Research Aim
To advance research in iron and heme disorders.
Resources and Services Available from CCEH
The Cooperative Centers of Excellence in Hematology (CCEH) generate investigative resources that can be made available to the broader research community. They involve integrated teams of investigators from a wide range of disciplines, share specialized equipment, and serve as regional or national resources. The CCEH support pilot and feasibility programs that fund small projects aimed to generate preliminary data for inclusion in larger grant applications as well as short-term enrichment activities.
The CCEH provide a focus for multidisciplinary investigations into gene structure and function; the cellular and molecular mechanisms involved in the production, maturation, and function of blood cells; and the development of strategies to treat nonmalignant hematologic diseases. The CCEH offer unique resources and established hematology expertise through scientific cores on a fee-for-service basis.
Core Facilities
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Iron and Heme Core:
Analyzes biological samples for metal, porphyrin, heme content, heme biosynthetic enzyme activity and metals by ICP-MS.
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Protein-Metabolite Discovery Core:
Protein-metabolite interactome discovery services to validate and identify, known and novel transient interactions with their target proteins including substrates, cofactors, products, and allosteric and orthosteric regulators.
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Metabolomics Core:
LC-MS & GC-MS metabolic profiling, lipidomics and isotope tracer analysis.
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Mutation Generation Detection Core:
The Mutation Generation and Detection Core (MGD) Facility specializes in providing custom TALEN and Crispr-Cas9 DNA nucleases to induce targeted mutations in a genomic region of your interest. TALEN and Crispr-Cas9 DNA nucleases are a cutting edge technology for performing reverse genetic studies in multiple model systems, including, but not limited to Zebrafish, Drosophila, C. elegans, Mouse, and mammalian tissue culture.
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Enrichment Core:
We support investigators in the field of non-malignant hematology through workshops, pilot and feasibility programs, and career development.
