2024 Publications

November

Mitochondrial-derived compartments are multilamellar domains that encase membrane cargo and cytosol.

Wilson ZN, West M, English AM, Odorizzi G, Hughes AL.J Cell Biol. 2024 Nov 4;223(11):e202307035. doi: 10.1083/jcb.202307035. Epub 2024 Aug 13.PMID: 39136939

 

Mitochondrial-derived compartments remove surplus proteins from the outer mitochondrial membrane.

Wilson ZN, Balasubramaniam SS, Wong S, Schuler MH, Wopat MJ, Hughes AL.J Cell Biol. 2024 Nov 4;223(11):e202307036. doi: 10.1083/jcb.202307036. Epub 2024 Aug 13.PMID: 39136938

 

October

Cellular taxonomy of the preleukemic bone marrow niche of acute myeloid leukemia.

Goda C, Kulkarni R, Bustos Y, Li W, Rudich A, Balcioglu O, Chidester S, Urs AP, Karunasiri M, Al-Marrawi Y, Korn E, Kanna S, Garfinkle EAR, Shah N, Wooten A, Mundy-Bosse B, Sehgal L, Zhang B, Marcucci G, Mardis ER, Garzon R, Bowman RL, Viny AD, Miles LA, Miller KE, Dorrance AM.Leukemia. 2024 Oct 2. doi: 10.1038/s41375-024-02415-3. Online ahead of print.PMID: 39358541

 

The number of blood transfusions received and the incidence and severity of chronic lung disease among NICU patients born >31 weeks gestation.

Bahr TM, Ohls RK, Henry E, Davenport P, Ilstrup SJ, Kelley WE, Yoder BA, Sola-Visner MC, Christensen RD.J Perinatol. 2024 Oct 15. doi: 10.1038/s41372-024-02135-7. Online ahead of print.PMID: 39402132


Prospective, international, multisite comparison of platelet isolation techniques for genome-wide transcriptomics: communication from the SSC of the ISTH.

Banerjee M, Rowley JW, Stubben CJ, Tolley ND, Freson K, Nelson B, Nagy B Jr, Fejes Z, Blair AM, Turro E, Gresele P, Taranta GC, Bury L, Falcinelli E, Lordkipanidzé M, Alessi MC, Johnson AD, Bakchoul T, Ramstrom S, Frontini M, Camera M, Brambilla M, Campbell RA, Rondina MT.J Thromb Haemost. 2024 Oct;22(10):2922-2934. doi: 10.1016/j.jtha.2024.06.017. Epub 2024 Jul 3.PMID: 38969303

 

 

September 2024

What does the FOX(O) say? High iron: hepcidin!

Yien YY.Blood. 2024 Sep 19;144(12):1243-1245. doi: 10.1182/blood.2024025595.PMID: 39298162

Spns1 is an iron transporter essential for megalin-dependent endocytosis.

Beenken A, Shen T, Jin G, Ghotra A, Xu K, Nesanir K, Sturley RE, Vijayakumar S, Kahn A, Levitman A, Stauber J, Chavez EY, Robbins-Juarez SY, Hao L, Field TB, Erdjument-Bromage H, Neubert TA, Shapiro L, Qiu A, Barasch J.Am J Physiol Renal Physiol. 2024 Sep 12. doi: 10.1152/ajprenal.00172.2024. Online ahead of print.PMID: 39265081

Update on heme biosynthesis, tissue-specific regulation, heme transport, relation to iron metabolism and cellular energy.

Belot A, Puy H, Hamza I, Bonkovsky HL.Liver Int. 2024 Sep;44(9):2235-2250. doi: 10.1111/liv.15965. Epub 2024 Jun 18.PMID: 38888238

HAF prevents hepatocyte apoptosis and progression to MASH and hepatocellular carcinoma through transcriptional regulation of the NF-κB pathway.

Acuña-Pilarte K, Reichert EC, Song Green Y, Halberg LM, Golkowski M, Maguire KM, Mimche PN, Kamdem SD, Hu PA, Wright J, Ducker GS, Voth WP, O’Connell RM, McFarland SA, Egal ESA, Chaix A, Summers SA, Reelitz JW, Maschek JA, Cox JE, Evason KJ, Koh MY.Hepatology. 2024 Sep 10. doi: 10.1097/HEP.0000000000001070. Online ahead of print.PMID: 39255518

The prodomain of bone morphogenetic protein 2 promotes dimerization and cleavage of BMP6 homodimers and BMP2/6 heterodimers.

Chauhan P, Xue Y, Kim HS, Fisher AL, Babitt JL, Christian JL.J Biol Chem. 2024 Sep 19;300(10):107790. doi: 10.1016/j.jbc.2024.107790. Online ahead of print.PMID: 39303917

Instantaneous visual genotyping and facile site-specific transgenesis via CRISPR-Cas9 and phiC31 integrase.

Ma J, Zhang W, Rahimialiabadi S, Ganesh NU, Sun Z, Parvez S, Peterson RT, Yeh JJ.Biol Open. 2024 Sep 15;13(9):bio061666. doi: 10.1242/bio.061666. Epub 2024 Sep 3.PMID: 39225039

Aging-related alterations in mechanistic target of rapamycin signaling promote platelet hyperreactivity and thrombosis.

Portier I, Manne BK, Kosaka Y, Tolley ND, Denorme F, Babur Ö, Reddy AP, Wilmarth PA, Aslan JE, Weyrich AS, Rondina MT, Campbell RA.J Thromb Haemost. 2024 Sep;22(9):2576-2588. doi: 10.1016/j.jtha.2024.05.025. Epub 2024 Jun 6.PMID: 38849085

 

August 2024

Direct Spectroscopic Ferrochelatase Assay.
Dailey HA, Medlock AE.Methods Mol Biol. 2024;2839:243-247. doi: 10.1007/978-1-0716-4043-2_14.PMID: 39008258

Congenital erythropoietic porphyria.
To-Figueras J, Erwin AL, Aguilera P, Millet O, Desnick RJ.Liver Int. 2024 Aug;44(8):1842-1855. doi: 10.1111/liv.15958. Epub 2024 May 8.PMID: 38717058

Methods for Cultivation of Bacteroides thetaiotaomicron and Analysis of Heme Metabolism by Mass Spectrometry and Spectroscopic Approaches.
da Silva RR, Adedoyin V, DuBois JL.Methods Mol Biol. 2024;2839:113-130. doi: 10.1007/978-1-0716-4043-2_7.PMID: 39008251

Maternal prolactin or estrogen signaling in hepatocytes does not regulate iron homeostasis during pregnancy.
Zhang V, Fisher AL, Hewitt MS, Ganz T, Nemeth E, Sangkhae V.Haematologica. 2024 Aug 1. doi: 10.3324/haematol.2024.285456. Online ahead of print.PMID: 39086305

Proximity Ligation Assay for the Analysis of Iron-Mediated Protein-Protein Interactions in the Nucleus.
Novoa-Aponte L, Philpott CC.Methods Mol Biol. 2024;2839:53-75. doi: 10.1007/978-1-0716-4043-2_4.PMID: 39008248

Fluorometric Methods to Measure Bioavailable and Total Heme.
Dominic IM, Willoughby MM, Freer AK, Moore CM, Donegan RK, Martinez-Guzman O, Hanna DA, Reddi AR.Methods Mol Biol. 2024;2839:151-194. doi: 10.1007/978-1-0716-4043-2_9.PMID: 39008253

Radiolabeling Heme and Porphyrin with 14C-Glycine or 14C δ-Aminolevulinic Acid.
Ward DM, Gillis S, Yien YY.Methods Mol Biol. 2024;2839:225-231. doi: 10.1007/978-1-0716-4043-2_12.PMID: 39008256

Improving CORM technology for the treatment of delayed hemolytic transfusion reaction.
Asperti M, Vinchi F.Hemasphere. 2024 Aug 5;8(8):e140. doi: 10.1002/hem3.140. eCollection 2024 Aug.PMID: 39104765

 

July 2024

Recommendations for diagnosis, treatment, and prevention of iron deficiency and iron deficiency anemia.
Iolascon A, Andolfo I, Russo R, Sanchez M, Busti F, Swinkels D, Aguilar Martinez P, Bou-Fakhredin R, Muckenthaler MU, Unal S, Porto G, Ganz T, Kattamis A, De Franceschi L, Cappellini MD, Munro MG, Taher A; from EHA‐SWG Red Cell and Iron.Hemasphere. 2024 Jul 15;8(7):e108. doi: 10.1002/hem3.108. eCollection 2024 Jul.PMID: 39011129

