Welcome

NIDDK-Sponsored Center for Iron & Hematology Disorders at The University of Utah School of Medicine

The Center for Iron and Hematology Disorders (CIHD) at the University of Utah School of Medicine consists of three scientific core facilities which include the Mutation Generation & Detection Core, the Metabolomics Core, and the Iron & Heme Core. In addition to these Cores, there is an Enrichment Program, Internal and External Advisory Committees, and a Pilot and Feasibility program for the Center for Iron and Hematology Disorders. These cores offer many different services to a large majority of members within the CIHD as well as The University of Utah. To contact Core directors, find out services provided, and the rates of these services, click on the respective page. To find out upcoming events these Cores and programs will be providing, click on Events Calendar.

News

1.  Application deadline, April 19, 2019

2.  CaDeTS, April 19, 2019

 

3.  Teaching Observation Program for Core Educators

 

4.  Biochemistry Seminary Series Monday, May 13, 2019

 

5.  2019 Hematology and Metals in Medicine Symposium on Friday, June 14, 2019

 

6.  Spring 2019 Community Read

Join us for the Spring 2019 Community Read (Waking Up White) and our Film Screening (Race: The Power of An Illusion) – co-sponsored by the Office of Health Equity and Inclusion (OHEI) and the Spencer S. Eccles Health Sciences Library (EHSL)
Coming in February… Film Screening and Discussion: Race: the Power of an Illusion

 

7.  CIHD Pilot and Feasibility Program Grant Awards 2018-19

Dean Tantin, Tracey Lamb Tantin, Associate Professor. Does Oct1 loss-of-function in bone marrow progenitor cells exacerbate the severity of malarial anemia?

Oleh Khalimonchuk, Amit Reddi. co-investigator Assoc Prof, University of Nebraska, Department of Biochemistry Mitochondrial Behavior and Heme Transport in Erythropoiesis

Betty Leibold. Professor, University of Utah. Cell-Cycle Regulation of IRP2 Phosphorylation during Hematopoiesis

Amy Medlock, Amit Reddi. co-investigator Assoc Prof, University of Georgia. Creation of Transgenic Zebrafish with Erythroid Expressed Heme Sensors

Ryan O’Connell. Assoc Prof University of Utah Dept of Pathology. Determine the role of Rab27a/b during mitochondria release from maturing erythroblasts

Joe Prchal. Professor, University of Utah. Search for Novel Parameters of Augmentation of Erythropoiesis. Deciphering Molecular Differences of VHL Mutated Congenital

Polycythemia versus Tumor-Predisposition

Paul Sigala. Assistant Professor, University of Utah. Structure and Function of a Divergent Eukaryotic Cytochrome c

Diane Ward. Research Associate Professor, University of Utah. The role of Abcb10 in red cell hemoglobinization

 

8.  Recently Published

Congratulations to the Plenary Paper in Blood published by CIHD Members John Phillips, Harry Dailey, Amy Medlock and the CIHD-Sponsored Metabolomics (James Cox and John Alan Maschek) and Iron and Heme Cores (Laurie Jackson).

link to article, link to UGA

 

9. Metabolism Core Fuels Innovative Research.

Recent article highlights James Cox, PhD and the Metabolomics Core at the University of Utah. 

Read More

10. HELM 2nd Friday

Effective mentoring and leadership development are some of the most critical components of a successful academic career. The University of Utah will launch the Utah Health Equity Leadership & Mentoring (U-HELM) program in 2018 with the goal of enhancing the academic excellence and leadership capacity of faculty and postdocs from underrepresented populations in the health sciences as well as health equity fields at UU. U-HELM will focus on some of the challenges that trainees from minority and underserved groups as well as other faculty whose research is addressing health equity may face.

Monthly Seminar Series Sessions: 2nd Fridays of each month from 11:30-1:30 pm (October 2018-June 2019)

Visit the U-HELM webpage for more information and to apply.

