Welcome

NIDDK-Sponsored Center for Iron & Hematology Disorders at The University of Utah School of Medicine

The Center for Iron and Hematology Disorders (CIHD) at the University of Utah School of Medicine consists of three scientific core facilities which include the Mutation Generation & Detection Core, the Metabolomics Core, and the Iron & Heme Core. In addition to these Cores, there is an Enrichment Program, Internal and External Advisory Committees, and a Pilot and Feasibility program for the Center for Iron and Hematology Disorders. These cores offer many different services to a large majority of members within the CIHD as well as The University of Utah. To contact Core directors, find out services provided, and the rates of these services, click on the respective page. To find out upcoming events these Cores and programs will be providing, click on Events Calendar.

News

1. Metabolism Core Fuels Innovative Research.

Recent article highlights James Cox, PhD and the Metabolomics Core at the University of Utah. 

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2.  CIHD Pilot and Feasibility Program Grant Awards 2017

Congratulations to the the following five investigators whose proposals were funded in the CIHD 2017 Pilot and Feasibility Grants Program:

Matthew Barber: Host-pathogen conflicts shaping bloodstream hemeprotein evolution

Adam Hughes: The role of lysosomes in maintenance of cellular iron metabolism

Elizabeth Leibold: Cell-cycle regulation of IRP2 phosphorylation during hematopoiesis

Paul Sigala: Role of Acyl Carrier Protein in Iron/Sulfur Cluster Biogenesis by Malaria Parasites

Diane Ward: The role of Abcb10 in red cell hemoglobinization

3. Recent Publications

Current CIHD Highlights and Accomplishments:

Publications:

* Research results supported by CIHD Core use.

*J. Chung, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, Cantor AB, Maeda T, Phillips JD, Coon JJ, Pagliarini DJ, Dailey HA, Paw BH.  Erythropoietin signaling regulates heme biosynthesis (2017 May 29) eLIFE 6:e24767. PMID: 28553927. PMCID: PMC5478267.

*Seguin A, Takahashi-Makise N, Yien YY, Huston NC, Whitman JC, Musso G, Wallace JA, Bradley T, Bergonia HA, Kafina MD, Matsumoto M, Igarashi K, Phillips JD, Paw BH, Kaplan J, Ward DM. Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes (2017 Sep 29) J. Biol. Chem. 292(39):16284-99. PMID: 28808058. PMCID: PMC5625058 [Available on 2018-09-29].

*Yien YY, Ducamp S, van der Vorm LN, Kardon JR, Manceau H, Kannengiesser C, Bergonia HA, Kafina MD, Karim Z, Gouya L, Baker TA, Puy H, Phillips JD, Nicolas G, Paw BH. Mutation in human CLPX elevates levels of delta-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E8045-E8052. PMID: 28874591. PMCID: PMC5617249 [Available on 2018-03-19].

*Yaish HM, Farrell CP, Christensen RD, MacQueen BC, Jackson LK, Trochez-Enciso J, Kaplan J, Ward DM, Salah WK, Phillips JD. Two novel mutations in TMPRSS6 associated with iron-refractory iron deficiency anemia in a mother and child. Blood Cells Mol Dis. 2017 Jun; 65:38-40. PMID: 28460265. PMCID: PMC5656052.

Li, L, Kaplan, J and Ward, DM. The glucose sensor Snf1 and the transcription factors Msn2 and Msn4 regulate transcription of the vacuolar iron importer gene CCC1 and iron resistance in yeast.  J Biol Chem. 2017 Sep 15; 292(37):15577-15586. PMID: 28760824. PMCID: PMC5602413 [Available on 2018-09-15].

*Seguin, A, Takahashi-Makise, N, Yien, YY, Huston, NC, Whitman, JC, Musso, G, Wallace, JA, Bradley, T, Bergonia, H, Kafina, MD, Matsumoto, M, Igarashi, K, Phillips, JD, Paw, BH, Kaplan, J and Ward, DM.  Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes.  J Biol Chem. 2017 Sep 29; 292(39):16284-16299. PMID: 28808058. PMCID: PMC5625058 [Available on 2018-09-29].

*Goldberg DE, Sigala PA. Plasmodium heme biosynthesis: To be or not to be essential? PLoS Pathog. 2017 Sep 28;13(9):e1006511. PMID: 28957449. PMCID: PMC5619821.

 

4. Recent Workshop

Some attendees of the CIHD-sponsored Iron and Heme and Metabolomics Core Workshops at the University of Utah School of Medicine Dec 5th 2017

 

5.  Workshop

Getting Published Hands-On Workshop: Second Call

This Spring, Professors Anthea Letsou (Human Genetics), Suzi Mansour (Human Genetics), and Gary Schoenwolf (Neurobiology and Anatomy) will be leading an intensive hands-on workshop on how to write a manuscript for publication. Getting your research/fellowship funded goes hand-in-hand with being a productive investigator, that is, publishing high-quality manuscripts that significantly advance the field. Modeled on the highly successful Fall workshop entitled, “Getting Your Fellowship Funded,” the Getting Published workshop will meet for five 3-hour sessions on Thursdays, beginning on January 11th, 2018, and ending on March 8th, with four interspersed weeks left unscheduled to allow time to write and revise a manuscript. Each session will occur from 1:00-4:00pm on the Health Sciences Campus in HSEB (Health Sciences Education Building) 5100B. The schedule has been designed with the expectation that manuscripts will be completed and submitted within 3-6 months of the end of the workshop. The workshop is limited to 12 attendees and several slots were reserved after the first call. For the remaining slots, equal priority will be given to graduate students and postdoctoral fellows.

If you are interested, please respond by email at your earliest convenience (schoenwolf@neuro.utah.edu) providing the following information:

  • Your name:
  • PI’s name, department, and email address:
  • Whether you are a graduate student (list program and must have already passed preliminary exam to be eligible) or postdoctoral fellow, and how long you’ve been in your current lab:
  • If you are a postdoc, the name of the Department and Institution you received your Ph.D. from:
  • A list of any previous publications that you are an author on, and your specific role(s) in that/those publications:
  • A brief abstract (no more than 150 words) of the manuscript you are in the process of writing, listing the question/hypothesis you are addressing, why it is important, and an overview of how you addressed the question/hypothesis:
  • An estimate of the percentage of data still required to be collected/analyzed for your manuscript, and an estimate of when you expect to have that completed:
  • The name of the journal you expect to submit to:
  • Whether you have discussed participation in this workshop with your PI, and whether you both agree to commit the necessary time to prepare a high-quality manuscript over the course of the workshop.