Heme- and iron-activated macrophages in sickle cell disease: an updated perspective.
Navaneethabalakrishnan S, An X, Vinchi F.Curr Opin Hematol. 2024 Jul 17. doi: 10.1097/MOH.0000000000000836. Online ahead of print.PMID: 39046855

Novel germline JAK2R715T mutation causing PV-like erythrocytosis in 3 generations. Amelioration by Ropeg-Interferon.
Song J, Lanikova L, Kim SJ, Papadopoulos N, Meznarich J, Constantinescu SN, Parsegov B, Prchal JT.Am J Hematol. 2024 Jul;99(7):1220-1229. doi: 10.1002/ajh.27311. Epub 2024 Apr 17.PMID: 38629639

Epithelial cell states associated with kidney and allograft injury.
Hinze C, Lovric S, Halloran PF, Barasch J, Schmidt-Ott KM.Nat Rev Nephrol. 2024 Jul;20(7):447-459. doi: 10.1038/s41581-024-00834-0. Epub 2024 Apr 17.PMID: 38632381

Treating preterm infants with erythropoietin does not increase the risk of retinopathy of prematurity.
Bahr TM, Ohls RK, Christensen RD.J Perinatol. 2024 Jul 18. doi: 10.1038/s41372-024-02047-6. Online ahead of print.PMID: 39025955

Complementing evidence-based restrictive neonatal intensive care unit platelet transfusion guidelines.
Christensen RD, Bahr TM, Davenport P, Sola-Visner MC, Ohls RK, Ilstrup SJ, Kelley WE.J Perinatol. 2024 Jul 16. doi: 10.1038/s41372-024-02050-x. Online ahead of print.PMID: 39009717

Prenatal inflammation remodels lung immunity and function by programming ILC2 hyperactivation.
López DA, Griffin A, Aguilar LM, Deering-Rice C, Myers EJ, Warren KJ, Welner RS, Beaudin AE.Cell Rep. 2024 Jul 23;43(7):114365. doi: 10.1016/j.celrep.2024.114365. Epub 2024 Jun 22.PMID: 38909363

Consistency of Spleen and Symptom Reduction Regardless of Cytopenia in Patients With Myelofibrosis Treated With Pacritinib.
Gagelmann N, Bose P, Gupta V, McLornan DP, Vachhani P, Al-Ali HK, Ali H, Treskes P, Buckley S, Roman-Torres K, Scott B.Clin Lymphoma Myeloma Leuk. 2024 Jul 2:S2152-2650(24)00246-5. doi: 10.1016/j.clml.2024.06.012. Online ahead of print.PMID: 39034203

Prospective, international, multisite comparison of platelet isolation techniques for genome-wide transcriptomics: communication from the SSC of the ISTH.
Banerjee M, Rowley JW, Stubben CJ, Tolley ND, Freson K, Nelson B, Nagy B Jr, Fejes Z, Blair AM, Turro E, Gresele P, Taranta GC, Bury L, Falcinelli E, Lordkipanidzé M, Alessi MC, Johnson AD, Bakchoul T, Ramstrom S, Frontini M, Camera M, Brambilla M, Campbell RA, Rondina MT.J Thromb Haemost. 2024 Jul 3:S1538-7836(24)00376-3. doi: 10.1016/j.jtha.2024.06.017. Online ahead of print.PMID: 38969303

Neonatal NET-inhibitory factor inhibits macrophage extracellular trap formation.
Bircher JS, Denorme F, Cody MJ, de Araujo CV, Petrey AC, Middleton EA, Campbell RA, Yost CC.Blood Adv. 2024 Jul 23;8(14):3686-3690. doi: 10.1182/bloodadvances.2024013094.PMID: 38810257

Vitamin B5 metabolism is essential for vacuolar and mitochondrial functions and drug detoxification in fungi.
Choi JY, Gihaz S, Munshi M, Singh P, Vydyam P, Hamel P, Adams EM, Sun X, Khalimonchuk O, Fuller K, Ben Mamoun C.Commun Biol. 2024 Jul 23;7(1):894. doi: 10.1038/s42003-024-06595-7.PMID: 39043829

N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma.
Geroyska S, Mejia I, Chan AA, Navarrete M, Pandey V, Kharpatin S, Noguti J, Wang F, Srole D, Chou TF, Wohlschlegel J, Nemeth E, Damoiseaux R, Shackelford DB, Lee DJ, Díaz B.Cancer Res Commun. 2024 Jul 1;4(7):1815-1833. doi: 10.1158/2767-9764.CRC-23-0428.PMID: 38949950

Enhancing mitochondrial pyruvate metabolism ameliorates ischemic reperfusion injury in the heart.
Visker JR, Cluntun AA, Velasco-Silva JN, Eberhardt DR, Cedeno-Rosario L, Shankar TS, Hamouche R, Ling J, Kwak H, Hillas JY, Aist I, Tseliou E, Navankasattusas S, Chaudhuri D, Ducker GS, Drakos SG, Rutter J.JCI Insight. 2024 Jul 25:e180906. doi: 10.1172/jci.insight.180906. Online ahead of print.PMID: 39052437

 

June 2024

Multiple Infections, Nutrient Deficiencies, and Inflammation as Determinants of Anemia and Iron Status during Pregnancy: The MINDI Cohort.
González-Fernández D, Nemeth E, Pons EDC, Rueda D, Sinisterra OT, Murillo E, Sangkhae V, Starr L, Scott ME, Koski KG.Nutrients. 2024 Jun 2;16(11):1748. doi: 10.3390/nu16111748.PMID: 38892681

Update on heme biosynthesis, tissue-specific regulation, heme transport, relation to iron metabolism and cellular energy.
Belot A, Puy H, Hamza I, Bonkovsky HL.Liver Int. 2024 Jun 18. doi: 10.1111/liv.15965. Online ahead of print.PMID: 38888238

Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice.
Fisher AL, Phillips S, Wang CY, Paulo JA, Xiao X, Moschetta GA, Sridhar A, Mancias JD, Babitt JL.Blood. 2024 Jun 6;143(23):2433-2437. doi: 10.1182/blood.2023023385.PMID: 38518102

An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis.
Poscablo DM, Worthington AK, Smith-Berdan S, Rommel MGE, Manso BA, Adili R, Mok L, Reggiardo RE, Cool T, Mogharrab R, Myers J, Dahmen S, Medina P, Beaudin AE, Boyer SW, Holinstat M, Jonsson VD, Forsberg EC.Cell. 2024 Jun 6;187(12):3090-3107.e21. doi: 10.1016/j.cell.2024.04.018. Epub 2024 May 14.PMID: 38749423

Aging-related alterations in mechanistic target of rapamycin signaling promote platelet hyperreactivity and thrombosis.
Portier I, Manne BK, Kosaka Y, Tolley ND, Denorme F, Babur Ö, Reddy AP, Wilmarth PA, Aslan JE, Weyrich AS, Rondina MT, Campbell RA.J Thromb Haemost. 2024 Jun 6:S1538-7836(24)00317-9. doi: 10.1016/j.jtha.2024.05.025. Online ahead of print.PMID: 38849085

Low-Iron Diet-Induced Fatty Liver Development Is Microbiota Dependent and Exacerbated by Loss of the Mitochondrial Iron Importer Mitoferrin2.
Klag KA, Bell R, Jia X, Seguin A, Maschek JA, Bronner M, Cox JE, Round JL, Ward DM.Nutrients. 2024 Jun 8;16(12):1804. doi: 10.3390/nu16121804.PMID: 38931165

Impact of Phosphorylation at Various Sites on the Active Pocket of Human Ferrochelatase: Insights from Molecular Dynamics Simulations.
Guo M, Lin Y, Obi CD, Zhao P, Dailey HA, Medlock AE, Shen Y.Int J Mol Sci. 2024 Jun 8;25(12):6360. doi: 10.3390/ijms25126360.PMID: 38928065

Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints.
Veit EC, Salim MS, Jung MJ, Richardson RB, Boys IN, Quinlan M, Barrall EA, Bednarski E, Hamilton RE, Kikawa C, Elde NC, García-Sastre A, Evans MJ.Nat Commun. 2024 Jun 26;15(1):5426. doi: 10.1038/s41467-024-49758-0.PMID: 38926343

Understanding the stability of a plastic-degrading Rieske iron oxidoreductase system. Beech JL, Maurya AK, Rodrigues da Silva R, Akpoto E, Asundi A, Fecko JA, Yennawar NH, Sarangi R, Tassone C, Weiss TM, DuBois JL.Protein Sci. 2024 Jun;33(6):e4997. doi: 10.1002/pro.4997.PMID: 38723110

