD, University of Wisconsin-Madison: Iron regulation of erythropoietin expression
Amy Medlock, PhD and Amit Reddi, PhD, University of Georgia: Creation of Transgenic Zebrafish with Hepatic and Erythroid Expressed Heme Sensors
Yvette Yien, PhD, University of Delaware: Regulation of erythroid heme synthesis and vertebrate development by the mitochondrial unfoldase, CLPX
Dean Tantin, PhD, Tracey Lamb PhD: Does Oct1 loss-of-function in bone marrow progenitor cells exacerbate the severity of malarial anemia?
Oleh Khalimonchuk, PhD, Amit Reddi PhD, University of Nebraska, Department of Biochemistry: Mitochondrial Behavior and Heme Transport in Erythropoiesis
Betty Leibold, PhD, University of Utah: Cell-Cycle Regulation of IRP2 Phosphorylation during Hematopoiesis
Amy Medlock PhD, Amit Reddi PhD, University of Georgia: Creation of Transgenic Zebrafish with Erythroid Expressed Heme Sensors
Ryan O’Connell PhD, University of Utah: Determine the role of Rab27a/b during mitochondria release from maturing erythroblasts
Joe Prchal MD, University of Utah: Search for Novel Parameters of Augmentation of Erythropoiesis. Deciphering Molecular Differences of VHL Mutated Congenital Polycythemia versus Tumor-Predisposition
Paul Sigala, PhD, University of Utah: Structure and Function of a Divergent Eukaryotic Cytochrome c
Diane Ward, PhD. University of Utah: The role of Abcb10 in red cell hemoglobinization
Congratulations to the the following five investigators whose proposals were funded in the CIHD 2017 Pilot and Feasibility Grants Program:
Matthew Barber, PhD, University of Oregon: Host-pathogen conflicts shaping bloodstream hemeprotein evolution
Adam Hughes, PhD, University of Utah: The role of lysosomes in maintenance of cellular iron metabolism
Elizabeth Leibold, PhD, University of Utah: Cell-cycle regulation of IRP2 phosphorylation during hematopoiesis
Paul Sigala, PhD, University of Utah: Role of Acyl Carrier Protein in Iron/Sulfur Cluster Biogenesis by Malaria Parasites
Diane Ward, PhD, University of Utah: The role of Abcb10 in red cell hemoglobinization
Our NIDDK-funded Center for Iron and Hematology Disorders has awarded three pilot research grants for the 2016/2017 fiscal year. Six proposals were considered for funding and the three successful applicants include the following:
Dr. Paul Sigala PhD, University of Utah, Department of Biochemistry, University of Utah: the role of the acyl-carrier proteins present in the mitochondria and apicoplast of Plasmodium in iron-sulfur cluster biogenesis in the two organelles and the role of each pathway in the physiology of Plasmodium parasites. A long-term goal of his research is developing new therapeutic targets in treating malaria.
Dr. Amy Medlock PhD, University of Georgia: the role of two novel proteins PGRMC1 and PGRMC2 in modulating heme synthesis in mammalian cells. She demonstrated that these proteins interact with ferrochelatase and regulate its activity. She proposes to generate knockout cell lines in culture and zebrafish to investigate the physiological consequences of loss of these proteins on heme production.
Dr. Matt Barber, PhD, University of Oregon: the evolutionary battle between pathogens and primate hosts for access to iron and heme. He will address how primates evolved in response to iron and heme piracy by pathogenic bacteria. In his proposed studies, Dr. Barber will focus on phylogenetic analyses of hemoglobin and hemeopexin.
Adam Hughes, University of Utah School of Medicine
NIH/NIGMS R35 GM 119694 utilized CIHD-sponsored metabolism core for application
Investigating the Mitochondrial-Derived Compartment Pathway
6/1/2021-5/51/2026
R01 DK125740 PI: Iqbal Hamza, PhD
NIH/NIDDK
7/1/20 – 6/30/24
Heme trafficking and recycling in iron metabolism
Philpott lab postdoc
PI: Shyamalagauri Jadhav, Ph.D.
ODS Research Scholars Award
10/1/2018-9/30/2019
Liver-specific loss of iron chaperone PCBP1 leads to dysregulated iron and hepatic steatosis
R01 DK128068-01 PI: J. Christian and Jodie Babitt, MPIs
NIDDK
2021-2026
BMP Ligands in Hepcidin Regulation
R21 HD102668-01, PI: J. Christian
NICHD
2020-2021
Analysis of BMP Heterodimer formation and function, Diversity supplement
Matthew F. Barber, PhD, University of Oregon:
Recently awarded an NIH R35 MIRA award in which he included CIHD-sponsored work in his application. Here is the grant info:
NIH Maximizing Investigators’ Research Award (R35GM133652) 2019 – 2024
National Institutes of Health (NIGMS)
Title: Molecular mechanisms of evolution at the host-microbe interface
Paul Sigala, PhD, University of Utah:
Received a 5-year R35 MIRA (1R35GM133764) from NIGMS based on last year’s PF award, entitled “Comparative Heme Metabolism in Divergent Eukaryotes”, that featured preliminary data obtained during out CIHD Pilot Grant period.
Amy Medlock, PhD, University of Georgia
Awarded a SHINE grant 2018
R01 DK111653 Title: Identifying the function of the mitochondrial heme biosynthesis complex in erythropoiesis
Adam Hughes, Ph.D. University of Utah
Awarded R01 2019
R01 AG061376 Title: The role of the lysosome in aging