2023 – 2024
Ella Nemeth, PhD, University of California Los Angeles: Iron Deficiency enhances endothelial damage in sepsis: the role of heme
Jan Christian, PhD, University of Utah and Jodie Babitt, M.D. Mass General Hospital, Harvard: Analysis of a mouse model of a BMP6 mutation associated with iron overload in humans
2022 – 2023
Anna Beaudin, PhD, University of Utah: Delaying age and obesity-mediated hematopoietic dysfunction with time-restricted feeding.
Dean Tantin, PhD, University of Utah: Test the hypothesis that Oct1 can be used to improve blood cell development.
2021 – 2022
Paul Sigala, PhD, University of Utah: Unraveling the Mechanism and Biological Significance of Hemozoin Motion in Malaria Parasites.
Diane Ward, PhD, University of Utah: The role of macrophage Cyb561a3/Lcytb in lysosomal iron recycling for erythropoiesis.
Iqbal Hamza, PhD University of Maryland, College Park: Interactions of HRG1 heme transporter in reticuloendothelial macrophages.
2020 – 2021
Ryan O’Connell, PhD, University of Utah: The role of Rab27a/b during mitochondria release from maturing erythroblasts
Paul Sigala, PhD, University of Utah: Mechanism of Iron Acquisition by Malaria Parasites
Diane Ward, PhD, University of Utah: The role of the reductases Lcytb and Steap3 in lysosomal iron recycling in macrophages
Adam Hughes, PhD, University of Utah: Elucidating the role of the LON protease in the regulation of cellular iron metabolism.
Robert Christensen, MD, University of Utah: Neonatal iron deficiency; defining pathogenic mechanisms & improving detection.
Tomas Ganz, MD, UCLA: Metabolic Effects of Pathologically Increased Erythroferrone in Anemias with Ineffective Erythropoiesis.
Amy Medlock, PhD, University of Georgia: Creation of Transgenic Zebrafish with Hepatic and Erythroid Expressed Heme Sensors
Yvette Yien, PhD, University of Pittsburg: Regulation of erythroid heme synthesis and vertebrate development by the mitochondrial unfoldase, CLPX.
Francesca Vinchi, PhD, New York Blood Center: Characterization of macrophage immune-metabolic skewing induced by heme, iron and erythrophagocytosis.
Timothy M Barr, MS MD, University of Utah: Iron deficiency in preterm neonates: prevalence, surveillance, contributing factors.
Makiko Yasuda, MD PhD, Icahn School of Medicine at Mt Sinai: Investigations of hepatic heme homeostatic mechanisms using ALAS-deficient mice.
2019 – 2020
Ryan O’Connell, PhD, University of Utah: The role of Rab27a/b during mitochondria release from maturing erythroblasts
Paul Sigala, PhD, University of Utah: Mechanism of Iron Acquisition by Malaria Parasites 3.
Diane Ward, PhD, University of Utah: The role of the reductases Lcytb and Steap3 in lysosomal iron recycling in macrophages
2018 – 2019
Dean Tantin, PhD, Tracey Lamb, PhD: Does Oct1 loss-of-function in bone marrow progenitor cells exacerbate the severity of malarial anemia?
Oleh Khalimonchuk, PhD, Amit Reddi, PhD: Mitochondrial Behavior and Heme Transport in Erythropoiesis
Elizabeth Leibold, PhD, University of Utah: Cell-Cycle Regulation of IRP2 Phosphorylation during Hematopoiesis
Amy Medlock, PhD, Amit Reddi, PhD: Creation of Transgenic Zebrafish with Erythroid Expressed Heme Sensors
Ryan O’Connell, PhD University of Utah: Determine the role of Rab27a/b during mitochondria release from maturing erythroblasts
Joe Prchal, University of Utah: Search for Novel Parameters of Augmentation of Erythropoiesis. Deciphering Molecular Differences of VHL Mutated Congenital Polycythemia versus Tumor-Predisposition
Paul Sigala, PhD, University of Utah: Structure and Function of a Divergent Eukaryotic Cytochrome c
Diane Ward, PhD, University of Utah: The role of Abcb10 in red cell hemoglobinization
2017 – 2018
Matthew Barber, PhD, University of Oregon: Host-pathogen conflicts shaping bloodstream hemeprotein evolution
Adam Hughes, PhD, University of Utah: The role of lysosomes in maintenance of cellular iron metabolism
Elizabeth Leibold, PhD, University of Utah: Cell-cycle regulation of IRP2 phosphorylation during hematopoiesis
Paul Sigala, PhD, University of Utah: Role of Acyl Carrier Protein in Iron/Sulfur Cluster Biogenesis by Malaria Parasites
Diane Ward, PhD, University of Utah: The role of Abcb10 in red cell hemoglobinization
2016 – 2017
Dr. Paul Sigala PhD, University of Utah: Department of Biochemistry, University of Utah: the role of the acyl-carrier proteins present in the mitochondria and apicoplast of Plasmodium in iron-sulfur cluster biogenesis in the two organelles and the role of each pathway in the physiology of Plasmodium parasites.
Dr. Amy Medlock PhD, University of Georgia: the role of two novel proteins PGRMC1 and PGRMC2 in modulating heme synthesis in mammalian cells.
Dr. Matt Barber, PhD, University of Oregon: the evolutionary battle between pathogens and primate hosts for access to iron and heme.