Neonatal and Obstetrical Outcomes of Pregnancies Complicated by Alloimmunization. Bahr TM, Tweddell SM, Zalla JM, Dizon-Townson D, Ohls RK, Henry E, Ilstrup SJ, Kelley WE, Ling CY, Lindgren PC, O’Brien EA, Christensen RD.Pediatrics. 2024 Jun 1;153(6):e2023064604. doi: 10.1542/peds.2023-064604.PMID: 38784990

Iron Deficiency and Incident Heart Failure in Older Community-Dwelling Individuals. Sharma S, Katz R, Chaves PHM, Hoofnagle AN, Kizer JR, Bansal N, Ganz T, Ix JH.ESC Heart Fail. 2024 Jun;11(3):1435-1442. doi: 10.1002/ehf2.14724. Epub 2024 Feb 26.PMID: 38407565

SET domain containing 2 promotes megakaryocyte polyploidization and platelet generation through methylation of α-tubulin. Chen L, Liu J, Chen K, Su Y, Chen Y, Lei Y, Si J, Zhang J, Zhang Z, Zou W, Zhang X, Rondina MT, Wang QF, Li Y.J Thromb Haemost. 2024 Jun;22(6):1727-1741. doi: 10.1016/j.jtha.2024.03.010. Epub 2024 Mar 25.PMID: 38537781

Evaluation of EGFR and COX pathway inhibition in human colon organoids of serrated polyposis and other hereditary cancer syndromes. Kanth P, Hazel MW, Schell JC, Rutter J, Yao R, Mills AP, Delker DA.Fam Cancer. 2024 Apr 12. doi: 10.1007/s10689-024-00370-7. Online ahead of print.PMID: 38609520

 

May 2024

Low-Titer Type O Whole Blood for Transfusing Perinatal Patients after Acute Hemorrhage: A Case Series. Carr NR, Bahr TM, Ohls RK, Tweddell SM, Morris DS, Rees T, Ilstrup SJ, Kelley WE, Christensen RD. AJP Rep. 2024 May 3;14(2):e129-e132. doi: 10.1055/s-0044-1786712. eCollection 2024 Apr.PMID: 38707262 

Oct4 redox sensitivity potentiates reprogramming and differentiation. Shen Z, Wu Y, Manna A, Yi C, Cairns BR, Evason KJ, Chandrasekharan MB, Tantin D. GenesDev. 2024 May 21;38(7-8):308-321. doi: 10.1101/gad.351411.123.PMID: 38719541

An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis. Poscablo DM, Worthington AK, Smith-Berdan S, Rommel MGE, Manso BA, Adili R, Mok L, Reggiardo RE, Cool T, Mogharrab R, Myers J, Dahmen S, Medina P, Beaudin AE, Boyer SW, Holinstat M, Jonsson VD, Forsberg EC.Cell. 2024 May 8:S0092-8674(24)00413-6. doi: 10.1016/j.cell.2024.04.018. Online ahead of print.PMID: 38749423

Neonatal NET-Inhibitory Factor inhibits macrophage extracellular trap formation. Bircher JS, Denorme F, Cody MJ, de Araujo CV, Petrey AC, Middleton EA, Campbell RA, Yost CC.Blood Adv. 2024 May 29:bloodadvances.2024013094. doi: 10.1182/bloodadvances.2024013094. Online ahead of print.

Molecular mechanism of choline and ethanolamine transport in humans. Ri K, Weng TH, Claveras Cabezudo A, Jösting W, Zhang Y, Bazzone A, Leong NCP, Welsch S, Doty RT, Gursu G, Lim TJY, Schmidt SL, Abkowitz JL, Hummer G, Wu D, Nguyen LN, Safarian S.Nature. 2024 May 22. doi: 10.1038/s41586-024-07444-7. Online ahead of print.PMID: 38778100

 Microbe transmission from pet shop to lab-reared zebrafish reveals a pathogenic birnavirus. Rice MC, Janik AJ, Elde NC, Gagnon JA, Balla KM.PLoS Biol. 2024 May 30;22(5):e3002606. doi: 10.1371/journal.pbio.3002606. eCollection 2024 May.PMID: 38814944

GAGE-seq concurrently profiles multiscale 3D genome organization and gene expression in single cells. Zhou T, Zhang R, Jia D, Doty RT, Munday AD, Gao D, Xin L, Abkowitz JL, Duan Z, Ma J.NatGenet. 2024 May 14. doi: 10.1038/s41588-024-01745-3. Online ahead of print.PMID: 38744973

Dose-Adjusted EPOCH Plus Inotuzumab Ozogamicin in Adults With Relapsed or Refractory B-Cell ALL: A Phase 1 Dose-Escalation Trial. Kopmar NE, Quach K, Gooley TA, Martino CH, Cherian S, Percival MM, Halpern AB, GhiuzeliCM, Oehler VG, Abkowitz JL, Walter RB, Cassaday RD.JAMA Oncol. 2024 May 9:e240967. doi: 10.1001/jamaoncol.2024.0967. Online ahead of print.PMID: 38722664

Treatment of refractory/relapsed Diamond-Blackfan anaemia with eltrombopag. Duncan BB, Lotter JL, Superata J, Barranta ME, Machado T, Darden I, Venugopal S, Wu CO, Abkowitz JL, Dunbar CE, Young DJ.Br J Haematol. 2024 May;204(5):2077-2085. doi: 10.1111/bjh.19357. Epub 2024 Mar 10.PMID: 38462764

Phospholipid isotope tracing suggests β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma. VanSant-Webb C, Low HK, Kuramoto J, Stanley CE, Qiang H, Su AY, Ross AN, Cooper CG, Cox JE, Summers SA, Evason KJ, Ducker GS.Biochim Biophys Acta Mol Cell Biol Lipids. 2024 May 23;1869(6):159514. doi: 10.1016/j.bbalip.2024.159514. Online ahead of print.PMID: 38795827

Hyperferritinemia among very-low-birthweight infants in Thailand: a prospective cohort study. Laohajeeraphan C, Tantanate C, Christensen RD, Ngerncham S.J Perinatol. 2024 May;44(5):709-716. doi: 10.1038/s41372-023-01839-6. Epub 2023 Dec 7.PMID: 38062158

The phospholipids cardiolipin and phosphatidylethanolamine differentially regulate MDC biogenesis. Xiao T, English AM, Wilson ZN, Maschek JA, Cox JE, Hughes AL. J Cell Biol. 2024 May 6;223(5):e202302069. doi: 10.1083/jcb.202302069. Epub 2024 Mar 18.PMID: 38497895

The clinical management of porphyria cutanea tarda: An update. Sarkany RPE, Phillips JD.Liver Int. 2024 May 30. doi: 10.1111/liv.15980. Online ahead of print.PMID: 38813949

The mechanism of covalent inhibition of LAR phosphatase by illudalic acid. Hansen DT, Rueb NJ, Levinzon ND, Cheatham TE 3rd, Gaston R Jr, Tanvir Ahmed K, Osburn-Staker S, Cox JE, Dudley GB, Barrios AM.Bioorg Med Chem Lett. 2024 May 15;104:129740. doi: 10.1016/j.bmcl.2024.129740. Epub 2024 Apr 9.PMID: 38599294

Congenital erythropoietic porphyria. To-Figueras J, Erwin AL, Aguilera P, Millet O, Desnick RJ.Liver Int. 2024 May 8. doi: 10.1111/liv.15958. Online ahead of print.PMID: 38717058

 

April 2024

Novel germline JAK2R715T mutation causing PV-like erythrocytosis in 3 generations. Amelioration by Ropeg-Interferon. Song J, Lanikova L, Kim SJ, Papadopoulos N, Meznarich J, Constantinescu SN, ParsegovB, Prchal JF, Prchal JT.Am J Hematol. 2024 Apr 17. doi: 10.1002/ajh.27311. Online ahead of print.PMID: 38629639

Iron biology. Del Vecchio L, Girelli D, Vinchi F, Cozzolino M, Elliott S, Mark PB, Valenti L, Qian C, Guo Q, Qian ZM, Ciceri P, Locatelli F.Nephrol Dial Transplant. 2024 Apr 24:gfae095. doi: 10.1093/ndt/gfae095. Online ahead of print.PMID: 38658189

Utility of Blood Biomarkers to Predict Marrow Iron Stores in Children. Sharma S, Pereira RC, Nemeth E, Hanudel MR, Ix JH, Salusky IB, Ganz T.Clin J Am Soc Nephrol. 2024 Apr 30. doi: 10.2215/CJN.0000000000000469. Online ahead of print.PMID: 38687125

