Welcome

NIDDK-Sponsored Center for Iron & Hematology Disorders at The University of Utah School of Medicine

The Center for Iron and Hematology Disorders (CIHD) at the University of Utah School of Medicine consists of three scientific core facilities which include the Mutation Generation & Detection Core, the Metabolomics Core, and the Iron & Heme Core. In addition to these Cores, there is an Enrichment Program, Internal and External Advisory Committees, and a Pilot and Feasibility program for the Center for Iron and Hematology Disorders. These cores offer many different services to a large majority of members within the CIHD as well as The University of Utah. To contact Core directors, find out services provided, and the rates of these services, click on the respective page. To find out upcoming events these Cores and programs will be providing, click on Events Calendar.

News

1.  Just Published

Congratulations to the Plenary Paper in Blood published by CIHD Members John Phillips, Harry Dailey, Amy Medlock and the CIHD-Sponsored Metabolomics (James Cox and John Alan Maschek) and Iron and Heme Cores (Laurie Jackson).

 

link to article, link to UGA

 

2. HELM 2nd Friday

Effective mentoring and leadership development are some of the most critical components of a successful academic career. The University of Utah will launch the Utah Health Equity Leadership & Mentoring (U-HELM) program in 2018 with the goal of enhancing the academic excellence and leadership capacity of faculty and postdocs from underrepresented populations in the health sciences as well as health equity fields at UU. U-HELM will focus on some of the challenges that trainees from minority and underserved groups as well as other faculty whose research is addressing health equity may face.

Who? 

Current UU postdocs and junior faculty from and/or working with minority or underserved populations who are interested in mentoring, leadership development, and networking.  This is not a research training program and fellows from all areas of University of Utah Health are encouraged to apply.

When? 

Monthly Seminar Series Sessions: 2nd Fridays of each month from 11:30-1:30 pm (October 2018-June 2019)

Visit the U-HELM webpage for more information and to apply.

 

3. Metabolism Core Fuels Innovative Research.

Recent article highlights James Cox, PhD and the Metabolomics Core at the University of Utah. 

Read More

 

 

 

 

 

4.  CIHD Pilot and Feasibility Program Grant Awards 2017

Congratulations to the the following five investigators whose proposals were funded in the CIHD 2017 Pilot and Feasibility Grants Program:

Matthew Barber: Host-pathogen conflicts shaping bloodstream hemeprotein evolution

Adam Hughes: The role of lysosomes in maintenance of cellular iron metabolism

Elizabeth Leibold: Cell-cycle regulation of IRP2 phosphorylation during hematopoiesis

Paul Sigala: Role of Acyl Carrier Protein in Iron/Sulfur Cluster Biogenesis by Malaria Parasites

Diane Ward: The role of Abcb10 in red cell hemoglobinization

 

5. Recent Publications

Current CIHD Highlights and Accomplishments:

New funding/publications received June 2018 – Oct 2018:

DIANE WARD

Publications:

1.Altered sterol metabolism in budding yeast affects mitochondrial iron-sulfur (Fe-S) cluster synthesis.

Ward DM, Chen OS, Li L, Kaplan J, Bhuiyan SA, Natarajan SK, Bard M, Cox JE.

J Biol Chem. 2018 Jul 6;293(27):10782-10795. doi: 10.1074/jbc.RA118.001781. Epub 2018 May 17.

PMID:29773647  PMCID:PMC6036212

 

2.Fetal presentation of congenital dyserythropoietic anemia type 1 with novel compound heterozygous CDAN1 mutations.  Meznarich JA, Draper L, Christensen RD, Yaish HM, Luem ND, Pysher TJ, Jung G, Nemeth E, Ganz T, Ward DM. Blood Cells Mol Dis. 2018 Jul;71:63-66. doi: 10.1016/j.bcmd.2018.03.002. Epub 2018 Mar 20. PMID: 29599085

 

Funding:

received a Friedreich Ataxia Research Foundation Grant 2018-2020 entitled “Identification of the mechanism of oxidant-mediated Yfh1/frataxin turnover and screen for compounds that suppress the effects of reduced Yfh1/frataxin levels”

 

ADAM HUGHES

Funding:

awarded an R01 from NIH/NIA titled “The Role of the Lysosome in Aging.” Preliminary data in the grant was generated with CIHD cores and from funds given through the CIHD pilot grant program.

HARRY DAILEY

Publications:

  1. Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis. Burch JS, Marcero JR, Maschek JA, Cox JE, Jackson LK, Medlock AE, Phillips JD, Dailey HA Jr.Blood. 2018 Sep 6;132(10):987-998. PMID:29991557

 

  1. Disulfide-masked iron prochelators: Effects on cell death, proliferation, and hemoglobin production.

Akam EA, Utterback RD, Marcero JR, Dailey HA, Tomat E. J Inorg Biochem. 2018 Mar;180:186-193.

PMID:29324291

 

  1. Antibacterial photosensitization through activation of coproporphyrinogen oxidase.

Surdel MC, Horvath DJ Jr, Lojek LJ, Fullen AR, Simpson J, Dutter BF, Salleng KJ, Ford JB, Jenkins JL, Nagarajan R, Teixeira PL, Albertolle M, Georgiev IS, Jansen ED, Sulikowski GA, Lacy DB, Dailey HA, Skaar EP. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6652-E6659.

PMID:28739897

 

PAUL SIGALA

Funding:

Two grants that fund projects using CIHD cores:

 

-Dept. of Defense Discovery Award: “Evaluation of Carotenoid Biosynthesis as an Antimalarial Drug Target”

-Pew Biomedical Scholarship: “Unraveling Organelle Function and Adaptation in Malaria Parasites”

 

DEAN TANTIN

Publications:

1.Mol Cancer Res. 2018 Mar;16(3):439-452. doi: 10.1158/1541-7786.MCR-17-0364. Epub 2018 Jan 12.

BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism.Vázquez-Arreguín K1, Maddox J1, Kang J1, Park D2, Cano RR1, Factor RE1, Ludwig T2, Tantin D3.

 

2.Oct1 degradation to promote oxidative metabolism and restrict tumorigenicity. Mol Cancer Res; 16(3); 439-52. ©2018 AACR. PMID: 29330289

 

DENNIS WINGE

Publications:

 

1.ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly. Van Vranken JG, Nowinski SM, Clowers KJ, Jeong MY, Ouyang Y, Berg JA, Gygi JP, Gygi SP, Winge DR, Rutter J. Mol Cell. 2018 Aug 16;71(4):567-580.e4. doi: 10.1016/j.molcel.2018.06.039.

PMID: 30118679

 

JOHN PHILLIPS

Publications:

  1. Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis. Burch JS, Marcero JR, Maschek JA, Cox JE, Jackson LK, Medlock AE, Phillips JD, Dailey HA Jr.Blood. 2018 Sep 6;132(10):987-998. PMID:29991557

 

2.Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes.

Barton JC, McLaren CE, Chen WP, Ramm GA, Anderson GJ, Powell LW, Subramaniam VN, Adams PC, Phatak PD, Gurrin LC, Phillips JD, Parker CJ, Emond MJ, McLaren GD. Ann Hepatol. 2018 Aug 24;17(5):871-879. doi: 10.5604/01.3001.0012.3169.PMID: 30145563