2023
September 2023
Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a mutation in adenylyl cyclase with trade-offs for pathogenicity. Hilbert ZA, Bednarek JM, Schwiesow MJW, Chung KY, Moreau CT, Brown JCS, Elde NC.Curr Biol. 2023 Sep 8:S0960-9822(23)01134-X. doi: 10.1016/j.cub.2023.08.054. Online ahead of print.PMID: 37708888
The transcriptomic landscape of normal and ineffective erythropoiesis at single-cell resolution. Doty RT, Lausted CG, Munday AD, Yang Z, Yan X, Meng C, Tian Q, Abkowitz JL.Blood Adv. 2023 Sep 12;7(17):4848-4868. doi: 10.1182/bloodadvances.2023010382.PMID: 37352261
Platelet mitochondria: the mighty few. Ajanel A, Campbell RA, Denorme F.Curr Opin Hematol. 2023 Sep 1;30(5):167-174. doi: 10.1097/MOH.0000000000000772. Epub 2023 Jul 17.PMID: 37459354
The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes. Denorme F, Armstrong ND, Stoller ML, Portier I, Tugolukova EA, Tanner RM, Montenont E, Bhatlekar S, Cody M, Rustad JL, Ajanel A, Tolley ND, Murray DC, Boyle JL, Nieman MT, McKenzie SE, Yost CC, Lange LA, Cushman M, Irvin MR, Bray PF, Campbell RA.J Clin Invest. 2023 Sep 15;133(18):e169608. doi: 10.1172/JCI169608.PMID: 37471144
Animal FAS-like polyketide synthases produce diverse polypropionates. Li F, Lin Z, Krug PJ, Catrow JL, Cox JE, Schmidt EW.Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2305575120. doi: 10.1073/pnas.2305575120. Epub 2023 Sep 11.PMID: 37695909
August 2023
Microbe transmission from pet shop to lab-reared zebrafish reveals a pathogenic birnavirus. Rice MC, Elde NC, Gagnon JA, Balla KM.bioRxiv. 2023 Aug 28:2023.08.28.555169. doi: 10.1101/2023.08.28.555169. Preprint.PMID: 37693489 Free PMC article.
Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity. Boys IN, Johnson AG, Quinlan MR, Kranzusch PJ, Elde NC.Cell Rep. 2023 Aug 29;42(8):112878. doi: 10.1016/j.celrep.2023.112878. Epub 2023 Jul 25.PMID: 37494187
Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. Zhang S, Williams KJ, Verlande-Ferrero A, Chan AP, Su GB, Kershaw EE, Cox JE, Maschek JA, Shapira SN, Christofk HR, de Aguiar Vallim TQ, Masri S, Villanueva CJ.J Lipid Res. 2023 Aug 26:100434. doi: 10.1016/j.jlr.2023.100434. Online ahead of print.PMID: 37640283
Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease. Ocañas SR, Pham KD, Cox JEJ, Keck AW, Ko S, Ampadu FA, Porter HL, Ansere VA, Kulpa A, Kellogg CM, Machalinski AH, Thomas MA, Wright Z, Chucair-Elliott AJ, Freeman WM.J Neuroinflammation. 2023 Aug 16;20(1):188. doi: 10.1186/s12974-023-02870-2.PMID: 37587511 Free PMC article.
Feasibility of a non-invasive method to assess fetal hemolysis in utero during the third trimester. Bahr TM, Christensen TR, Cheatham LS, Page JM, Christensen RD.J Perinatol. 2023 Aug 31. doi: 10.1038/s41372-023-01764-8. Online ahead of print.PMID: 37653077 No abstract available.