Diabetes and pancreatic cancer risk in a multiracial cohort. Conway RBN, Hudson AG, Munro H, Fu D, McClain DA, Blot WJ.Diabet Med. 2024 Apr;41(4):e15234. doi: 10.1111/dme.15234. Epub 2023 Oct 15.PMID: 37779225

Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism. Siripoksup P, Cao G, Cluntun AA, Maschek JA, Pearce Q, Brothwell MJ, Jeong MY, Eshima H, Ferrara PJ, Opurum PC, Mahmassani ZS, Peterlin AD, Watanabe S, Walsh MA, Taylor EB, Cox JE, Drummond MJ, Rutter J, Funai K.J Clin Invest. 2024 Apr 23;134(11):e167371. doi: 10.1172/JCI167371.PMID: 38652544

Anderson-Fabry disease management: role of the cardiologist. Pieroni M, Namdar M, Olivotto I, Desnick RJ.Eur Heart J. 2024 Apr 21;45(16):1395-1409. doi: 10.1093/eurheartj/ehae148.PMID: 38486361

A survey of iron supplementation, iron status surveillance, and erythropoiesis stimulating agent use in level III NICUs in the United States. Tuttle JJ, Bahr TM, Tweddell SM, Christensen RD, Ohls RK.J Perinatol. 2024 Apr 25. doi: 10.1038/s41372-024-01950-2. Online ahead of print.PMID: 38664494 

Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5 for Ubiquitylation and Degradation. Swenson SA, Dobish KK, Peters HC, Bea Winship C, Willow Hynes-Smith R, Caplan M, Wittorf KJ, Ghosal G, Buckley SM.Stem Cells. 2024 Apr 15;42(4):317-328. doi: 10.1093/stmcls/sxae004.PMID: 38227647

Epithelial cell states associated with kidney and allograft injury. Hinze C, Lovric S, Halloran PF, Barasch J, Schmidt-Ott KM.Nat Rev Nephrol. 2024 Apr 17. doi: 10.1038/s41581-024-00834-0. Online ahead of print.PMID: 38632381

 

March 2024

Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice. Fisher AL, Phillips S, Wang CY, Paulo JA, Xiao X, Moschetta GA, Sridhar A, ManciasJD, Babitt JL.Blood. 2024 Mar 22:blood.2023023385. doi: 10.1182/blood.2023023385.

The alternative coproporphyrinogen III oxidase (CgoN) catalyzes the oxygen-independent conversion of coproporphyrinogen III into coproporphyrin III. Mingers T, Barthels S, Mass V, Acuña JMB, Biedendieck R, Cooke A, Dailey TA, Gerdes S, Blankenfeldt W, Dailey HA, Warren MJ, Jahn M, Jahn D.Front Microbiol. 2024 Mar 13;15:1378989. doi: 10.3389/fmicb.2024.1378989. eCollection 2024.PMID: 38544863

HJV mutations causing hemochromatosis: variable phenotypic expression in a pair of twins. Vadivelan A, Zhang S, Srole DN, Marcus EA, Neto GC, Nemeth E, Ganz T, De Oliveira S.Haematologica. 2024 Mar 7. doi: 10.3324/haematol.2023.284134. Online ahead of print.PMID: 38450514

Measurement of red cell, plasma and blood volume: Essential components of diagnostic and research studies of oxygen transport. Lichtman MA, Prchal JT.Blood Cells Mol Dis. 2024 Mar;105:102819. doi: 10.1016/j.bcmd.2023.102819. Epub 2023 Dec 7.PMID: 38101224

 

February 2024

Iron Deficiency and Incident Heart Failure in Older Community-Dwelling Individuals. Sharma S, Katz R, Chaves PHM, Hoofnagle AN, Kizer JR, Bansal N, Ganz T, Ix JH.ESC Heart Fail. 2024 Feb 26. doi: 10.1002/ehf2.14724. Online ahead of print.PMID: 38407565

Iron restriction in sickle cell disease: When less is more. Castro OL, De Franceschi L, Ganz T, Kanter J, Kato GJ, Pasricha SR, Rivella S, Wood JC.Am J Hematol. 2024 Feb 23. doi: 10.1002/ajh.27267. Online ahead of print.PMID: 38400590

Finding a fountain of youth in the blood. Portier I, Andrianova I, Campbell RA.J Thromb Haemost. 2024 Feb;22(2):311-314. doi: 10.1016/j.jtha.2023.10.024. Epub 2023 Nov 7.PMID: 37940049

Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration. Byrnes JR, Lee T, Sharaby S, Campbell RA, Dobson DA, Holle LA, Luo M, Kangro K, Homeister JW, Aleman MM, Luyendyk JP, Kerlin BA, Dumond JB, Wolberg AS.Blood. 2024 Feb 1;143(5):444-455. doi: 10.1182/blood.2023022042.PMID: 37883802

Inhibition of the skeletal muscle Lands cycle ameliorates weakness induced by physical inactivity. Shahtout JL, Eshima H, Ferrara PJ, Maschek JA, Cox JE, Drummond MJ, Funai K.J Cachexia Sarcopenia Muscle. 2024 Feb;15(1):319-330. doi: 10.1002/jcsm.13406. Epub 2023 Dec 20.PMID: 38123161

A shift between mineral and nonmineral sources of iron and sulfur causes proteome-wide changes in Methanosarcina barkeri. Fausset H, Spietz RL, Cox S, Cooper G, Spurzem S, Tokmina-Lukaszewska M, DuBois J, Broderick JB, Shepard EM, Boyd ES, Bothner B.Microbiol Spectr. 2024 Feb 6;12(2):e0041823. doi: 10.1128/spectrum.00418-23. Epub 2024 Jan 5.PMID: 38179920 Free PMC article.

Homologous acetone carboxylases select Fe(II) or Mn(II) as the catalytic cofactor. Shisler KA, Kincannon WM, Mattice JR, Larson J, Valaydon-Pillay A, Mus F, Flusche T, Kumar Nath A, Stoian SA, Raugei S, Bothner B, DuBois JL, Peters JW.mBio. 2024 Feb 14;15(2):e0298723. doi: 10.1128/mbio.02987-23. Epub 2023 Dec 21.PMID: 38126751

Durable CD4+ T cell immunity: cherchez la stem. Hughes EP, Syage AR, Tantin D. Trends Immunol. 2024 Feb 21:S1471-4906(24)00004-8. doi: 10.1016/j.it.2024.01.004. Online ahead of print.PMID: 38388231

OCA-B/Pou2af1 is sufficient to promote CD4+ T cell memory and prospectively identifies memory precursors. Sun W, Hughes EP, Kim H, Perovanovic J, Charley KR, Perkins B, Du J, Ibarra A, Syage AR, Hale JS, Williams MA, Tantin D.Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2309153121. doi: 10.1073/pnas.2309153121. Epub 2024 Feb 22.PMID: 38386711

 

January 2024

Novel frontiers in gene therapy: In vivo gene editing. Vinchi F. Hemasphere. 2024 Jan 28;8(1):e25. doi: 10.1002/hem3.25. eCollection 2024 Jan.PMID: 38434529

Measurement of red cell, plasma, and blood volume: A perspective. Prchal JT, Lichtman MA.Am J Hematol. 2024 Jan;99(1):9-11. doi: 10.1002/ajh.27158. Epub 2023 Nov 15.PMID: 37966977

Ubiquitin E3 ligase FBXO9 regulates pluripotency by targeting DPPA5 for ubiquitylation and degradation. Swenson SA, Dobish KK, Peters HC, Winship CB, Hynes-Smith RW, Caplan M, Wittorf KJ, Ghosal G, Buckley SM.Stem Cells. 2024 Jan 16:sxae004. doi: 10.1093/stmcls/sxae004. Online ahead of print.PMID: 38227647

Recurrent viral capture of cellular phosphodiesterases that antagonize OAS-RNase L. Goldstein SA, Elde NC.Proc Natl Acad Sci U S A. 2024 Jan 30;121(5):e2312691121. doi: 10.1073/pnas.2312691121. Epub 2024 Jan 26.PMID: 38277437

Immunothrombosis in neurovascular disease. Denorme F, Ajanel A, Campbell RA.Res Pract Thromb Haemost. 2023 Dec 20;8(1):102298. doi: 10.1016/j.rpth.2023.102298. eCollection 2024 Jan.PMID: 38292352

