Postdoctoral Fellow to Elucidate Mechanisms of Ferroptosis
Seeking highly motivated candidates to perform mechanistic studies for the characterization of pathways involved in iron sensing and ferroptosis in cancer cells. PI Dr. Mei Koh’s lab at the University of Utah College of Pharmacy focuses on the identification of new therapeutic strategies that exploit the inflammatory and hypoxic tumor microenvironment within solid tumors. The funded project focuses on the role of Fe-S assembly proteins in driving kidney cancer and modulating sensitivity to ferroptosis.
Candidates must possess a PhD degree in biology, biochemistry, molecular pharmacology or related field. Candidates should have high proficiency in iron metabolism and in general cell biology and molecular biology techniques including cell culture, molecular cloning, western blots, PCR, and cell viability/reporter assays. Experience in cancer cell signaling is desirable but not essential. Experience in animal handling/surgery is desirable but not essential. Candidates should be organized, able to work independently and as part of a team in a highly collaborative research environment. Fluency in English is required. Candidates should be eligible to work in the USA.
Responsibilities include:
1) Perform laboratory experiments, which may include cell culture, molecular cloning, western blotting, PCR, animal handling/surgery, and protein purification.
2) Plan and execute experiments, perform data analysis, have ability to work independently and as part of a team.
3) Present data in group meetings, and at local and international meetings.
4) Contribute to general lab management including supervising lab technicians and students where necessary.
5) Prepare manuscripts.
The University of Utah and the Huntsman Cancer Institute:
Founded in 1850, The University of Utah (the U) is the flagship institution of higher learning in Utah, and offers over 100 undergraduate and more than 90 graduate degree programs to over 30,000 students. As a preeminent research and teaching institution, the University ranks among the top 50 U.S. universities by total research expenditures. Huntsman Cancer Institute (HCI) at the University of Utah is a nationally recognized research center and treatment hospital, and an NCI-designated Comprehensive Cancer Center. HCI and the U are located in Salt Lake City, a vibrant, increasingly diverse and family friendly city; nestled against the mountains of the Wasatch Front, which provide world class skiing, hiking, biking and other alpine activities.
If interested, please send resume, cover letter and the contact information of 3 references to mei.koh@utah.edu.
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We are seeking a Lab Specialist to join our HSC Cell Imaging Core. The ideal candidate will have a strong passion for microscopy and expertise in a research program coordinating role. Key responsibilities include maintaining microscopy equipment, organizing daily core activities, and ensuring effective communication with our users. For more details, please use this link https://utah.peopleadmin.com/postings/165605.
If you have any additional questions about this position, please don’t hesitate to contact Xiang Wang (Xiang.wang@cores.utah.edu).
| Job Summary |
The University of Utah Cell Imaging Core is seeking a Lab Technician (Specialist?) to organize, inventory, and clean sophisticated microscopy equipment and train new users in Standard Operating Procedures. The candidate will support the cell imaging needs of the University of Utah scientific community by maintaining equipment functionality and instructing new users on proficiency. The candidate will work closely with the Core Director and other Core staff members to learn all necessary protocols for the care and use of the microscopes. |
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| Responsibilities |
This job description is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.
Work Environment and Level of Frequency that may be required:
Nearly Continuously: Office environment.
Often: Infectious disease, oils (there is air or skin exposure to oils or other cutting fluids), hazards (includes a variety of physical conditions, such as proximity to moving mechanical parts, moving vehicles, electrical current, working on scaffolding and high places, or exposure to chemicals).
Seldom: Exposure to animals.
Physical Requirements and Level of Frequency that may be required
Nearly Continuously: Hearing, listening, talking.
Often: Repetitive hand motion (such as typing), walking, standing, sitting.
Seldom: Bending, reaching overhead.