Serum ferritin values in neonates <29 weeks’ gestation are highly variable and do not correlate with reticulocyte hemoglobin content. Bahr TM, Tan S, Smith E, Beauman SS, Schibler KR, Grisby CA, Lowe JR, Bell EF, Laptook AR, Shankaran S, Carlton DP, Rau C, Baserga MC, Flibotte J, Zaterka-Baxter K, Walsh MC, Das A, Christensen RD, Ohls RK; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.J Perinatol. 2023 Aug 18. doi: 10.1038/s41372-023-01751-z. Online ahead of print.PMID: 37596391
Neonatal Thrombocytopenia: Factors Associated With the Platelet Count Increment Following Platelet Transfusion. Christensen RD, Bahr TM, Davenport P, Sola-Visner MC, Kelley WE, Ilstrup SJ, Ohls RK.J Pediatr. 2023 Aug 11;263:113666. doi: 10.1016/j.jpeds.2023.113666. Online ahead of print.PMID: 37572863
Lactate modulates iron metabolism by binding soluble adenylyl cyclase. Liu W, Zhang S, Li Q, Wu Y, Jia X, Feng W, Li Z, Shi Y, Hou Q, Ma J, Liu Y, Gao P, Ganz T, Liu S.Cell Metab. 2023 Sep 5;35(9):1597-1612.e6. doi: 10.1016/j.cmet.2023.06.017. Epub 2023 Jul 21.PMID: 37480842
Increased transferrin protects from thrombosis in Chuvash erythrocytosis. Shah BN, Zhang X, Sergueeva AI, Miasnikova GY, Ganz T, Prchal JT, Gordeuk VR.Am J Hematol. 2023 Oct;98(10):1532-1539. doi: 10.1002/ajh.27021. Epub 2023 Jul 12.PMID: 37435906
Increased blood reactive oxygen species and hepcidin in obstructive sleep apnea precludes expected erythrocytosis. Song J, Sundar KM, Horvathova M, Gangaraju R, Indrak K, Christensen RD, Genzor S, Lundby C, Divoky V, Ganz T, Prchal JT.Am J Hematol. 2023 Aug;98(8):1265-1276. doi: 10.1002/ajh.26992. Epub 2023 Jun 23.PMID: 37350302
Iron Homeostasis During Pregnancy: Maternal, Placental, and Fetal Regulatory Mechanisms. Sangkhae V, Fisher AL, Ganz T, Nemeth E.Annu Rev Nutr. 2023 Aug 21;43:279-300. doi: 10.1146/annurev-nutr-061021-030404. Epub 2023 May 30.PMID: 37253681
Evidence that the catalytic mechanism of heme a synthase involves the formation of a carbocation stabilized by a conserved glutamate. Rivett ED, Addis HG, Dietz JV, Carroll-Deaton JA, Gupta S, Foreman KL, Dang MA, Fox JL, Khalimonchuk O, Hegg EL.Arch Biochem Biophys. 2023 Aug;744:109665. doi: 10.1016/j.abb.2023.109665. Epub 2023 Jun 20.PMID: 37348627
The complex relationship between iron status and anemia in pregnant and postpartum women in India: Analysis of two Indian study cohorts of uncomplicated pregnancies. Nair M, Choudhury SS, Rani A, Solomi C 5th, Kakoty SD, Medhi R, Rao S, Mahanta P, Zahir F, Roy I, Chhabra S, Deka G, Minz B, Deka R, Opondo C, Churchill D, Lakhal-Littleton S, Nemeth E; MaatHRI collaboration.Am J Hematol. 2023 Aug 31. doi: 10.1002/ajh.27059. Online ahead of print.PMID: 37651649
The iron chaperone poly C binding protein 1 regulates iron efflux through intestinal ferroportin in mice. Wang Y, Protchenko O, Duck Huber K, Shakoury-Elizeh M, Ghosh MC, Philpott CC.Blood. 2023 Aug 25:blood.2023020504. doi: 10.1182/blood.2023020504. Online ahead of print.PMID: 37624904
Cardiac gene therapy rescues diabetic cardiomyopathy and lowers blood glucose. Li J, Richmond B, Cluntun AA, Bia R, Walsh MA, Shaw K, Symons JD, Franklin S, Rutter J, Funai K, Shaw RM, Hong T.JCI Insight. 2023 Aug 24:e166713. doi: 10.1172/jci.insight.166713. Online ahead of print.PMID: 37639557
Ceramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk. Li Y, Chaurasia B, Rahman MM, Kaddai V, Maschek JA, Berg JA, Wilkerson JL, Mahmassani ZS, Cox J, Wei P, Meikle PJ, Atkinson D, Wang L, Poss AM, Playdon MC, Tippetts TS, Mousa EM, Nittayaboon K, Babu PVA, Drummond MJ, Clevers H, Shayman JA, Hirabayashi Y, Holland WL, Rutter J, Edgar B, Summers SA.Gastroenterology. 2023 Aug 2:S0016-5085(23)04837-0. doi: 10.1053/j.gastro.2023.07.017. Online ahead of print.PMID: 37541526
UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. Tsai JM, Aguirre JD, Li YD, Brown J, Focht V, Kater L, Kempf G, Sandoval B, Schmitt S, Rutter JC, Galli P, Sandate CR, Cutler JA, Zou C, Donovan KA, Lumpkin RJ, Cavadini S, Park PMC, Sievers Q, Hatton C, Ener E, Regalado BD, Sperling MT, Słabicki M, Kim J, Zon R, Zhang Z, Miller PG, Belizaire R, Sperling AS, Fischer ES, Irizarry R, Armstrong SA, Thomä NH, Ebert BL.Mol Cell. 2023 Aug 3;83(15):2753-2767.e10. doi: 10.1016/j.molcel.2023.06.028. Epub 2023 Jul 20.PMID: 37478846
Oct4 redox sensitivity potentiates reprogramming and differentiation. Shen Z, Wu Y, Manna A, Evason KJ, Chandrasekharan MB, Tantin D.bioRxiv. 2023 Aug 24:2023.02.21.529404. doi: 10.1101/2023.02.21.529404. Preprint.PMID: 36865286
July 2023
Mon1a and FCHO2 are required for maintenance of Golgi architecture. Bagley DC, Morham SG, Kaplan J, Ward DM.bioRxiv. 2023 Jul 7:2023.07.06.547837. doi: 10.1101/2023.07.06.547837. Preprint.PMID: 37461455
Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4. Miljkovic M, Seguin A, Jia X, Cox JE, Catrow JL, Bergonia H, Phillips JD, Stephens WZ, Ward DM.J Biol Chem. 2023 Jul;299(7):104877. doi: 10.1016/j.jbc.2023.104877. Epub 2023 Jun 1.PMID: 37269954
Disuse-induced muscle fibrosis, cellular senescence, and senescence-associated secretory phenotype in older adults are alleviated during re-ambulation with metformin pre-treatment. Petrocelli JJ, McKenzie AI, de Hart NMMP, Reidy PT, Mahmassani ZS, Keeble AR, Kaput KL, Wahl MP, Rondina MT, Marcus RL, Welt CK, Holland WL, Funai K, Fry CS, Drummond MJ.Aging Cell. 2023 Jul 24:e13936. doi: 10.1111/acel.13936. Online ahead of print.PMID: 37486024
Actin-bundling protein L-plastin promotes megakaryocyte rigidity and dampens proplatelet formation. Guo L, Jacob S, Manne BK, Kolawole EM, Guo S, Wang X, Murray D, Tugolukova EA, Portier I, Kosaka Y, Barba C, Rondina MT, Evavold B, Morley C, Bhatlekar S, Bray PF.Haematologica. 2023 Jul 13. doi: 10.3324/haematol.2023.283016. Online ahead of print.PMID: 37439340
Notes from the Underground: Heme Homeostasis in C. elegans. Chen C, Hamza I.Biomolecules. 2023 Jul 19;13(7):1149. doi: 10.3390/biom13071149.PMID: 37509184
Mitochondrial-Derived Compartments are Multilamellar Domains that Encase Membrane Cargo and Cytosol. Wilson ZN, West M, English AM, Odorizzi G, Hughes AL.bioRxiv. 2023 Jul 7:2023.07.07.548169. doi: 10.1101/2023.07.07.548169. Preprint.PMID: 37461645
Placental Erythroferrone and Erythropoietin mRNA Expression is not Associated with Maternal or Neonatal Iron Status in Adolescents Carrying Singletons and Adult Women Carrying Multiples. Delaney KM, Barad A, Castillo LF, Hasund CM, Guillet R, Pressman EK, Katzman PJ, Ganz T, Nemeth E, O’Brien KO.J Nutr. 2023 Jul;153(7):1950-1958. doi: 10.1016/j.tjnut.2023.05.023. Epub 2023 May 28.PMID: 37253412