Mitofusin-2 Regulates Platelet Mitochondria and Function. Jacob S, Kosaka Y, Bhatlekar S, Denorme F, Benzon H, Moody A, Moody V, Tugolukova EA, Hull G, Kishimoto N, Manne BK, Guo L, Souvenir R, Seliger BJ, Eustes AS, Hoerger K, Tolley ND, Fatahian AN, Boudina S, Christiani DC, Wei Y, Ju C, Campbell RA, Rondina MT, Abel ED, Bray PF, Weyrich AS, Rowley JW.Circ Res. 2024 Jan 19;134(2):143-161. doi: 10.1161/CIRCRESAHA.123.322914. Epub 2023 Dec 29.PMID: 38156445

Erythrokinetic mechanism(s) causing the “late anemia” of hemolytic disease of the fetus and newborn. Christensen RD, Bahr TM, Ohls RK, Ilstrup SJ, Moise KJ Jr, Lopriore E, Meznarich JA.J Perinatol. 2024 Jan 12. doi: 10.1038/s41372-024-01872-z. Online ahead of print.PMID: 38216678

Lactate administration improves laboratory parameters in murine models of iron overload. Liu W, Wu Y, Wei H, Ma J, Feng W, Yang Q, Zhang S, Ganz T, Liu S.Blood. 2024 Jan 9:blood.2023021695. doi: 10.1182/blood.2023021695. Online ahead of print.PMID: 38194678

Exploring the relationship between hyperlactatemia and anemia. Zhang S, Liu W, Ganz T, Liu S.Trends Endocrinol Metab. 2024 Jan 6:S1043-2760(23)00251-5. doi: 10.1016/j.tem.2023.12.006. Online ahead of print.PMID: 38185594

Placental ferroportin protein abundance is associated with neonatal erythropoietic activity and iron status in newborns at high risk for iron deficiency and anemia. Barad A, Guillet R, Pressman EK, Katzman PJ, Ganz T, Nemeth E, O’Brien KO.Am J Clin Nutr. 2024 Jan;119(1):76-86. doi: 10.1016/j.ajcnut.2023.10.022. Epub 2023 Oct 27.PMID: 37890671

2023 Publications

December 2023

Cimetidine Does Not Inhibit 5-Aminolevulinic Acid Synthase or Heme Oxygenase Activity: Implications for Treatment of Acute Intermittent Porphyria and Erythropoietic Protoporphyria. Yasuda M, Lee S, Gan L, Bergonia HA, Desnick RJ, Phillips JD.Biomolecules. 2023 Dec 24;14(1):27. doi: 10.3390/biom14010027.PMID: 38254627

The hepatokine FGL1 regulates hepcidin and iron metabolism during anemia in mice by antagonizing BMP signaling. Sardo U, Perrier P, Cormier K, Sotin M, Personnaz J, Medjbeur T, Desquesnes A, Cannizzo L, Ruiz-Martinez M, Thevenin J, Billoré B, Jung G, Abboud E, Peyssonnaux C, Nemeth E, Ginzburg YZ, Ganz T, Kautz L.Blood. 2023 Dec 24:blood.2023022724. doi: 10.1182/blood.2023022724. Online ahead of print.PMID: 38232308

Characterization of erythroferrone structural domains relevant to its iron-regulatory function. Srole DN, Jung G, Waring AJ, Nemeth E, Ganz T.J Biol Chem. 2023 Dec;299(12):105374. doi: 10.1016/j.jbc.2023.105374. Epub 2023 Oct 20.PMID: 37866631

Role of Anemia in Dementia Risk Among Veterans With Incident CKD. Koyama AK, Nee R, Yu W, Choudhury D, Heng F, Cheung AK, Norris KC, Cho ME, Yan G.Am J Kidney Dis. 2023 Dec;82(6):706-714. doi: 10.1053/j.ajkd.2023.04.013. Epub 2023 Jul 28.PMID: 37516301
Hyperferritinemia among very-low-birthweight infants in Thailand: a prospective cohort study. Laohajeeraphan C, Tantanate C, Christensen RD, Ngerncham S.J Perinatol. 2023 Dec 7. doi: 10.1038/s41372-023-01839-6. Online ahead of print.PMID: 38062158

Measurement of red cell, plasma and blood volume: Essential components of diagnostic and research studies of oxygen transport. Lichtman MA, Prchal JT.Blood Cells Mol Dis. 2023 Dec 7;105:102819. doi: 10.1016/j.bcmd.2023.102819. Online ahead of print.PMID: 38101224

A randomized, double-blinded, placebo-controlled clinical trial of sterile filtered human amniotic fluid for treatment of COVID-19. Tonna JE, Pierce J, Brintz BJ, Bardsley T, Hatton N, Lewis G, Phillips JD, Skidmore CR, Selzman CH.BMC Infect Dis. 2023 Dec 8;23(1):864. doi: 10.1186/s12879-023-08856-y.PMID: 38066442

The conducting state of TRPA1 modulates channel lateral mobility. Sampieri A, Padilla-Flores T, Thawani AR, Lam PY, Fuchter MJ, Peterson R, Vaca L.Cell Calcium. 2023 Dec;116:102800. doi: 10.1016/j.ceca.2023.102800. Epub 2023 Sep 18.PMID: 37776645

Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma. Wu Y, Chen S, Yang X, Sato K, Lal P, Wang Y, Shinkle AT, Wendl MC, Primeau TM, Zhao Y, Gould A, Sun H, Mudd JL, Hoog J, Mashl RJ, Wyczalkowski MA, Mo CK, Liu R, Herndon JM, Davies SR, Liu D, Ding X, Evrard YA, Welm BE, Lum D, Koh MY, Welm AL, Chuang JH, Moscow JA, Meric-Bernstam F, Govindan R, Li S, Hsieh J, Fields RC, Lim KH, Ma CX, Zhang H, Ding L, Chen F.Cancer Res. 2023 Dec 15;83(24):4161-4178. doi: 10.1158/0008-5472.CAN-23-0604.PMID: 38098449

A “Gold Standard” Test for Diagnosing and Quantifying Hemolysis in Neonates and Infants. Christensen RD, Bahr TM, Wong RJ, Vreman HJ, Bhutani VK, Stevenson DK.J Perinatol. 2023 Dec;43(12):1541-1547. doi: 10.1038/s41372-023-01730-4. Epub 2023 Jul 19.PMID: 37468612

Neonatal Thrombocytopenia: Factors Associated With the Platelet Count Increment Following Platelet Transfusion. Christensen RD, Bahr TM, Davenport P, Sola-Visner MC, Kelley WE, Ilstrup SJ, Ohls RK.J Pediatr. 2023 Dec;263:113666. doi: 10.1016/j.jpeds.2023.113666. Epub 2023 Aug 11.PMID: 37572863

Hyperferritinemia among very-low-birthweight infants in Thailand: a prospective cohort study. Laohajeeraphan C, Tantanate C, Christensen RD, Ngerncham S.J Perinatol. 2023 Dec 7. doi: 10.1038/s41372-023-01839-6. Online ahead of print.PMID: 38062158

Alloimmune hemolytic disease of the fetus and newborn: genetics, structure, and function of the commonly involved erythrocyte antigens. Christensen RD, Bahr TM, Ilstrup SJ, Dizon-Townson DS.J Perinatol. 2023 Dec;43(12):1459-1467. doi: 10.1038/s41372-023-01785-3. Epub 2023 Oct 17.PMID: 37848604 Review.

 

November 2023

Quantitative proteomics and RNA-sequencing of mouse liver endothelial cells identify novel regulators of BMP6 by iron. Fisher AL, Wang CY, Xu Y, Phillips S, Paulo JA, Małachowska B, Xiao X, Fendler W, Mancias JD, Babitt JL.iScience. 2023 Nov 22;26(12):108555. doi: 10.1016/j.isci.2023.108555. eCollection 2023 Dec 15.PMID: 38125029

Sexual dimorphism of osteoclast reliance on mitochondrial oxidation of energy substrates in the mouse. Song C, Valeri A, Song F, Ji X, Liao X, Marmo T, Seeley RA, Rutter J, Long F.JCI Insight. 2023 Nov 2:e174293. doi: 10.1172/jci.insight.174293. Online ahead of print.PMID: 37917194

Targeting prostacyclin: all gain with no pain? Rondina MT.Blood. 2023 Nov 2;142(18):1506-1507. doi: 10.1182/blood.2023022227.PMID: 37917084

Disuse-induced muscle fibrosis, cellular senescence, and senescence-associated secretory phenotype in older adults are alleviated during re-ambulation with metformin pre-treatment. Petrocelli JJ, McKenzie AI, de Hart NMMP, Reidy PT, Mahmassani ZS, Keeble AR, Kaput KL, Wahl MP, Rondina MT, Marcus RL, Welt CK, Holland WL, Funai K, Fry CS, Drummond MJ.Aging Cell. 2023 Nov;22(11):e13936. doi: 10.1111/acel.13936. Epub 2023 Jul 24.PMID: 37486024