 

11. Publications

  1. ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly. Van Vranken JG, Nowinski SM, Clowers KJ, Jeong MY, Ouyang Y, Berg JA, Gygi JP, Gygi SP, Winge DR, Rutter J. Mol Cell. 2018 Aug 16;71(4):567-580.e4. doi: 10.1016/j.molcel.2018.06.039.PMID:30118679
  2. FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.Yien YY, Shi J, Chen C, Cheung JTM, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon LI, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH. J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26.PMID:30366982
  3. Ferritin in serum and urine: A pilot study. Bahr TM, Christensen RD, Ward DM, Meng F, Jackson LK, Doyle K, Christensen DR, Harvey AG, Yaish HM. Blood Cells Mol Dis. 2019 May;76:59-62. doi: 10.1016/j.bcmd.2019.02.001. Epub 2019 Feb 8. PMID;30777730
  4. Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis. Burch JS, Marcero JR, Maschek JA, Cox JE, Jackson LK, Medlock AE, Phillips JD, Dailey HA Jr. Blood. 2018 Sep 6;132(10):987-998. doi: 10.1182/blood-2018-01-829036. Epub 2018 Jul 10. PMID:29991557
  5. Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes. Barton JC, McLaren CE, Chen WP, Ramm GA, Anderson GJ, Powell LW, Subramaniam VN, Adams PC, Phatak PD, Gurrin LC, Phillips JD, Parker CJ, Emond MJ, McLaren GD. Ann Hepatol. 2018 Aug 24;17(5):871-879. doi: 10.5604/01.3001.0012.3169.PMID:30145563
  6. Homozygous hydroxymethylbilane synthase knock-in mice provide pathogenic insights into the severe neurological impairments present in human homozygous dominant acute intermittent porphyria. Yasuda M, Gan L, Chen B, Yu C, Zhang J, Gama-Sosa MA, Pollak DD, Berger S, Phillips JD, Edelmann W, Desnick RJ. Hum Mol Genet. 2019 Jan 7. doi: 10.1093/hmg/ddz003. [Epub ahead of print] PMID:30615115
  7. Identification and characterization of 40 novel hydroxymethylbilane synthase mutations that cause acute intermittent porphyria. Chen B, Solis-Villa C, Erwin AL, Balwani M, Nazarenko I, Phillips JD, Desnick RJ, Yasuda M. J Inherit Metab Dis. 2019 Jan;42(1):186-194. doi: 10.1002/jimd.12040. PMID: 30740734
  8. Harderoporphyria: Case of lifelong photosensitivity associated with compound heterozygous coproporphyrinogen oxidase (CPOX) mutations. Moghe A, Ramanujam VMS, Phillips JD, Desnick RJ, Anderson KE. Mol Genet Metab Rep. 2019 Feb 19;19:100457. doi: 10.1016/j.ymgmr.2019.100457. eCollection 2019 Jun. PMID:30828546
  9. The mitochondrial heme metabolon: Insights into the complex(ity) of heme synthesis and distribution. Piel RB 3rd, Dailey HA Jr, Medlock AE. Mol Genet Metab. 2019 Jan 17. pii: S1096-7192(18)30634-6. doi: 10.1016/j.ymgme.2019.01.006. [Epub ahead of print] Review. PMID:30709775
  10. Vazquez-Arreguin K, Bensard C, Schell JC, Swanson E, Chen X, Rutter J, Tantin D. (2019) Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy. PLoS Genetics (in press)

Grants

Diane Ward and June Round – University of Utah Immunity, Inflammation, Infection P&F grant: The effects of low iron diet on gut immunity and the development of Fatty Liver Disease 01/2019-12/31/2019.

Dennis Winge and Jared Rutter: National Institutes of Health RO1 GM110755-05. Mitochondrial Fatty Acid Synthesis and the Coordinate Regulation of Respiration.  Funded 9/20/2018-8/31/2022