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| Minimum Qualifications |
Bachelor’s degree in Biology, Chemistry or other scientific discipline or equivalency (one year of education can be substituted for two years of related work experience); two years full-time laboratory experience; and demonstrated human relations and effective communication skills required. Working knowledge of advanced scientific techniques and procedures as well as the ability to make statistical calculations, analyze results, prepare reports and perform specialized tests also required. Applicants must demonstrate the potential ability to perform the essential functions of the job as outlined in the position description. |
| Preferences |
Operate and maintain high-end microscopic imaging systems within the Core Facility under the direction of the facility manager. Train and assist researchers in using the microscopy systems within the Core Facility. Keep records of the microscope’s utilization. Assist with lab administrative duties. Perform other related functions as assigned. Prior experience with fluorescence microscopy and confocal microscopy is preferred. Previous laboratory experience in a basic science field, with knowledge of common lab practices and safety, is preferred. Excellent communication, organizational, and interpersonal skills. Good working knowledge of MS Office suite (Word, Excel, PowerPoint). Highly detail-oriented, enjoys problem-solving and brainstorming, and is team-oriented. Optional:
Familiarity with digital image analysis tools (ImageJ, Imaris, Nikon Elements, and other image analysis software). |
| Type | Benefited Staff |
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Post/Doctoral position available at the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda MD, for a young researcher interested in joining a young and dynamic research group in mammalian iron metabolism, iron sulfur cofactors, iron related neurodegeneration, iron sulfur dependent viral replication, RNA protein interactions and systems biology analysis of iron regulation.
Terms: 24 months, with yearly extensions possible after initial contract. The NIH is dedicated to building an inclusive and diverse community in its training and employment programs.
DHHS, NIH, and NICHD are Equal Employment Opportunity Employers
For further information, contact: rouault@mail.nih.gov.
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Postdoctoral position is available in the Krause laboratory at Yale (krauselab.net). Our lab focuses on how hematopoietic stem and progenitor cells function to maintain hematopoiesis in health, and the molecular mechanisms that dysregulate these cells in leukemia and other disease states. We use in vitro and in vivo cell and molecular approaches to reveal mechanisms of cell fate determination and transformation. The Krauselab specifically and Yale in general is a highly collaborative environment. We are looking for a candidate who enjoys both working independently and also as part of a team.
Eligibility: US citizen or Green Card holder.
Qualifications: PhD, MD, or both with a strong track record of training and independent research in Cell and Molecular Biology, Genetics or related transdisciplinary fields. Experience in cell culture and molecular biology as well as excellent communication and interpersonal skills are required.
Candidates should have a strong publication track record with first author publications in English journals.
Interested candidates should send a CV with names of references to diane.krause@yale.edu.
Please visit our lab website at krauselab for more information about our ongoing projects and recent publications. We look forward to welcoming an enthusiastic and dedicated postdoctoral fellow to contribute to our exciting research endeavors at Yale University.
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The University of Maryland Baltimore, School of Medicine’s, interdisciplinary Center for Blood Oxygen Transport & Hemostasis includes a team of physicians, biochemists, and engineers and will help answer fundamental, challenging questions related to blood function in health and disease.
This fellowship is funded by an NIH post-doctoral training grant and will focus on mechanisms that drive sickle cell disease (SCD) pulmonary hypertension (PH). Accumulation of pulmonary vascular macrophage iron is a new and unique finding observed in SCD, suggesting that erythrophagocytosis mediated iron overload is a pathological driver of progressive pulmonary vascular disease. This is in striking contrast to idiopathic pulmonary arterial hypertension (iPAH), which is exacerbated by iron depletion states and may be improved in some cases by iron administration. The study of macrophage processing of sickled red blood cells, macrophage migration to the pulmonary vasculature and iron driven pulmonary vascular remodeling will be the primary focus of this post-doctoral fellowship. Secondarily, mechanisms such as inflammation and complement activation will also be studied as processes that exacerbate PH. Both murine models and patient samples will be studies to define proof-of-concept for experimental therapeutics that slow the progression of pulmonary vascular complications in SCD.
The fellow will assist in research studies to advance knowledge in a training-based setting under the direction of Dr. Paul Buehler, a federally funded pharmacologist and toxicologist with specialization in hematotoxicology. The position requires an ability to carry out general laboratory techniques (e.g., spectrophotometry, ELISAs, Western blotting, flow cytometry, histopathology, and microscopy). Evaluation of RBC deformability, oxygen equilibrium, preparation for microscopy (light and EM), capability to assess RBC morphological changes consistent with disease states will be taught. Further, a knowledge and/or desire to expand expertise in techniques that evaluate tissue oxygenation and perfusion (e.g., MRI, EPR, PET, Phosphorescence Quenching, Laser Doppler Flowmetry) is critical to this position’s goals.
Minimum Education: Recent graduate applicants with a PhD or applicants that are expected to graduate from a Bioengineering, Physiology, or related discipline PhD program and are required to be a green card holder or US citizen. The candidate will be expected to possess strong communication and independent writing skills.
Interested candidates should email their CV and Research Statement to PBuehler@som.umaryland.edu.
Salary: In accordance with NIH guidelines (NIH 0–3-year experience level)