The iron chaperone poly(rC)-binding protein 1 regulates iron efflux through intestinal ferroportin in mice. Wang Y, Protchenko O, Huber KD, Shakoury-Elizeh M, Ghosh MC, Philpott CC.Blood. 2023 Nov 9;142(19):1658-1671. doi: 10.1182/blood.2023020504.PMID: 37624904

Feasibility of a non-invasive method to assess fetal hemolysis in utero during the third trimester. Bahr TM, Christensen TR, Cheatham LS, Page JM, Christensen RD.J Perinatol. 2023 Nov;43(11):1437-1439. doi: 10.1038/s41372-023-01764-8. Epub 2023 Aug 31.PMID: 37653077

Serum ferritin values in neonates <29 weeks’ gestation are highly variable and do not correlate with reticulocyte hemoglobin content. Bahr TM, Tan S, Smith E, Beauman SS, Schibler KR, Grisby CA, Lowe JR, Bell EF, Laptook AR, Shankaran S, Carlton DP, Rau C, Baserga MC, Flibotte J, Zaterka-Baxter K, Walsh MC, Das A, Christensen RD, Ohls RK; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.J Perinatol. 2023 Nov;43(11):1368-1373. doi: 10.1038/s41372-023-01751-z. Epub 2023 Aug 18.PMID: 37596391

Banked term umbilical cord blood to meet the packed red blood cell transfusion needs of extremely-low-gestational-age neonates: a feasibility analysis. Christensen RD, Bahr TM, Christensen TR, Ohls RK, Krong J, Carlton LC, Henry E, Sheffield MJ, Gerday E, Ilstrup SJ, Kelley WE.J Perinatol. 2023 Nov 29. doi: 10.1038/s41372-023-01833-y. Online ahead of print.PMID: 38030793

Can Red Blood Cell and Platelet Transfusions Have a Pathogenic Role in Bronchopulmonary Dysplasia? Bahr TM, Snow GL, Christensen TR, Davenport P, Henry E, Tweddell SM, Ilstrup SJ, Yoder BA, Ohls RK, Sola-Visner MC, Christensen RD.J Pediatr. 2023 Nov 20;265:113836. doi: 10.1016/j.jpeds.2023.113836. Online ahead of print.PMID: 37992802

FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia. Dobish KK, Wittorf KJ, Swenson SA, Bean DC, Gavile CM, Woods NT, Ghosal G, Hyde RK, Buckley SM.Leukemia. 2023 Nov;37(11):2197-2208. doi: 10.1038/s41375-023-02020-w. Epub 2023 Sep 9.PMID: 37689825

Age-specific impact of type I interferons on cerebral thrombosis and inflammation. Denorme F, Andrianova I, Cody MJ, Kosaka Y, Campbell RA.Blood Adv. 2023 Nov 14;7(21):6672-6675. doi: 10.1182/bloodadvances.2023010495.PMID: 37738163

Finding a fountain of youth in the blood. Portier I, Andrianova I, Campbell RA.J Thromb Haemost. 2023 Nov 7:S1538-7836(23)00794-8. doi: 10.1016/j.jtha.2023.10.024. Online ahead of print.PMID: 37940049

Characterization of all small RNAs in and comparisons across cultured megakaryocytes and platelets of healthy individuals and COVID-19 patients. Nersisyan S, Montenont E, Loher P, Middleton EA, Campbell R, Bray P, Rigoutsos I.J Thromb Haemost. 2023 Nov;21(11):3252-3267. doi: 10.1016/j.jtha.2023.07.028. Epub 2023 Aug 7.PMID: 37558133

BOLA3 and NFU1 link mitoribosome iron-sulfur cluster assembly to multiple mitochondrial dysfunctions syndrome. Zhong H, Janer A, Khalimonchuk O, Antonicka H, Shoubridge EA, Barrientos A.Nucleic Acids Res. 2023 Nov 27;51(21):11797-11812. doi: 10.1093/nar/gkad842.PMID: 37823603

Investigating the Replacement of Carboxylates with Carboxamides to Modulate the Safety and Efficacy of Platinum(II) Thioether Cyanide Scavengers. Behymer MM, Mo H, Fujii N, Suresh V, Arzumanian AS, Chan A, Nath AK, McCain R, MacRae CA, Peterson R, Boss GR, Davisson VJ, Knipp GT.Toxicol Sci. 2023 Nov 11:kfad119. doi: 10.1093/toxsci/kfad119. Online ahead of print.PMID: 37952247

 

October 2023

Flavor of Iron at EHA2023: Novel Regulatory Mechanisms and Therapeutic Options for the Correction of Anemia. Vinchi F, Asperti M, Marques O, Nai A, Silvestri L.Hemasphere. 2023 Oct 3;7(10):e955. doi: 10.1097/HS9.0000000000000955. eCollection 2023 Oct.PMID: 37799346

The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites. Okada M, Sigala PA.PLoS Pathog. 2023 Oct 26;19(10):e1011713. doi: 10.1371/journal.ppat.1011713. eCollection 2023 Oct.PMID: 37883328

Integrating the dynamic and energetic fields of metabolism and development. Finley L, Gendron J, Miguel-Aliaga I, Rutter J.Development. 2023 Oct 15;150(20):dev202424. doi: 10.1242/dev.202424. Epub 2023 Oct 26.PMID: 37883064

Diabetes and pancreatic cancer risk in a multiracial cohort. Conway RBN, Hudson AG, Munro H, Fu D, McClain DA, Blot WJ.Diabet Med. 2023 Oct 1:e15234. doi: 10.1111/dme.15234. Online ahead of print.PMID: 37779225
Characterization of erythroferrone structural domains relevant to its iron-regulatory function. Srole DN, Jung G, Waring AJ, Nemeth E, Ganz T.J Biol Chem. 2023 Oct 20;299(12):105374. doi: 10.1016/j.jbc.2023.105374. Online ahead of print.PMID: 37866631

Placental ferroportin protein abundance is associated with neonatal erythropoietic activity and iron status in newborns at high risk for iron deficiency and anemia. Barad A, Guillet R, Pressman EK, Katzman PJ, Ganz T, Nemeth E, O’Brien KO.Am J Clin Nutr. 2023 Oct 27:S0002-9165(23)66226-4. doi: 10.1016/j.ajcnut.2023.10.022. Online ahead of print.PMID: 37890671

Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a mutation in adenylyl cyclase with trade-offs for pathogenicity. Hilbert ZA, Bednarek JM, Schwiesow MJW, Chung KY, Moreau CT, Brown JCS, Elde NC.Curr Biol. 2023 Oct 9;33(19):4136-4149.e9. doi: 10.1016/j.cub.2023.08.054. Epub 2023 Sep 13.PMID: 37708888

Exploiting Differences in Heme Biosynthesis between Bacterial Species to Screen for Novel Antimicrobials. Jackson LK, Dailey TA, Anderle B, Warren MJ, Bergonia HA, Dailey HA, Phillips JD.Biomolecules. 2023 Oct 6;13(10):1485. doi: 10.3390/biom13101485.PMID: 37892169

Reciprocal stabilization of coagulation factor XIII-A and -B subunits determines plasma FXIII concentration. Byrnes JR, Lee TK, Sharaby S, Campbell RA, Dobson D, Holle LA, Luo M, Kangro K, Homeister J, Aleman MM, Luyendyk JP, Kerlin BA, Dumond JB, Wolberg AS.Blood. 2023 Oct 26:blood.2023022042. doi: 10.1182/blood.2023022042. Online ahead of print.PMID: 37883802

Platelets net neutrophils during ALI. Denorme F, Campbell RA.Blood. 2023 Oct 26;142(17):1409-1410. doi: 10.1182/blood.2023021641.PMID: 37883112

Dynamic Evolution of Bacterial Ligand Recognition by Formyl Peptide Receptors. Paterson NM, Al-Zubieri H, Ragona J, Kohler KM, Tirado J, Geisbrecht BV, Barber MF.Genome Biol Evol. 2023 Oct 6;15(10):evad175. doi: 10.1093/gbe/evad175.PMID: 37776517

 

September 2023

Phase 1/2 study of sorafenib added to cladribine, high-dose cytarabine, G-CSF, and mitoxantrone in untreated AML. Halpern AB, Rodríguez-Arbolí E, Othus M, Garcia KA, Percival MM, Cassaday RD, Oehler VG, Becker PS, Appelbaum JS, Abkowitz JL, Orozco JJ, Keel SB, Hendrie PC, Scott BL, Ghiuzeli MC, Estey EH, Walter RB.Blood Adv. 2023 Sep 12;7(17):4950-4961. doi: 10.1182/bloodadvances.2023010392.PMID: 37339483

Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a mutation in adenylyl cyclase with trade-offs for pathogenicity. Hilbert ZA, Bednarek JM, Schwiesow MJW, Chung KY, Moreau CT, Brown JCS, Elde NC.Curr Biol. 2023 Sep 8:S0960-9822(23)01134-X. doi: 10.1016/j.cub.2023.08.054. Online ahead of print.PMID: 37708888

The transcriptomic landscape of normal and ineffective erythropoiesis at single-cell resolution. Doty RT, Lausted CG, Munday AD, Yang Z, Yan X, Meng C, Tian Q, Abkowitz JL.Blood Adv. 2023 Sep 12;7(17):4848-4868. doi: 10.1182/bloodadvances.2023010382.PMID: 37352261

Platelet mitochondria: the mighty few. Ajanel A, Campbell RA, Denorme F.Curr Opin Hematol. 2023 Sep 1;30(5):167-174. doi: 10.1097/MOH.0000000000000772. Epub 2023 Jul 17.PMID: 37459354

The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes. Denorme F, Armstrong ND, Stoller ML, Portier I, Tugolukova EA, Tanner RM, Montenont E, Bhatlekar S, Cody M, Rustad JL, Ajanel A, Tolley ND, Murray DC, Boyle JL, Nieman MT, McKenzie SE, Yost CC, Lange LA, Cushman M, Irvin MR, Bray PF, Campbell RA.J Clin Invest. 2023 Sep 15;133(18):e169608. doi: 10.1172/JCI169608.PMID: 37471144

Animal FAS-like polyketide synthases produce diverse polypropionates. Li F, Lin Z, Krug PJ, Catrow JL, Cox JE, Schmidt EW.Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2305575120. doi: 10.1073/pnas.2305575120. Epub 2023 Sep 11.PMID: 37695909

 

August 2023

Microbe transmission from pet shop to lab-reared zebrafish reveals a pathogenic birnavirus. Rice MC, Elde NC, Gagnon JA, Balla KM.bioRxiv. 2023 Aug 28:2023.08.28.555169. doi: 10.1101/2023.08.28.555169. Preprint.PMID: 37693489 Free PMC article.

Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity. Boys IN, Johnson AG, Quinlan MR, Kranzusch PJ, Elde NC.Cell Rep. 2023 Aug 29;42(8):112878. doi: 10.1016/j.celrep.2023.112878. Epub 2023 Jul 25.PMID: 37494187

Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. Zhang S, Williams KJ, Verlande-Ferrero A, Chan AP, Su GB, Kershaw EE, Cox JE, Maschek JA, Shapira SN, Christofk HR, de Aguiar Vallim TQ, Masri S, Villanueva CJ.J Lipid Res. 2023 Aug 26:100434. doi: 10.1016/j.jlr.2023.100434. Online ahead of print.PMID: 37640283

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease. Ocañas SR, Pham KD, Cox JEJ, Keck AW, Ko S, Ampadu FA, Porter HL, Ansere VA, Kulpa A, Kellogg CM, Machalinski AH, Thomas MA, Wright Z, Chucair-Elliott AJ, Freeman WM.J Neuroinflammation. 2023 Aug 16;20(1):188. doi: 10.1186/s12974-023-02870-2.PMID: 37587511 Free PMC article.

Feasibility of a non-invasive method to assess fetal hemolysis in utero during the third trimester. Bahr TM, Christensen TR, Cheatham LS, Page JM, Christensen RD.J Perinatol. 2023 Aug 31. doi: 10.1038/s41372-023-01764-8. Online ahead of print.PMID: 37653077 No abstract available.

Serum ferritin values in neonates <29 weeks’ gestation are highly variable and do not correlate with reticulocyte hemoglobin content. Bahr TM, Tan S, Smith E, Beauman SS, Schibler KR, Grisby CA, Lowe JR, Bell EF, Laptook AR, Shankaran S, Carlton DP, Rau C, Baserga MC, Flibotte J, Zaterka-Baxter K, Walsh MC, Das A, Christensen RD, Ohls RK; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.J Perinatol. 2023 Aug 18. doi: 10.1038/s41372-023-01751-z. Online ahead of print.PMID: 37596391

Neonatal Thrombocytopenia: Factors Associated With the Platelet Count Increment Following Platelet Transfusion. Christensen RD, Bahr TM, Davenport P, Sola-Visner MC, Kelley WE, Ilstrup SJ, Ohls RK.J Pediatr. 2023 Aug 11;263:113666. doi: 10.1016/j.jpeds.2023.113666. Online ahead of print.PMID: 37572863

Lactate modulates iron metabolism by binding soluble adenylyl cyclase. Liu W, Zhang S, Li Q, Wu Y, Jia X, Feng W, Li Z, Shi Y, Hou Q, Ma J, Liu Y, Gao P, Ganz T, Liu S.Cell Metab. 2023 Sep 5;35(9):1597-1612.e6. doi: 10.1016/j.cmet.2023.06.017. Epub 2023 Jul 21.PMID: 37480842

Increased transferrin protects from thrombosis in Chuvash erythrocytosis. Shah BN, Zhang X, Sergueeva AI, Miasnikova GY, Ganz T, Prchal JT, Gordeuk VR.Am J Hematol. 2023 Oct;98(10):1532-1539. doi: 10.1002/ajh.27021. Epub 2023 Jul 12.PMID: 37435906

Increased blood reactive oxygen species and hepcidin in obstructive sleep apnea precludes expected erythrocytosis. Song J, Sundar KM, Horvathova M, Gangaraju R, Indrak K, Christensen RD, Genzor S, Lundby C, Divoky V, Ganz T, Prchal JT.Am J Hematol. 2023 Aug;98(8):1265-1276. doi: 10.1002/ajh.26992. Epub 2023 Jun 23.PMID: 37350302

Iron Homeostasis During Pregnancy: Maternal, Placental, and Fetal Regulatory Mechanisms. Sangkhae V, Fisher AL, Ganz T, Nemeth E.Annu Rev Nutr. 2023 Aug 21;43:279-300. doi: 10.1146/annurev-nutr-061021-030404. Epub 2023 May 30.PMID: 37253681

Evidence that the catalytic mechanism of heme a synthase involves the formation of a carbocation stabilized by a conserved glutamate. Rivett ED, Addis HG, Dietz JV, Carroll-Deaton JA, Gupta S, Foreman KL, Dang MA, Fox JL, Khalimonchuk O, Hegg EL.Arch Biochem Biophys. 2023 Aug;744:109665. doi: 10.1016/j.abb.2023.109665. Epub 2023 Jun 20.PMID: 37348627

The complex relationship between iron status and anemia in pregnant and postpartum women in India: Analysis of two Indian study cohorts of uncomplicated pregnancies. Nair M, Choudhury SS, Rani A, Solomi C 5th, Kakoty SD, Medhi R, Rao S, Mahanta P, Zahir F, Roy I, Chhabra S, Deka G, Minz B, Deka R, Opondo C, Churchill D, Lakhal-Littleton S, Nemeth E; MaatHRI collaboration.Am J Hematol. 2023 Aug 31. doi: 10.1002/ajh.27059. Online ahead of print.PMID: 37651649

The iron chaperone poly C binding protein 1 regulates iron efflux through intestinal ferroportin in mice. Wang Y, Protchenko O, Duck Huber K, Shakoury-Elizeh M, Ghosh MC, Philpott CC.Blood. 2023 Aug 25:blood.2023020504. doi: 10.1182/blood.2023020504. Online ahead of print.PMID: 37624904

Cardiac gene therapy rescues diabetic cardiomyopathy and lowers blood glucose. Li J, Richmond B, Cluntun AA, Bia R, Walsh MA, Shaw K, Symons JD, Franklin S, Rutter J, Funai K, Shaw RM, Hong T.JCI Insight. 2023 Aug 24:e166713. doi: 10.1172/jci.insight.166713. Online ahead of print.PMID: 37639557

Ceramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk. Li Y, Chaurasia B, Rahman MM, Kaddai V, Maschek JA, Berg JA, Wilkerson JL, Mahmassani ZS, Cox J, Wei P, Meikle PJ, Atkinson D, Wang L, Poss AM, Playdon MC, Tippetts TS, Mousa EM, Nittayaboon K, Babu PVA, Drummond MJ, Clevers H, Shayman JA, Hirabayashi Y, Holland WL, Rutter J, Edgar B, Summers SA.Gastroenterology. 2023 Aug 2:S0016-5085(23)04837-0. doi: 10.1053/j.gastro.2023.07.017. Online ahead of print.PMID: 37541526