Inhibition of skeletal muscle Lands cycle ameliorates weakness induced by physical inactivity. Shahtout JL, Eshima H, Ferrara PJ, Maschek JA, Cox JE, Drummond MJ, Funai K.bioRxiv. 2023 Jul 28:2023.07.25.550576. doi: 10.1101/2023.07.25.550576. Preprint.PMID: 37546754
Rapid Evolution of Glycan Recognition Receptors Reveals an Axis of Host-Microbe Arms Races beyond Canonical Protein-Protein Interfaces. Hilbert ZA, Haffener PE, Young HJ, Schwiesow MJW, Leffler EM, Elde NC.Genome Biol Evol. 2023 Jul 3;15(7):evad119. doi: 10.1093/gbe/evad119.PMID: 37390614
Concurrent profiling of multiscale 3D genome organization and gene expression in single mammalian cells. Zhou T, Zhang R, Jia D, Doty RT, Munday AD, Gao D, Xin L, Abkowitz JL, Duan Z, Ma J.bioRxiv. 2023 Jul 25:2023.07.20.549578. doi: 10.1101/2023.07.20.549578. Preprint.PMID: 37546900
BMP5 contributes to hepcidin regulation and systemic iron homeostasis in mice. Xiao X, Xu Y, Moschetta GA, Yu Y, Fisher AL, Alfaro-Magallanes VM, McMillen S, Phillips S, Wang CY, Christian J, Babitt JL.Blood. 2023 Jul 21:blood.2022019195. doi: 10.1182/blood.2022019195. Online ahead of print.PMID: 37478395
Both maternal IFNγ exposure and acute prenatal infection with Toxoplasma gondii activate fetal hematopoietic stem cells. López DA, Otsuka KS, Apostol AC, Posada J, Sánchez-Arcila JC, Jensen KD, Beaudin AE. EMBO J. 2023 Jul 17;42(14):e112693. doi: 10.15252/embj.2022112693. Epub 2023 Jun 1.PMID: 37259639
Renin-Angiotensin System Components and Arachidonic Acid Metabolites as Biomarkers of COVID-19. Ghimire B, Pour SK, Middleton E, Campbell RA, Nies MA, Aghazadeh-Habashi A.Biomedicines. 2023 Jul 27;11(8):2118. doi: 10.3390/biomedicines11082118.PMID: 37626615
Role of Anemia in Dementia Risk Among Veterans With Incident CKD. Koyama AK, Nee R, Yu W, Choudhury D, Heng F, Cheung AK, Norris KC, Cho ME, Yan G.Am J Kidney Dis. 2023 Jul 27:S0272-6386(23)00735-7. doi: 10.1053/j.ajkd.2023.04.013. Online ahead of print.PMID: 37516301
A “Gold Standard” Test for Diagnosing and Quantifying Hemolysis in Neonates and Infants. Christensen RD, Bahr TM, Wong RJ, Vreman HJ, Bhutani VK, Stevenson DK.J Perinatol. 2023 Jul 19. doi: 10.1038/s41372-023-01730-4. Online ahead of print.PMID: 37468612 Review.
Associations between blood donor sex and age, and outcomes of transfused newborn infants. Bahr TM, Christensen TR, Tweddell SM, Henry E, Rees T, Astin ME, Kelley WE, Ilstrup SJ, Ohls RK, Christensen RD.Transfusion. 2023 Jul;63(7):1290-1297. doi: 10.1111/trf.17417. Epub 2023 May 22.PMID: 37218104
June 2023
Iron Parameters in Patients Treated with Roxadustat for Anemia of Chronic Kidney Disease. Ganz T, Locatelli F, Arici M, Akizawa T, Reusch M.J Clin Med. 2023 Jun 22;12(13):4217. doi: 10.3390/jcm12134217.PMID: 37445252
Diagnosing Anemia in Neonates: An Evidence-Based Approach. Christensen RD, Bahr TM, Tweddell SM, Ohls RK, Henry E.Neoreviews. 2023 Jun 1;24(6):e343-e355. doi: 10.1542/neo.24-6-e343.PMID: 37258503 Review.
May 2023
Novel anemia therapies in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Ku E, Del Vecchio L, Eckardt KU, Haase VH, Johansen KL, Nangaku M, Tangri N, Waikar SS, Więcek A, Cheung M, Jadoul M, Winkelmayer WC, Wheeler DC, Babitt JL; for Conference Participants.Kidney Int. 2023 May 24:S0085-2538(23)00379-4. doi: 10.1016/j.kint.2023.05.009. Online ahead of print.PMID: 37236424