Welcome

NIDDK-Sponsored Center for Iron & Hematology Disorders at The University of Utah School of Medicine

The Center for Iron and Hematology Disorders (CIHD) at the University of Utah School of Medicine consists of three scientific core facilities which include the Mutation Generation & Detection Core, the Metabolomics Core, and the Iron & Heme Core. In addition to these Cores, there is an Enrichment Program, Internal and External Advisory Committees, and a Pilot and Feasibility program for the Center for Iron and Hematology Disorders. These cores offer many different services to a large majority of members within the CIHD as well as The University of Utah. To contact Core directors, find out services provided, and the rates of these services, click on the respective page. To find out upcoming events these Cores and programs will be providing, click on Events Calendar.

News

  1. HELM

Effective mentoring and leadership development are some of the most critical components of a successful academic career. The University of Utah will launch the Utah Health Equity Leadership & Mentoring (U-HELM) program in 2018 with the goal of enhancing the academic excellence and leadership capacity of faculty and postdocs from underrepresented populations in the health sciences as well as health equity fields at UU. U-HELM will focus on some of the challenges that trainees from minority and underserved groups as well as other faculty whose research is addressing health equity may face.

Who? 

Current UU postdocs and junior faculty from and/or working with minority or underserved populations who are interested in mentoring, leadership development, and networking.  This is not a research training program and fellows from all areas of University of Utah Health are encouraged to apply.

When? 

U-HELM Application Deadline: Monday, August 20 at 12pm

Kickoff: Monday, September 17, 2018 from 12:00-4:30 pm

Monthly Seminar Series Sessions: 2nd Fridays of each month from 11:30-1:30 pm (October 2018-June 2019)

Visit the U-HELM webpage for more information and to apply.

 

2. Getting Your Fellowship Funded

This Fall, Professors Suzi Mansour (Human Genetics) and Gary Schoenwolf (Neurobiology and Anatomy) will be leading an intensive hands-on workshop on how to write a fundable fellowship application (including K99/R00 applications). This will be the third time this highly successful workshop has been offered and slots fill up quickly, so we encourage you to respond quickly if interested. ~50% of the past attendees received fellowship funding on their first submission.

The workshop will meet for six 3-hour sessions on Thursdays, beginning on September 6, 2018 and ending on November 15th, with 5 interspersed weeks left unscheduled to allow time to write and revise an application. Each session will occur from 1:00-4:00pm on the Health Sciences Campus in HSEB (Health Sciences Education Building) 2938. The schedule has been designed with the expectation that applications will be completed and submitted for the December NIH NRSA deadline, or similar deadlines for non-NIH fellowships. The workshop is limited to 12 attendees.

If you are interested, please email one or both of us (smansour@genetics.utah.edu; schoenwolf@neuro.utah.edu) providing the following information:

  • Your name:
  • PI’s name, department, and email address:
  • Whether you are a graduate student (list program and must have already passed preliminary exam to be eligible) or postdoctoral fellow, and how long you’ve been in your current lab:
  • If you are a postdoc, the name of the Department and Institution you received your Ph.D. from:
  • A brief abstract (no more than 150 words) of your proposed project listing the question/hypothesis you are addressing, why it is important, and an overview of how you will address the question/hypothesis:
  • The name of the funding agency (e.g., NIH, NSF, American Heart Association, etc.) you will apply to, and the application deadline you are writing for:
  • Whether you will fully participate in this workshop, and whether both you and your PI agree to commit the necessary time to prepare a fundable proposal over the course of the workshop:

 

3. Metabolism Core Fuels Innovative Research.

Recent article highlights James Cox, PhD and the Metabolomics Core at the University of Utah. 

Read More

 

 

 

 

 

4.  CIHD Pilot and Feasibility Program Grant Awards 2017

Congratulations to the the following five investigators whose proposals were funded in the CIHD 2017 Pilot and Feasibility Grants Program:

Matthew Barber: Host-pathogen conflicts shaping bloodstream hemeprotein evolution

Adam Hughes: The role of lysosomes in maintenance of cellular iron metabolism

Elizabeth Leibold: Cell-cycle regulation of IRP2 phosphorylation during hematopoiesis

Paul Sigala: Role of Acyl Carrier Protein in Iron/Sulfur Cluster Biogenesis by Malaria Parasites

Diane Ward: The role of Abcb10 in red cell hemoglobinization

 

5. Recent Publications

Current CIHD Highlights and Accomplishments:

Publications:

* Research results supported by CIHD Core use.

*J. Chung, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, Cantor AB, Maeda T, Phillips JD, Coon JJ, Pagliarini DJ, Dailey HA, Paw BH.  Erythropoietin signaling regulates heme biosynthesis (2017 May 29) eLIFE 6:e24767. PMID: 28553927. PMCID: PMC5478267.

*Seguin A, Takahashi-Makise N, Yien YY, Huston NC, Whitman JC, Musso G, Wallace JA, Bradley T, Bergonia HA, Kafina MD, Matsumoto M, Igarashi K, Phillips JD, Paw BH, Kaplan J, Ward DM. Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes (2017 Sep 29) J. Biol. Chem. 292(39):16284-99. PMID: 28808058. PMCID: PMC5625058 [Available on 2018-09-29].

*Yien YY, Ducamp S, van der Vorm LN, Kardon JR, Manceau H, Kannengiesser C, Bergonia HA, Kafina MD, Karim Z, Gouya L, Baker TA, Puy H, Phillips JD, Nicolas G, Paw BH. Mutation in human CLPX elevates levels of delta-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E8045-E8052. PMID: 28874591. PMCID: PMC5617249 [Available on 2018-03-19].

*Yaish HM, Farrell CP, Christensen RD, MacQueen BC, Jackson LK, Trochez-Enciso J, Kaplan J, Ward DM, Salah WK, Phillips JD. Two novel mutations in TMPRSS6 associated with iron-refractory iron deficiency anemia in a mother and child. Blood Cells Mol Dis. 2017 Jun; 65:38-40. PMID: 28460265. PMCID: PMC5656052.

Li, L, Kaplan, J and Ward, DM. The glucose sensor Snf1 and the transcription factors Msn2 and Msn4 regulate transcription of the vacuolar iron importer gene CCC1 and iron resistance in yeast.  J Biol Chem. 2017 Sep 15; 292(37):15577-15586. PMID: 28760824. PMCID: PMC5602413 [Available on 2018-09-15].

*Seguin, A, Takahashi-Makise, N, Yien, YY, Huston, NC, Whitman, JC, Musso, G, Wallace, JA, Bradley, T, Bergonia, H, Kafina, MD, Matsumoto, M, Igarashi, K, Phillips, JD, Paw, BH, Kaplan, J and Ward, DM.  Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes.  J Biol Chem. 2017 Sep 29; 292(39):16284-16299. PMID: 28808058. PMCID: PMC5625058 [Available on 2018-09-29].

*Goldberg DE, Sigala PA. Plasmodium heme biosynthesis: To be or not to be essential? PLoS Pathog. 2017 Sep 28;13(9):e1006511. PMID: 28957449. PMCID: PMC5619821.