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. Tsai JM, Aguirre JD, Li YD, Brown J, Focht V, Kater L, Kempf G, Sandoval B, Schmitt S, Rutter JC, Galli P, Sandate CR, Cutler JA, Zou C, Donovan KA, Lumpkin RJ, Cavadini S, Park PMC, Sievers Q, Hatton C, Ener E, Regalado BD, Sperling MT, Słabicki M, Kim J, Zon R, Zhang Z, Miller PG, Belizaire R, Sperling AS, Fischer ES, Irizarry R, Armstrong SA, Thomä NH, Ebert BL.Mol Cell. 2023 Aug 3;83(15):2753-2767.e10. doi: 10.1016/j.molcel.2023.06.028. Epub 2023 Jul 20.PMID: 37478846

Oct4 redox sensitivity potentiates reprogramming and differentiation. Shen Z, Wu Y, Manna A, Evason KJ, Chandrasekharan MB, Tantin D.bioRxiv. 2023 Aug 24:2023.02.21.529404. doi: 10.1101/2023.02.21.529404. Preprint.PMID: 36865286

 

July 2023

Mon1a and FCHO2 are required for maintenance of Golgi architecture. Bagley DC, Morham SG, Kaplan J, Ward DM.bioRxiv. 2023 Jul 7:2023.07.06.547837. doi: 10.1101/2023.07.06.547837. Preprint.PMID: 37461455

Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4. Miljkovic M, Seguin A, Jia X, Cox JE, Catrow JL, Bergonia H, Phillips JD, Stephens WZ, Ward DM.J Biol Chem. 2023 Jul;299(7):104877. doi: 10.1016/j.jbc.2023.104877. Epub 2023 Jun 1.PMID: 37269954

Disuse-induced muscle fibrosis, cellular senescence, and senescence-associated secretory phenotype in older adults are alleviated during re-ambulation with metformin pre-treatment. Petrocelli JJ, McKenzie AI, de Hart NMMP, Reidy PT, Mahmassani ZS, Keeble AR, Kaput KL, Wahl MP, Rondina MT, Marcus RL, Welt CK, Holland WL, Funai K, Fry CS, Drummond MJ.Aging Cell. 2023 Jul 24:e13936. doi: 10.1111/acel.13936. Online ahead of print.PMID: 37486024

Actin-bundling protein L-plastin promotes megakaryocyte rigidity and dampens proplatelet formation. Guo L, Jacob S, Manne BK, Kolawole EM, Guo S, Wang X, Murray D, Tugolukova EA, Portier I, Kosaka Y, Barba C, Rondina MT, Evavold B, Morley C, Bhatlekar S, Bray PF.Haematologica. 2023 Jul 13. doi: 10.3324/haematol.2023.283016. Online ahead of print.PMID: 37439340

Notes from the Underground: Heme Homeostasis in C. elegans. Chen C, Hamza I.Biomolecules. 2023 Jul 19;13(7):1149. doi: 10.3390/biom13071149.PMID: 37509184

Mitochondrial-Derived Compartments are Multilamellar Domains that Encase Membrane Cargo and Cytosol. Wilson ZN, West M, English AM, Odorizzi G, Hughes AL.bioRxiv. 2023 Jul 7:2023.07.07.548169. doi: 10.1101/2023.07.07.548169. Preprint.PMID: 37461645

Placental Erythroferrone and Erythropoietin mRNA Expression is not Associated with Maternal or Neonatal Iron Status in Adolescents Carrying Singletons and Adult Women Carrying Multiples. Delaney KM, Barad A, Castillo LF, Hasund CM, Guillet R, Pressman EK, Katzman PJ, Ganz T, Nemeth E, O’Brien KO.J Nutr. 2023 Jul;153(7):1950-1958. doi: 10.1016/j.tjnut.2023.05.023. Epub 2023 May 28.PMID: 37253412

Inhibition of skeletal muscle Lands cycle ameliorates weakness induced by physical inactivity. Shahtout JL, Eshima H, Ferrara PJ, Maschek JA, Cox JE, Drummond MJ, Funai K.bioRxiv. 2023 Jul 28:2023.07.25.550576. doi: 10.1101/2023.07.25.550576. Preprint.PMID: 37546754

Rapid Evolution of Glycan Recognition Receptors Reveals an Axis of Host-Microbe Arms Races beyond Canonical Protein-Protein Interfaces. Hilbert ZA, Haffener PE, Young HJ, Schwiesow MJW, Leffler EM, Elde NC.Genome Biol Evol. 2023 Jul 3;15(7):evad119. doi: 10.1093/gbe/evad119.PMID: 37390614

Concurrent profiling of multiscale 3D genome organization and gene expression in single mammalian cells. Zhou T, Zhang R, Jia D, Doty RT, Munday AD, Gao D, Xin L, Abkowitz JL, Duan Z, Ma J.bioRxiv. 2023 Jul 25:2023.07.20.549578. doi: 10.1101/2023.07.20.549578. Preprint.PMID: 37546900

BMP5 contributes to hepcidin regulation and systemic iron homeostasis in mice. Xiao X, Xu Y, Moschetta GA, Yu Y, Fisher AL, Alfaro-Magallanes VM, McMillen S, Phillips S, Wang CY, Christian J, Babitt JL.Blood. 2023 Jul 21:blood.2022019195. doi: 10.1182/blood.2022019195. Online ahead of print.PMID: 37478395

Both maternal IFNγ exposure and acute prenatal infection with Toxoplasma gondii activate fetal hematopoietic stem cells. López DA, Otsuka KS, Apostol AC, Posada J, Sánchez-Arcila JC, Jensen KD, Beaudin AE. EMBO J. 2023 Jul 17;42(14):e112693. doi: 10.15252/embj.2022112693. Epub 2023 Jun 1.PMID: 37259639

Renin-Angiotensin System Components and Arachidonic Acid Metabolites as Biomarkers of COVID-19. Ghimire B, Pour SK, Middleton E, Campbell RA, Nies MA, Aghazadeh-Habashi A.Biomedicines. 2023 Jul 27;11(8):2118. doi: 10.3390/biomedicines11082118.PMID: 37626615

Role of Anemia in Dementia Risk Among Veterans With Incident CKD. Koyama AK, Nee R, Yu W, Choudhury D, Heng F, Cheung AK, Norris KC, Cho ME, Yan G.Am J Kidney Dis. 2023 Jul 27:S0272-6386(23)00735-7. doi: 10.1053/j.ajkd.2023.04.013. Online ahead of print.PMID: 37516301

A “Gold Standard” Test for Diagnosing and Quantifying Hemolysis in Neonates and Infants. Christensen RD, Bahr TM, Wong RJ, Vreman HJ, Bhutani VK, Stevenson DK.J Perinatol. 2023 Jul 19. doi: 10.1038/s41372-023-01730-4. Online ahead of print.PMID: 37468612 Review.

Associations between blood donor sex and age, and outcomes of transfused newborn infants. Bahr TM, Christensen TR, Tweddell SM, Henry E, Rees T, Astin ME, Kelley WE, Ilstrup SJ, Ohls RK, Christensen RD.Transfusion. 2023 Jul;63(7):1290-1297. doi: 10.1111/trf.17417. Epub 2023 May 22.PMID: 37218104

 

June 2023

Iron Parameters in Patients Treated with Roxadustat for Anemia of Chronic Kidney Disease. Ganz T, Locatelli F, Arici M, Akizawa T, Reusch M.J Clin Med. 2023 Jun 22;12(13):4217. doi: 10.3390/jcm12134217.PMID: 37445252

Diagnosing Anemia in Neonates: An Evidence-Based Approach. Christensen RD, Bahr TM, Tweddell SM, Ohls RK, Henry E.Neoreviews. 2023 Jun 1;24(6):e343-e355. doi: 10.1542/neo.24-6-e343.PMID: 37258503 Review.

 

May 2023

Novel anemia therapies in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Ku E, Del Vecchio L, Eckardt KU, Haase VH, Johansen KL, Nangaku M, Tangri N, Waikar SS, Więcek A, Cheung M, Jadoul M, Winkelmayer WC, Wheeler DC, Babitt JL; for Conference Participants.Kidney Int. 2023 May 24:S0085-2538(23)00379-4. doi: 10.1016/j.kint.2023.05.009. Online ahead of print.PMID: 37236424

2022 Publications

2021 Publications

2020 Publications

2019 Publications

2018 Publications